6면 프리즘 렌즈가 장착된 Lensmeter에서 시험 렌즈의 편심 위치 계산

Maria Lin,박종대,,조창호,김현규 배재대학교 자연과학연구소 2005 自然科學論文集 Vol.16 No.1

6면 프리즘 렌즈가 장착된 렌즈메터에서 상점의 위치로부터 시험렌즈의 편심의 위치를 알아 낼 수 있는 알고리즘을 개발하였다. 6개의 프리즘에 의해 형성되는 6개의 상점은 시험렌즈의 편심의 극좌표에 의해 변하게 되며, 비틀린 광선 추적으로 계산할 수 있다. 광학 설계 프로그램인 Code V를 사용하여 렌즈메터 광학계를 분석하고, 시험렌즈의 위치에 따른 상점의 위치 변화를 함수로 나타내서 역으로 상점의 위치로부터 시험렌즈의 편심의 위치를 알아낼 수 있는 방법을 개발하였다. We have developed an algorithm to determine the decenter position from the image points in a lensmeter with 6-sided prism lens. The positions of the image points which are formed by six prisms depends on the decenter position of a test lens and can be calculated by skew ray tracing. The optical characteristics of the lens meter was analyzed using the Code V program and the positions of the image points was expressed as a function of the decenter position of the test lens. By minimizing the expectation error, we can determine the decenter position of a test lens from the image positions.

Pressure-induced semiconductor-to-metal phase transition of a charge-ordered indium halide perovskite

Lin, Jia,Chen, Hong,Gao, Yang,Cai, Yao,Jin, Jianbo,Etman, Ahmed S.,Kang, Joohoon,Lei, Teng,Lin, Zhenni,Folgueras, Maria C.,Quan, Li Na,Kong, Qiao,Sherburne, Matthew,Asta, Mark,Sun, Junliang,Toney, Mic National Academy of Sciences 2019 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.116 No.47

<P><B>Significance</B></P><P>Metal halide perovskites attract great interest for a wide range of applications due to their remarkable optoelectronic properties. The development of environmentally friendly halide perovskite materials with various crystal structures and compositions offers unprecedented opportunities to achieve desired properties and applications. In this work, we demonstrated an In-based, charge-ordered all-inorganic halide double perovskite with the composition of Cs<SUB>2</SUB>In(I)In(III)Cl<SUB>6</SUB> synthesized by solid-state reaction. High-pressure optical properties were studied, and a pressure-driven, fully reversible semiconductor–metal phase transition was discovered. This In-based charge-ordered structure may inspire new understanding of halide perovskite as well as provide a platform for future discovery of exotic electronic phenomena such as high-<I>T</I><SUB>C</SUB> superconductivity in halide perovskite compounds.</P><P>Phase transitions in halide perovskites triggered by external stimuli generate significantly different material properties, providing a great opportunity for broad applications. Here, we demonstrate an In-based, charge-ordered (In<SUP>+</SUP>/In<SUP>3+</SUP>) inorganic halide perovskite with the composition of Cs<SUB>2</SUB>In(I)In(III)Cl<SUB>6</SUB> in which a pressure-driven semiconductor-to-metal phase transition exists. The single crystals, synthesized via a solid-state reaction method, crystallize in a distorted perovskite structure with space group <I>I</I>4/<I>m</I> with <I>a</I> = 17.2604(12) Å, <I>c</I> = 11.0113(16) Å if both the strong reflections and superstructures are considered. The supercell was further confirmed by rotation electron diffraction measurement. The pressure-induced semiconductor-to-metal phase transition was demonstrated by high-pressure Raman and absorbance spectroscopies and was consistent with theoretical modeling. This type of charge-ordered inorganic halide perovskite with a pressure-induced semiconductor-to-metal phase transition may inspire a range of potential applications.</P>

In vivo and in vitro studies of magnetic silica nanocomposites decorated with Pluronic F127 for controlled drug delivery system

Maria Janina Carrera Espinoza,KUEN-SONG LIN,Meng-Tzu Weng,Sikhumbuzo Charles Kunene,Shin-Yun Liu,You-Sheng Lin 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

