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Mathew, Aleyamma,George, Preethi Sara,Arjunan, Asha,Augustine, Paul,Kalavathy, MC,Padmakumari, G,Mathew, Beela Sarah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors
Mathew, Bijo,Baek, Seung Cheol,Grace Thomas Parambi, Della,Pil Lee, Jae,Joy, Monu,Annie Rilda, P. R.,Randev, Rugma V.,Nithyamol, P.,Vijayan, Vijitha,Inasu, Sini T.,Mathew, Githa Elizabeth,Lohidakshan, The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.11
<P>A series of 13 phenyl substituted thiosemicarbazones (SB1-SB13) were synthesized and evaluated for their inhibitory potential towards human recombinant monoamine oxidase A and B (MAO-A and MAO-B, respectively) and acetylcholinesterase. The solid state structure of SB4 was ascertained by the single X-ray diffraction technique. Compounds SB5 and SB11 were potent for MAO-A (IC50 1.82 ± 0.14) and MAO-B (IC50 0.27 ± 0.015 μM), respectively. Furthermore, SB11 showed a high selectivity index (SI > 37.0) for MAO-B. The effects of fluorine orientation revealed that SB11 (<I>m</I>-fluorine) showed 28.2 times higher inhibitory activity than SB12 (<I>o</I>-fluorine) against MAO-B. Furthermore, inhibitions by SB5 and SB11 against MAO-A and MAO-B, respectively, were recovered to near reference levels in reversibility experiments. Both SB5 and SB11 showed competitive inhibition modes, with <I>K</I>i values of 0.97 ± 0.042 and 0.12 ± 0.006 μM, respectively. These results indicate that SB5 and SB11 are selective, reversible and competitive inhibitors of MAO-A and MAO-B, respectively. Compounds SB5, SB7 and SB11 showed moderate inhibition against acetylcholinesterase with IC50 values of 35.35 ± 0.47, 15.61 ± 0.057 and 26.61 ± 0.338 μM, respectively. Blood-brain barrier (BBB) permeation was studied using the parallel artificial membrane permeation assay (PAMPA) method. Molecular docking studies were carried out using AutoDock 4.2.</P>
A Short Note on Inclusive and Exclusive Plurals in Korean
Michael Jonathan Mathew Barrie(Michael Jonathan Mathew Barrie ),Éric Mathieu(Éric Mathieu ) 한국생성문법학회 2023 생성문법연구 Vol.33 No.1
The aim of this short article is to give a comprehensive analysis of number in Korean, adding a novel observation about the interpretation of plurals in that language. Based on the new data, our proposal is that number is distributed along the nominal spine with different effects depending on the type of functional head (and semantic features) it is associated with. In particular, we propose that number in Korean is associated with two number projections, NumP1 and NumP2, (see Watanabe 2010 for Japanese, Vazquez Rojas Maldonado 2012 for Purépecha (isolate, tsz), Dali and Mathieu 2021 for Tunisian Arabic (Afro-Asiatic, aeb)). By shedding light on the distinction between inclusive and exclusive plurals in Korean and the relationship between definiteness and plurality, we contribute to the current debate related to the distribution of the Korean plural.
Dissecting Inchoatives and Causatives: English get constructions
Barrie Michael Jonathan Mathew,성문현 한국언어정보학회 2018 언어와 정보 Vol.22 No.3
Barrie, Michael Jonathan Mathew and Sung, Moonhyun. 2018. Dissecting Inchoatives and Causatives: English get Constructions. Language and Information, 22.3. 91-108. In this paper, we present data from English get-constructions and from Northern Iroquoian to challenge the recent consensus that in no languages are causatives built on inchoatives. Our data suggest the need for distinct functional projections for the causative and inchoative. We argue that while they are bundled in other situations, the functional heads for the causative and inchoative can be split as described in the present paper. This line of research follows recent trends in investigating the fine structure of the vP layer (Alexiadou et al. 2015, Harley 2013, Kim 2011, Marantz 2013, Pylkkänen 2008, Ramchand 2008, Legate 2014). We propose a syntactic mechanism for bundling and, in doing so, account for differences in the range of possible meanings with adverbs between canonical causatives and get-causatives. Briefly, get-causatives have unbundled causative and inchoative heads and have a wider ranger of adverbial meanings due to the projection of independent CausP and InchP. Canonical causatives have a bundled Caus-Inch head, projecting a single Caus/InchP, which leads to fewer sites for adverbs to adjoin and accordingly to a narrower range of adverbial meanings. (Sogang University)
Party Competition and Ideology in Hong Kong: A New Manifesto Coding Dataset
Mathew Y. H. Wong 동아시아연구원 2020 Journal of East Asian Studies Vol.20 No.2
This study provides a new dataset on the ideological positions of political parties in Hong Kong, which is a hybrid regime with electoral elements. Using this dataset, the study challenges the non-ideological view of party competition in Hong Kong by identifying an ideological dimension to the elections held between 1998 and 2016. It is shown that parties do position themselves along an identifiable left–right spectrum, with shifts that can be meaningfully interpreted, and that the aggregate ideology of the electorate appears to be linked to the level of economic growth. The ideological dimension provides a novel perspective on local politics that looks beyond the dominant pro-democracy versus pro-Beijing divide while also shedding light on the recent changes underlying the latter. This study provides valuable objective data for analyzing political competition dynamics and contributes to the comparative literature by incorporating Hong Kong into the framework of the manifesto coding project.
