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      • KCI등재

        Effects of short-term atorvastatin use in patients with calcium stones: A randomized placebo-controlled clinical trial

        Fatemeh Taheri,Maryam Taheri,Abbas Basiri,Alireza Khoshdel,Fariba Samadian,Sanaz Tavasoli 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.6

        Purpose: A few experimental and observational studies have reported that atorvastatin prevents calcium oxalate stone formation. Our study is the first to investigate the effect of atorvastatin on 24-hour urinary metabolites, urinary malondialdehyde (U-MDA) (an oxidative stress marker) and urinary neutrophil gelatinase-associated lipocalin (U-NGAL) (a renal tubular injury marker) in patients with calcium stones and hyperoxaluria. Materials and Methods: This randomized, double-blind, placebo-controlled, parallel-group clinical trial included 32 adults with recurrent calcium stone formation and hyperoxaluria. All participants received a 3-month course of either atorvastatin (20 mg/d) or placebo of an identical shape. Both groups received the usual nutritional care based on the European Association of Urology guidelines. Results: Twenty-eight participants completed the study. Serum levels of total and low-density lipoprotein cholesterol decreased in the atorvastatin group, and these changes were significantly different between groups (p<0.001). No statistically significant differences were observed between intergroup changes of the 24-hour urinary metabolite analysis, the U-MDA to creatinine ratio and the U-NGAL to creatinine ratio. Conclusions: Atorvastatin administration at a dose of 20 mg/d for 3 months did not affect 24-hour urinary metabolite, U-MDA and U-NGAL levels in recurrent calcium stone formers. However, this study could not disprove the preventive role of atorvastatin in kidney stone formation. Future studies should consider a larger sample size, longer follow-up, different drug doses, and measurements of multiple biomarkers of oxidative stress and tubular injury.

      • KCI등재

        Spatial Distribution and Biodiversity of Macrofauna in the Southeast of the Caspian Sea, Gorgan Bay in Relation to Environmental Conditions

        Mehrshad Taheri,Maryam Yazdani Foshtomi,Majid Noranian,Seyed Sahab Mira 한국해양과학기술원 2012 Ocean science journal Vol.47 No.2

        Spatial distribution and biodiversity of macrofauna in the Gorgan Bay, southeast of the Caspian Sea, were studied at fifteen stations in June 2010. Also, depth, temperature, salinity, dissolved oxygen, total organic matter content and sediment particle size were measured in each station. A total 3,356 individuals belonged to eight families and ten species were identified. Polychaeta were numerically dominated groups and Streblospio gynobranchiata, was constant and dominant species with 60.28% of total individuals but Bivalvia with four species had highest species number, though the density of them were low. The maximum density (4,500 ind/m2) was obtained at station 1 while the minimum (411 ind/m2) was observed at station 6. There was not significant correlation between the density of macrofauna with all environmental conditions. In total, six feeding group were considered but surface deposit feeder and deposit feeder were dominant in all stations. The maximum mean species number, diversity, richness, and evenness were obtained, 6.33, 1.46, 1.38 and 0.87, respectively. Based on the M-AMBI and the AMBI classification it seems that bentic environment in Gorgan Bay was not bad but the results of Shannon-Wiener, Margalef and Simpson indices the results were vice versa. In general, the values of the mentioned indices decreased from the western to the eastern part of the bay. Furthermore, the nonmetric multidimensional scaling (nMDS) showed that the structure of the macrofaunal assemblages was divides to six groups.

      • Poster Session : PS 0348 ; Epidemiology and Public Health : Comparison of Health Related Quality of Life Between Two Groups of Veteran and Non-Veteran Spinal Cord Injured Patients

        ( Payman Salamati ),( Reza Rostami ),( Soheil Saadat ),( Taher Taheri ),( Maryam Tajabadi ),( Ghazale Ranjbari ),( Zohrehsadat Naji ),( Saba Jafarpour ),( Vafa Rahimi Movaghar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Patients with spinal cord injury (SCI) have a lower health related quality of life (HRQOL) in comparison with both healthy controls and the normal population. The aim of this study was to compare HRQOL between two groups of veteran and non-veteran SCI patients. Methods: Male paraplegic non-veterans who had sustained complete SCI before the year 1988 and were residents of Tehran province, Iran, and a similar group of SCI veterans were enrolled in this study. The participants were interviewed based on the Iranian version of SF-36 questionnaire by two psychologists. Eight sub-scales and two physical and mental component summaries of the instrument were assessed. We used chi-square, odds ratio, Mann-Whitney U, independent t-test, and linear regression for analysis. Results: Overall, 25 veterans and 22 non-veterans were enrolled in the study. The mean age, time since injury, and presence of comorbid illnesses were not signifi cantly different between veterans and non-veterans. A greater number of veterans were married (P=0. 003) and employed (P=0. 047). On average, veterans had more years of formal education than non-veterans (P=0. 001). The mean (SD) bodily pain sub-scale was 72. 73(31. 253) for non-veterans and 49. 7(28. 287) for veterans (P=0. 011). Absence of comorbid illnesses was associated with a better physical component summary (P<0. 001). Employment was associated with a better mental component summary (P=0. 022). Conclusions: We did not fi nd any difference in HRQOL between the two groups except for the bodily pain sub-scale. Further studies with larger sample sizes are recommended.

      • Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

        Tadbir, Azadeh Andisheh,Pardis, Soheil,Ashkavandi, Zohreh Jafari,Najvani, Ali Dehghani,Ashraf, Mohammad Javad,Taheri, Ali,Zadeh, Maryam Asad,Sardari, Yasaman Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

        Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms ($2.61{\pm}3.1$) as compared to PA ($0.46{\pm}0.6$). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and $10.7{\pm}10.8$ respectively) compared to PA (50% and $0.78{\pm}0.2$) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

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