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- 저자 : Man Ha Huh (검색결과 107 건)
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췌아세포종에 관한 조직병리학적 및 전자현미경적 관찰 : 한국인에 발생한 4례에 관하여
허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1
A pathological observation of four cases of pancreatoblastoma in Korean, associated with a review of Korean language literature, is performed. By light microscopy, all cases revealed similar histological findings which support the opinion that pancreatoblastoma has a characteristic morphological features and the tumor is an independent disease entity. The four cases reveals squamoid corpuscles and organoid architecture with a variable degree of acinic differentiation plus areas of sheets of cells which are less differentiated. Electron microscopic observations show an admixture of dark cells and light cells. In the cells showing acinic differentiation, a large number of electron-dense membrane bound zymogen-like granules are seen in cytoplasm. At the apical border, the cells show microvilli. The cells of the squamoid corpuscles show filamentous structure and electron dense granules in cytoplasm. A clinicopathological review of the four cases of pancreatoblastoma in Korean, with focuses on age, sex, site of neoplasm, diagnostic criteria, validity of subclassification with respect to prognosis, and significance of elevation of serum AFP etc is performed.
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장희경,김혜숙,허방,허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1
A case of metastatic clear cell carcinoma of the thyroid in a 60 year old Korean male, ensuing clear cell carcinoma of the kidney after 15 years, is reported, associated with a literature review, in view of its rarity and the method of surgicopathological access we adopted toward the final anatomic diagnosis. An emphasis is placed on the way of differential diagnosis of metastatic carcinoma from primary clear cell carcinoma of the thyroid and secondary malignancy from primary parathyroid carcinoma. Not only gross and ordinary microscopic observations including special stains, an immunoperoxidase method is performed to confirm that the thyroid lesion is not of the thyroid cell origin, which reconfirms the immunopathological method is a useful tool in surgical pathology.
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소 태아 혈청이 연골의 Proteoglycan 합성에 미치는 영향
김흥준,김재도,김영옥,허만하 고신대학교 의학부 1994 高神大學校 醫學部 論文集 Vol.10 No.1
Articular cartilage is a highly specialized connective tissue that covers the ends of long bones within the synovial joint cavity. It contains no blood vessels, no nerve fibers, and no lymphatics, accordingly it is nourished from the synovial fluid by diffusion. Articular cartilage is composed of an extracellular matrix(ECM), collagen and proteoglycan. A small number of specific cells, chondrocytes, are embedded in the matrix. They are influenced by the alteration of components in synovial fluid which is derived from serum. To examine the effect of serum on biosynthesis of proteoglycan, this experiment was performed using human articular cartilages which were obtained from the patients who were operated due to various diseases. The human articular cartilages were incubated in 3 kinds of media : DMEM without fetal calf serum(FCS) (control), DMEM containing 1 % FCS, and DMEM containing 20 % FCS. The synthethized proteoglycan, incorporated with labeled S^(35) sulfate, was extracted through PD-10 column after digestion by papain and measured the uptake of [35S] sulfate labeled proteoglycan by scintillation counter. To examine whether difference in concentration of fetal. calf serum is reflected in staining intensity of immunohistochemistry for proteoglycan (avidin-biotin peroxidase complex), immunohistochemical staining was performed. The results were as followings : 1) Biosyntheses of proteoglycan in 1 % and 20% FCS were increased 1.77 times and 2.27 respectively comparing with the control group. 2) In FCS groups, biosynthesis of proteoglycan in 20% FCS was 1.29 times higher than that in 1% FCS. 3) No difference in staining intensity for proteoglycan in the variable concentrations of fetal calf serum was seen. The above results suggest that the compositional alteration of synovial fluid due to various factors influence the synthesis of the ECM in the articular cartilage and immunohistochemical staining is not sensitive enough to differentiate the quantitative difference of antigen.
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Colchicine 독성에 따른 골격근의 형태학적 변화에 관한 연구 : 막성소체 출현에 관한 전자현미경적 검색 Electron Microscopic Study
이화동,김경수,장희경,허만하 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.11
To investigate the morphological changes in skeletal muscle produced by colchicine toxicity, 42 rats were given a single intraperitoneal dose(0.4mg/kg) of colchicine, and the animals were killed at daily intervals up to 7 days. The results of light microscopic and electron microscopic observations are summarized as follows : 1) At the light microscopic level, colchicine treated rats show non-inflammatory, nonspecific scattered degeneration or necrosis of myofibers irrrspective of location of the skeletal muscle. No significant pathologic changes in peripheral nerve fibers distributed in affected muscles are seen.2) The general ultrastructural changes are dilation of sarcoplasmic reticulum, swelling and pleomorphism of mitochondria, and appearance of membraneous bodies characterized by a single or multiple concentric layers of membranes in subsarcolemmal zones and intermyosbrillar zones, and focal necrosis or loss of myofibrils. The incidence and severity of these changes show gradual increase and reach maximal peak 3 days after colchicine administration, and then they show gradual decrease. Nerve fibers and motor-end plates show no difference compared with the control. 3) The observations are consistent with the opinion that the muscle weakness or paresis produced by toxic dose of colchicine is not of neuropathic, but of myopathic alterations. 4) The membraneous bodies are classified into the following 3 types : Type Ⅰ is those bodies outlined by a few concentric membranes with osmiophilic granules, small vesicles, free ribosomes, and mitochondria in central zone. Type Ⅱ is those outlined by several concentric layers of membranes with osmiophilic gradules, small vesicles, free ribosomes, and mitochondria in center. Type Ⅲ is those outlined by multilayered or thick concentric membranes with osmiophilic granules, small vesicles, free ribosomes, and mitochondria in central zone, frequently with complicated lamellar structures. 5) The skeletal muscle lesions produred by colchicine toxicity may be categorized into those degenerative changes characterized by the appearance of membraneous bodies. And, morphologically, it is presumed that the membraneous bodies are heterogenous in origin, alterations of subcellular structures such as sarcoplasmic reticulum, mitochondria, and lysosome.
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