무치하악에서 임플랜트를 이용한 고정성 및 가철성 보철물의 삼차원 유한요소 분석

임헌송(Heon-Song Lim),조인호(In-Ho Cho),임주환(Ju-Hwan Lim) 대한턱관절교합학회 2002 구강회복응용과학지 Vol.18 No.4

Residual Multi-dilated convolution U-Net을 이용한 다중 심장 영역 분할 알고리즘 연구

임상헌 ( Sang-heon Lim ),최한승 ( H. S. Choi ),배희진 ( S. K. Jung ),정서경 ( J. K. Jung ),정진교 ( Myung-suk Lee ),이명숙 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.1

본 연구에서는 딥 러닝을 이용하여 완전 자동화된 다중 클래스 전체 심장 분할 알고리즘을 제안하였다. 제안된 방법은 recurrent convolutional block과 residual multi-dilated block을 삽입하여 기존 U-Net을 개선한 인공신경망 모델을 사용하였다. 평가는 자동화 분석 결과와 수동 평가를 비교하였다. 그 결과 96.88%의 평균 DSC, 95.60%의 정확도, 97.00%의 recall을 얻었다. 이 실험 결과는 제안된 방법이 다양한 심장 구조에서 효과적으로 구분되어 수행되었음을 알 수 있다. 본 연구에서 제안된 알고리즘이 의사와 방사선 의사가 영상을 판독하거나 임상 결정을 내리는데 보조적 역할을 할 것을 기대한다.

The Effects of Virtual Upper Extremity Training Using the RAPAEL Smart Glove on Physical and Cognitive Function in Stroke Survivors -A Single Group Study-

Song, Chiang-Soon,Lim, Jae-Heon,Jeon, Byeong-Hyeon,Lee, Hye-Sun Korea Proprioceptive Neuromuscular Facilitation As 2019 PNF and Movement Vol.17 No.2

Purpose: The purpose of this study was to evaluate the effects of a virtual upper extremity training program using the RAPAEL Smart Glove on upper extremity function in stroke survivors with chronic hemiparesis and to focus the training program development using the Smart Glove as a feasibility study. Methods: This study was conducted using a single group and pre-post test research design in the outpatient departments of local rehabilitation units. Ten chronic hemiparetic stroke survivors with a diagnosis of first stroke received therapeutic rehabilitation at the rehabilitation units. All the participants used a virtual reality program with the RAPAEL Smart Glove for 30 minutes per session 3 days a week over 8 weeks. They also received conventional occupational therapy with functional electrical stimulation for 40 minutes per session 3 days a week for 8 weeks as an additional therapy. To analyze the effects of this therapeutic intervention, four clinical measures, including the box-block test (BBT), the Wolf motor function test (WMFT), the trail-making score, the Jebsen Taylor hand function test (JTHFT), and grip strength, were used. Results: Upon completion of the intervention in week 8, all the participants demonstrated significant WMFT, JTT, BBT, grip strength, and trail-making score gains compared to the respective baselines at week 0. Conclusion: This study suggests that virtual upper extremity training using the RAPAEL Smart Glove has a reasonable and beneficial effects on upper extremity function in chronic hemiparetic stroke survivors.

규칙 집합 학습에서의 개체 정보 극대화 알고리즘

송두현,임순범 建國大學校 自然科學硏究所 2000 建國自然科學硏究誌 Vol.11 No.-

Machine learning, as to find a definition of unknown function, usually separates the training example set as the set of rules it induces grows. Two popular strategies, "divide and conquer" and "separate and conquer", pay for the schemes as getting inaccurate for the domains whose training set size is relatively small or as enhancing "small disjunct" problem. One way of alleviating the problem is to use entity information as maximum-not to exclude any example during training. LERUS(Learning Entire Rules Set) algorithm we propose here gives an idea how to avoid the learning anomaly while using maximum information. The result shows that LERUS is as competitive as CN2 for most learning domains and is superior to domains whose size of training set is small or reportedly conspicious as noisy. We hope this strategy could be helpful for domains of medical chemistry or related fields whose characteristic is noisy and relatively less experiment result is available.

Delphinidin inhibits BDNF-induced migration and invasion in SKOV3 ovarian cancer cells

Lim, Won-Chul,Kim, Hyunhee,Kim, Young-Joo,Park, Seung-Ho,Song, Ji-Hye,Lee, Ki Heon,Lee, In Ho,Lee, Yoo-Kyung,So, Kyeong A.,Choi, Kyung-Chul,Ko, Hyeonseok Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.23

