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안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성
안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.
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Yu-Chuan Chiu(Yu-Chuan Chiu), Chun-Hao Liu(Chun-Hao Liu), Shan-Mei Chang(Shan-Mei Chang) 대한신경정신의학회 2025 PSYCHIATRY INVESTIGATION Vol.22 No.9
Objective Sexting has been linked to negative mental health outcomes. This Taiwan-based study addresses the links between sexting, cyberbullying, self-harm, and gender differences in the association of sexting and self-harm behavior. Methods A two-stage stratified sampling of 5,190 Taiwanese adolescents aged 11–18 completed an online questionnaire measuring sexting, bullying/cyberbullying, and self-harm. Two-way interaction model was used to identify the effect of gender on the relationship between sexting and self-harm behavior. The relationship between sexting and self-harm risk was tested in both the total sample and in different gender groups using univariable and multivariable linear regression models. Results 2.5% of adolescents engaged in some form of sexting in the past year. 1.7% had sent their own picture or video. 1.0% had experienced non-consensual sexting, and 0.9% had sexted under pressure. Female gender, sexting one’s own information, non-consensual sexting, and pressured sexting were associated with higher self-harm scores. Conclusion This is the first study to focus on gender differences in the association between different types of sexting and self-harm in a non-Western society. The impact of sexting on self-harm was found to differ between males and females. Different types of sexting may also be associated with different risks of self-harm.
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Chang-Yu Wu,Shu-Mei Dai,Chin-Gi Huang,Yu-Hsien Chen,Wen-Ting Wang,Chien-Yu Chen,Ju-Chun Hsu 한국응용곤충학회 2025 Journal of Asia-Pacific Entomology Vol.28 No.2
Aedes aegypti mosquitoes spread a number of diseases that cause significant impacts to public health. In Taiwan, Ae. aegypti are mainly controlled using chemical insecticides, but previous studies indicate that Ae. aegypti may have developed resistance to several insecticides. We hypothesized that Ae. aegypti resistance levels could be affected by insecticide application frequencies and therefore compared transcriptome information, expressions of metabolic resistance genes, and gene mutations of field adult mosquitoes collected from Kaohsiung City (frequent application area, insecticides applied once a week) and Tainan City (infrequent application area, insecticides applied only when dengue cases were discovered); a laboratory strain was established as control. Nextgeneration sequencing was used to identify potential resistance genes from four main detoxification cate gories, bioassays were used to determine knockdown effects and mortality rates, and point mutations relating to target resistance were further analyzed. A total of 50 detoxification differential transcripts were identified following comparison with the laboratory strain, and more differential transcripts were found in mosquitos collected from the frequent application area (Kaohsiung). Mosquitoes from areas with frequent applications displayed lower mortality rates, confirming a difference in resistance levels. Additionally, mosquitoes from frequent application areas showed higher levels of resistance to pyrethroids compared with organophosphates. We found silent mutations at G923, L982, and A1007, as well as point mutations at S989P, V1016G, F1534C, and D1763Y. V1016G occurred in all four strains we collected, indicating that pyrethroid resistance in Ae. aegypti has begun to develop in all regions.
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I-Mei Lin,Sheng-Yu Fan,Cheng-Fang Yen,Yi-Chun Yeh,Tze‐Chun Tang,Mei-Feng Huang,Tai-Ling Liu,Peng-Wei Wang,Huang-Chi Lin,Hsin-Yi Tsai,Yu-Che Tsai 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: Autonomic imbalance is considered a psychopathological mechanism underlying major depressive disorder (MDD). Heart rate variability (HRV) is an index for autonomic activation. Poor sleep quality is common among patients with MDD. HRV biofeedback (BF) has been used for regulating autonomic balance among patients with physical illness and mental disorders. The purpose of present study was to examine the effects of HRV-BF on depressive symptoms, sleep quality, pre-sleep arousal, and HRV indices, in patients with MDD and insomnia. Methods: In this case-controlled study, patients with MDD and Pittsburgh Sleep Quality Index (PSQI) score higher than 6 were recruited. The HRV-BF group received weekly 60-minute protocol for 6 weeks, and the control group who have matched the age and sex received medical care only. All participants were assessed on Beck Depression Inventory-II, Back Anxiety Inventory, PSQI, and Pre-Sleep Arousal Scale. Breathing rates and electrocardiography were also performed under resting state at pre-testing, and post-testing conditions and for the HRV-BF group, also at 1-month follow-up. Results: In the HRV-BF group, symptoms of depression and anxiety, sleep quality, and pre-sleep arousal were significantly improved, and increased HRV indices, compared with the control group. Moreover, in the HRV-BF group, significantly improved symptoms of depression and anxiety, decreased breathing rates, and increased HRV indices were detected at post-testing and at 1-month follow-up, compared with pre-testing values. Conclusion: This study confirmed that HRV-BF is a useful psychosocial intervention for improving autonomic balance, baroreflex, and symptoms of depression and insomnia in MDD patients.
