Investigation of thermo-structural behaviors of different ventilation applications on brake discs

Mesut Duzgun 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.1

One of the most common problems related to brake discs is overheating, which negatively affects braking performance especially under the continuous braking conditions of vehicles. Ventilation applications on brake discs can significantly improve the brake system performance by reducing the heating of the discs. In this study, the thermal behaviors of ventilated brake discs using three different configurations were investigated at continuous brake conditions in terms of heat generation and thermal stresses with finite element analysis. The results were compared with a solid disc. Heat generation on solid brake discs reduced to a maximum of 24% with ventilation applications. The experimental study indicated finite element temperature analysis results in the range between 1.13% and 10.87%. However,thermal stress formations were higher with ventilated brake discs in comparison to those with solid discs.

Forced vibration of an embedded single-walled carbon nanotube traversed by a moving load using nonlocal Timoshenko beam theory

Mesut Simsek 국제구조공학회 2011 Steel and Composite Structures, An International J Vol.11 No.1

Dynamic analysis of an embedded single-walled carbon nanotube (SWCNT) traversed by a moving nanoparticle, which is modeled as a moving load, is investigated in this study based on the nonlocal Timoshenko beam theory, including transverse shear deformation and rotary inertia. The governing equations and boundary conditions are derived by using the principle of virtual displacement. The Galerkin method and the direct integration method of Newmark are employed to find the dynamic response of the SWCNT. A detailed parametric study is conducted to study the influences of the nonlocal parameter, aspect ratio of the SWCNT, elastic medium constant and the moving load velocity on the dynamic responses of SWCNT. For comparison purpose, free vibration frequencies of the SWCNT are obtained and compared with a previously published study. Good agreement is observed. The results show that the above mentioned effects play an important role on the dynamic behaviour of the SWCNT.

Resveratrol-induced Depression of the Mechanical and Electrical Activities of the Rat Heart is Reversed by Glyburide: Evidence for Possible KATP Channels Activation

Mesut Buluc,Murat Ayaz,Belma Turan,Emine Demirel-Yilmaz 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5

Resveratrol, a natural phytoalexin found in wine, has been suggested to have benefits in preventing cardiovascular diseases. However, the direct effects of resveratrol on the activity of cardiac tissues and its mechanism of action have not been determined. This study examined the effects of resveratrol on the right and left atrium and left papillary muscle isolated from the rat heart. The contractile responses of the right atrium and papillary muscle and the action potential from the left atrium were recorded and the effects of resveratrol on these responses were observed. The resting force of the isolated right atrium and the peak developed force of the left papillary muscle were depressed by resveratrol (0.1 nM - 0.1 mM). Exposure to the KATP channel blocker glyburide (3 µM) prevented significantly the resveratrol-induced decrease. Resveratrol (0.1 mM) shortened the repolarization phase of action potential recorded from the left atrium and this effect of resveratrol was reversed by glyburide (3 µM). These results indicated that resveratrol depressed cardiac muscle contraction and shortened action potential duration probably due to the activation of KATP channels in the rat heart.

Utilization of Waste Loquat (Eriobotrya Japonica Lindley) Kernels as Substrate for Scleroglucan Production by Locally Isolated Sclerotium rolfsii

Mesut Taskin,Serkan Erdal,Ozden Canli 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4

Present study mainly focused on investigating the feasibility of waste loquat kernels as substrate in submerged culture of Sclerotium rolfsii MT-6 for scleroglucan production. Loquat kernel contained high protein (22.5%)and total carbohydrate (71.2%) contents. Dried and powdered kernels were subjected to acid hydrolysis with 2N HCl. The obtained hydrolysate was used for the preparation of loquat kernel extract (LKE) and detoxified loquat kernel extract (DLKE). S. rolfsii MT-6 was isolated from fermented squash (Cucurbita pepo). Optimal conditions for scleroglucan production were initial pH 5.0, shaking speed 150 rpm, 28℃, and cultivation time of 72 hr. Production media prepared with DLKE or LKE gave maximum biomass concentrations of 17.06 and 16.21 g/L,and maximum scleroglucan concentrations of 12.08 and 10.53 g/L, respectively. DLKE was also favorable substrate for mycelial growth in a uniform pellet form. This is a first report on the application of waste loquat kernels as scleroglucan production substrate and on the use of a local S. rolfsii isolate for this purpose.

