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- 저자 : Mercuri, Nicola B (검색결과 3 건)
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Targeting synaptic dysfunction in Alzheimer's disease therapy.
Nistic?, Robert,Pignatelli, Marco,Piccinin, Sonia,Mercuri, Nicola B,Collingridge, Graham Humana Press 2012 Molecular neurobiology Vol.46 No.3
<P>In the past years, major efforts have been made to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been translated into extensive experimental approaches aimed at slowing down or halting disease progression. Advances in transgenic (Tg) technologies allowed the engineering of different mouse models of AD recapitulating a range of AD-like features. These Tg models provided excellent opportunities to analyze the bases for the temporal evolution of the disease. Several lines of evidence point to synaptic dysfunction as a cause of AD and that synapse loss is a pathological correlate associated with cognitive decline. Therefore, the phenotypic characterization of these animals has included electrophysiological studies to analyze hippocampal synaptic transmission and long-term potentiation, a widely recognized cellular model for learning and memory. Transgenic mice, along with non-Tg models derived mainly from exogenous application of Aβ, have also been useful experimental tools to test the various therapeutic approaches. As a result, numerous pharmacological interventions have been reported to attenuate synaptic dysfunction and improve behavior in the different AD models. To date, however, very few of these findings have resulted in target validation or successful translation into disease-modifying compounds in humans. Here, we will briefly review the synaptic alterations across the different animal models and we will recapitulate the pharmacological strategies aimed at rescuing hippocampal plasticity phenotypes. Finally, we will highlight intrinsic limitations in the use of experimental systems and related challenges in translating preclinical studies into human clinical trials.</P>
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Advancements in temporomandibular joint total joint replacements (TMJR)
Siva Kumar Mamidi,Klutcharch,Shradha Rao,Julio C. M. Souza,Louis G. Mercuri,Mathew T. Mathew 대한의용생체공학회 2019 Biomedical Engineering Letters (BMEL) Vol.9 No.2
The goal of this paper is to review the advantages and disadvantages of the various treatment options of temporomandibularjoint (TMJ) total joint replacement (TJR). TMJ articles published within the last 20 years were reviewed to collect the informationon non-invasive and invasive TMD treatment methods. Recent technological advancements helped the evolution oftreatment methods and off ered signifi cant value to TMD patients and surgeons. Considering the TMD levels, the therapeuticprocedures can involve general health examiniations, physical therapy, medication, oral rehabilation or as an end stage clinicalinvention, temporomandibular joint replacement. In fact when intra-articular TMD is present, the eff ective treatmentmethod appears to be TJR. However, concern for infection, material hypersensitivity, device longevity and screws looseningissues still exists. Further combined research utilizing the knowledge and expertise of, surgeons, material scientists, andbioengineers is needed for the development of improved TMD therapeutic treatment.
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Bone loss in aseptic revision total knee arthroplasty: management and outcomes
( Thomas Bieganowski ),( Daniel B. Buchalter ),( Vivek Singh ),( John J. Mercuri ),( Vinay K. Aggarwal ),( Joshua C. Rozell ),( Ran Schwarzkopf ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-
Background: Although several techniques and implants have been developed to address bone loss in revision total knee arthroplasty (rTKA), management of these defects remains challenging. This review article discusses the indications and management options of bone loss following total knee arthroplasty based on preoperative workup and intraoperative findings. Main text: Various imaging modalities are available that can be augmented with intraoperative examination to provide a clear classification of a bony defect. For this reason, the Anderson Orthopaedic Research Institute (AORI) classification is frequently used to guide treatment. The AORI provides a reliable system by which surgeons can classify lesions based on their size and involvement of surrounding structures. AORI type I defects are managed with cement with or without screws as well as impaction bone grafting. For AORI type IIA lesions, wedge or block augmentation is available. For large defects encompassing AORI type IIB and type III defects, bulk allografts, cones, sleeves, and megaprostheses can be used in conjunction with intramedullary stems. Conclusions: Treatment of bone loss in rTKA continues to evolve as different techniques and approaches have been validated through short- and mid-term follow-up. Extensive preoperative planning with imaging, accurate intraoperative evaluation of the bone loss, and comprehensive understanding of all the implant options available for the bone loss are paramount to success.
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