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Minhas, Sachin,Bhalla, Sunita,Shokeen, Yogender,Jauhri, Mayank,Saxena, Renu,Verma, Ishwar Chandra,Aggarwal, Shyam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important protein involved in the regulation of the immune system. The +49 G/A polymorphism is the only genetic variation in the CTLA-4 gene that causes an amino acid change in the resulting protein. It is therefore the most extensively studied polymorphism among all CTLA-4 genetic variants and contributions to increasing the likelihood of developing cancer are well known in various populations, especially Asians. However, there have hiterto been no data with respect to the effect of this polymorphism on breast cancer susceptibility in our North Indian population. We therefore assayed genomic DNA of 250 breast cancer subjects and an equal number of age-, sex- and ethnicity-matched healthy controls for the CTLA-4 +49 G/A polymorphism but no significant differences in either the gene or allele frequency were found. Thus the CTLA-4 +49 G/A polymorphism may be associated with breast cancer in other Asians, but it appears to have no such effect in North Indians. The study also highlights the importance of conducting genetic association studies in different ethnic populations.
The Impact of Network Coding Cluster Size on Approximate Decoding Performance
( Minhae Kwon ),( Hyunggon Park ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.3
In this paper, delay-constrained data transmission is considered over error-prone networks. Network coding is deployed for efficient information exchange, and an approximate decoding approach is deployed to overcome potential all-or-nothing problems. Our focus is on determining the cluster size and its impact on approximate decoding performance. Decoding performance is quantified, and we show that performance is determined only by the number of packets. Moreover, the fundamental tradeoff between approximate decoding performance and data transfer rate improvement is analyzed; as the cluster size increases, the data transfer rate improves and decoding performance is degraded. This tradeoff can lead to an optimal cluster size of network coding-based networks that achieves the target decoding performance of applications. A set of experiment results confirms the analysis.
Multi-Target Radar Tracking Estimation Algorithm for Automotive Embedded Applications
Minha Park,Seunghwan Seo,Gyutae Jung,Kukki Im 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
This paper presents tracking estimation algorithm and its feasibility analysis in computation load for the situation of multi-target automotive radar applications. Tracking algorithms have been evolved for many decades and played very important roles in space, military, and civilian sectors. Among many tracking methods, it is very critical task to utilize the most appropriate approach for each target application because there is always trade-off among performance, robustness, the computation load and etc. In the automotive world, unlike space and military industries, more constraints like cost and size should be taken into account in development within a certain limited time frame. Among them, the computation load is very significant in real-time embedded applications because the more computation capability is totally proportional to the cost increase of the system indeed. Based on literature researches and simulations, a couple of Kalman Filters were proposed as multi-target radar tracking estimation method and simulated and both elapsed time in simulation environments and in target board were compared and analyzed. As the system needs better performance and robustness in all situations, it will require more computation load in the processor resulting in the higher cost to the end. In the further research, the computation load should be analyzed in more details to adopt the most appropriate model for the specific application.
Minhas, Atul S.,Jeong, Woo Chul,Kim, Young Tae,Han, Yeqing,Kim, Hyung Joong,Woo, Eung Je Wiley Subscription Services, Inc., A Wiley Company 2011 Magnetic resonance in medicine Vol.66 No.4
<P><B>Abstract</B></P><P>Latest experimental results in magnetic resonance electrical impedance tomography (MREIT) demonstrated high‐resolution in vivo conductivity imaging of animal and human subjects using imaging currents of 5 to 9 mA. Externally injected imaging currents induce magnetic flux density distributions, which are affected by a conductivity distribution. Since we extract the induced magnetic flux density images from MR phase images, it is essential to reduce noise in the phase images. In vivo human and disease model animal experiments require reduction of imaging current amplitudes and scan times. In this article, we investigate a multi‐echo based MREIT pulse sequence where we utilize a remaining time after the first echo within one TR to obtain more echo signals. It also allows us to prolong the total current injection time. From phantom and animal imaging experiments, we found that this method significantly reduces the noise level in measured magnetic flux density images. We describe experimental validation of the multi‐echo sequence by comparing its performance with a single‐echo method using 3 mA imaging currents. The proposed method will be advantageous for an imaging region with long T2 values such as the brain and knee. Depending on T2 values, we suggest using two or three echoes in future experimental studies. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.</P>
Minha Hong,Young Sik Lee,Bongseog Kim,Yoo Sook Joung,Hanik K Yoo,Eui-Jung Kim,Soyoung Irene Lee,Soo Young Bhang,Seung Yup Lee,Doughyun Han,Geon Ho Bahn 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.3
Objectives: This study was conducted to re-validate the clinical efficacy of the Korean Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Rating Scale (K-AARS), which is a self-report scale for ADHD in adults, and to determine the clinical utility and cut-off scores of K-AARS. Methods: The participants were 135 drug naïve adults with ADHD and 144 healthy controls. To diagnose ADHD based on the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, two board-certified pediatric psychiatrists interviewed the participants and completed the Mini International Neuropsychiatric Interview. K-AARS was applied to all participants. K-AARS comprises six clinical subscales, one impairment subscale, and one driving behavior subscale. The receiver operating characteristic analysis was conducted to calculate the cut-off scores of K-AARS. Results: All subscale scores, including six clinical subscale, impairment subscale, and driving behavior subscale scores, were found to be significant in distinguishing adults with ADHD from healthy controls. The sensitivity and specificity of the six clinical subscales were 63.0–77.0% and 66.7–79.9%, respectively. The combined total score of the six clinical subscales, had a sensitivity of 80.0% and specificity of 79.9%. Conclusion: The discriminative power of K-AARS for the diagnosis of ADHD in adults was excellent, and K-AARS and the empirical diagnosis of adults can be useful in diagnosing ADHD in adulthood.
Minha Hong,Seung-Yup Lee,Young Sik Lee,Bongseog Kim,Yoo Sook Joung,Hanik K Yoo,Eui-Jung Kim,Soyoung Irene Lee,Su-Bin Park,Soo-Young Bhang,Doughyun Han,Geon Ho Bahn 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.3
Objectives: Awareness of attention-deficit/hyperactivity disorder (ADHD) in adults has significantly increased; however, clinical data specific to the Korean population are insufficient. Clinical experience of ADHD may differ based on whether psychiatrists have received pediatric psychiatry-specific training. In order to prepare a practice parameter for adult ADHD patients in Korea, we examined questionnaire data to observe how pediatric psychiatry training could affect clinical practice for adults with ADHD. Methods: A questionnaire about the diagnosis and treatment process was distributed to both general psychiatrists (GPsy) and child and adolescent psychiatrists (CAP) at the summer and winter workshop meetings of Korean Academy of Child and Adolescent Psychiatry. Results: In total, 142 psychiatrists participated in the survey (86 GPsy, 56 CAP). GPsy and CAP preferred pharmacotherapy (GPsy 82.40%, CAP 64.30%) as the primary treatment option and answered that the clinical psychiatric interview is the most necessary step in diagnostic assessment (GPsy 22.16%, CAP 19.00%). The GPsy responded with an optimal and average treatment duration that was shorter than that reported by CAP. Conclusion: Identification of the initial presenting symptom as the correct diagnosis and the optimal duration of pharmacotherapy differed between GPsy and CAP in practice, whereas concepts in diagnosis and treatment of ADHD in adults were similar for both groups. These results suggest the urgent need for the Continuing Medical Education program for psychiatrists treating adults with ADHD.