White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

Ramp-Strike Risk Evaluation Making of Carrier-Based Aircraft

Hai-tao Jiang,Xiao-dong Su,Hui Li 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10

To make “Ramp-Strike Risk” evaluation making accurately, this paper introduces a new wave-off risk assessment method based on neural network of carrier-based aircraft. On account of defining “Wave-Off Retain Clearance”, the wave-off operation system with military power and vertical elevator is established as evaluation medium. The “Wave-Off Risk State Area” established by limited wave-off envelope can reduce network training burden, and the quantitative “Ramp-Strike Risk” function with flight state is presented through BP neural network finally. Simulation results show that the risk with flight states can be predicted by using new estimation method, moreover auxiliary rectification and early-warning for landing is provided.

Staged Improvement in Awareness of Disease for Elderly Cancer Patients in Southern China

Li, Xing,Dong, Min,Wen, Jing-Yun,Wei, Li,Ma, Xiao-Kun,Xing, Yan-Fang,Deng, Yun,Chen, Zhan-Hong,Chen, Jie,Ruan, Dan-Yun,Lin, Ze-Xiao,Wang, Tian-Tian,Wu, Dong-Hao,Liu, Xu,Hu, Hai-Tao,Lin, Jia-Yu,Li, Zhu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: In mainland China, awareness of disease of elderly cancer patients largely relies on the patients' families. We developed a staged procedure to improve their awareness of disease. Materials and Methods: Participants were 224 elderly cancer patients from 9 leading hospitals across Southern China. A questionnaire was given to the oncologists in charge of each patient to evaluate the interaction between family and patients, patient awareness of their disease and participation in medical decision-making. After first cycles of treatment, increased information of disease was given to patients with cooperation of the family. Then patient awareness of their disease and participation in medical decision-making was documented. Results: Among the 224 cancer elderly patients, 26 (11.6%) made decisions by themselves and 125 (55.8%) delegated their rights of decision-making to their family. Subordinate family members tended to play a passive role in decision-making significantly. Patients participating more in medical decision-making tended to know more about their disease. However, in contrast to the awareness of disease, patient awareness of violation of medical recommendations was reversely associated with their participation in medical decision-making. Improvement in awareness of diagnosis, stages and prognosis was achieved in about 20% elderly cancer patients. About 5% participated more actively in medical decision-making. Conclusions: Chinese elderly cancer patient awareness of disease and participation in medical decision-making is limited and relies on their family status. The staged procedure we developed to improve patient awareness of disease proved effective.

Characterization of Phenolic Compounds from Rhododendron alutaceum

Hai-Zhou Li,Rong-Tao Li,He-Jiao Song,Hong-Mei Li,Yu-Yin Pan 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11

A new phenolic glycoside, 3'-keto rhododendrin (1) and a new sesquilignan, alutaceuol (2), together with twelve known phenolic compounds, were isolated from the leaves of Rhododendron alutaceum. Their structures were elucidated by extensive spectroscopic data analysis and comparison with literature values. In addition, the detailed analysis of 2D NMR data led us to conclude that the chemical shifts of dihydrobuddlenol B (5) need to be revised.

