Can Robotic Gastrectomy Surpass Laparoscopic Gastrectomy by Acquiring Long-Term Experience? A Propensity Score Analysis of a 7-Year Experience at a Single Institution

홍성수,손상용,신호정,Long-Hai Cui,허훈,한상욱 대한위암학회 2016 Journal of gastric cancer Vol.16 No.4

Purpose: It is hypothesized that robotic gastrectomy may surpass laparoscopic gastrectomy after the operators acquire long-term experience and skills in the manipulation of robotic arms. This study aimed to evaluate the long-term learning curve of robotic distal gastrectomy (RDG) for gastric cancer compared with laparoscopic distal gastrectomy (LDG). Materials and Methods: From October 2008 to December 2015, patients who underwent LDG (n=809) were matched to patients who underwent RDG (n=232) at a 1:1 ratio, by using a propensity score matching method after stratification for the operative year. The surgical outcomes, such as trends of operative time, blood loss, and complication rate, were compared between the two groups. Results: The RDG group showed a longer operative time (171.3 minutes vs. 147.6 minutes, P<0.001) but less estimated blood loss (77.6 ml vs. 116.6 ml, P<0.001). The complication rate and postoperative recovery did not differ between the two groups. The RDG group showed a longer operative time and similar estimated blood loss compared with the LDG group after 5 years of experience (operative time: 159.2 minutes vs. 136.0 minutes in 2015, P=0.003; estimated blood loss: 72.9 ml vs. 78.1 ml in 2015, P=0.793). Conclusions: In terms of short-term surgical outcomes, RDG may not surpass LDG after a long-term experience with the technique.

Can Robotic Gastrectomy Surpass Laparoscopic Gastrectomy by Acquiring Long-Term Experience? A Propensity Score Analysis of a 7-Year Experience at a Single Institution

Hong, Sung-Soo,Son, Sang-Yong,Shin, Ho-Jung,Cui, Long-Hai,Hur, Hoon,Han, Sang-Uk The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.4

Purpose: It is hypothesized that robotic gastrectomy may surpass laparoscopic gastrectomy after the operators acquire long-term experience and skills in the manipulation of robotic arms. This study aimed to evaluate the long-term learning curve of robotic distal gastrectomy (RDG) for gastric cancer compared with laparoscopic distal gastrectomy (LDG). Materials and Methods: From October 2008 to December 2015, patients who underwent LDG (n=809) were matched to patients who underwent RDG (n=232) at a 1:1 ratio, by using a propensity score matching method after stratification for the operative year. The surgical outcomes, such as trends of operative time, blood loss, and complication rate, were compared between the two groups. Results: The RDG group showed a longer operative time (171.3 minutes vs. 147.6 minutes, P<0.001) but less estimated blood loss (77.6 ml vs. 116.6 ml, P<0.001). The complication rate and postoperative recovery did not differ between the two groups. The RDG group showed a longer operative time and similar estimated blood loss compared with the LDG group after 5 years of experience (operative time: 159.2 minutes vs. 136.0 minutes in 2015, P=0.003; estimated blood loss: 72.9 ml vs. 78.1 ml in 2015, P=0.793). Conclusions: In terms of short-term surgical outcomes, RDG may not surpass LDG after a long-term experience with the technique.

Billroth II with Braun Enteroenterostomy Is a Good Alternative Reconstruction to Roux-en-Y Gastrojejunostomy in Laparoscopic Distal Gastrectomy

Cui, Long-Hai,Son, Sang-Yong,Shin, Ho-Jung,Byun, Cheulsu,Hur, Hoon,Han, Sang-Uk,Cho, Yong Kwan Hindawi Publishing Corporation 2017 Gastroenterology Research and Practice Vol.2017 No.-

<P><I>Background</I>. Although Billroth II (BII) reconstruction is simpler and faster than Billroth I or Roux-en-Y (RY) reconstruction in patients undergoing totally laparoscopic distal gastrectomy (TLDG), BII reconstruction is associated with several complications, including more severe bile reflux. BII Braun anastomosis may be a better alternative to RY reconstruction.<I> Methods</I>. This retrospective study included 56 consecutive patients who underwent TLDG for gastric cancer, followed by BII Braun or RY reconstruction, between January 2013 and December 2015. Surgical outcomes, including length of operation, quantity of blood lost, and postoperative complications, were compared in the two groups.<I> Results</I>. Clinicopathological characteristics did not differ between the BII Braun and RY groups. Mean length of operation was significantly longer in the RY than the BII Braun group (157.3 min versus 134.6 min,<I> p</I> < 0.010), but length of hospital stay, blood loss, and complication rate did not differ between the two groups. Ileus occurred in three patients (10.0%) in the RY group. Endoscopic findings 6 months after surgery showed bile reflux in seven (28%) patients in the BII Braun group and five (17.2%) in the RY group (<I>p</I> = 0.343), but no significant differences in rate of gastric residue or degree of gastritis in the remnant stomach in the two groups.<I> Conclusions</I>. B-II Braun anastomosis is a good alternative to RY reconstruction, reducing length of operation and ileus after TLDG.</P>

Robust Control Guaranteeing Uniform Ultimate Boundedness for a Class of Mismatched Uncertain Parabolic Distributed Parameter Systems

Hai-Long Xing,Dong-Hai Li,Wen-Shan Cui 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.4

The robust control problem for a class of mismatched uncertain parabolic distributed parameter systems is studied under conditions of the uncertain terms being norm-bounded. The proposed robust controller can guarantee the system states to be the uniform ultimate boundedness, and their bound can be arbitrarily small. And, the proposed control method is successfully applied to a typical diffusion-reaction process with uncertain terms.

