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<P>Advancement of biological process for the synthesis of bionanoparticles is evolving into a key area of research in nanotechnology. The present study deals with the biosynthesis, characterization of gold bionanoparticles by Nocardiopsis sp. MBRC-48 and evaluation of their antimicrobial, antioxidant and cytotoxic activities. The gold bionanoparticles obtained were characterized by UV-visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis and transmission electron microscopy (TEM). The synthesized gold bionanoparticles were spherical in shape with an average of 11.57 +/- A 1.24 nm as determined by TEM and dynamic light scattering (DLS) particle size analyzer, respectively. The biosynthesized gold nanoparticles exhibited good antimicrobial activity against pathogenic microorganisms. It showed strong antioxidant activity as well as cytotoxicity against HeLa cervical cancer cell line. The present study demonstrated the potential use of the marine actinobacterial strain of Nocardiopsis sp. MBRC-48 as an important source for gold nanoparticles with improved biomedical applications including antimicrobial, antioxidant as well as cytotoxic agent.</P>
Manivasagan, Panchanathan,Bharathiraja, Subramaniyan,Santha Moorthy, Madhappan,Oh, Yun-Ok,Song, Kyeongeun,Seo, Hansu,Oh, Junghwan American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.17
<P>The development of novel photothermal ablation agents as cancer nanotheranostics has received a great deal of attention in-recent decades. Biocompatible fucoidan (Fu) is used as the coating material for gold nanorods (AuNRs) and subsequently conjugated with monoclonal antibodies against epidermal growth factor receptor (anti-EGFR) novel photothermal ablation agents for,cancer nanotheranostics because of their excellent biocompatibility, biodegradability, nontoxicity, water solubility, photostability, ease of Surface modification, strongly enhanced absorption in near-infrared (NIR) regions, target specificity, minimal invasiveness, fast recovery, and prevention. of damage to normal tissues: Anti-EGFRFu-AuNRs have an average particle size of 96.37 +/- 3.73 nm. Under 808 nm NIR laser at 2 W/cm(2) for 5 min, the ternperathre of the solution containing anti-EGFR Fu-AuNRs,(30 mu g/mL) increased by 52.1 degrees C. The anti-EGFR Fu-AuNRs exhibited high efficiency for the ablation of MDA-MB-231 cells in vitro. In viva- photothermal ablation exhibited that tumor tissues fully recovered without recurrence and finally were reconstructed with normal-tissues by-the 808 nm NIER. laser irradiatiOn after injection of anti-EGFR Fu-AuNRs. These results suggest that the anti-BUR Fu-AuNRs would be novel photoablation agents for future cancer nanotheranostics:</P>
Manivasagan, Panchanathan,Jun, Seung Won,Nguyen, Van Tu,Truong, Nguyen Thanh Phong,Hoang, Giang,Mondal, Sudip,Santha Moorthy, Madhappan,Kim, Hyehyun,Vy Phan, Thi Tuong,Doan, Vu Hoang Minh,Kim, Chang-S The Royal Society of Chemistry 2019 Journal of materials chemistry. B, Materials for b Vol.7 No.24
<P>The development of a new generation of multifunctional nanomaterials as a drug delivery system for chemo-photothermal therapy is of great necessity. In this study, we first prepared folic acid-conjugated and doxorubicin-loaded chitosan oligosaccharide encapsulated gold nanorods (FA-COS-TGA-GNRs-DOX) as a new photothermal agent for the delivery of drugs and heat to tumor areas. FA-COS-TGA-GNRs-DOX nanomaterials combine the advantages of COS, GNRs, FA, TGA, and DOX and have excellent biocompatibility, strong absorbance in the near-infrared (NIR) region, photostability, photothermal conversion efficiency, high targeting efficiency, fast drug release under laser irradiation, and tumor cell killing efficiency. FA-COS-TGA-GNRs-DOX exhibited significantly greater cell killing after laser irradiation. The intracellular uptake behavior of the targeted FA-COS-TGA-GNRs-DOX was confirmed by flow cytometry, two-photon fluorescence microscopy (TPFM), and confocal laser scanning microscopy (CLSM). More interestingly, the tumors in the presence of FA-COS-TGA-GNRs-DOX under laser irradiation were efficiently ablated and did not recur, showing an outstanding combined therapy of tumors. The combination of photothermal therapy (PTT) and photoacoustic imaging (PAI) could accurately locate and fully destroy tumor tissues after the intravenous injection of FA-COS-TGA-GNRs-DOX. Hence, this work offers a new avenue to develop a novel class of multifunctional nanomaterials as a drug delivery system for cancer therapy.</P>
Manivasagan, Panchanathan,Nguyen, Van Tu,Jun, Seung Won,Hoang, Giang,Mondal, Sudip,Kim, Hyehyun,Doan, Vu Hoang Minh,Kim, Jeehyun,Kim, Chang-Seok,Oh, Junghwan Elsevier 2019 Journal of controlled release Vol.311 No.-
