구강관리 프로토콜 적용이 항암화학요법을 받는 고형암 환자의 구강상태 및 자가간호수행에 미치는 효과

정미숙(Mi Sook Jeong),송지은(Chi Eun Song),이애리(Ae Ri Lee),정은숙(Eun-Suk Jung),김광숙(Gwang Sug Kim) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.8

본 연구의 목적은 항암화학요법을 받는 고형암 환자를 대상으로 구강관리 개별교육과 냉동요법 및 벤지다민 구강함수를 포함한 구강관리 프로토콜 적용이 대상자의 구강상태와 수행에 미치는 효과를 파악하기 위함이다. 총 연구 대상자는 31명이었으며, 실험군에 13명, 대조군에 18명이 배정되었다. 실험군에게는 구강관리교육, 냉동요법 및 벤지다민 구강함수를 적용하였으며 대조군은 기존의 구강간호를 제공하였고, 대상자의 구강상태와 자가간호 수행정도를 측정하였다. 수집된 자료는 Mann-Whitney test, Friedman test, 및 Chi-square test로 분석하였다. 연구결과, 매 측정 시기 별 두 그룹 간 구강상태의 차이는 없는 것으로 나타났다. 그러나 두 그룹 모두 측정시기에 따른 구강상태의 변화는 유의하였는데 항암치료 후 14일경에 구강상태점수가 가장 낮게 측정되었다. 자가간호 수행정도는 실험군이 대조군보다 유의하게 높았으며 연구 완료 후 4개월까지 유지되는 것으로 나타났다. 이러한 결과는 종양간호사에 의한 환자개별교육의 효과로 여겨지며 고형암 환자의 구강상태 개선을 위하여 냉동요법과 벤지다민 구강함수에 대한 효과를 파악하기 위한 추가적인 연구가 요구된다. The purpose of this study was to identify the effectiveness of oral care protocol including individual oral care education, cryotherapy and benzydamine gargling on oral cavity status and self-care performance in solid cancer patients receiving chemotherapy. Thirty-one patients were enrolled by convenience sampling in this study and allocated to control (n=18) and experimental group (n=13). In the intervention group, individual oral care education, oral cryotherapy and benzydamine gargling were applied, while the control group received pre-existed oral care. Oral cavity status and self-oral care behavior were measured in five periods. The data were analyzed using the Mann-Whitney test, Friedman test, and Chi-square test. There was no significant difference in oral cavity status between the groups. But the two groups showed the poorest oral cavity status on 14th day. Self-care behavior was significantly higher in the intervention group than the control group. This effect had maintained for 4months after completion of study. The results showed that individual oral care education by oncology nurse is effective to encourage patients to do self-care behavior and a further study is needed to explore the effect of cryotherapy and benzydamine gargling on oral cavity status of patient with solid tumor.

발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

응집과 흡착에 의한 음용수중 유해 중금속의 제거

옥치상,김정아,박미연 高神大學校 保健科學硏究所 1992 보건과학연구소보 Vol.2 No.-

Water added with humic acid(10㎎/L) and heavy metals(??, ??, ??, ??, ??) were investigated the advanced removal effects of heavy metals in drinking water by alum, ion exchange resin and activated carbon. Based on the results, the removal rates of heavy metals in optimum alum coagulation (5mg/L) were ??, 38.7%; ??, 35.5%; ??, 34.8%; ??, 19.7%; ??, 4.3%. And the removal effect series of heavy metals were ??, ?? for contact time 1hr in batch with ion exchange and ?? for filtration time 1hr in column packed with ion exchange, and ?? for contact time 1hr in batch with activated carbon and ??, ?? for filtration time 1hr in column packed with activated carbon. The removal of heavy metals by continuous treatment by column packed with ion exchange and activated carbon after alum coagulation were more increase than those of each treatment, was a marked increase as contact time was increased.

H_2O_2에 의한 亞黃酸 암모늄의 酸化

高美智,李明雨,李正子 梨花女子大學校 藥學硏究所 1965 梨花藥學硏究 Vol.- No.6

Sulfites are easily oxidized by oxigen or air. In this experiment, H_2O_2 was used to oxidize the Ammonium Sulfite. And it was known that as increasing the concentration of solution, the order of its reaction is different. And when the solution reach certain concentration the reaction is zero order. We determinated the variation of concentration of sulfite ion with iodometry which is ever used. On the other hand, we could determinate with refractometry which is new method. On each method the rate constant of the reaction was calculated and it was treated with statistics. In this result, it was known that refractometry can be used instead of Indometry.

Mongolian gerbil 심장동맥의 해부학적 연구

송치원,정주영,이미영,김무강,현병화 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

The arterial supply to heart of mongolian gerbil has been described. Observations were made by the specimens injected with latex after the flowing through in left ventricle. The results were summaried as follows; 1. A. coronaria arose from the initial portion of Aorta in heart and A. coronaria dextra and sinistus arose in Aortic sinus on 10 specimens. A. coronaria sinistra arose more near boundary of Aortic sinus than A. coronaria dextra. 2. A. coronaria sinistra which arose from Aortic sinus divided into Ramus interventricularis sinistra and Ramus circumflexus sinistra. A. coronaria dextra which arose from Aortic sinus only runed continously as Ramus interventriculares dextra. 3. Ramus interventricular sinistra not reach the heart apex through the sulcus interventricula but stopped in thoracocostal plan extending to under part. 4. R. circumflexus runed theough sulcus coronarius, thereafter it runed from left ventricle to Sulcus interventricularis dorsalis. 5. A. coronaria dextra runed to diaphargm side through sulcus interventricula dorsi thereafter it became Ramus interventricular dextra. It distrubuted left and right ventricle wall on 8 specimens and 2 specimen stopped margo obtusus.