The current study presents the synthesis and characterization of magnetic silica nanocomposites(MSNCs) decorated with Pluronic F127. The nanocomposites were loaded with doxorubicin (DOX) forhepatocellular carcinoma (HCC) therapy. The X-ray diffraction (XRD) patterns proved that the nanocompositeswere crystalline with diffraction peaks at 2h = 35.44 corresponding to (311) plane of Fe3O4. Thein vitro test demonstrated cell viability of above 90% revealing that MSNCs-F127 were biocompatible andnontoxic to the HEK293T and HepG2 cell lines; however, the MSNCs-F127-DOX formulations exhibited asignificant therapeutic effect against HepG2 cells. A pH-responsive drug release was detected, showing aHiguchi kinetic model at acidic and physiological conditions which demonstrated the best correlationcoefficient with R2 values of 0.969, and 0.932, respectively. The highest level of cell inhibitory rate, necrosis,and apoptosis in mice treated with MSNCs-F127-DOX was achieved by in vivo experiment, hematoxylinand eosin (H&E), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)staining. The in vivo experiment revealed a significant tumor inhibition after treatment with MSNCs-F127-DOX. The prepared MSNCs-F127-DOX formulations could be utilized as an innovative drug deliverysystem (DDS) for anticancer therapy for several cancer types.

Biomimetic targeting magnetite hollow nanostructures based on pH-responsive benzoic-imine bonds for antitumor activity

Sikhumbuzo Charles Kunene,Kuen-Song Lin,Meng-Tzu Weng,Maria Janina Carrera Espinoza,You-Sheng Lin,Yi-Ting Lin 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

In this study, versatile homotypic-targeting and PEGylated magnetite hollow nanostructures (MHNs) thatare pH-responsive used as doxorubicin (DOX) nanocarriers are demonstrated. Cancer cell membrane(CM) and polyethylene glycol (PEG) functionalization through benzoic imine bonds endows DOXconjugatednanocarriers with enhanced tumor accumulation and penetration, biomimetic-targetingspecificity, as well as on-demand drug release, which improves their antitumor efficacy. The characteristicdiffraction peaks of magnetite nanocarriers at 35 indexed as (311) plane of magnetite can beobserved. Hierarchical mesoporous nanostructures with specific pore size distributions of approximately99.9, 97.2, and 95.6%, were developed. In vitro studies revealed that drug-free nanostructures exhibitedexcellent biocompatibility with more than 95% cell viability. In contrast, drug-conjugated nanostructuresdemonstrated high therapeutic effect, pH-responsive drug release, and enhanced intracellular uptake inHepG2 cells. In vivostudies showed that the MHNC–DOX–PEG/CM formulations displayed the best antitumorefficacy, with the lowest tumor volume and weight. Furthermore, significantly large apoptotic andnecrotic areas were identified in the tumor tissues from the DOX-conjugated groups, but no noticeableinflammation or hemorrhage was observed in the main organs. Therefore, these results suggest thatthe formulated nanostructures have great potential for cancer therapies.

E-Beam Processing of Collagen-Poly(N-vinyl-2-pyrrolidone) Double-Network Superabsorbent Hydrogels: Structural and Rheological Investigations

Maria Demeter,Ion Călina,Cătălin Vancea,Murat Şen,Mădălina Georgiana Albu Kaya,Elena Mănăilă,Marius Dumitru,Viorica Meltzer 한국고분자학회 2019 Macromolecular Research Vol.27 No.3