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Correlations Between Fasciology and Yin Yang Doctrine
Hui Tao,Mei-chun Yu,Hui-ying Yang,Rong-mei Qu,Chun Yang,Xin Zhou,Yu Bai,Jing-peng Wu,Jun Wang,Ou Sha,Lin Yuan 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.2
The aim of this study is to explore the correlations between fasciology and yin yang doctrine. Professor Yuan developed fasciology by three-dimensional reconstruction of connective tissue (fascia) in the trunk and limbs of the human body and tracing back to tissue origins in light of biological evolution and developmental biology. Fasciology states that the human body can be divided into two systems: the supporting-storing system and the functional system. This article elaborates on the roles of the two systems and their mutual relationship. The two systems are used to analyze the yin,the yang, and their relationship. The two systems are promoted but also restricted in different contexts. The supporting-storing system is formed by undifferentiated connective tissue and provides undifferentiated cells and nutrients for differentiated cells of the functional system. Thus, the supporting-storing system could be classified as quiet, similar to yin. The functional system continuously maintains the various functional activities of the human body. Thus, the functional system could be classified as active, similar to yang. In interpreting the yin yang doctrine from the point of view of fasciology, yin can be compared with the supporting-storing system and yang can be compared with the functional system.
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Flavones from the Bark of Lindera caudata and Their Anti-Tobacco Mosaic Virus Activity
Yu-Chun Yang,Ying Qin,Xian-Xue Wu,Cong-Fang Xia,Yan-Lin Meng,Bin Zhou,Yan-Qing Ye,Xue-Mei Gao,Yin-Ke Li,Qiu-Fen Hu 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.4
Two new flavones, 5-hydroxy-8-hydroxymethyl-7,4′-dimethoxy-flavone (1) and 6-hydroxy-8-hydroxymethyl-7,4′-dimethoxy-flavone (2), together with six known flavones (3–8), were isolated from the bark of Lindera caudata. The structures of 1–8 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1–8 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that Compounds 1 and 2 showed high anti-TMV activity with inhibition rates of 31.2 and 28.8%, respectively. These values are close to those of positive control.
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Liriodenine Inhibits Dopamine Biosynthesis and L-DOPA-Induced Dopamine Content in PC12 Cells
Chun Mei Jin,Jae Joon Lee,Yoo Jung Yang,Yu Mi Kim,Young Kyoon Kim,Shi Yong Ryu,이명구 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
The inhibitory effects of liriodenine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and L-DOPA-induced dopamine content increases in PC12 cells were investigated. Treatment of PC12 cells with 5-10 μM liriodenine significantly decreased the intracellular dopamine content in a concentration-dependent manner (IC50 value, 8.4 μM). Liriodenine was not cytotoxic toward PC12 cells at concentrations up to 20 μM. Tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities were inhibited by 10 μM liriodenine to 20-70% and 10-14% of control levels at 3-12 h, respectively; TH activity was more influenced than AADC activity. The levels of TH mRNA, intracellular cyclic AMP and basal Ca2+ concentration were also decreased by 10 μM liriodenine. In addition, 10 μM liriodenine reduced L-DOPA (20-100 μM)-induced increases in dopamine content. However, 10 μM liriodenine resulted in a protective effect against L-DOPA (50-100 μM)-induced cytotoxicity. These results suggest that liriodenine regulates dopamine biosynthesis by partially reducing TH activity and TH gene expression and has protective effects against L-DOPA-induced cytotoxicity in PC12 cells.
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Mei-Feng Lai,Chen-Hung Huang,Ching-Wen Lou,Yu-Chun Chuang,Cyun-Yu Wei,Jia-Horng Lin 한국섬유공학회 2022 Fibers and polymers Vol.23 No.3
In this study, polypropylene (PP) and multi-walled carbon nanotubes (MWCNTs) are used to coat stainless steel(SS) wrapped yarns, the product of which is then fabricated into conductive textiles. Afterwards, the tensile properties,surface resistivity, and electromagnetic shielding effectiveness (EMSE) of conductive textiles are evaluated, therebydetermining the influences of the MWCNTs content. The test results show that using MWCNT can effectively improve themechanical properties of the coated yarns and conductive woven fabrics. In addition, 5 wt % of MWCNT provides the wovenfabrics with a lower surface resistivity and higher EMSE. The influences of the lamination angle and number of laminationlayers on EMSE are investigated, and the maximum EMSE of -49.89 dB occurs when the lamination angle is 0 °/90 °/0 °.
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