6차 산업으로서 농촌체험관광의 선택속성과 체험 프로그램 선호도가 농촌관광 행동의도 및 개발 지지도에 미치는 영향

최해용(Hai Long Cui),윤유식(Yoo Shik Yoon),박재덕(Jae Deok Park) 한국관광연구학회 2014 관광연구저널 Vol.28 No.2

This study was conducted as an exploratory study of the effects of selection attributes of agritourism as a sextic industry and the preference levels of experience programs on behavior intentions and support levels to pursue the development of rural area based on the recent creative economy policies. Variables were derived through exploration centering on the preference levels of existing rural area tourism destination selection attributes and experience programs in rural areas and analyses were conducted in an attempt to prsent new implications. This study can be considered meaningful when seen from the viewpoint of activation and future development of rural areas as a sextic industry. Through factor analyses, six dimensions of selection attributes of agritourism as a sextic industry were derived and three dimensions of preference levels of experience programs were derived. The effects of these selection attributes and experience programs on future agritourism behavior intentions and support levels were presented in more details by inputting individual variables. The results indicated that behavior intentions were affected by diverse surrounding environments of villages, quality of accommodations, foods and beverage, and regional residents` attitudes and service and support levels were also affected by similar attributes including accessibility. Among the preference levels of rural tourism village experience programs, all of those of farming experience, educational learning experience, and festival and events were shown to have significant effects on behavior intentions and among the support levels, only those of farming experience and educational learning experience were shown to have significant effects. The above results provide basic data to grasp the meanings of the attributes for giving implications for the activation and future development of agritourism as a sextic industry and present directions of continuous development of agritourism as a sextic industry. Therefore, the above results are considered easily utilizable for the establishment of strategies to develop agritourism as a more competitive sextic industry.

컨벤션 모바일 어플리케이션 특성에 따른 이용만족도 및 충성도 연구

최해용(Hai-long Cui),윤유식(Yooshik Yoon),원원(Yuan Yuan) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.4

본 연구는 최근에 스마트폰을 활용한 모바일 정보탐색 및 활용정도가 급격히 증가함에 이를 이용한 소비자들의 행동특성 활용가치에 대한 연구가 중요하다고 강조되고 있으며 많은 연구가 진행되어왔다. 이에 컨벤션산업에서의 모바일을 활용한 정보제공이 점차 늘어나고 있으며, 특히 모바일 어플리케이션을 활용한 컨텐츠 제공이 점차 늘어나고 있으며 이에 따라 컨벤션 참가객들의 정보수집 및 획득 특성에 변화가 나타나고 있다. 따라서 본 연구에서는 컨벤션 모바일 어플리케이션 특성에 따른 이용만족도 및 충성도와의 관계를 분석하였고 모바일 어플리케이션 특성 중 이용편리성, 정보성, 편재성, 오락성 등이 영향을 주는 것으로 파악되었다. 따라서 컨벤션 모바일 어플리케이션에 대한 활용정도 및 고객품질 증진을 위하는 것이 결과적으로 컨벤션 개최 성과도 영향을 주고 있음에 따라 컨벤션 모바일 어플리케이션에 대한 관리에 신중할 필요가 있다고 본다. This study was to explore the relationships between convention mobile applications, and convention participants satisfaction and loyalty. Recently mobile applications by using smart-phone have been utilized to provide relevant information and contents, Similarly, convention industry utilize mobile application to provide convention program, speakers, and other information and contents, However, only few research has been conducted to investigate convention mobile application characteristics and benefits. This study provides the results of convention mobile application characteristics and its impacts on participants satisfaction and loyalty. Among convention mobile application characteristics, conveniency and information are important factors to enhance convention participants satisfaction and loyalty. More discussion and implication is provided in the conclusion section.

