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Sharon, Daniel,Sharon, Pessia,Hirshberg, Daniel,Salama, Michael,Afri, Michal,Shimon, Linda J. W.,Kwak, Won-Jin,Sun, Yang-Kook,Frimer, Aryeh A.,Aurbach, Doron American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.34
<P>In this study, we present a new aprotic solvent, 2,4-dimethoxy-2,4-dimethylpentan-3-one (DMDMP), which is designed to resist nucleophilic attack and hydrogen abstraction by reduced oxygen species. Li-O-2 cells using DMDMP solutions were successfully cycled. By various analytical measurements, we showed that even after prolonged cycling only a negligible amount of DMDMP was degraded. We suggest that the observed capacity fading of the Li-O-2 DMDMP-based cells was due to instability of the lithium anode during cycling. The stability toward oxygen species makes DMDMP an excellent solvent candidate for many kinds of electrochemical systems which involve oxygen reduction and assorted evaluation reactions.</P>
OROMANDIBULAR DYSTONIA: DEMOGRAPHICS AND CLINICAL DATA FROM 240 PATIENTS
Linda SLAIM,Myriam COHEN,Patrick KLAP,Marie VIDAILHET,Alain PERRIN,Daniel BRASNU,Denis AYACHE,Marie MAILLY 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
Objective: to report demographic data from a large cohort of patients with oromandibular dystonia (OMD). Methods: This is a retrospective review of patients with OMD referred to our institution, between 1989 and 2015. Demographic (age of onset, sex, familial history of dystonia) and clinical (type of OMD, associated dystonia, etiology of dystonia) data were collected from a cohort of 240 individuals. Results: The mean age of onset was 51.6 year-old, with a female predominance (2:1). A family history of dystonia was found in 6 patients (2.5%). One hundred and forty nine patients (62.1%) had the jaw-opening OMD; 48 patients (20.0%) had the jaw-closing type, and 43 patients (17.9%) had mixed OMD; 64 patients (26.7%) had associated lingual dystonia. Eighty-two patients (34.2%) had a focal dystonia, 131 patients (54.6%) had segmental dystonia, and 27 patients (11.3%) had generalized dystonia. One hundred and seventy one patients (71.3%) had idiopathic OMD. Conclusions: OMD is a chronic, disabling focal dystonia. Our study finds a female prevalence, onset in middle age and mostly idiopathic etiology. Unlike in other studies, jaw-opening was the most frequent clinical type of OMD.
Effect of Genotype on Whole-body and Intestinal Metabolic Response to Monensin in Mice
Fan, Y.K.,Croom, W.J.,Daniel, Linda,McBride, B.W.,Koci, M.,Havenstein, G.B.,Eisen, E.J. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.4
Two lines of mice, M16 selected for rapid growth and a randomly selected control ICR as well as their reciprocal crosses were used to study the effects of genotype on whole-body energetics and intestinal responses to monensin. Six mice, eight weeks of age, from each line or reciprocal cross were assigned to one of two treatments, 1) drinking water containing 20 mmol/L monensin dissolved in 0.5% V/V ethanol, and 2) drinking water containing 0.5% V/V ethanol (control) for two weeks. After 11 days (age of 9 weeks and 4 days), whole-body $O_2$ consumption was measured. At the end of two weeks, jejunal $O_2$ consumption, intestinal tissue composition and histomorphometrics as well as the rate and efficiency of glucose absorption were estimated. In comparison with the control, monensin administration in drinking water resulted in less daily water intake (13.4 vs. 15.5 ml/mouse, p<0.01), less protein to DNA ratio of jejunal mucosa (5.41 vs. 6.01 mg/mg, p<0.05), lower villus width (88 vs. $100{\mu}m$, p<0.05), and less jejunal tissue $O_2$ consumption enhancement by alcohol (7.2 vs. 10.5%, p<0.01) in mice. Other than those changes, monensin had little (p>0.05) effect on variables measured in either line of mice or their reciprocal cross. In contrast, the M16 line, selected for rapid growth, as compared to the ICR