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새로운 Acetylcholinesterase inhibitors의 합성
최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1
노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.
[P5-34] Monitoring of Vibrio parahaemolyticus Contaminated Level in Fishery Products, Korea, 2006
Yeong-Min Sin,Jong Mi Lim,Seung Hwan Kim,Soon Han Kim,Chang Yong Yoon,Kil Jin Kang,In Sun Joo,Ok Soon Heo,Kun-Sang Park,Ok Hee Kim,Dae Hyun Cho,Dai Byung Kim 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10
Kim, Hwan-Young,Kim, Hye-Ran,Kang, Min-Gu,Trang, Nguyen Thi Dai,Baek, Hee-Jo,Moon, Jae-Dong,Shin, Jong-Hee,Suh, Soon-Pal,Ryang, Dong-Wook,Kook, Hoon,Shin, Myung-Geun Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-
<P>This study investigated the profiling of polycyclic aromatic hydrocarbon- (PAH-) induced genotoxicity in cell lines and zebrafish. Each type of cells displayed different proportionality of apoptosis. Mitochondrial DNA (mtDNA) copy number was dramatically elevated after 5-day treatment of fluoranthene and pyrene. The notable deregulated proteins for PAHs exposure were displayed as follows: lamin-A/C isoform 3 and annexin A1 for benzopyrene; lamin-A/C isoform 3 and DNA topoisomerase 2-alpha for pentacene; poly[ADP-ribose] polymerase 1 (PARP-1) for fluoranthene; and talin-1 and DNA topoisomerase 2-alpha for pyrene. Among them, lamin-A/C isoform 3 and PARP-1 were further confirmed using mRNA and protein expression study. Obvious morphological abnormalities including curved backbone and cardiomegaly in zebrafish were observed in the 54 hpf with more than 400 nM of benzopyrene. In conclusion, the change of mitochondrial genome (increased mtDNA copy number) was closely associated with PAH exposure in cell lines and mesenchymal stem cells. Lamin-A/C isoform 3, talin-1, and annexin A1 were identified as universal biomarkers for PAHs exposure. Zebrafish, specifically at embryo stage, showed suitable <I>in vivo</I> model for monitoring PAHs exposure to hematopoietic tissue and other organs.</P>
Continuous Pretilt Angle Controlled No-Bias-Bend Pi Cell via Blended Polyimide Liquid Crystal System
Kim, Dai-Hyun,Park, Hong-Gyu,Kim, Young-Hwan,Kim, Byoung-Yong,Ok, Chul-Ho,Hwang, Jeong-Yeon,Han, Jeong-Min,Park, Yong-Pil,Seo, Dae-Shik Informa UK (TaylorFrancis) 2010 Molecular Crystals and Liquid Crystals Vol.529 No.1
Le, Dai,Lim, Soyeon,Min, Kwang Wook,Park, Joon Woo,Kim, Youjoung,Ha, Taejeong,Moon, Kyeong Hwan,Wagner, Kay-Uwe,Kim, Jin Woo Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.3
The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking. Thus, we deleted tumor susceptibility gene 101 (Tsg101), a key component of endosomal sorting complexes required for transport (ESCRT), in embryonic and mature RPE to determine whether ESCRT-mediated endocytic protein trafficking correlated with the establishment and maintenance of RPE polarity. Loss of Tsg101 severely disturbed the polarity of RPE, which forms irregular aggregates exhibiting non-polarized distribution of cell adhesion proteins and activation of epidermal growth factor receptor signaling. These findings suggest that ESCRT-mediated protein trafficking is essential for the development and maintenance of RPE cell polarity.