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Kang, Seong Jae,Jeong, Hwa Yeon,Kim, Min Woo,Jeong, In Ho,Choi, Moon Jung,You, Young Myoung,Im, Chan Su,Song, In Ho,Lee, Tae Sup,Park, Yong Serk The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.41
<P>Cancer theranosis is an emerging field of personalized medicine which enables individual anti-cancer treatment by monitoring the therapeutic responses of cancer patients. Based on a consideration of the nano-bio interactions related to the blood circulation of systemically administered nanoparticles in humans, as well as extravasation and active targeting, lipid micellar nanoparticles were co-loaded with paclitaxel (PTX) and quantum dots (QDs) to generate a theranostic delivery vehicle. To provide with a tumor-targeting capability, either an antibody or an aptamer against the epidermal growth factor receptor (EGFR) was conjugated to the micelle surface. The QD-containing micelles (QDMs), antibody-coupled QDMs (immuno-QDMs), and aptamer-coupled QDMs (aptamo-QDMs) were able to effectively circulate in blood for at least 8 h when administered intravenously into mice bearing EGFR-positive LS174T tumor xenografts. <I>In vivo</I> fluorescence imaging and a bio-distribution study showed that both the immuno-QDMs and aptamo-QDMs were largely localized in the tumor tissue. The tumor targeting capability enhanced the therapeutic efficacy of PTX for the target cancer cells. Both the immuno-PTX-QDMs and the aptamo-PTX-QDMs caused a stronger inhibition of LS174T tumor growth in mice, compared to the non-targeted PTX-QDMs. These results suggest that the anti-EGFR immuno-PTX-QDMs and anti-EGFR aptamo-PTX-QDMs could be utilized as a tumor-targeted theranostic delivery system for cancer treatment in the clinic.</P>
Kang Uk Kim,Kyung Min Kim,Yong-Ho Choi,Byung-Serk Hurh,IN HYUNG LEE 한국미생물학회 2019 The journal of microbiology Vol.57 No.10
Aspergillus sojae is a koji (starter) mold that has been applied for food fermentation in Asia. The whole genome of A. sojae SMF 134, which was isolated from meju (Korean soybean fermented brick), was analyzed at the genomic level to evaluate its potential as a starter for soybean fermentation. The genome size was 40.1 Mbp, which was expected to be composed of eight chromosomes with 13,748 ORFs. Strain SMF 134 had a total of 151 protease genes, among which two more leucine aminopeptidase (lap) genes were found in addition to the previously known lap1, and three γ-glutamyltranspeptidase (ggt) genes were newly identified. Such genomic characteristics of SMF 134 with many protease and flavor-related (lap and ggt) genes support its merits as a starter for soybean fermentation. In addition, this first complete genome of A. sojae will allow for further genetic studies to better understand the production of various enzymes, including proteases, LAPs, and GGTs, as well as other characteristics as a starter mold for soybean fermentation.
AN EFFECTIVE RHODIUM CATALYST SYSTEM ON THE SYNTHESIS OF ACETIC ACID FROM METHYL FORMATE
Cheong, Min Serk,Kang, Hyun Ju 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.3
Rh/LiI/SnR₄ is an effective catalyst system for the conversion of methyl formate to acetic acid under carbon monoxide pressure. The effects of solvent and initial CO partial pressure on the turnover rate of the reaction were investigated. The possibility of replacing some of the iodide promoters by tin compounds has been probed.
An Effective Rhodium Catalyst System on the Synthesis of Acetic Acid from Methyl Formate
Cheong, Min Serk,Kang, Hyun Ju 한국화학공학회 1995 NICE Vol.13 No.6
Rh/LiI/SnR₄ is an effective catalyst system for the conversion of methyl formate to acetic acid under carbon monoxide pressure. The effects of solvent and initial CO partial pressure on the turnover rate of the reaction were investigated. The possibility of replacing some of the iodide promoters by tin compounds has been probed.
Palgunadi, Jelliarko,Kang, Je-Eun,Cheong, Min-Serk,Kim, Hong-Gon,Lee, Hyun-Joo,Kim, Hoon-Sik Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.8
Solubilities of carbon dioxide (C$O_2$) in a series of fluorine-free room temperature ionic liquids (RTILs), dialkylimidazolium dialkylphosphates and dialkylimidazolium alkylphosphites, were measured at 313∼333 K and pressures up to 5 MPa. Henry’s law coefficients as the solubility parameter of C$O_2$ in RTILs were derived from the isotherm of fugacity versus C$O_2$ mole fraction. The C$O_2$ solubility in a phosphorus-containing RTIL was found to increase with the increasing molar volume of the RTIL. In general, dialkylimidazolium dialkylphosphate exhibited higher absorption capacity than dialkylimidazolium alkylphosphite as long as the RTILs possess an identical cation. Among RTILs tested, 1-butyl-3-methylimidazolium dibutylphosphate [BMIM][B$u_2PO_4$] and 1-butyl-3-methylimidazolium butylphosphite [BMIM][BuHP$O_3$] exhibited similar Henry’s law coefficients to 1-butyl-3-methylimidazolium bis (trifluoromethylsulfonyl)imide ([BMIM][T$f_2$N]) and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][B$F_4$]), respectively. The Krichevsky-Kasarnovsky equation was employed to derive the C$O_2$ solubility parameter (Henry’s law coefficient) from the solubility data measured at elevated pressures.
Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles
Kim, Jung Seok,Kim, Min Woo,Kang, Seong Jae,Jeong, Hwa Yeon,Park, Sang Il,Lee, Yeon Kyung,Kim, Hong Sung,Kim, Keun Sik,Park, Yong Serk Dove Medical Press 2018 International journal of nanomedicine Vol.13 No.-
<P><B>Background</B></P><P>Efficient target-specific siRNA delivery has always been a primary concern in the field of siRNA clinical application.</P><P><B>Purpose</B></P><P>In this study, four different types of anti-epidermal growth factor receptor (EGFR) antibody-conjugated immunonanoparticles were prepared and tested for cancer cell-targeted therapeutic siRNA delivery.</P><P><B>Materials and methods</B></P><P>The prepared nanoparticles encapsulating siRNAs were character-ized by gel retardation and particle analysis using a Zetasizer. In vitro transfection and reduction of target genes, vimentin and JAK3, were determined using quantitative reverse transcription polymerase chain reaction. In vivo tumor targeting and antitumoral efficacies of the nanoparticles were evaluated in mice carrying tumors.</P><P><B>Results</B></P><P>Among these immunonanoparticles, anti-EGFR immunolipoplexes and immunoviroplexes exhibited remarkable cell binding and siRNA delivery to EGFR-expressing tumor cells compared to immunoliposomes and immunovirosomes. Especially, the anti-EGFR immunoviroplexes exhibited the most efficient siRNA transfection to target tumor cells. Therefore, antitumoral vimentin and Janus kinase-3 siRNAs were loaded in the anti-EGFR immunolipoplexes and immunoviroplexes, which were tested in mice carrying SK-OV-3 tumor xenografts. In fact, the therapeutic siRNAs were efficiently delivered to the tumor tissues by both delivery vehicles, resulting in significant inhibition of tumor growth. Moreover, administration of doxorubicin in combination with anti-EGFR immunoviroplexes resulted in remarkable and synergistic tumor growth inhibition.</P><P><B>Conclusion</B></P><P>This study provides experimental proof that cancer cell-targeted immunoviroplexes are an efficient siRNA delivery system for cancer therapy. Moreover, this study also suggests that a combination of conventional chemotherapy and tumor-directed anticancer siRNA therapy would be a better modality for cancer treatment.</P>