중국에서의 한국유학사상사 연구의 방법론 고찰 -학술사적 회고-

이해도 ( Hai Tao Li ) 경북대학교 영남문화연구원 2014 嶺南學 Vol.0 No.26

한국유학은 儒學發展史上중요한 지위와 특징을 가지고 있다. 현재 중국에서의 韓國儒學思想史연구는 크게 세 가지 형태가 있다. 첫째는 연변대학을 중심으로 한 연구로, 초기에는 유물론적 사관에 치우쳐 한국유학사상을 인식하며 고찰했다. 그러나 후기에 이르러서는 동아시아유학의 시각에서 출발하여 中·朝·韓·日유학의 비교 속에서 한국유학사상 및 그 특징에 대해 연구했다. 둘째는 북경을 중심으로 한 연구로, 연구 방법에 있어서는 중국유학을 참조하였으나, 초점은 동아시아 의식에 두고 한국유학을 바라보았다. 셋째는 대만을 중심으로 한 연구로, 유학의 다원론으로부터 출발하여 동아시아유학의 범주인 경전 해석 연구를 이룩하였다. 그리하여 동아시아를 연구 범위로하고 유가경전을 핵심 연구대상으로 삼았다. 또한 중·한 유학의 상호작용을 중요시하고, 한국유학경전과 가치이념의 변천에 대하여 논하였다. as an important form in Confucianism development, South Korea Confucianism has its unique status and character. At present, the methodologies of China on the study of South Korea Confucianism Intellectual History can be divided into three kinds. The first kind is Yanbian-centered, the study of which was focus on inspecting and understanding South Korea Confucianism intellectual history basing on historical materialism at the earlier stage, and gave priority to inspect and understand the thoughts and features of Korea Confucianism thought by comparing the Confucianism of China, North Korea, South Korea and Japan at later period, highlighting the shaping of South Korea Culture on the South Korea Confucianism thoughts; the second kind is Beijing-centered, which tends to take China Confucianism as basis and reference on the method and tends to view South Korea Confucianism on the consciousness of East Asia on the angle of view. The third kind is Taiwan-centered, which starts from the Confucianism pluralism, and forms classics annotation study under the sight of East Asia Confucianism on the method, taking East Asia as study view, treating the Confucian classics as the core of the study, and paying attention to the interaction between China and South Korea Confucianism, in order to discuss the transition between Confucian classics in South Korea and the value idea.

Radiological gastrostomy: A comparative analysis of different image-guided methods

Hong-Tao Hu,Hang Yuan,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Hong-Tao Cheng,Jun-Li Ma,Yan Zhao,Li Jiang,Yu-Qing Zhao,Hai-Liang Li 소화기인터벤션의학회 2021 Gastrointestinal Intervention Vol.10 No.2

Background: Radiographic guided percutaneous gastrostomy has become a safe and effective enteral nutrition method for patients who can not eat by mouth. Fluoroscopy, computed tomography (CT) and cone-beam CT have been routinely used clinically. The aim of this study was to compare the advantages and disadvantages of percutaneous gastrostomy using different radiographic guided methods. Methods: We retrospectively analyzed the clinical data of 538 patients undergoing percutaneous gastrostomy in our department. According to the image guidance method used in gastrostomy, the patients were divided into groups A by fluoroscopy guidance, group B by fluoroscopy combined with C-arm CT guidance, and group C with the whole process CT guidance. The gastrostomy success rate, complication rate, procedure time, and patient radiation dose were analyzed in the three groups. Results: Among 538 patients, 534 were successful and the success rates are 94.3%, 99.3%, and 100% in group A, B, and C, respectively (P > 0.05). There were 3 cases occurred postoperative bleeding as serious adverse events and transferred to surgical gastrostomy. The minor complications include local infection, hyperplasia of granulation tissue, tube obstruction or prolapse, and local pain of the ostomy. The minor complication rates were 10.5%, 10.4%, and 7.7% in group A, B, and C, respectively (P > 0.05). The average procedure time was 25.57 ± 5.99 minutes, 29.01 ± 6.63 minutes, and 45.47 ± 8.98 minutes, respectively (χ2 = 87.98, P < 0.001). The average radiation dosage was 27.30 ± 19.27 mGy, 145.07 ± 106.08 mGy, and 2,590.26 ± 1,088.22 mGy, respectively (χ2 = 204.44, P < 0.001). Conclusion: There were no significant differences in the success rates and complication rates of gastrostomy under the three guiding methods. For difficult cases, CT-guided gastrostomy may be a very useful supplemental method.

Radiological gastrostomy: A comparative analysis of different image-guided methods

Hong-Tao Hu,Hang Yuan,Chen-Yang Guo,Quan-Jun Yao,Xiang Geng,Hong-Tao Cheng,Jun-Li Ma,Yan Zhao,Li Jiang,Yu-Qing Zhao,Hai-Liang Li 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.2