Collagen (C)-poly(N-vinyl-2-pyrrolidone) (PVP) double-network superabsorbent hydrogels were synthesized by e-beam (electron beam) radiation processing, both with the addition of water-soluble cross-linking agents (CA), as well as without CA. The aim of the study was to develop a hydrogel for future application as wound dressings via e-beam radiation cross-linking of two biocompatible polymers. The formation of C-PVP hydrogels was confirmed by Fourier transform infrared (FTIR) spectroscopy and their performance was determined from morphological and rheological experiments, such as sol-gel analysis, swelling capacity, storage (G') and viscous (G'') moduli, cross-linking density, and pore size. Sol-gel analysis was performed in order to determine the gel properties as function of absorbed dose and it was found that the degradation density (p0)/cross-linking density (q0) ratio indicates a negligible contribution of chain scission processes. The rheological data confirmed that the elastic properties were predominant: G' moduli were larger than G'' moduli, as is specific to elastic solids and indicate the formation of a permanent hydrogel network were cross-links are present. Moreover, the swelling studies indicated that the hydrogels have good stability both in deionized water and phosphate-buffered saline (PBS) solution at 37 oC, and superabsorbent properties. The hydrogels network parameters obtained with lower content of CA, could be controlled by changing the absorbed dose.

Effects of catalysts on structural and adsorptive properties of iron oxide-silica nanocomposites

Cătălin Ianăși,Paula Ianăși (b. Svera),Adina Negrea,Mihaela Ciopec,Oleksandr I. Ivankov,Alexander I. Kuklin,László Almásy,Ana-Maria Putz 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2

Iron oxide-silica nanocomposites were prepared by sol-gel method using ammonia (NH3), acetic acid (CH3COOH) and hydrochloric acid (HCl) catalysts to generate different pH values for the reaction conditions. As starting precursors, for the silica, respectively, for the iron oxide, tetraethylorthosilicate (TEOS) and iron-III-acetylacetonate were used. The physico-chemical characterization of the materials revealed that the sample obtained with HCl catalyst displays the largest surface area (300m2/g), the most compact network structure, highest surface roughness, biggest crystallite size (14 nm), magnetization (7 emu/g) and superparamagnetic behavior. These materials were tested for adsorption of Cr6+ and Zn2+ from aqueous solution. Sample M-HCl presented the highest surface area and was further used for adsorption of metal ions. Kinetic, thermodynamic and equilibrium adsorption measurements studies were made for Cr6+ and Zn2+. To establish the material behavior from a thermodynamic point of view, temperature and contact time of adsorption process, activation energy, free energy, of standard enthalpy and entropy were calculated. The kinetic behavior was modelled by pseudo-first-order, pseudo-second-order and intraparticle diffusion kinetic models and the adsorption characteristics were determined by modelling the experimental data with Langmuir, Freundlich and Sips isotherms.

Removal of cadmium from aqueous solutions using inorganic porous nanocomposites

Cătălin Ianăşi,Mirela Picioruş,Roxana Nicola,Mihaela Ciopec,Adina Negrea,Daniel Nižňanský,Adél Len,László Almásy,Ana-Maria Putz 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.5

The present paper reports a one-pot synthesis of magnetic nanocomposites samples through acid catalyzed sol-gel method. Fe(III) acetylacetonate was used as precursor of the iron oxide phase: tetraethylortosilicate for the silica phase and polyvinyl alcohol (PVA, molecular mass 49000) as pore former. Different concentrations of Fe2O3 in composites matrices were prepared and studied ranging from 0% to 20%. All reactions took place in one pot at room temperature; the materials were subsequently heat treated at 300 oC, to ensure the crystallinity for the iron oxide having spinel structure, forming nanoparticles confined in the silica matrix. The materials were characterized using X-ray diffraction, small-angle neutron scattering, FT-IR spectroscopy, nitrogen adsorption, Mössbauer spectroscopy and magnetization measurements. The maximum value of room temperature saturation magnetization of ~54 emu/g and 0.11 kOe coercive field was achieved for the magnetic nanocomposite sample with 20% Fe2O3. The highest surface area of 680m2/g was obtained for the sample with 10% Fe2O3. The potential applicability of the obtained materials was studied for adsorption performance for cadmium in aqueous solutions. The Langmuir isotherm model described well the adsorption data, indicating monolayer adsorption of Cd(II) on the heterogeneous composite surface.

