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Association of FASN and SCD genes with fatty acid composition in broilers
Maharani, Dyah,Seo, Dong-Won,Choi, Nu-Ri,Jin, Shil,Cahyadi, Muhammad,Jo, Cheorun,Lee, Jun-Heon Institute of Agricultural Science 2013 Korean Journal of Agricultural Science Vol.40 No.3
Fatty acids (FAs) were considered in activating nuclear hormone receptors that play significant roles in the cellular lipid metabolism by the regulation of several genes. Previously, fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) genes have been known to regulating the FA metabolism. In this study, associations of FASN and SCD genes with fatty acid (FA) composition in broilers were investigated. Tissue samples from 95 Cobb 500 broilers were used for DNA extraction. The g.1222 A>G SNP located in intron 42 of FASN gene and 2 SNPs in SCD gene, one in exon 2 (g.3728A>G) and the other in exon 4 (g.12903G>A), were subjected for genotyping using PCR-RFLP method. One of the SNPs in SCD gene, SNP g.3728A>G had significant association with myristoleic acid (C14:1; P<0.05), palmitic acid (C16:0; P<0.05), palmitoleic acid (C16:1; P<0.05) and saturated FA (SFA; P<0.05). However, the SNP g.1222A>G in FASN gene had only suggestive association with arachidic acid (C20:0; P=0.08). The findings in this study suggest that the SNP in exon 2 of SCD gene can be used as a molecular marker for selecting birds having desirable FA composition in broilers.
Evaluation of Three Candidate Genes Affecting Fatty Acid Composition in Pigs
Maharani, Dyah,Jung, Yeon-kuk,Jo, Cheorun,Jung, Woo-Young,Nam, Ki-Chang,Seo, Kang-Seok,Lee, Seung-Hwan,Lee, Jun-Heon Korean Society for Food Science of Animal Resource 2012 한국축산식품학회지 Vol.32 No.1
The association of three candidate genes, fatty acid synthase (FASN), microsomal triglyceride transfer protein (MTTP) and fatty acid binding protein 3 (FABP3), with fatty acid (FA) composition in Duroc pigs was investigated. Identified single nucleotide polymorphisms (SNPs) were used for polymerase chain reaction-restriction fragment length polymorphism genotyping. The c.265C>T SNP of FASN gene was significantly associated with high levels of palmitoleic acid (C16:1) (p<0.05), oleic acid (C18:1) (p<0.01), and mono-unsaturated fatty acid (MUFA) (p<0.01), but low levels of linoleic acid (C18:2) (p<0.01), alpha linolenic acid (C18:3) (p<0.05), and poly-unsaturated fatty acid (PUFA) (p<0.01) in animals having the CT genotype. The c.2573T>C SNP in the MTTP gene had a significant effect only in elevating the level of palmitoleic acid (C16:1) (p<0.05) in heterozygote animals. The polymorphism in FABP3 showed no significant effects on any fatty acid composition traits. These results suggest that the identified SNPs in the FASN and MTTP genes can be useful markers for selecting Duroc pigs having desirable healthy fatty acid composition.
Maharani, Dyah,Park, Hee-Bok,Jung, Yeon-Kook,Jung, Samooel,Jo, Cheo-Run,Lee, Jun-Heon The Korean Society of Poultry Science 2011 韓國家禽學會誌 Vol.38 No.3
There is limited information of the genetic effect for fatty acid composition in chicken meat. This study assessed the association of FABP3 and FABP4 genes affecting fatty acid composition in broilers. Two single nucleotide polymorphisms (SNPs) were detected in FABP3 gene and five SNPs were identified in FABP4 gene. The SNPs located in intron 1 and exon 1 of FABP3 and FABP4, respectively, were used for genotyping using PCR-RFLP method. The SNPg.285C >T in FABP4 showed suggestive association with high arachidonic acid (C20 : 4) in CT genotypes (P = 0.068). However, the SNP g.508C > T in FABP3 showed no significant associations with fatty acid composition. These results are the first report to investigate the SNPs in FABP3 and FABP4 genes and their associations with fatty acid composition, although we only found the possible association of FABP4 SNP with fatty acid composition. These results should provide valuable information for further investigation of the genes affecting fatty acid composition in chicken.
Quantitative Trait Loci and Candidate Genes Affecting Fatty Acid Composition in Cattle and Pig
Maharani, Dyah,Jo, Cheo-Run,Jeon, Jin-Tae,Lee, Jun-Heon Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.3
Investigations into fatty acid composition in meats are becoming more important due to consumer demand for high quality healthy food. Marker-assisted selection has been applied to livestock to improve meat quality by directly selecting animals for favorable alleles that affect economic traits. Quantitative trait loci affecting fatty acid composition in cattle and pigs were investigated, and five candidate genes (ACACA, FASN, SCD, FABPs, and SREBP-1) were significantly associated with fatty acid composition. The information presented here should provide valuable guidelines to detect causative mutations affecting fatty acid composition in cattle and pigs.
