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RISS 인기검색어
- 검색키워드
- 저자 : Mahrous Ali M.A. (검색결과 5 건)
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Sroor Farid M.,Basyouni Wahid M.,Aly Hanan F.,Younis Eman A.,Mahrous Karima F.,Haroun Ahmed A. 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.6
The most frequent type of primary liver cancer is hepatocellular carcinoma (HCC), accounting for approximately 90% of primary liver cancers and a third leading cause of cancer deaths. In the current study, the synthesized compound 3 was re-formulated using tetraethyl orthosilicate (TEOS) with weight ratio (1:1) via sol-gel technique. The prepared material has been examined using Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray elemental analysis (EDX), and scanning and transmission electron microscopes (SEM and TEM). Herein, we investigate the mode of action of 3 as potent anti-liver cancer in vivo as normal and nano-forms. Rats were given a single dosage of 50 mg/kg b.wt. of HCC through an intraperitoneal injection (ip). A single dosage of CCl4 (2 ml/kg IP) was also given to rats 2 weeks later. Several liver, tumor and oxidative stress biomarkers were detected including liver enzymes; alanine and aspartate aminotransferases (ALT and AST), alkaline phosphatse (ALP), gamma glutamyl transferase (GGT), glutathione (GSH), lipid peroxide (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), α-fetoprotein and α-L-Fucosidase. Hepatic pathological pictures were also performed for the documentation of the presence of HCC and supported the biochemical results. Moreover, the DNA damage in liver tissues of male rats using comet assay was studied. The results showed that the HePG2 (− ve) group of rats exhibited a significant reduction (P < 0.05) in DNA damage values (9.30 ± 0.89) relative to other treatment groups. Nevertheless, the DNA damage values in the HePG2 (+ ve) and 5-flurouracil groups were significantly higher (P < 0.01) compared to the HePG2 (− ve) group. Additionally, HePG2 (coated 3) and HePG2 (3) groups exhibited significant decrease in the DNA damage compared to those in HePG2 (+ ve) group.
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Performance of pillar design in underground stone mines that include discontinuities
Hyung-Sik Yang,Won-Beom Kim,Mahrous A.M. Ali 한국자원공학회 2012 Geosystem engineering Vol.15 No.3
This paper describes a pillar design methodology that was developed from a study of pillar performance in operating stone mines. A number of methodologies have been developed to calculate full-scale mine pillar strengths based on laboratory scale strength obtained from specimens. Data were collected on rock mass quality, pillar conditions, mining dimensions and intact rock strength. Results showed that current mining practices have resulted in generally stable pillar layouts, without recent cases of extensive pillar collapses; however, failure of the pillars was found to be related to spalling of hard brittle rock, shearing along pre-existing angular discontinuities or progressive extrusion of soft infill material on bedding planes. A numerical model (FLAC3D) for the entire rock mass has been developed in order to analyze the stability of the entire underground opening. A preliminary monitoring phase has been realized, aimed at controlling abandoned rock structure movement at the most significant discontinuities. Some measurements of the vertical stress in the pillars and in the walls have also been performed and were used for model calibration. Once the model has been calibrated, analysis of the actual stress and deformation conditions can then be evaluated, the stability condition of the entire structure can be computed and a forecast analysis of what intervention could be realized to guarantee underground public access can be performed. The developed strength equation can be used to design stable pillar layouts, keeping in mind that the safety factor is greater than 1.5 and the width:height ratio of the pillars is between 0.6 and 0.8. It is concluded that, by applying the developed equation and selecting appropriate input parameters, it should then be possible to calculate the factor of safety.
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Abdellah Wael R.,Kim Jong-Gwan,Hassan Mohamed M.A.,Ali Mahrous A. M. 한국자원공학회 2022 Geosystem engineering Vol.25 No.2
Digital transformation (DT) is defined as a strategy for boosting mining assets by attempting significant changes to of own properties through the integration of communication, data computing, and property technologies. Making large-scale changes will be difficult with digital technology, especially if the business is not well-positioned to do so. Increasing cybersecurity protection levels is the most effective way to ensure the success of the transformation. When making significant changes, a clear digital vision should be outlined and implemented with strong leadership. However, the majority of digital transformation initiatives fail before they are completed. The problem does not just affect the mining industry. The purpose of this paper is to investigate the major challenges encountered in digital transformation projects and to propose a strategic solution for implementing and scaling digital initiatives.
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Study of Thin Double-Gap RPCs for the CMS Muon System
K. S. Lee,S. W. Cho,S. Choi,B. Hong,M. Kang,J. H. Lim,Y. M. Jo,S. K. Park,K. R. Ryoo,R. Aly,S. Aly,Y. Assran,A. Mohamed,A. Mahrous,S. Constantini,M. Abbrescia,A. Gelmi,M. Maggi,G. Iaselli,G. Pugliese 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.8
High-sensitivity double-gap phenolic resistive plate chambers (RPCs) are studied for the Phase-2 upgrade of the Compact Muon Solenoid (CMS) muon system at high pseudorapidity . Whereas the present CMS RPCs have a gas gap thickness of 2 mm, we propose to use thinner gas gaps, which will improve the performance of these RPCs. To validate this proposal, we constructed double-gap RPCs with two different gap thicknesses of 1.2 and 1.4 mm by using high-pressure laminated plates having a mean resistivity of about 5 1010 -cm. This paper presents test results using cosmic muons and 137Cs gamma rays. The rate capabilities of these thin-gap RPCs measured with the gamma source exceed the maximum rate expected in the new high- endcap RPCs planned for future Phase-2 runs of the Large Hadron Collider (LHC).
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