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Fashion Marketing Research in a Turbulent Environment: A Global Network to the Special Issue
Burns, Leslie Davis,Kim, Eun-Young Korean Academy of Marketing Science 2010 마케팅과학연구 Vol.20 No.1
作?全球??科???本期特刊的合作??, 我?非常高?出版了?????相???注?前??的高水平?究?文. 全球??科???本期特刊是????科???(KAMS)和????服??合?(ITAA)通?不?努力宣?全球的?????者的成果. 本期出版的所有?文均在2009年????服??合?和????科???的 "在??激烈的?境中的?????究" 的?合?????中首次?表. 此次?合??????????服??合?的年?一起在美??盛?的????行. ??延世大?的高?珠博士和美?俄勒?州立大?的Leslie Burns博士共同??此次?????. 我?鼓??自不同?家和?究机?的?表者和作者?本期特刊完善他?的文稿. 稿件投至合作??, 在本期特刊出版前所有的投稿稿件都被??公正的??和再次??. 本期特刊增强了全球????机制的合作?究和跨文化??. 特刊中?文的主?可以?????方面: ??市?中的消?者行?和有?企?社??任的??.
Leslie A Bilello1,Céline Pascheles,Kiersten Gurley,Douglas Rappaport,David T Chiu,Shamai A. Grossman,Carlo L Rosen 대한응급의학회 2020 Clinical and Experimental Emergency Medicine Vol.7 No.3
Objective Electrocardiogram (ECG) interpretation skills are of critical importance for diagnostic accuracy and patient safety. In our emergency department (ED), senior third-year emergency medicine residents (EM3s) are the initial interpreters of all ED ECGs. While this is an integral part of emergency medicine education, the accuracy of ECG interpretation is unknown. We aimed to review the adverse quality assurance (QA) events associated with ECG interpretation by EM3s. Methods We conducted a retrospective study of all ED ECGs performed between October 2015 and October 2018, which were read primarily by EM3s, at an urban tertiary care medical center treating 56,000 patients per year. All cases referred to the ED QA committee during this time were reviewed. Cases involving a perceived error were referred to a 20-member committee of ED leadership staff, attendings, residents, and nurses for further consensus review. Ninety-five percent confidence intervals (CIs) were calculated. Results EM3s read 92,928 ECGs during the study period. Of the 3,983 total ED QA cases reviewed, errors were identified in 268 (6.7%; 95% CI, 6.0%–7.6%). Four of the 268 errors involved ECG misinterpretation or failure to act on an ECG abnormality by a resident (1.5%; 95% CI, 0.0%–2.9%). Conclusion A small percentage of the cases referred to the QA committee were a result of EM3 misinterpretation of ECGs. The majority of emergency medicine residencies do not include the senior resident as a primary interpreter of ECGs. These findings support the use of EM3s as initial ED ECG interpreters to increase their clinical exposure.
Risks and Legal Protections in the World of Big-Data
Leslie E. Wolf 이화여자대학교 생명의료법연구소 2018 Asia Pacific Journal of Health Law & Ethics Vol.11 No.2
The development of large electronic data sets, whether from electronic health records, health registries, or largescale gene-environment interaction studies, offer an unparalleled, innovative opportunities to learn more about human health and disease. However, because these data may be used in unexpected ways, without the knowledge or consent of individuals whose data are being used, they also raise critical concerns about protections of individuals against risks. Traditional approaches to protecting research participants and patients may not address new or heightened risks in the “big data” era. My research colleagues and I conducted legal research to elucidate the web of legal protections afforded research participants in genomic research, including laws governing human subjects research, privacy, consent, discrimination, and use of research participants’ genetic information. It has revealed substantial regulatory activity and variation across the 50 states that may fill known gaps in federal protections. For example, some states go further than the Genetic Nondiscrimination Act (GINA) by extending genetic antidiscrimination statutes to life and disability insurers or to employers with less than 15 employees. In addition, states explicitly provide remedies, such as statutory damages, attorneys’ fees, and costs that can facilitate enforcement of legal rights not afforded in federal laws. This research has broader implications for data use in other research or in health care settings. In this paper, I suggest how this research can inform approaches to data privacy law in the United States and beyond to provide appropriate protections as health systems and scientists seek to harness the promise of big data while respecting individuals’ interests in their data.
A SOLUTION TO THE PROBLEM WITH ABSORBED DOSE
LESLIE A. BRABY 한국원자력학회 2008 Nuclear Engineering and Technology Vol.40 No.7
In some situations, for example at very low doses, in microbeam irradiation experiments, or around high energy heavy ion tracks, use of the absorbed dose to describe the energy transferred to the irradiated target can be misleading. Since absorbed dose is the expected value of energy per mass it takes into account all of the targets which do not have any energy deposition. In many situations that results in numerical values, in Joules per kg, which are much less than the energy deposited in targets that have been crossed by a charged particle track. This can lead to confusion about the biochemical processes that lead to the consequences of irradiation. There are a few alternative approaches to describing radiation that avoid this potential confusion. Examples of specific situations that can lead to confusion are given. It is concluded that using the particle radiance spectrum and the exposure time, instead of absorbed dose, to describe these irradiations minimizes the potential for confusion about the actual nature of the energy deposition.
Vulnerable Patients and End-of-Life Decision-Making
Leslie E. Wolf,Sylvia Caley 이화여자대학교 생명의료법연구소 2016 Asia Pacific Journal of Health Law & Ethics Vol.10 No.1
Over several decades, U.S. physicians, medical ethicists, and policy-makers have worked to enhance patient decision-making at the end-of-life. States have passed laws allowing patients to express their preferences through advance directives and to appoint a surrogate to make decisions if they are unable to do so. Both the federal and state governments have provided incentives to encourage patients to complete advance directives and discuss their care preferences with their physicians. Despite these efforts, for a variety of reasons, few people actually complete an advance directive or appoint a health care surrogate. However, real world medical decision-making frequently deviates from the ideal of the empowered patient with capacity exercising her autonomy over what happens to her body. In this paper, we explore how the legal and ethical frameworks that have developed around end-of-life decision-making in the United States may fail in the case of the most vulnerable patients. We argue that it is time to shift the focus from patients to providers and the health care system to achieve the goal of improved end-of-life decision-making, and suggest specific ways toward making this transition.
Distribution and Features of the Six Classes of Peroxiredoxins
Leslie B. Poole,Kimberly J. Nelson 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.1
Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ~3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).