<P><B>Abstract</B></P> <P>Developing a novel multifunctional theranostic agent for cancer combination therapy has attracted tremendous attention in recent years. In this report, we designed and developed a new multifunctional nanocarrier based on anti-epidermal growth factor receptor antibody-conjugated and paclitaxel loaded-thiol chitosan-layered gold nanoshells (anti-EGFR-PTX-TCS-GNSs) as a theranostic agent for the first time used for fluorescence/photoacoustic dual-modal imaging-guided chemophotothermal synergistic therapy. The resulting anti-EGFR-PTX-TCS-GNSs showed excellent biosafety, biocompatibility, broad near-infrared (NIR) absorbance, photostability, fast and laser irradiation-controllable drug release, and higher targeting efficiency for efficient chemophotothermal combination therapy of cancer under the guidance of photoacoustic imaging (PAI). The combination therapy was investigated <I>in vitro</I> and <I>in vivo,</I> displaying a powerful anticancer efficiency. More importantly, an <I>in vivo</I> experiment of anti-EGFR-PTX-TCS-GNSs with laser irradiation showed heavy damage to the tumor tissue, killing the tumor cells almost completely. Anti-EGFR-PTX-TCS-GNSs also showed a powerful capacity to visualize tumors, and therefore it is considered a new PAI contrast agent for subsequent therapy. Histological analysis and TUNEL assay further showed much more apoptotic cells, confirming the value of anti-EGFR-PTX-TCS-GNSs. Our results provide a new concept and a promising strategy to develop a novel multifunctional nanotheranostic agent for future clinical applications in diagnosis and therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Bharathiraja, Subramaniyan,Manivasagan, Panchanathan,Santha Moorthy, Madhappan,Bui, Nhat Quang,Jang, Bian,Phan, Thi Tuong Vy,Jung, Won-Kyo,Kim, Young-Mok,Lee, Kang Dae,Oh, Junghwan Elsevier 2018 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEU Vol.123 No.-
<P><B>Abstract</B></P> <P>Photodynamic therapy (PDT) and photothermal therapy (PTT) using nanoparticles have gained significant attention for its therapeutic effect for cancer treatment. In the present study, we fabricated polypyrrole nanoparticles by employing bovine serum albumin-phycocyanin complex and the formulated particles were stable in various physiological solutions like water, phosphate buffered saline and culture media. The formulated nanoparticles did not cause any noticeable toxicity to MDA-MB-231 and HEK-293 cells. The obtained nanoparticles effectively killed MDA-MB-231 cells in a dual way upon laser illumination, one is through phycocyanin propagated reactive oxygen species (PDT) upon laser illumination and in another way it eradicated the treated cells by converting optical energy into heat energy (PTT). Additionally, the nanoparticles generated good amplitude of ultrasound signals under photoacoustic imaging (PAT) system that facilitates imaging of treated cells. In conclusion, the fabricated particles could be used as a multimodal therapeutic agent for treatment of cancer in the biomedical field.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phycocyanin-BSA stabilized polypyrrole nanoparticles (Ppy@BSA-Pc) formulated. </LI> <LI> Ppy@BSA-Pc can be applied to PDT and PTT treatment. </LI> <LI> Ppy@BSA-Pc facilitates imaging of treated cells under PAI system. </LI> <LI> Ppy@BSA-Pc can act as a theranostic agent in biomedical field. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
<P><B>Abstract</B></P> <P> <I>Pseudomonas aeruginosa</I> is an opportunistic human pathogen which exhibits its property of pathogenesis due to several factors, including the formation of biofilm and production of several virulence factors. Development of resistance properties against antibiotics leads to the discovery of certain alternative strategies to combat its pathogenesis. In the present study, a highly stable, biocompatible and water soluble nanocomposites (NCs) are synthesized from chitosan (CS) and the polypyrrole (PPy). The resultant chitosan-polypyrrole nanocomposites (CS-PPy NCs) inhibit the establishment of biofilm and also eradicate the preformed matured biofilm formed by <I>P. aeruginosa</I>. CS-PPy NCs inhibit the hemolytic and protease activities of <I>P. aeruginosa</I>. The NCs significantly reduce the production of many virulence factors such as pyocyanin, pyroverdine and rhamnolipid. CS-PPy NCs also suppress the bacterial motility such as swimming and swarming. The present study showed that highly stable CS-PPy NCs act as a potent antibiofilm and antivirulence drug for the treatment of <I>P. aeruginosa</I> infection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CS-PPy is a water soluble and highly stable nanocomposites. </LI> <LI> CS-PPy NCs inhibits the formation of biofilm of <I>P. aeruginosa.</I> </LI> <LI> CS-PPy NCs exhibits antihemolytic and antivirulence properties to <I>P. aeruginosa.</I> </LI> <LI> CS-PPy NCs impairs the motilities properties of <I>P. aeruginosa.</I> </LI> <LI> CS-PPy NCs can be used as a potent antibiofilm and antivirulence drug. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>