RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 원문제공처
          펼치기
        • 등재정보
          펼치기
        • 학술지명
          펼치기
        • 주제분류
          펼치기
        • 발행연도
          펼치기
        • 작성언어
        • 저자
          펼치기

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • Temporal Trends and Future Prediction of Breast Cancer Incidence Across Age Groups in Trivandrum, South India

        Mathew, Aleyamma,George, Preethi Sara,Arjunan, Asha,Augustine, Paul,Kalavathy, MC,Padmakumari, G,Mathew, Beela Sarah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6

        Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.

      • Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors

        Mathew, Bijo,Baek, Seung Cheol,Grace Thomas Parambi, Della,Pil Lee, Jae,Joy, Monu,Annie Rilda, P. R.,Randev, Rugma V.,Nithyamol, P.,Vijayan, Vijitha,Inasu, Sini T.,Mathew, Githa Elizabeth,Lohidakshan, The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.11

        <P>A series of 13 phenyl substituted thiosemicarbazones (SB1-SB13) were synthesized and evaluated for their inhibitory potential towards human recombinant monoamine oxidase A and B (MAO-A and MAO-B, respectively) and acetylcholinesterase. The solid state structure of SB4 was ascertained by the single X-ray diffraction technique. Compounds SB5 and SB11 were potent for MAO-A (IC50 1.82 ± 0.14) and MAO-B (IC50 0.27 ± 0.015 μM), respectively. Furthermore, SB11 showed a high selectivity index (SI > 37.0) for MAO-B. The effects of fluorine orientation revealed that SB11 (<I>m</I>-fluorine) showed 28.2 times higher inhibitory activity than SB12 (<I>o</I>-fluorine) against MAO-B. Furthermore, inhibitions by SB5 and SB11 against MAO-A and MAO-B, respectively, were recovered to near reference levels in reversibility experiments. Both SB5 and SB11 showed competitive inhibition modes, with <I>K</I>i values of 0.97 ± 0.042 and 0.12 ± 0.006 μM, respectively. These results indicate that SB5 and SB11 are selective, reversible and competitive inhibitors of MAO-A and MAO-B, respectively. Compounds SB5, SB7 and SB11 showed moderate inhibition against acetylcholinesterase with IC50 values of 35.35 ± 0.47, 15.61 ± 0.057 and 26.61 ± 0.338 μM, respectively. Blood-brain barrier (BBB) permeation was studied using the parallel artificial membrane permeation assay (PAMPA) method. Molecular docking studies were carried out using AutoDock 4.2.</P>

      • KCI등재

        Numeral Classifiers in Eastern Tamang

        Barrie Michael Jonathan Mathew,전재현 대한언어학회 2022 언어학 Vol.30 No.1

        Barrie, Michael Jonathan Mathew & Jun, Jaehyun. (2022). Numeral classifiers in Eastern Tamang. The Linguistic Association of Korea Journal, 30(1), 113-131. In this paper, we examine numeral classifiers and number marking in one dialect of Eastern Tamang. As Tamang is a relatively understudied dialect continuum, we give a basic description of the empirical facts. We then employ various diagnostics from the literature and one we created ourselves to determine whether classifiers compose with nouns or with numerals. We conclude that since the classifier composes with numerals, the numeral classifier is a constituent that composes with the NP. We also examine number marking and observe that the plural marker is obligatory in some environments for animate nouns, but not for inanimate nouns. We conclude by making some tentative remarks that this dialect of Eastern Tamang might be undergoing a transition from a classifier language to a number language.

      • KCI등재

        Dissecting Inchoatives and Causatives: English get constructions

        Barrie Michael Jonathan Mathew,성문현 한국언어정보학회 2018 언어와 정보 Vol.22 No.3

        Barrie, Michael Jonathan Mathew and Sung, Moonhyun. 2018. Dissecting Inchoatives and Causatives: English get Constructions. Language and Information, 22.3. 91-108. In this paper, we present data from English get-constructions and from Northern Iroquoian to challenge the recent consensus that in no languages are causatives built on inchoatives. Our data suggest the need for distinct functional projections for the causative and inchoative. We argue that while they are bundled in other situations, the functional heads for the causative and inchoative can be split as described in the present paper. This line of research follows recent trends in investigating the fine structure of the vP layer (Alexiadou et al. 2015, Harley 2013, Kim 2011, Marantz 2013, Pylkkänen 2008, Ramchand 2008, Legate 2014). We propose a syntactic mechanism for bundling and, in doing so, account for differences in the range of possible meanings with adverbs between canonical causatives and get-causatives. Briefly, get-causatives have unbundled causative and inchoative heads and have a wider ranger of adverbial meanings due to the projection of independent CausP and InchP. Canonical causatives have a bundled Caus-Inch head, projecting a single Caus/InchP, which leads to fewer sites for adverbs to adjoin and accordingly to a narrower range of adverbial meanings. (Sogang University)

      • Exploring Sport Management as an Academic Profession: A Critical Review of Occupational Theory

        Mathew Dowling 글로벌지식마케팅경영학회 2018 Journal of Global Sport Management Vol.3 No.4

        The discussions surrounding the current state of sport management as an academic discipline have traditionally been the responsibility of key addresses and editorials. In drawing upon the sociological and management literature surrounding professions, this article critically reflects upon the characteristics of the field and the extent to which it can be viewed as a profession. More specifically, Abbott's general theory of the profession and Greenwood's five attributes (systematic theory, authority, community sanction, ethical codes, and professional culture) that characterize a professionalized occupation are drawn upon and discussed in relation to the evolution and current state of the field. The findings elucidate the complexities of the professionalization process surrounding occupations and suggest that there are burgeoning signs of a profession emerging within sport management academia, but the field, at best, can be labelled a semi or quasi-profession. The implications of these findings for the future direction of the field are discussed.