Topographical Factors for Wind Speed in Undulating Terrain: A Case Study for Korean Peninsula
Maharani, Yohana Noradika,이승수,이영규,김학선 한국풍공학회 2009 한국풍공학회지 Vol.13 No.2
In this study, an analysis of topographical effects using five different codes was undertaken and four case studies for Korean Peninsula are presented. The five different codes are ASCE 7-05, AS/NZS 1170.2:2002, EUROCODE 2004, AIJ 2004, and KBC 2005. The present work investigates conditions to conjecture topographic factor effects using five different codes for undulating terrain in equally spaced eight wind directions. As a consequence of insufficient specifications from most wind codes, it is required to adopt parameter for upwind obstruction identified in ASCE 7-05 to other codes, which, in this paper, we called the mixing parameter method (MPM). This work compares topographic factors between the original codes and the codes using MPM in order to demonstrate the effects of undulating terrain, and also presented rationalized formula to comprehend the influential factors in each code. The resulting topographic factors are shown to be by the influence of different parameter in each code and slope of topography in the upwind direction.
Association of an SNP in FASN gene with fatty acid composition in broiler chicken
D. Maharani,S. L. Yu,Y. Jung,B. D. Lee,C. Jo,J. H. Lee 한국가금학회 2010 한국가금학회 정기총회 및 학술발표회 Vol.27 No.-
Single nucleotide polymorphisms (SNPs) in Fatty acid synthase (FASN) were associated with fatty acid composition in ruminant animals. However, only few studies for the FASN gene have been observed in non-ruminant animals including chicken. The objective of this study was to identify the association of g. 1222 A>G SNP, located in intron 42 of chicken FASN gene, with fatty acid composition in broiler chicken. DNAs from 95 Cobb 500 broiler tissue samples were extracted and the g. 1222 A>G SNP was genotyped by PCR-RFLP using HaeIII restriction enzyme. The birds having AA, AG and GG genotypes were 14, 53 and 28, respectively. The results indicated that the g.1222 A>G SNP in chicken FASN gene was not associated with fatty acid composition. The results also indicated that birds may have different mechanism of fatty acid composition as compared with ruminant animals. Also this result indicated that more candidate genes have to be investigated for the fatty acid composition in chicken.
Quantitative Trait Loci and Candidate Genes Affecting Fatty Acid Composition in Cattle and Pig
Dyah Maharani,조철훈,전진태,이준헌 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.3
Investigations into fatty acid composition in meats are becoming more important due to consumer demand for high quality healthy food. Marker-assisted selection has been applied to livestock to improve meat quality by directly selecting animals for favorable alleles that affect economic traits. Quantitative trait loci affecting fatty acid composition in cattle and pigs were investigated, and five candidate genes (ACACA, FASN, SCD, FABPs, and SREBP-1) were significantly associated with fatty acid composition. The information presented here should provide valuable guidelines to detect causative mutations affecting fatty acid composition in cattle and pigs.
Factors Influencing Purchase Intention on Private Label Products
Nina MAHARANI,Arief HELMI,Asep MULYANA,Meydia HASAN 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
This study aims to develop propositions about the factors that influence the purchase intention of private label products. These factors are: in-store promotion, visual merchandising, store image, and customer value. This study elaborates on some of the results of previous studies that have examined the factors that influence purchase intention of private label products that have been published on Google Scholar and indexed by Scopus between 1991- 2020, to develop a proposition. This paper fills a lack of Studies which discuss purchase intention from a consumer behavior perspective. From the perspective of consumer behavior, purchase intention is influenced by three factors, namely: intrinsic factors including: consumer value, extrinsic factors including: in-store promotions, visual merchandising and store image, and consumer factors. This paper defines purchase intention as the effort and strong urge to buy a particular product in the future, the possibility of considering buying the product, the decision to rebuy the product and the desire to recommend the product. The main findings of this research are several propositions, namely: in-store promotion, visual merchandising and store image directly affect customer value and purchase intention. The following propositions are: In-store promotion, visual merchandising and store image influence purchase intention mediated by customer value.
Association between feeding intolerance and intestinal dysbiosis in very premature infants
Putri Maharani Tristanita Marsubrin,Agus Firmansyah,Rinawati Rohsiswatmo,Zakiudin Munasir,Saptawati Bardosono,Safarina Golfiani Malik,Yuditiya Purwosunu,Ina Susianti Timan,Tetty Yuniati,Maya Yulindhin 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.11