Background: Radiographic guided percutaneous gastrostomy has become a safe and effective enteral nutrition method for patients who can not eat by mouth. Fluoroscopy, computed tomography (CT) and cone-beam CT have been routinely used clinically. The aim of this study was to compare the advantages and disadvantages of percutaneous gastrostomy using different radiographic guided methods. Methods: We retrospectively analyzed the clinical data of 538 patients undergoing percutaneous gastrostomy in our department. According to the image guidance method used in gastrostomy, the patients were divided into groups A by fluoroscopy guidance, group B by fluoroscopy combined with C-arm CT guidance, and group C with the whole process CT guidance. The gastrostomy success rate, complication rate, procedure time, and patient radiation dose were analyzed in the three groups. Results: Among 538 patients, 534 were successful and the success rates are 94.3%, 99.3%, and 100% in group A, B, and C, respectively (P > 0.05). There were 3 cases occurred postoperative bleeding as serious adverse events and transferred to surgical gastrostomy. The minor complications include local infection, hyperplasia of granulation tissue, tube obstruction or prolapse, and local pain of the ostomy. The minor complication rates were 10.5%, 10.4%, and 7.7% in group A, B, and C, respectively (P > 0.05). The average procedure time was 25.57 ± 5.99 minutes, 29.01 ± 6.63 minutes, and 45.47 ± 8.98 minutes, respectively (χ2 = 87.98, P < 0.001). The average radiation dosage was 27.30 ± 19.27 mGy, 145.07 ± 106.08 mGy, and 2,590.26 ± 1,088.22 mGy, respectively (χ2 = 204.44, P < 0.001). Conclusion: There were no significant differences in the success rates and complication rates of gastrostomy under the three guiding methods. For difficult cases, CT-guided gastrostomy may be a very useful supplemental method.

투고눈문 : 崔承老的種崇儒仰佛觀

이해도 ( Hai Tao Li ) 경북대학교 퇴계연구소 2011 퇴계학과 유교문화 Vol.49 No.-

Korea confucianist Cui Chenglao, according to the social condition of the day and Chengzong`s attitude of advocating Confucianism, brought forward the opinion of advocating Confucianism and restraining Buddhism. which emphasized the thought of taking Confucianism as the best way to rule a country and restrained social corruption of Buddhism. The Confucianism that Cui Chenglao advocated is Hang-Tang Confucianism. Cui advocated the thoughts of benevolent governance, moral codes and human relations, at the same time, he used these thoughts criticized Korean state religion-Buddhism. He thought that Korean Buddhism collided with Confucianism in many ways and caused much social corruption. It is observed that Cui mainly criticized Buddhism in terms of social corruption, and he didn`t negate the creeds and dogmata of Buddhism. In other words, he just wanted to restrain Buddhism with Confucianism, but not eliminated Buddhism.

Rapid Detection and Monitoring Therapeutic Efficacy of Mycobacterium tuberculosis Complex Using a Novel Real-Time Assay

( Jiang Li Juan ),( Wen Juan Wu ),( Hai Wu ),( Son Sik Ryang ),( Jian Zhou ),( Wei Wu ),( Tao Li ),( Jian Guo ),( Hong Hai Wang ),( Shui Hua Lu ),( Yao Li ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.9

We combined real-time RT-PCR and real-time PCR (R/P) assays using a hydrolysis probe to detect Mycobacterium tuberculosis complex (MTBC)-specific 16S rRNA and its rRNA gene (rDNA). The assay was applied to 28 nonrespiratory and 207 respiratory specimens from 218 patients. Total nucleic acids (including RNA and DNA) were extracted from samples, and results were considered positive if the repeat RT-PCR threshold cycle was ≤35 and the ratio of real-time RT-PCR and real-time PCR load was ≥1.51. The results were compared with those from existing methods, including smear, culture, and real-time PCR. Following resolution of the discrepant results between R/P assay and culture, the overall sensitivity, specificity, positive predictive values (PPV), and negative predictive values (NPV) of all samples (including nonrespiratory and respiratory specimens) were 98.2%, 97.2%, 91.7%, and 99.4%, respectively, for R/P assay, and 83.9%, 89.9%, 72.3%, and 94.7%, respectively, for real-time PCR. Furthermore, the R/P assay of four patient samples showed a higher ratio before treatment than after several days of treatment. We conclude that the R/P assay is a rapid and accurate method for direct detection of MTBC, which can distinguish viable and nonviable MTBC, and thus may guide patient therapy and public health decisions.

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.