      • KCI등재

        Vimentin Targeted Nano-gene Carrier for Treatment of Renal Diseases

        Mathew Ansuja Pulickal,Uthaman Saji,Bae Eun Hui,Lee Jae Young,Park In-Kyu 대한의학회 2021 Journal of Korean medical science Vol.36 No.49

        Background: Chronic kidney disease (CKD) is a global health problem, and there is no permanent treatment for reversing kidney failure; thus, early diagnosis and effective treatment are required. Gene therapy has outstanding potential; however, the lack of safe gene delivery vectors, a reasonable transfection rate, and kidney targeting ability limit its application. Nanoparticles can offer innovative ways to diagnose and treat kidney diseases as they facilitate targetability and therapeutic efficacy. Methods: Herein, we developed a proximal renal tubule-targeting gene delivery system based on alternative copolymer (PS) of sorbitol and polyethyleneimine (PEI), modified with vimentin-specific chitobionic acid (CA), producing PS-conjugated CA (PSC) for targeting toward vimentin-expressing cells in the kidneys. In vitro studies were used to determine cell viability, transfection efficiency, serum influence, and specific uptake in the human proximal renal tubular epithelial cell line (HK-2). Finally, the targeting efficiency of the prepared PSC gene carriers was checked in a murine model of Alport syndrome. Results: Our results suggested that the prepared polyplex showed low cytotoxicity, enhanced transfection efficiency, specific uptake toward HK-2 cells, and excellent targeting efficiency toward the kidneys. Conclusion: Collectively, from these results it can be inferred that the PSC can be further evaluated as a potential gene carrier for the kidney-targeted delivery of therapeutic genes for treating diseases.

      • KCI등재

        Party Competition and Ideology in Hong Kong: A New Manifesto Coding Dataset

        Mathew Y. H. Wong 동아시아연구원 2020 Journal of East Asian Studies Vol.20 No.2

        This study provides a new dataset on the ideological positions of political parties in Hong Kong, which is a hybrid regime with electoral elements. Using this dataset, the study challenges the non-ideological view of party competition in Hong Kong by identifying an ideological dimension to the elections held between 1998 and 2016. It is shown that parties do position themselves along an identifiable left–right spectrum, with shifts that can be meaningfully interpreted, and that the aggregate ideology of the electorate appears to be linked to the level of economic growth. The ideological dimension provides a novel perspective on local politics that looks beyond the dominant pro-democracy versus pro-Beijing divide while also shedding light on the recent changes underlying the latter. This study provides valuable objective data for analyzing political competition dynamics and contributes to the comparative literature by incorporating Hong Kong into the framework of the manifesto coding project.

      • European Union Interregionalism and the Capability-Expectations Gap

        ( Mathew Doidge ) 한국EU학회 2009 Asia-Pacific Journal of EU Studies Vol.7 No.1

        This article addresses interregionalism in EU external relations. It considers the nature of interregionalism centred on two functional varieties-an internally focused, capacity building interregionalism and an externally focused, globally active form-and, in broad brush strokes, the evidence for each of these forms in EU interregional strategies. On this basis, it notes a capability-expectations gap in the EU`s approach to interregionalism, with a certain dissonance between the Union`s apparent acknowledgement of limited regional actorness in its partner groupings on the one hand and, on the other, its coincident high-level expectations as to what is achievable in the context of these relationships. The article concludes by suggesting priority areas for EU interregional strategy.

      • SCIESCOPUSKCI등재

        Efficient Query Retrieval from Social Data in Neo4j using LIndex

        Mathew, Anita Brigit Korean Society for Internet Information 2018 KSII Transactions on Internet and Information Syst Vol.12 No.5

        The unstructured and semi-structured big data in social network poses new challenges in query retrieval. This requirement needs to be met by introducing quality retrieval time measures like indexing. Due to the huge volume of data storage, there originate the need for efficient index algorithms to promote query processing. However, conventional algorithms fail to index the huge amount of frequently obtained information in real time and fall short of providing scalable indexing service. In this paper, a new LIndex algorithm, which is a heuristic on Lucene is built on Neo4jHA architecture that holds the social network Big data. LIndex is a flexible and simplified adaptive indexing scheme that ascendancy decomposed shortest paths around term neighbors as basic indexing unit. This newfangled index proves to be effectual in query space pruning of graph database Neo4j, scalable in index construction and deployment. A graph query is processed and optimized beyond the traditional Lucene in a time-based manner to a more efficient path method in LIndex. This advanced algorithm significantly reduces query fetch without compromising the quality of results in time. The experiments are conducted to confirm the efficiency of the proposed query retrieval in Neo4j graph NoSQL database.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