일본 중학교에서의 지역학습 : the Case of Japan

박선미,정치영 한국지리환경교육학회 2003 한국지리환경교육학회지 Vol.11 No.1

본 연구에서는 우리나라 중학생들이 배우고 있는 지역학습의 목적과 내용간에 정합성이 결여되었다는 문제점을 인식하고 이러한 문제 해결의 실마리를 마련하기 위하여 1998년에 개정된 일본의‘학습지도요령’과 帝國書院과 東京書籍의 중학교 지리교과서를 대상으로 학습지역을 선정하는 기준과 지역학습 내용 및 활동을 분석한다. 일본 지역학습은 우리나라와 같이 개별 지역 낱낱을 모두 학습하도록 되어 있던 종전의 틀을 과감하게 탈피하여 다양한 규모의 지역적 특색을 파악하는 관점과 방법을 체득하도록 내용을 구성하고 있다. 우리나라 교육과정과 달리, 일본의 학습지도요령은 학습해야 할 지역을 선정하는 기준과 해당 규모에서 성취해야 할 목표를 제시하고, 교과서 집필진과 출판사가 교과서에서 다루는 지역과 구체적인 내용을 선택한다. 일본의 지역학습은 학습의 넓이 대신에 깊이를 선택했다. 이러한 전환은 한 영역의 깊이 있는 학습이 학생들의 사고를 외연적으로 확대시키기 때문에 학습의 넓이를 결코 희생시키지 않으리라는 믿음을 전제로 한 것이다. This study examines criteria of selecting regions, contents, and activities for regional studies based on the revised version of Japanese national curriculum in social studies (1998) and middle school textbooks of Imperial Books and Tokyo Books. By referring to the Japanese case, the authors hope to find possible solutions to the gap between aims and contents of regional studies in the middle school level social studies in Korea. Regional studies in Japan differs from those in Korea in the sense that the contents include methods and viewpoints by which students can understand regional characteristics in different scales, which extends its scope far beyond simple poking and soaking of each specific region. Furthermore, unlike National Curriculum in Korea, instructions for learning and teaching in Japan suggest relevant criteria for selecting regions and main purposes that students should achieve in each scale. Also in Japan, selection of regions and contents for textbooks is decided by the editorial board and the publishers. Regional studies in Japan is focusing on the depth details rather than the comprehensiveness. This focus is based on the belief that in depth study on a particular are should not sacrifice the comprehensiveness because it helps students to extend their scope of reasoning.

Dynamic Elastic Matching Method를 이용한 3차원 물체의 Reconstruction

이미선,황치정 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

This paper proposed the method of reconstructing 3D object from serial cross sections. First, A series of intermediate contours is generated iteratively based on the dynamic elastic matching method between adjacent contours. Then, the empty region between contours and points on a contour is filled by linear interpolation and cubic spline interpolation. Using this method, we can produce realistic smooth 3D object, even if the contours are not closely space.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.

폴리카프로락톤 매트릭스로부터 세파드록실의 방출에 미치는 BSA의 영향

김승렬,정연진,김영미,이치호,김대덕 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

In order to investigate the effect of bovine serum albumin (BSA), as a pore former, on the controlled release of an antibiotic from a biodegradable polymeric device, polycaprolactone (PCL)-cefadroxil matrices were prepared by the solvent casting method. The amount of cefadroxil released from various formulations at 37℃ was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). The release rate and extent of cefadroxil from PCL matrix increased as the loading dose and particle size of BSA/cefadroxil mixture powder increased. Cefadroxil released from the matrix exhibited antibacterial activity for up to 4 days. SEM of the cross-section of matrix showed the typical channel formation after 3 days of release study. Thus, a biodegradable polymeric matrix loaded with antibiotic/BSA mixture can effectively prevent bacterial infection on its surface, thereby bringing about an enhancement of biocompatibility of biomaterials.

절수에 의한 Mongolian Gerbil 장기중량변화에 관한 분석연구

김무강,이기훈,이강이,송치원,이경열,권효정,박미선,정승혁,이행연,김명철 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study, authors measured the each organ weight of the long term water deprived Mongolian gerbil, after then we calculated the mean, standard deviation, variance coefficient of the real measured organ weight and induced the organ weight change quantity, rate of quantity, deviation between measured and theological organ weight, deviation rate, sum of deviation rate, organ weight change rate, rate of organ weight by the mathematical formula. The results obtained as follow 1. The weight of the brains, lung, and testis were abruptly decreased after water deprived until the 5th day, after then slowly decreased until the 20th day. 2. The weight of the heart was decreased gradually from the first day until the 20th day. 3. The weight of the liver was abruptly decreased until the 10th day, after then the more slowly decreased until the 20th day. 4. The weight of the thymus, spleen, kidney, and pancreas were abruptly decreased until the 15th day, after then increased slowly until 20th day but the weight of the kidney was abruptly increased from the 10th day. 5. The organ weight change rate and the rate of the each day organ weight were very diversified.