<P><B>Abstract</B></P> <P>Brain-derived neurotrophic factor (BDNF), the TrkB ligand, is associated with aggressive malignant behavior, including migration and invasion, in tumor cells and a poor prognosis in patients with various types of cancer. Delphinidin is a diphenylpropane-based polyphenolic ring structure-harboring compound, which exhibits a wide range of pharmacological activities, anti-tumor, anti-oxidant, anti-inflammatory, anti-angiogenic and anti-mutagenic activity. However, the possible role of delphinidin in the cancer migration and invasion is unclear. We investigated the suppressive effect of delphinidin on the cancer migration and invasion. Thus, we found that BDNF enhanced cancer migration and invasion in SKOV3 ovarian cancer cell. To exam the inhibitory role of delphinidin in SKOV3 ovarian cancer migration and invasion, we investigated the use of delphinidin as inhibitors of BDNF-induced motility and invasiveness in SKOV3 ovarian cancer cells <I>in vitro</I>. Here, we found that delphinidin prominently inhibited the BDNF-induced increase in cell migration and invasion of SKOV3 ovarian cancer cells. Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9. Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-κB permitted by the BDNF in SKOV3 ovarian cancer cells. Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Effects of Glasswort (Salicornia herbacea L.) Hydrates on Quality Characteristics of Reduced-salt, Reduced-fat Frankfurters

Lim, Yun-Bin,Kim, Hyun-Wook,Hwang, Ko-Eun,Song, Dong-Heon,Kim, Yong-Jae,Ham, Youn-Kyung,Jang, Sung-Jin,Lee, Choong-Hee,He, Fu-Yi,Choi, Yun-Sang,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.6

Abstract This study evaluated the effects of adding glasswort hydrate containing non-meat ingredient (GM, carboxy methyl cellulose; GC, carrageenan; GI, isolated soy protein; GS, sodium caseinate) on the quality characteristics of reduced-salt, reduced-fat frankfurters. The pH and color evaluation showed significant differences, depending on the type of glasswort hydrate added (p<0.05). In the raw batters and cooked frankfurters, the addition of glasswort hydrate decreased the redness and increased the yellowness in comparison with frankfurters without glasswort hydrate. The reduction in salt and fat content significantly increased cooking loss and decreased hardness, tenderness and juiciness (p<0.05). Glasswort hydrate containing non-meat ingredient improved cooking loss, water holding capacity, emulsion stability, hardness, and viscosity of reduced-salt, reduced-fat frankfurters. The GM treatment had the highest myofibiliar protein solubility among all treatments, which was associated with emulsion stability and viscosity. The GC treatment had higher values for all texture parameters than the control. In the sensory evaluation, the addition of glasswort hydrate with non-meat ingredient improved tenderness and juiciness of reduced-salt, reduced-fat frankfurters. GM, GC, and GI treatments improved not only the physicochemical properties but also the sensory characteristics of reduced-salt, reduced-fat frankfurters. The results indicated that the use of glasswort hydrate containing non-meat ingredient was improved the quality characteristics of reduced-salt, reduced-fat frankfurters.

측두하악장애 환자 중 하악과두의 퇴행성 골 변화를 보이는 환자의 분포 및 임상적 특징

임용규,김민지,김연중,송윤헌,이동렬 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.6

측두하악장애 환자 중 하악과두의 퇴행성 골 변화를 보이는 환자의 분포와 임상적 특징을 규명하고자 측두하악장애로 진단받은 6,070명의 환자들을 대상으로 연구를 시행하였다. 환자들의 초진 시 파노라마와 TMJ 파노라마 사진을 관찰하여 하악과두의 퇴행성 골 변화 유무를 기준으로 환자들을 퇴행성 골 변화를 보이는 군(DJD군)과 골 변화를 보이지 않는 군(non-DJD군)으로 나누고, 환자들의 초진 의무기록을 바탕으로 두 군 간의 특징을 비교, 분석하였으며, 각종 변수들이 DJD 발병에 미치는 상대적 위험성을 측정하기 위하여 로지스틱 회귀분석을 시행하였다. 연구 결과 전체 환자 중 DJD군에 속한 환자는 31.7%였고, non-DJD군에 속하는 환자는 68.3%였다. DJD군은 성별에 따라 다른 분포를 보여 남자보다 여자의 이환율이 높았고, 10대와 20대에서 가장 높은 분포를 보였다. 환자의 내원 주소 중에서는 전치부 개방교합, 턱의 후퇴감, 안모 비대칭, 개구장애를 주소로 내원한 환자가 다른 주소로 내원한 환자들에 비해 DJD를 보일 위험성이 높았으며, 교정치료 경력이나 중심위-중심교합위 변위 그리고 염발음을 보이는 환자도 DJD군에 속할 위험성이 큰 것으로 나타났다. 따라서 측두하악장애를 가진 환자 중 30세 이하의 여성이 위와 같은 임상적 특징을 보이는 경우, 교정치료를 계획할 때 DJD에 이환 되었을 가능성에 대하여 충분히 주의를 기울여야 할 것으로 생각된다. (대치교정지 2006;36(6):402-11) Objective: This study was carried out to evaluate the distribution and clinical features of patients with degenerative change of the mandibular condyle. Methods: Six thousand and seventy patients with TMD (temporomandibular disorder) were selected for this study, who had complete initial clinical records and radiographs. Panorama and TMJ panorama radiographs were used to screen the degenerative change in the condyle, and the patients were divided into DJD (degenerative joint disease) and non-DJD groups. Results: The distribution and clinical features of the two groups were compared. Out of the total number of patients, 31.7% were in the DJD group, and 68.3% were in the non-DJD group. The portion of females was larger in the DJD group (80.8%) than in the non-DJD group (67.5%), and the DJD group had high prevalence in the second and third decades. Lack of incisal contact, retrusive chin, facial asymmetry, and mouth opening limitation were the chief complaints of the patients who had positive relation to DJD. Conclusion: Patients with an orthodontic treatment history, CO-CR discrepancy and crepitation were at possible risk of having DJD. (Korean J Orthod 2006;36(6):402-11)

