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- 저자 : Meejung (검색결과 158 건)
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Meejung Kim-Marandet 한국문화재보존과학회 2024 보존과학회지 Vol.40 No.5
This study examines the rarity of surviving original mounts of traditional Korean paintings and the challenges posed by remounting such works in Chinese or Japanese styles, which often detract from the authentic form of the works. This paper compares two paintings of Yi Jeong (1554–1626) to assess the use and significance of colophons and their role in enhancing scholarly appreciation. The investigation reveals how the refined materials and style used in these mounts reflect the aristocratic origins of Yi Jeong and the high regard his art received during the Joseon dynasty. Furthermore, I will examine historical connections between Yi Jeong’s works and the broader context of Korean literati culture, emphasizing the importance of these works as aesthetic objects and rich cultural artifacts. The findings of this research deepen the understanding of Korean traditional paintings, underscoring the necessity of preserving their authentic mounting styles to honor their historical significance.
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Catechin reduces liver inflammation by regulating Kupffer cell activation in rats
Meejung Ahn 대한수의학회 2024 대한수의학회지 Vol.64 No.3
The liver is a defense against infections due to its strategic location between the gastrointestinal and systemic circulations. In dogs and cats, infectious hepatitis encompasses a range of contagious diseases affecting the liver either directly or as part of a broader systemic infection, including bacterial, mycobacterial, viral, fungal, protozoal, parasitic, and rickettsial diseases. Catechins possess well-recognized natural antioxidant properties. This study investigated their therapeutic potential for applications in hepatology, evaluating whether catechins reduce hepatic inflammation in rats repeatedly exposed to carbon tetrachloride (CCl4). Sprague-Dawley rats were given catechin 50 (C50) or 100 (C100) mg/kg body weight orally daily for 3 days. This treatment was given with or without concurrent intraperitoneal injections of CCl4. Phosphate-buffered saline served as the vehicle control, while silymarin administered at 100 mg/kg was used as the positive control. Gross examination revealed significant enlargement, edema, and darker tissue in CCl4-induced livers treated with vehicle. Additionally, spotty discoloration was observed on the surface. Kupffer cell activation suppressed the expression of inflammatory mediators, including inducible nitric oxide synthase (iNOS), in groups co-treated with catechin and CCl4; this effect was reversed when catalase replaced catechin in CCl4-injured rats. Catechin alleviates hepatic inflammation in rats repeatedly exposed to CCl4; it also modulates the activation of Kupffer cells and monocytes. These results should lead to new treatments for liver inflammation in veterinary practice.
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Meejung Ahn,Poornima D. E. Weerasinghe-Mud,Hyobin Kim,Minju Kwon,Jeongtae Kim,Taekyun Shin 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Progranulin (PGRN) which is a secreted neurotrophin mediates cell cycle progression and cell motility that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. To evaluate the involvement of PGRN in experimental autoimmune neuritis (EAN) pathogenesis, as a model of human demyelinating diseases such as Guillain- Barré Syndrome. The expression of PGRN in rat sciatic nerves with EAN was studied. PGRN expression was increased significantly in EAN-affected sciatic nerves compared with normal rat sciatic nerves. The elevated levels of PGRN in the sciatic nerves of rats with EAN at the peak stage and then its expression was decreased significant at the recovery stage. The cellular phenotype of PGRN in EAN lesions consisted mainly of inflammatory cells including macrophages and Schwann cells whereas it was expressed constitutively in axons. Collectively, this study suggests that PGRN secreted by a variety of cells including macrophage, vascular endothelial cells and Schwann cells, plays either pro-inflammatory or tissue regenerative effects, or both depending on PGRN containing cell type, during the course of EAN, an animal model of human demyelinating disease. (Acknowledgement: This work was supported by the National Research Foundation of Korea: Grant number NRF-2017R1A2B4012478)
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Factors Associated with the Timeliness of Electronic Nursing Documentation
Meejung Ahn,최모나,YoungAh Kim 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.4
Objectives: To investigate the factors associated with the timeliness of electronic nursing documentation using the entry time on the Electronic Medical Record (EMR) system. Methods: As a retrospective study, data were extracted from January 1 to February 28, 2014 from a hospital EMR system and a nurses’ personnel information system. The timeliness of instances of nursing documentation was categorized into ‘timely’ or ‘untimely’ according to whether the entry time was time-stamped within the working hours during each day, evening, or night shift. Factors associated with the timeliness of the electronic nursing documentation were included in the logistic regression models as nurse- and patient-associated factors. Results: Among 1,700,247 instances of electronic nursing documentation, 79.3% (n = 1,347,711) were completed within the working hours. Years of nursing experience, nursing shift, days of the week, patients’ age, and medical department had a statistically significant associated with the timeliness of nursing records. Nurses with experience of more than 1 year entered nursing records over 2 times more during their working hours than did less experienced nurses. During the evening and night shifts, nurses were 1.49 times and 9.19 times more likely to enter nursing documents in a timely manner, respectively, as compared to those in the day shift. Conclusions: Nursing documentation was typically completed outside of working hours when a nurse had little experience, worked during the day shift or weekdays, and when tasks were unpredictable. This shows that new nurses need support to familiarize them with various tasks and the overall workflow.
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Meejung Ahn The Korean Society of Veterinary Science 2024 Journal of Veterinary Science Vol.25 No.1
Importance: Guillain-Barré syndrome (GBS)-like neuropathy mimics the leading cause of sporadic acute nontraumatic limb paralysis in individuals from developed countries. Experimental autoimmune neuritis (EAN) is an animal model of GBS and of syndromes such as acute canine polyradiculoneuritis, seen in dogs and cats. Objective: The involvement of glycogen synthase kinase (GSK)-3β, a pro-inflammatory molecule, in rat EAN is not fully understood. This study evaluated the potential role of GSK-3β in EAN through its inhibition by lithium. Methods: Lewis rats were injected with SP26 antigen to induce EAN. Lithium was administered from 1 day before immunization to day 14 post-immunization (PI). Then the rats were euthanized and their neural tissues were prepared for histological and Western blotting analyses. Results: Lithium, an inhibitor of GSK-3, significantly ameliorated EAN paralysis in rats, when administered from day 1 to day 14 PI. This corresponded with reduced inflammation in the sciatic nerves of EAN rats, where phosphorylation of GSK-3β was also upregulated, indicating suppression of GSK-3. Conclusions and Relevance: These findings suggest that lithium, an inhibitor of GSK-3β, plays a significant role in ameliorating rat EAN paralysis, by suppressing GSK-3β and its related signals in EAN-affected sciatic nerves.
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