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Milman, Boris L.,Zhurkovich, Inna K. Korean Society for Mass Spectrometry 2018 Mass spectrometry letters Vol.9 No.3
The number of matched peaks (NMP) is estimated as the spectral similarity measure in tandem mass spectral library searches of small molecules. In the high resolution mode, NMP provides the same reliable identification as in the case of a common dot-product function. Corresponding true positive rates are ($94{\pm}3$) % and ($96{\pm}3$) %, respectively.
Milman, Boris L.,Ostrovidova, Ekaterina V.,Zhurkovich, Inna K. Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.3
Algorithms and software for predicting tandem mass spectra have been developed in recent years. In this work, we explore how distinct in silico $MS^2$ spectra are predicted for isomers, i.e. compounds having the same formula and similar molecular structures, to differentiate between them. We used the CFM-ID 2.0/3.0 predictor with regard to (a) test compounds, whose experimental mass spectra had been randomly sampled from the MassBank of North America (MoNA) collection, and to (b) the most widespread isomers of test compounds searched in the PubChem database. In the first validation test, in silico mass spectra constitute a reference library, and library searches are performed for test experimental spectra of "unknowns". The searches led to the true positive rate (TPR) of ($46-48{\pm}10$)%. In the second test, in silico and experimental spectra were interchanged and this resulted in a TPR of ($58{\pm}10$)%. There were no significant differences between results obtained with different metrics of spectral similarity and predictor versions. In a comparison of test compounds vs. their isomers, a statistically significant correlation between mass spectral data and structural features was observed. The TPR values obtained should be regarded as reasonable results for predicting tandem mass spectra of related chemical structures.
Proton Beam Test for a CTOF System with a Counter Equipped Fine-mesh PMTs
E. Milman,V. Kuznetsov,김우영 한국물리학회 2011 새물리 Vol.61 No.1
The basic requirement for the central time-of-flight (CTOF) system for the CLAS12 upgrade in Hall B of TJNAF (JLab) is a TOF resolution of 50 ps. This requirement dictates a need to test CTOF prototype counters under the above-mentioned terms or to extrapolate obtained results to these conditions. In this study, we will present the test results for a CTOF counter equipped with magnetic-resistant fine-mesh photomultipliers tube (PMTs) for the proton beam of the MC50 Cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS).
LED Test of a CTOF Counter with Fine-mesh PMs and Ordinary PMs
E. Milman,H. Dho,J. Jang,김우영 한국물리학회 2012 새물리 Vol.62 No.3
We have made a CTOF prototype counter equipped with fine-mesh PMs for the CLAS12 upgrade program. The requirements for the CTOF counter are to achieve a timing resolution of less than 50 ps and a count rate of 1 MHz in a high magnetic field of 1.5 T. The timing resolution of the counter has been measured with a CAEN SP5601 LED pulser. The timing properties of the counter were compared with those of conventional ultra-fast Hamamatsu R2083 PMs. The results demonstrate that the CTOF design with fine-mesh PMs meets the basic requirements for the CLAS12 detector.
( Boris L. Milman ),( Ekaterina V. Ostrovidova ),( Inna K. Zhurkovich ) 한국질량분석학회 2019 Mass spectrometry letters Vol.10 No.3
Algorithms and software for predicting tandem mass spectra have been developed in recent years. In this work, we explore how distinct in silico MS<sup>2</sup> spectra are predicted for isomers, i.e. compounds having the same formula and similar molecular structures, to differentiate between them. We used the CFM-ID 2.0/3.0 predictor with regard to (a) test compounds, whose experimental mass spectra had been randomly sampled from the MassBank of North America (MoNA) collection, and to (b) the most widespread isomers of test compounds searched in the PubChem database. In the first validation test, in silico mass spectra constitute a reference library, and library searches are performed for test experimental spectra of “unknowns”. The searches led to the true positive rate (TPR) of (46-48 ± 10)%. In the second test, in silico and experimental spectra were interchanged and this resulted in a TPR of (58 ± 10)%. There were no significant differences between results obtained with different metrics of spectral similarity and predictor versions. In a comparison of test compounds vs. their isomers, a statistically significant correlation between mass spectral data and structural features was observed. The TPR values obtained should be regarded as reasonable results for predicting tandem mass spectra of related chemical structures.