Hydrophobically modified spherical MCM-41 as nanovalve system for controlled drug delivery
Mathew, A.,Parambadath, S.,Park, S.S.,Ha, C.S. Elsevier 2014 Microporous and mesoporous materials Vol.200 No.-
Spherical MCM-41 nanovalve having hydrophobically modified pore channels was synthesized via surfactant assisted sol-gel methodology and post modification process. The spherical MCM-41 has been tailored as a smart pH responsive drug carrier system by the insertion of N-3-(trimethoxysilyl)propyl aniline (TMSPA) at the pore opening before extracting the surfactant and further with phenyltrimethoxysilane (PTMS) to impart hydrophobicity on the inner surfaces of the pore channels. The surfactant extracted MCM-41 exhibits excellent textural properties such as very high specific surface area (1307 m<SUP>2</SUP>g<SUP>-1</SUP>), pore diameter (24 A) and pore volume (0.65 cm<SUP>3</SUP>g<SUP>-1</SUP>). The transmission electron microscope (TEM) and scanning electron microscope (SEM) images of mesosphere reflect the highly uniform and mono-dispersed spherical morphology having a particle size of 500nm. 5-Fluorouracil (5-Fu) and famotidine have been loaded into the hydrophobically modified channels followed with β-cyclodextrin (β-CD) as the gatekeeper to make the material as a pH responsive drug delivery system. The drug delivery has been carried out under in vitro condition at pH 4 and the amount of drug released from the nanovalve system was monitored by UV-Vis spectroscopy under regular intervals. The hydrophobically modified nanovalve was found to have delayed drug release of both 5-Fu and famotidine in comparison to the drug delivery from the nanovalve having unmodified pore channels synthesized from spherical MCM-41 under similar experimental conditions. The significance of functionalization as well as capping has been verified by the comparison of drug delivery behaviors among hydrophobically modified, unmodified, β-CD capped and uncapped nanocontainers.
Amorphous iron phosphate: potential host for various charge carrier ions
Mathew, Vinod,Kim, Sungjin,Kang, Jungwon,Gim, Jihyeon,Song, Jinju,Baboo, Joseph Paul,Park, Wangeun,Ahn, Docheon,Han, Junhee,Gu, Lin,Wang, Yuesheng,Hu, Yong-Sheng,Sun, Yang-Kook,Kim, Jaekook Springer Science and Business Media LLC 2014 NPG Asia Materials Vol.6 No.-
Design and Control of a Humanoid Avatar Head with Realtime Face Animation
Mathew Schwartz,Jaehoon Sim,Jaeheung Park 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
Human-robot interaction is composed of multiple aspects that together create a single experience. In this paper we present a humanoid head that is designed for human-robot interaction as a tele-operated robot meant to be controlled as a remote Avatar. A real-time audio signal processing algorithm is presented that uses an abstracted representation of speaking to provide users with a clear sense of presence during an interaction. We avoid using any video feeds of real human faces, nor creating artificial skins, which emphasizes the capabilities and intent of our robot to be a friendly and unique contribution to the emerging field of physical humanoid avatars.
Prevalence of rotavirus diarrhea among hospitalized under-five children
Mathew, M. A.,Paulose, A.,Chitralekha, S.,Nair, M. K.,Kang, G.,Kilgore, P. INDIAN PEDIATRIC 2014 Indian pediatrics Vol.51 No.1
Objectives: To estimate the prevalence of rotavirus diarrhea among hospitalized children less than 5 years of age in Kerala State and to determine the circulating strains of rotavirus in Kerala.Design: Multicenter, cross-sectional study.Setting: Eight representative hospitals in Kunnathunadu Thaluk, Ernakulam district, Kerala.Participants: Children in the age group under 5 yearsMethods: Hospitalized children admitted with acute diarrhea were examined and standardized case report form was used to collect demographic, clinical and health outcome. Stool specimens were collected and ELISA testing was done. ELISA rotavirus positive samples were tested by reverse transcription PCR for G and P typing (CMC Vellore).Results: Among the 1827 children, 648 (35.9%) were positive for rotavirus by the Rotaclone ELISA test. The prevalence of rotavirus diarrhea in infants less than 6 months of age was 24.7%; 6-11 months 31.9%; 12-23 months 41.9%; 24-35 months 46.9%; and 33.3% in 36- 59 months. Rotavirus infections were most common during the dry months from January through May. GIP[8] (49.7%) was the most common strain identified followed by G9P[8] (26.4%), G2P[4] (5.5%), G9P[4] (2.6%) and G12P[6] (1.3%).Conclusions: The prevalence of rotavirus diarrhea among hospitalized children less than 5 years is high in Ernakulam district, Kerala State.