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Wenxiang Zhang,Hucai Zhang,Jie Niu,Guoliang Lei,Fengqin Chang 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.6
Lacustrine deposits can provide insight into chemical weathering and climate change. Based on the analysis of the element concentrations and parameters of the acid-leaching residual fractions (AR) in the lacustrine deposits of the Qaidam Basin (QB), chemical weathering and paleoclimate changes in the northeastern Tibetan Plateau (NETP) have been studied. The results show that the characteristics of trace element concentrations exhibit two kinds of patterns by normalized element arbitrary units (a.u.). The rare earth element (REE) distribution patterns are moderately rich in light rare earth elements (LREEs) with slightly right-tilting and negative Eu anomalies. Triangular plots of the REEs and (La/Yb)n-ΣREE suggest that the sediments have a similar source. The geochemical records of climate proxies indicated warm-wet climate stages during 45.1–31.6 cal. ka BP., further proving that a megalake stage existed in the semi-arid area in marine isotope stage (MIS) 3. Strong evaporation resulted in a high paleolake level history in the northeastern Tibetan Plateau after the late period of MIS 3. Meanwhile, the geochemical records of the Qaidam Basin are synchronous with the global records.
Analysis of Gene Expression Profiles of Liver Stellate Cells During Liver Regeneration in Rats
Xu Cunshuan,Chen Xiaoguang,Chang Cuifang,Wang Gaiping,Wang Wenbo,Zhang Lianxing,Zhu Qiushi,Wang Lei,Zhang Fuchun 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.1
This study performed a large-scale, high-throughput analy-sis of transcriptional profiling of liver stellate cells (LSCs) at the cellular level to investigate changes in the biological activity of LSCs during rat liver regeneration (LR) and the relation of these changes to LR. First, a rat liver regeneration model was established by partial hepatectomy (PH). Stellate cells were isolated in high purity and yield from the regenerating rat liver by Percoll density gradient centrifugation and immunomagnetic bead sorting. The changes in gene expression of LSCs after PH were examined using a rat genome 230 2.0 array composed of 24622 genes. The results indicated that 10241 of the 24622 genes investigated on the array were differentially expressed in LSCs. Of the 10241 genes, 1563 known genes were related to LR, which were grouped into three major gene expression clusters according to three-fold cut-off threshold: the up-regulated gene cluster, the down-regulated gene cluster, and the cluster composed of genes showing complex changes in expression. Additionally, the genes were grouped into those involved in transcription regulation, signal transduction, transport, cellular metabolism, in-flammation and immunity by functional analysis. When gene expression profiles were combined with the results of gene functional analysis, most of the genes involved in cytokine secretion and retinol metabolism in LSCs were significantly enriched in the cluster characterized by decreased expression, whereas genes involved in lipid metabolism were mostly enriched in the cluster showing increased expression. Based on further analysis of genes expressed in a phase-dependent manner during LR, it was suggested that lipid metabolism in LSCs was enhanced in the whole regeneration process, and that immune response and cytokine secretion were impaired during all three regenerative phases.
Wei-Yi Lei,Tso-Tsai Liu,Wei-Chuan Chang,Chih-Hsun Yi,Jui-Sheng Hung,Ming-Wun Wong,Shu-Wei Liang,Lin Lin,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.1
Background/AimsThis study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM). MethodsEighteen IEM patients (8 women; mean age 37.8 years, range 23-64 years) were enrolled in the study. The patients underwent high-resolution manometry exams, consisting of 10 single wet swallows, multiple rapid swallows, and ten 20 mL rapid air injections to trigger secondary peristalsis. All participants completed 2 separate sessions, including acute administration of codeine (60 mg) and placebo, in a randomized order. ResultsCodeine significantly increased the distal contractile integral (566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001) and shortened distal latency (5.7 ± 0.2 seconds vs 6.5 ± 0.1 seconds, P < 0.001) for primary peristalsis compared with these parameters after placebo treatment. The mean total break length decreased significantly after codeine treatment compared with the length after placebo (P = 0.003). Codeine significantly increased esophagogastric junction-contractile integral (P = 0.028) but did not change the 4-second integrated relaxation pressure (P = 0.794). Codeine significantly decreased the frequency of weak (P = 0.039) and failed contractions (P = 0.009), resulting in increased frequency of normal primary peristalsis (P < 0.136). No significant differences in the ratio of impaired multiple rapid swallows inhibition and parameters of secondary peristalsis were detected. ConclusionsIn IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.
Design of efficient optimized wireless power transfer system
Wu, Qian,Wang, Lei,Ju, Dongqian,Chen, Chang,Chang, Changyuan The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.5
To balance the output stability and maximum efficiency of a system, an efficiency optimization method based on adaptive frequency control is proposed. In this paper, load transmission is carried out using a DC-DC converter at the receiving end. When the load changes, controlling the rectified output voltage is carried out to realize the maximum efficiency point tracking. Meanwhile, the duty cycle of the rear stage DC-DC converter is changed to keep the output voltage constant. The sampled rectified voltage is compared with the estimated value and the resulting error data are sent to the system transmitter through ASK modulation wireless communication. Then the transmitter demodulation communication information through PID algorithm control is used to achieve the frequency of the adaptive adjustment. The feasibility of the proposed method has been verified by the simulation and experimental results. When the output voltage is 5 V, the constant voltage accuracy is within±1%, the maximum efficiency is up to 79.2%, and the dynamic response time is only 160 ms.