Analyzing the bearing capacity of shallow foundations on two-layered soil using two novel cosmology-based optimization techniques

Mesut Gör 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.3

Due to the importance of accurate analysis of bearing capacity in civil engineering projects, this paper studies the efficiency of two novel metaheuristic-based models for this objective. To this end, black hole algorithm (BHA) and multi-verse optimizer (MVO) are synthesized with an artificial neural network (ANN) to build the proposed hybrid models. Based on the settlement of a two-layered soil (and a shallow footing) system, the stability values (SV) of 0 and 1 (indicating the stability and failure, respectively) are set as the targets. Each model predicted the SV for 901 stages. The results indicated that the BHA and MVO can increase the accuracy (i.e., the area under the receiving operating characteristic curve) of the ANN from 94.0% to 96.3 and 97.2% in analyzing the SV pattern. Moreover, the prediction accuracy rose from 93.1% to 94.4 and 95.0%. Also, a comparison between the ANN's error decreased by the BHA and MVO (7.92% vs. 18.08% in the training phase and 6.28% vs. 13.62% in the testing phase) showed that the MVO is a more efficient optimizer. Hence, the suggested MVO-ANN can be used as a reliable approach for the practical estimation of bearing capacity.

Effi cacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naïve Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study

Mesut Sezikli,Züleyha Akkan Çetinkaya,Fatih Güzelbulut,Atakan Yeşil,Mustafa Erhan Altınöz,Nuriye Ulu,Ayşe Oya Övünç Kurdaş 거트앤리버 소화기연관학회협의회 2012 Gut and Liver Vol.6 No.1

Background/Aims: The aim of this study was to evaluate the eradication rate of a triple therapy regimen that included a proton pump inhibitor, amoxicillin, and tetracycline instead of clarithromycin in treatment-naïve patients and in patients who did not respond to standard triple therapy. Methods: This study included 110 patients infected with Helicobacter pylori. Patients in groups A and B were treatment-naïve, and those in group C were not responsive to previous standard triple therapy. Patients in group A (n=40) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. Patients in groups B (n=40) and C (n=30) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and tetracycline 500 mg q.i.d. for 14 days. Results: In group A, eradication was achieved in 18 (45%) of the 40 patients included in the intention-to-treat (ITT) analysis and in 18 (47.4%) of the 38 patients included in the per-protocol (PP) analysis. In group B, eradication was achieved in 15 (37.5%) of the 40 patients included in the ITT analysis and in 15 (39.3%) of the 38 patients included in the PP analysis. In group C, eradication was achieved in 14 (46.6%) of the 30 patients included in the ITT analysis and in 14 (43.8%) of the 29 patients included in the PP analysis. There was no statistically signifi cant difference among the 3 groups with regard to eradication rates (p>0.05). Conclusions: Despite the low rate of resistance to tetracycline, the combination of lansoprazole, amoxicillin, and tetracycline instead of clarithromycin is not a good option for the eradication of H. pylori.

Effi cacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naive Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study

( Mesut Sezikli ),( Zuleyha Akkan Cetinkaya ),( Fatih Guzelbulut ),( Atakan Yesil ),( Mustafa Erhan Altınoz ),( Nuriye Ulu ),( Ayse Oya Ovunc Kurdas ) 대한소화기기능성질환·운동학회 2012 Gut and Liver Vol.6 No.1