controls or the reciprocal crosses, had less initial (pre-monensin treatment) whole-body $O_2$ consumption per gram of body weight (1.68 vs. $2.11-2.34{\mu}mol/min{\cdot}g$ BW, p<0.01) as compared to the ICR and reciprocal crosses. In addition, the M16 mice exhibited greater growth (412 vs. 137-210 mg/d, p<0.05), better feed efficiency (41.7 vs. 19.9-29.3 mg gain/g feed, p<0.05), shorter small intestines adjusted for fasted body weight (1.00 vs. 1.22-1.44 cm/g FBW, p<0.05), wider villi (109 vs. $87-93{\mu}m$, p<0.05), more mature height of enterocytes (28.8 vs. $24.4-25.1{\mu}m$, p<0.05) and a lower rate (91 vs. $133-145{\eta}mol\;glucose/min{\cdot}g$ jejunum, p<0.05) and less energetic efficiency (95 vs. $59-72{\eta}mol$ ATP expended/${\eta}mol$ glucose uptake, p<0.05) of glucose absorption compared to the ICR line and the reciprocal cross. Monensin had little (p>0.05) effect on whole-body $O_2$ consumption and jejunal function, whilst selection for rapid growth resulted in an apparent down-regulation of intestinal function. These data suggest that genetic selection for increased growth does not result in concomitant changes in intestinal function. This asynchrony in the selection for production traits and intestinal function may hinder full phenotypic expression of genotypic growth potential.
Condom and oral contraceptive use and risk of cervical intraepithelial neoplasia in Australian women
Hui Jun Chih,Andy H. Lee,Linda Colville,Daniel Xu,Colin W.Binns 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.3
Objective: To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN). Methods: A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and lifestyle characteristics such as the use of condom for contraception, consumption of oral contraceptive, and duration of oral contraceptive usage. Crude and adjusted odds ratio (OR) and associated 95% confidence interval (CI) were calculated using unconditional logistic regression models and reported as estimates of the relative risk. Results: The prevalence of CIN was found to be 15.8%. The duration of oral contraceptive consumption among women with abnormal Papanicolaou (Pap) smear result indicating CIN was significantly shorter than those without abnormal Pap smear result (mean±SD, 5.6±5.2 years vs. 8.2±7.6 years; p=0.002). Comparing to ≤3 years usage, prolonged consumption of oral contraceptive for ≥10 years reduced the risk of CIN (p=0.012). However, use of condom for contraception might not be associated with a reduced risk of CIN after accounting for the effects of confounding factors (adjusted OR, 0.52; 95% CI, 0.05 to 5.11; p=0.577). Conclusion: Use of oral contraceptives, but not condoms, for contraception appeared to be inversely associated with CIN. Prolonged use of oral contraceptive demonstrated its benefits of reducing the risk of CIN.
Yoana Fransiska Wahyuning Christi,Irmadita Citrashanty,Yuri Widia,Sylvia Anggraeni,Linda Astari,Daniel Edbert,Arthur Pohan Kawilarang,Evy Ervianti 대한의진균학회 2023 대한의진균학회지 Vol.28 No.3
Basidiobolomycosis is a rare deep fungal infection caused by Basidiobolus ranarum and characterized by the development of swollen erythematous nodular lesions. Several azoles have been shown to be an effective treatment for this condition. Herein, we report a case of basidiobolomycosis that was initially misdiagnosed as a different disease and resolved after itraconazole medication. A 25-year-old man presented with a 2.5-year history of extensive swelling on his right arm, face, and neck. Initially, he was diagnosed with lipoma and scapular tuberculosis; however, no improvements were observed post-surgery and with tuberculosis medication. Histopathological examinations revealed giant cells, aseptate hyphae, and the Splendore-Hoeppli phenomenon. Fungal culture confirmed the isolate to be Basidiobolus ranarum. The patient was given oral itraconazole 200 mg twice daily, and the complete resolution was achieved after 25 months of treatment.