Guo, Yong-Zhong,Pan, Lei,Du, Chang-Jun,Ren, Dun-Qiang,Xie, Xiao-Mei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Associations between elevated C-reactive protein (CRP) and cancer risk have been reported for many years, but the results from prospective cohort studies remains controversial. A meta-analysis of prospective cohort studies was therefore conducted to address this issue. Methods: Eligible studies were identified by searching the PubMed and EMBASE up to October 2012. Pooled hazard ratios (HR) was calculated by using random effects model. Results: Eleven prospective cohort studies involving a total of 194,796 participants and 11,459 cancer cases were included in this meta-analysis. The pooled HR per natural log unit change in CRP was 1.105 (95% confidence interval (CI): 1.033-1.178) for all-cancer, 1.308 (95% CI: 1.097-1.519) for lung cancer, 1.040 (95% CI: 0.910-1.170) for breast cancer, 1.063 (95% CI: 0.965-1.161) for prostate cancer, and 1.055 (95% CI: 0.925-1.184) for colorectal cancer. Dose-response analysis showed that the exponentiated linear trend for a change of one natural log unit in CRP was 1.012 (95% CI: 1.006-1.018) for all-cancer. No evidence of publication bias was observed. Conclusions: The results of this meta-analysis showed that the elevated levels of CRP are associated with an increased risk of all-cancer, lung cancer, and possibly breast, prostate and colorectal cancer. The result supports a role of chronic inflammation in carcinogenesis. Further research effort should be performed to identify whether CRP, as a marker of inflammation, has a direct role in carcinogenesis.
포도주스 침지 제조 흑삼의 Ginsenoside Rg<sub>3</sub> 함량 변화와 Acetylcholinesterase 억제효과
이미라,윤범식,손백신,류뢰,장동량,왕춘년,왕젠,이선영,모은경,성창근,Lee, Mi-Ra,Yun, Beom-Sik,Sun, Bai-Shen,Liu, Lei,Zhang, Dong-Liang,Wang, Chun-Yan,Wang, Zhen,Ly, Sun-Young,Mo, Eun-Kyung,Sung, Chang-Keun 고려인삼학회 2009 Journal of Ginseng Research Vol.33 No.4
흑삼의 속성제조와 ginsenoside $Rg_3$ 함량을 극대화하고자 흑삼 제조시 포도주스에 24시간 침지한 후 $120^{\circ}C$에서 30분간 3회 반복 증숙하여 흑삼을 제조한 후 HPLC 방법을 이용하여 ginsenosides를 분석하였다. 포도주스에 침지하여 제조한 흑삼의 ginsenoside $Rg_3$ 함량은 10.91 mg/g으로 구증구포 방법으로 제조한 흑삼보다 약 2배 가량 함량이 증가되었다. 총 사포닌 함량은 14.97 mg/g으로 전통적인 구증구포 방식으로 제조한 흑삼 (12.79 mg)보다 그 함량이 높았다. 흑삼의 단회투여 (200 mg/kg, p.o.)에 의한 뇌조직 AChE 활성은 투여 24시간 후에 유의적으로 억제되는 효과를 보여주었다. 따라서 본 연구에 적용한 새로운 제조방법은 ginsenoside $Rg_3$를 강화하는 흑삼의 속성제조에 효과적인 방법으로 판단된다. 또한, AChE 활성억제를 통해 흑삼이 뇌기능 개선에 대한 잠재적인 효능을 가지고 있는 것으로 사료된다. This study was conducted to develop a new method for enhancing ginsenoside $Rg_3$, which is abundant in black ginseng. The cognition-enhancing effect of black ginseng extract was investigated via the assay of acetylcholinesterase (AChE) activity. Black ginseng I was prepared through the traditional method (by steaming and drying nine times repetitions). Black ginseng II, on the other hand, was prepared by steaming the ginseng three times at $120^{\circ}C$ for 30 min after soaking it in grape juice for 24 h. The ginsenosides of white, red, and black ginseng I, and II were investigated using the HPLC method, respectively. In black ginseng II, the ginsenoside $Rg_3$ contents, which cannot be found in white ginseng, amounted to 10.91 mg/g, approximately 18 times more than that in red ginseng. In the in-vivo study, black ginseng extract (200 mg/kg, p.o.) inhibited the AChE activity after 24 h by a single administration in the brain. Thus, the new manufacturing method for black ginseng was found to more effective in the conversion of ginsenoside $Rg_3$ compared to the traditional method. Black ginseng may also have the effect of preventing the cognitive impairment induced by cholinergic dysfunction.