Background/Aims: The aim of this study was to evaluate the eradication rate of a triple therapy regimen that included a proton pump inhibitor, amoxicillin, and tetracycline instead of clarithromycin in treatment-naive patients and in patients who did not respond to standard triple therapy. Methods: This study included 110 patients infected with Helicobacter pylori. Patients in groups A and B were treatment-naive, and those in group C were not responsive to previous standard triple therapy. Patients in group A (n=40) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. Patients in groups B (n=40) and C (n=30) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and tetracycline 500 mg q.i.d. for 14 days. Results: In group A, eradication was achieved in 18 (45%) of the 40 patients included in the intention-to-treat (ITT) analysis and in 18 (47.4%) of the 38 patients included in the per-protocol (PP) analysis. In group B, eradication was achieved in 15 (37.5%) of the 40 patients included in the ITT analysis and in 15 (39.3%) of the 38 patients included in the PP analysis. In group C, eradication was achieved in 14 (46.6%) of the 30 patients included in the ITT analysis and in 14 (43.8%) of the 29 patients included in the PP analysis. There was no statistically signifi cant difference among the 3 groups with regard to eradication rates (p>0.05). Conclusions: Despite the low rate of resistance to tetracycline, the combination of lansoprazole, amoxicillin, and tetracycline instead of clarithromycin is not a good option for the eradication of H. pylori. (Gut Liver 2012;6:41-44)

On the Performance of RIS-aided LEO Satellite Networks

Mesut Toka,Jaein Lee,Jaehyup Seong,Wonjae Shin 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.6

Safety and efficacy analysis of ibrutinib in 32 patients with CLL and various B-cell lymphomas: real-world data from a single-center study in Turkey

Göçer Mesut,Kurtoğlu Erdal 대한혈액학회 2020 Blood Research Vol.55 No.4

Background Ibrutinib is an oral irreversible Bruton’s tyrosine kinase inhibitor. Here, we demonstrate the efficacy and safety of ibrutinib using real-life data from patients with marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), Waldenström macroglobulinemia (WM), and follicular lymphoma (FL), especially in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). Methods This is a retrospective, observational, non-interventional, and single-center study on 32 patients who received ibrutinib treatment between January 2017 and March 2020 regardless of their diagnosis. Results Of the 32 patients, 11 had CLL and 21 had other B-cell lymphomas. Patients with CLL were prescribed ibrutinib for a median of 4 months (range, 2‒18). In this group, diarrhea was observed in 3 (27.3%), pneumonia in 3 (27.3%), and thrombocytopenia and/or neutropenia in 2 (18.2%) patients. The overall response rate (ORR) was 85.6 % [28.5 % complete response (CR) and 57.1 % partial response (PR)] in the final response assessment during treatment with ibrutinib. Among other types of B-cell lymphoma, seven (33.4%) of the 21 patients were diagnosed with MCL, 5 (23.8%) with DLBCL, 4 (19.0%) with MZL, 3 (14.3%) with WM, and 2 (9.5%) with FL, upon follow-up. The median treatment duration was 4 months (range, 1‒28) in this group. The most common adverse event was diarrhea: 8 (38.1%) patients. The ORR was 66.6% (20.0% CR and 46.6% PR) in the final response assessment during the treatment. Conclusion Ibrutinib is a good treatment option for CLL and other B-cell lymphomas, with an acceptable side effect profile, and high and promising CR/PR response rates. Ibrutinib treatment at an early stage decreases the burden of cytotoxic therapy in fragile patients, thereby, increasing their quality of life.

Could the Platelet-to-Lymphocyte Ratio be a Novel Marker for Predicting Invasiveness of Cervical Pathologies?

Kose, Mesut,Celik, Fatih,Kose, Seda Kayman,Arioz, Dagistan Tolga,Yilmazer, Mehmet Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Purpose: To determine whether the preoperative platelet to lymphocyte ratio (PLR) could predict invasiveness of cervical pathologies. Materials and Methods: Patients with preinvasive and invasive diseases were reviewed retrospectively, over a nine-year period, 2005-2014. The pathological records and completed blood counts of the patients were collected and recorded in the SPSS program. Patients were divided in two groups, preinvasive and invasive. Results: The median PLR was significantly higher in the invasive group than in the preinvasive group (p=0.03). There was a correlation between invasion of cervical cancer and white blood cell count, red cell distributing width (RDW), neutrophil-lymphocyte ratio (NLR), and PLR. Conclusions: This study showed that patients with uterine cervical cancer may present with leukocytosis, increased RDW, NLR and PLR. These cheap and easily available parameters, especially PLR, may provide useful information about the invasiveness of cervical lesions.