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Antioxidant Effects of Garlic in Young and Aged Rat Brain In Vitro
Luigi Brunetti,Luigi Menghini,Giustino Orlando,Lucia Recinella,Sheila Leone,Francesco Epifano,Francesco Lazzarin,Annalisa Chiavaroli,Claudio Ferrante,Michele Vacca 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Oxidative stress plays a key role in the pathogenesis of age-related neurodegeneration, and the nonenzymatic production of 8-iso-prostaglandin F2α (8-iso-PGF2α) may represent a reliable index of cellular oxidative damage. Garlic (Allium sativum) has been associated with peripheral antioxidant activities and therefore might prevent or reverse 8-iso-PGF2α production, but scant data are available on its possible neuroprotective effects. Therefore, we have studied the possible antioxidant effects of a garlic extract in rat brain synaptosomes obtained from young (3-month-old) and aged (14-month-old) male Wistar rats that were perfused, in vitro, with graded concentrations of a garlic extract (10–500μg/mL). Release in the effluent was evaluated, both in the basal state and after hydrogen peroxide-induced oxidative stress. In young rats, we observed a concentration-dependent inhibitory effect of the garlic extract on brain 8-iso-PGF2α production, both basally and after hydrogen peroxide-induced oxidative stimulus. In aged rats, 8-iso-PGF2α production was not affected by the garlic extract in the basal state, whereas, after hydrogen peroxide-induced oxidative stimulus, an antioxidant effect of the garlic extract appeared only at the higher concentration tested. In conclusion, garlic supplementation could be effective in preventing brain oxidative damage in young animals, whereas the aging brain seems to be resistant to the antioxidant effects of garlic, in vitro.
Luigi Valentino Berra,Daniele Armocida,Mauro Palmieri,Valerio Di Norcia,Luca D’Angelo,Massimo Mongardini,Massimo Vigliotta,Edoardo Maccari,Antonio Santoro 대한척추신경외과학회 2022 Neurospine Vol.19 No.1
Objective: Chordomas are slow-growing tumors, with a high tendency to local relapse. En bloc resection is related to the most favorable outcome in terms of survival but is frequently associated with permanent neurological deficits involving sphincters and sexual functions. In the present article, we describe an innovative technique of en bloc resection followed by reconstruction of the sacral nerves with nerve grafts. Methods: The chordoma was excised through a posterior approach after dividing the proximal and distal sacral nerves using the established technique. After that, a microsurgical S2-S3-S4 nerve reconstruction was performed connecting the proximal and distal stumps with sural nerve grafts withdrawn from both lower limbs. Results: Immediately after surgery, the patient experienced complete impairment of sexual function and sphincters with urinary and fecal incontinence. After 6 months, there was a progressive recovery of sexual function and sphincter control. One year after the operation, the patient achieved an adequate sexual life (erection and ejaculation) and complete control of the bladder and anal sphincter. Conclusion: Reconstruction of nerves sacrificed during sacral tumor removal has been shown to be effective in restoring sphincter and sexual function and is a promising technique that may significantly improve patients' quality of life.
Luigi Petti,Giovanni Giannattasio,Massimiliano De Iuliis,Bruno Palazzo 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.1
This paper presents the most significant results obtained within a broad-ranging experimental program aiming to evaluate both the effectiveness and the robustness of a Base Isolation (BIS) and a Tuned Mass Damper (TMD) combined control strategy (BI & TMD). Following a brief description of the experimental model set-up and the adopted kinematic scaling technique, this paper describes the identification procedures carried out to characterize the system뭩 model. The dynamic response of a small-scale model to recorded earthquake excitations, which has been scaled by using the Buckingham pi-theorem, are later presented and discussed. Finally, the effectiveness and robustness of the combined control strategy is evaluated by comparing the model뭩 dynamic response. In particular, reduction in relative displacements and absolute accelerations due to the application of different mass damping systems is investigated.
Simplified method to design laterally loaded piles with optimum shape and length
Luigi Fenu,Bruno Briseghella,Giuseppe Carlo Marano 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.2
Optimum shape and length of laterally loaded piles can be obtained with different optimization techniques. Inparticular, the Fully Stress Design method (FSD) is an optimality condition that allows to obtain the optimum shape of the pile,while the optimum length can be obtained through a transversality condition at the pile lower end. Using this technique, the structureis analysed by finite elements and shaped through the FSD method by contemporarily checking that the transversality condition issatisfied. In this paper it is noted that laterally loaded piles with optimum shape and length have some peculiar characteristics,depending on the type of cross-section, that allow to design them with simple calculations without using finite element analysis. Some examples illustrating the proposed simplified design method of laterally loaded piles with optimum shape and length areintroduced.