( Boris L. Milman ),( Inna K. Zhurkovich ) 한국질량분석학회 2018 Mass spectrometry letters Vol.9 No.3
The number of matched peaks (NMP) is estimated as the spectral similarity measure in tandem mass spectral library searches of small molecules. In the high resolution mode, NMP provides the same reliable identification as in the case of a common dot-product function. Corresponding true positive rates are (94±3) % and (96±3) %, respectively.
Boris L. Milman,Ekaterina V. Ostrovidova,Inna K. Zhurkovich 사단법인 한국질량분석학회 2019 Mass spectrometry letters Vol.10 No.3
Algorithms and software for predicting tandem mass spectra have been developed in recent years. In this work, we explore how distinct in silico MS 2 spectra are predicted for isomers, i.e. compounds having the same formula and similar molec-ular structures, to differentiate between them. We used the CFM-ID 2.0/3.0 predictor with regard to (a) test compounds, whose experimental mass spectra had been randomly sampled from the MassBank of North America (MoNA) collection, and to (b) the most widespread isomers of test compounds searched in the PubChem database. In the first validation test, in silico mass spectra constitute a reference library, and library searches are performed for test experimental spectra of “unknowns”. The searches led to the true positive rate (TPR) of (46-48 ± 10)%. In the second test, in silico and experimental spectra were interchanged and this resulted in a TPR of (58 ± 10)%. There were no significant differences between results obtained with different metrics of spectral similarity and predictor versions. In a comparison of test compounds vs. their isomers, a statistically significant correlation between mass spectral data and structural features was observed. The TPR values obtained should be regarded as reasonable results for predicting tandem mass spectra of related chemical structures.
Conor Dunn,Michael Faloon,Edward Milman,Sina Pourtaheri,Kumar Sinah,Ki Hwang,Arash Emami 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.2
Study Design: Retrospective case series with prospective arm. Purpose: To assess the safety and accuracy of percutaneous lumbosacral pedicle screw placement (PLPSP) in the lumbosacral spine using intraoperative dual-planar fluoroscopy (DPF). Overview of Literature: There are several techniques available for achieving consistent, safe, and accurate results with PLPSP. There is a paucity of literature describing the beneficial operative, economic, and clinical outcomes of DPF, the most readily accessible image guidance system. Methods: From 2004 to 2014, 451 consecutive patients underwent PLPSP using DPF, for a total of 2,345 screw placement. The results of prospectively obtained postoperative computed tomography (CT) examinations of an additional 41 consecutive patients were compared with the results of 104 CT examinations obtained postoperatively due to clinical symptomatology; these results were interpreted by three reviewers. The rates of revision indicated by misplaced screws with consistent clinical symptomatology were compared between groups. Pedicle screw placement was graded according to 2-mm increments in medial pedicle wall breach and measurement of screw axis placement. Results: Seven of the 2,345 pedicle screws placed percutaneously with the use of the dual-planar fluoroscopic technique required revision because of a symptomatic misplaced screw, for a screw revision rate of 0.3%. There were no statistically significant demographic differences between patients who had screws revised and those who did not. All screws registered greater than 10 mA on electromyographic stimulation. In the 41 prospectively obtained CT examinations, one out of 141 screws (0.7%) was revised due to pedicle wall breach; whereas among the 104 patients with 352 screws, three screws were revised (0.9%). Conclusions: DPF is an extremely accurate, safe, and reproducible technique for placement of percutaneous pedicle screws and is a readily available and cost-effective alternative to CT-guided pedicle screw placement techniques. Postoperative CT evaluation is not necessary with PLPSP unless the patient is symptomatic. Acceptable electromyographic thresholds may need to be reevaluated.