Laparoscopic hybrid pancreaticoduodenectomy: Initial single center experience
Abdul Rahman Al-Sadairi,Antonio Mimmo,Rami Rhaiem,Francesco Esposito,Linda J. Rached,Ahmad Tashkandi,Perrine Zimmermann,Riccardo Memeo,Daniele Sommacale,Reza Kianmanesh,Tullio Piardi 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.1
Backgrounds/Aims: Pancreaticoduodenectomy (PD) is the gold standard for the treatment of periampullary tumors. Many specialized centers have adopted the totally laparoscopic or hybrid laparoscopic PD (LPD). However, this procedure has not yet been standardized and serious debate is taking place towards its safety and feasibility. Herein, we report our recent experience whit hybrid-LPD. Methods: During 2019 in our department 56 PD were performed and 21 (37.5%) underwent hybrid-LPD. We have retrospectively reviewed the short-term outcomes of these patients. Results: Main indication was pancreatic adenocarcinoma (71,4%). The median operative time and intraoperative blood loss were respectively 425 min (range, 226 to 576) and 317 ml (range 60 to 800 ml). Conversion to an open procedure was required in 4 patients (19%): 2 with suspected vein involvement, 1 for mesenteric panniculitis and 1 for biliary injury. The post-operative complication rate was 42.8% (9/21). Regarding post-operative pancreatic fistula, three patients (14.2%) had grade B and 1 grade C (4.7%). Median length of hospital stay was 14 days (range 9-23) and 90- days mortality was 4.7%. The mean number of harvested lymph nodes was 17.7 (range 12 to 26). The rate of margins R0 was 80%; R1 >0<1 mm was 10.5% and R1 0 mm was 9.5%. Conclusions: Hydrid–LPD is safe and feasible. Careful patient selection and increasing experience can reduce the risk of post-operative complications.
Cahill Kerin M.,Gartia Manas R.,Sahu Sushant,Bergeron Sarah R.,Heffernan Linda M.,Paulsen Daniel B.,Penn Arthur L.,Noël Alexandra 한국독성학회 2022 Toxicological Research Vol.38 No.2
Approximately 7% of pregnant women in the United States use electronic-cigarette (e-cig) devices during pregnancy. There is, however, no scientific evidence to support e-cig use as being ‘safe’ during pregnancy. Little is known about the effects of fetal exposures to e-cig aerosols on lung alveologenesis. In the present study, we tested the hypothesis that in utero exposure to e-cig aerosol impairs lung alveologenesis and pulmonary function in neonates. Pregnant BALB/c mice were exposed 2 h a day for 20 consecutive days during gestation to either filtered air or cinnamon-flavored e-cig aerosol (36 mg/ mL of nicotine). Lung tissue was collected in offspring during lung alveologenesis on postnatal day (PND) 5 and PND11. Lung function was measured at PND11. Exposure to e-cig aerosol in utero led to a significant decrease in body weights at birth which was sustained through PND5. At PND5, in utero e-cig exposures dysregulated genes related to Wnt signaling and epigenetic modifications in both females (~ 120 genes) and males (40 genes). These alterations were accompanied by reduced lung fibrillar collagen content at PND5—a time point when collagen content is close to its peak to support alveoli formation. In utero exposure to e-cig aerosol also increased the Newtonian resistance of offspring at PND11, suggesting a narrowing of the conducting airways. At PND11, in females, transcriptomic dysregulation associated with epigenetic alterations was sustained (17 genes), while WNT signaling dysregulation was largely resolved (10 genes). In males, at PND11, the expression of only 4 genes associated with epigenetics was dysregulated, while 16 Wnt related-genes were altered. These data demonstrate that in utero exposures to cinnamon-flavored e-cig aerosols alter lung structure and function and induce sex-specific molecular signatures during lung alveologenesis in neonatal mice. This may reflect epigenetic programming affecting lung disease development later in life.