해양레저관광 마리나 이해집단의 협력관계가 관계성과 및 개발성과에 미치는 영향 연구

최해용(Hai Long Cui),윤유식(Yoo Shik Yoon),박재덕(Jae Deok Park),김기현(Ki Hyun Kim) 한국관광연구학회 2015 관광연구저널 Vol.29 No.6

The purpose of this study was to measure the effects of the performance of cooperative relationships (understanding viewpoints, interdependence, mutual benefits) of the stakeholder of marine leisure tourism marinas on their relational performance (mutual trust, mutual immersion) and developmental performance, and to verify the control effects of conflict management on this influential relationship. From the literature review the measurement of cooperative relationships of understanding viewpoints, interdependence, mutual benefits has been developed and performance of performance of mutual trust, mutual immersion has been developed. The survey questionnaires were distributed to marine experts and stakeholder such as marine operators, professors, government officers, business man, regional residents, and etc. A total of 512 useful sample were collected and analyzed in SPSS, Factor and multiplre regression were conducted to test the proposed research hypotheses. The study``s results showed that in the relational performance according to cooperative relationships, interdependence and mutual benefits, except mutual reliability, had statistically significant influential relationships, and all cooperative relationships revealed statistically significant influential relationships in mutual immersion. Next, conflict management showed partial control effects on influential relationships between cooperative relationships, and relational and developmental performances. Based on these results, this study suggested theoretical and practical discussion and implications about cooperative relationships that influence the relational and developmental performances of the stakeholder of marinas in marine leisure tourism.

Six Degree-of-freedom Hydraulic Hexapod Platform for Large-amplitude Vibration Isolation

Long Cui,Hai Huang,Ze Zhang,Haiqiang Wang 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10

High resolution optical equipment needs a low noise environment, to realize high precision pointing and tracking function. However, the vehicular optical equipment will be influenced by the disturbance of vehicle body when the vehicle is moving. To solve this problem, a large stroke vibration isolation Hexapod platform with hydraulic actuator was proposed. A prototype platform and an experiment system were built, and performance test and vibration isolation experiment were carried out. The experiment result shows that the amplitude of the sinusoidal vibration was reduced by 90% in 4 ~ 20Hz frequency band and the peak-peak value of the random vibration was reduced by 75%.

Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes

Hai-Nan Lan,Hai-Long Jiang,Wei Li,Tian-Cheng Wu,Pan Hong,Yu Meng Li,Hui Zhang,Huan-Zhong Cui,Xin Zheng 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.4

B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonist, we determined that B-32 behaved as a typical Ab2β based on a series of enzyme-linked immunosorbent assay assays. The results of fluorescence-activated cell sorting, indirect immunofluorescence and competitive receptor binding assays demonstrated that B-32 specifically binds to the GHR expressed on target cells. Next, we examined the resulting signal transduction pathways triggered by this antibody in primary porcine hepatocytes. We found that B-32 can activate the GHR and Janus kinase (2)/signal transducers and activators of transcription (JAK2/STAT5) signalling pathways. The phosphorylation kinetics of JAK2/STAT5 induced by either GH or B-32 were analysed in dose-response and time course experiments. In addition, B32 could also stimulate porcine hepatocytes to secrete insulin-like growth factors-1. Our work indicates that a monoclonal anti-idiotypic antibody to GH (B-32) can serve as a GHR agonist or GH mimic and has application potential in domestic animal (pig) production.

Clinical Study of Thalidomide Combined with Dexamethasone for the Treatment of Elderly Patients with Newly Diagnosed Multiple Myeloma

Chen, Hai-Fei,Li, Zheng-Yang,Tang, Jie-Qing,Shen, Hong-Shi,Cui, Qing-Ya,Ren, Yong-Ya,Qin, Long-Mei,Jin, Ling-Juan,Zhu, Jing-Jing,Wang, Jing,Ding, Jie,Wang, Ke-Yuan,Yu, Zi-Qiang,Wang, Zhao-Yue,Wu, Tian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: To investigate the relationship between the efficacy and safety of different doses of thalidomide (Thal) plus dexamethasone (Dex) as the initial therapy in elderly patients with newly diagnosed multiple myeloma (MM). Methods: Clinical data of 28 elderly patients with newly diagnosed MM who underwent the TD regimen as the initial therapy were analyzed retrospectively. The patients were divided into two groups according to the maximal sustained dose of Thal: lower dose (group A) and higher dose (group B). The overall response rate (ORR), progression free survival (PFS), overall survival (OS), and adverse events (AES) were compared between the two groups. Results: A total of 28 patients were followed up with a median of 18 months. The ORR was 60.1%. The median response time and PFS were 2.0 and 17.0 months, respectively. The mean sustained dose of Thal in group B was significantly higher than group A (292.9 mg v 180.4 mg, P=0.01). There was no significantly difference in ORR (57.1% v 64.3%, P=1.00) and PFS (9.63months v 17.66 months, P=0.73) between groups A and B. During the follow up, only five patients died (<40%) and, therefore, median OS values were not available. It is estimated, however, that the mean survival time in the two groups was 35.6 and 33.4 months (P>0.05), respectively. All of the patients tolerated the treatment well. The incidence of AES in patients with a grading above 3 in group B was significantly higher than in group A (P=0.033). Conclusions: The TD regimen results in a high response rate and manageable AES as the initial therapy in elderly patients with MM. TD should be considered as the front line regimen for the treatment of elderly patients with MM in areas with financial constraints. The clinical response can be achieved at a low dose Thal with minimal toxicity.