Monoclinic Tm^3+:MgWO_4: a promising crystal for continuous-wave and passively Q-switched lasers at ∼2 μm

Loiko, Pavel,Serres, Josep Maria,Mateos, Xavier,Aguiló,, Magdalena,Dí,az, Francesc,Zhang, Lizhen,Lin, Zhoubin,Lin, Haifeng,Zhang, Ge,Yumashev, Konstantin,Petrov, Valentin,Griebner, Uwe,Wan Optical Society of America 2017 Optics letters Vol.42 No.6

Public health agencies’ use of social media for communication during pandemics: a scoping review of the literature

Babatunde Abiodun Balogun,Anne Hogden,Nenagh Kemp,Lin Yang,Maria Agaliotis 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.4

Public health agencies (PHAs) have increasingly incorporated social media into their communication mix during successive pandemics in the 21st century. However, the quality, timing, and accuracy of their health messages have varied significantly, resulting in mixed outcomes for communication, audience engagement, and pandemic management. This study aimed to identify factors influencing the effectiveness of pandemic-related health messages shared by PHAs on social media and to report their impact on public engagement as documented in the literature. A scoping literature review was conducted following a predefined protocol. An electronic search of 7 relevant databases and 5 grey literature repositories yielded 9,714 papers published between January 2003 and November 2022. Seventy-three papers were deemed eligible and selected for review. The results underscored the insufficiency of social media guidance policies for PHAs. Six themes were identified: message source, message topic, message style, message timing, content credibility and reliability, and message recipient profile. These themes encompassed 20 variables that could inform PHAs’ social media public health communication during pandemics. Additionally, the findings revealed potential interconnectedness among the variables, and this study concluded by proposing a conceptual model that expands upon existing theoretical foundations for developing and evaluating pandemic-related health messaging.

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq

Chen, Lihe,Lee, Jae Wook,Chou, Chung-Lin,Nair, Anil V.,Battistone, Maria A.,Pă,unescu, Teodor G.,Merkulova, Maria,Breton, Sylvie,Verlander, Jill W.,Wall, Susan M.,Brown, Dennis,Burg, Maurice B. National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.46

<P><B>Significance</B></P><P>A long-term goal in mammalian biology is to identify the genes expressed in every cell type of the body. In the kidney, the expressed genes (i.e., transcriptome) of all epithelial cell types have already been identified with the exception of the cells that make up the renal collecting duct, which is responsible for regulation of blood pressure and body fluid composition. Here, single-cell RNA-sequencing was used in mouse to identify transcriptomes for the major collecting duct cell types: type A intercalated cells, type B intercalated cells, and principal cells. The information was used to create a publicly accessible online resource. The data allowed identification of genes that are selectively expressed in each cell type, which is informative for cell-level understanding of physiology and pathophysiology.</P><P>Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most renal epithelial cell types. The exceptions are the cell types that make up the renal collecting duct, namely intercalated cells (ICs) and principal cells (PCs), which account for only a small fraction of the kidney mass, but play critical physiological roles in the regulation of blood pressure, extracellular fluid volume, and extracellular fluid composition. To enrich these cell types, we used FACS that employed well-established lectin cell surface markers for PCs and type B ICs, as well as a newly identified cell surface marker for type A ICs, c-Kit. Single-cell RNA-seq using the IC- and PC-enriched populations as input enabled identification of complete transcriptomes of A-ICs, B-ICs, and PCs. The data were used to create a freely accessible online gene-expression database for collecting duct cells. This database allowed identification of genes that are selectively expressed in each cell type, including cell-surface receptors, transcription factors, transporters, and secreted proteins. The analysis also identified a small fraction of hybrid cells expressing aquaporin-2 and anion exchanger 1 or pendrin transcripts. In many cases, mRNAs for receptors and their ligands were identified in different cells (e.g., <I>Notch2</I> chiefly in PCs vs. <I>Jag1</I> chiefly in ICs), suggesting signaling cross-talk among the three cell types. The identified patterns of gene expression among the three types of collecting duct cells provide a foundation for understanding physiological regulation and pathophysiology in the renal collecting duct.</P>