Selective growth of vertical ZnO nanowires with the control of hydrothermal synthesis and nano-imprint technology.

Song, Jaejin,Baek, Seonghoon,Lee, Heon,Lim, Sangwoo American Scientific Publishers 2009 Journal of nanoscience and nanotechnology Vol.9 No.6

<P>Nano-imprint technology is one of the most advanced technologies for the fabrication of nano-size patterning. In this study, nano-imprint technology was used for the selective growth of ZnO nanowires on the Si wafer. When the poly methyl-methacrylate (PMMA) was first patterned by a nano-imprint process and ZnO seed layer was deposited and patterned by lift-off, ZnO nanowires were not vertically grown on the whole area of the patterned seed layer. Synthesis in zinc sulfate solution exhibited well-structured ZnO nanowires compared to the zinc nitrate solution, but uniformly aligned vertical growth of ZnO nanowires was not observed in either cases. On the other hand, when the PMMA was patterned using a nano-imprint process in the presence of seed layer, and ZnO nanowires were synthesized in zinc sulfate solution, selective growth of vertically aligned ZnO nanowires on 0.5 microm pattern sizes was achieved. The observation in this study suggests that the selective growth of ZnO nanowires on a defined pattern size can be obtained with the modification of pattering sequence and the control of low temperature hydrothermal synthesis of ZnO nanowires.</P>

Increasing Prevalence of Metabolic Syndrome in Korea : The Korean National Health and Nutrition Examination Survey for 1998–2007

Lim, Soo,Shin, Hayley,Song, Jung Han,Kwak, Soo Heon,Kang, Seon Mee,Won Yoon, Ji,Choi, Sung Hee,Cho, Sung Il,Park, Kyong Soo,Lee, Hong Kyu,Jang, Hak Chul,Koh, Kwang Kon American Diabetes Association 2011 Diabetes care Vol.34 No.6

<P><B>OBJECTIVE</B></P><P>The number of people with metabolic syndrome is increasing worldwide, and changes in socioenvironmental factors contribute to this increase. Therefore, investigation of changes in metabolic syndrome and its components in South Korea, where rapid socioenvironmental changes have occurred in recent years, would be foundational in setting up an effective strategy for reducing this increasing trend.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We compared the prevalence and pattern of metabolic syndrome among participants in the Korean National Health and Nutrition Examination Surveys for 1998, 2001, 2005, and 2007. In each survey, stratified, multistage, probability–sampling designs and weighting adjustments were conducted to represent the entire Korean population. The revised National Cholesterol Education Program criteria were used as the definition of metabolic syndrome. All biochemical parameters were measured in a central laboratory.</P><P><B>RESULTS</B></P><P>A total of 6,907 (mean ± SE age 45.0 ± 0.2 years), 4,536 (45.5 ± 0.2), 5,373 (47.1 ± 0.2), and 2,890 (49.9 ± 0.3) Koreans over 20 years of age have participated in the studies in 1998, 2001, 2005, and 2007, respectively. The age-adjusted prevalence of metabolic syndrome increased significantly from 24.9% in 1998, 29.2% in 2001, and 30.4% in 2005 to 31.3% in 2007. Among the five components, the level of low HDL cholesterol increased the most, by 13.8% over the 10 years. Abdominal obesity and hypertriglyceridemia followed, with 8.7 and 4.9% increases, respectively.</P><P><B>CONCLUSIONS</B></P><P>Because dyslipidemia and abdominal obesity were major factors in increasing the prevalence of metabolic syndrome in Koreans for the past 10 years, lifestyle interventions should be conducted at the national level to reduce the burden and consequences of metabolic syndrome.</P>

Anti-cancer effect of bio-reductive drug <b>β</b>-lapachon is enhanced by activating NQO1 with heat shock

Song, Chang W.,Chae, Jongsun J.,Choi, Eun K.,Hwang, Tae S.,Kim, Chulhee,Lim, Byung Uk,Park, Heon Joo Informa UK (TaylorFrancis) 2008 International journal of hyperthermia Vol.24 No.2

<P>Bio-reduction/activation of anti-cancer drug beta-lapachone (beta-lap) is mediated by NAD(P)H: Quinone oxidoreductase (NQO1). We investigated the feasibility of using mild temperature hyperthermia to increase the anti-cancer effect of beta-lap by up-regulating NQO1 expression.</P>