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Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
Lee Yeongun,Dho So Hee,Lee Jiyeon,Hwang Ji-Hyun,Kim Minjung,Choi Won-Young,Lee Jin-Young,Lee Jongwon,Chang Woochul,Lee Min Young,Choi Jungmin,Kim Tae-You,Kim Lark Kyun 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Despite numerous observations regarding the relationship between DNA methylation changes and cancer progression, only a few genes have been verified as diagnostic biomarkers of colorectal cancer (CRC). To more practically detect methylation changes, we performed targeted bisulfite sequencing. Through co-analysis of RNA-seq, we identified cohort-specific DNA methylation markers: CpG islands of the intragenic regions of PDX1, EN2, and MSX1. We validated that these genes have oncogenic features in CRC and that their expression levels are increased in correlation with the hypermethylation of intragenic regions. The reliable depth of the targeted bisulfite sequencing data enabled us to design highly optimized quantitative methylation-specific PCR primer sets that can successfully detect subtle changes in the methylation levels of candidate regions. Furthermore, these methylation levels can divide CRC patients into two groups denoting good and poor prognoses. In this study, we present a streamlined workflow for screening clinically significant differentially methylated regions. Our discovery of methylation markers in the PDX1, EN2, and MSX1 genes suggests their promising performance as prognostic markers and their clinical application in CRC patients.
주파수 체배기를 이용한 13.05 GHz용 국부발진기의 설계 및 제작
具然健,李振碩 弘益大學校 科學技術硏究所 2002 科學技術硏究論文集 Vol.13 No.-
A Ku-band local oscillator is designed using a frequency multiplier. Multiplier/filter/amplifier-chain provides the moderate conversion gain at the 6th harmonics of the fundamental frequency(2.175GHz). This design will be attractive in phase lock loop(PLL), synthesizer and up/down converter applications. The techniques for HEMT modeling and circuit design were also presented in this thesis. The device parameters were provided by manufacturer's specification. The fabricated Circuits were simulated by the harmonic balance technique using ADS. Output power of the frequency multiplier, insertion loss of the filter and the gain of the 2-stage amplifier were -16.16dBm, -2.55dB, and 22.35dB, respectively.
Cho, Jangwhan,Ko, Yeongun,Cheon, Kwang Hee,Yun, Hui-Jun,Lee, Han-Koo,Kwon, Soon-Ki,Kim, Yun-Hi,Chang, Suk Tai,Chung, Dae Sung The Royal Society of Chemistry 2015 Journal of Materials Chemistry C Vol.3 No.12
<P>We report on a new class of microliter-scale solution processes for fabricating highly uniform and large-area transistor arrays with extremely low consumption of semiconducting polymers. These processes are accomplished by applying a vertical phase separation of polymers with an environmentally benign solvent, a random copolymerization strategy between two highly conductive repeating units, and a meniscus-dragging deposition technique. The successful realization of these three processes, as confirmed by the structural and morphological in-depth characterizations, has enabled the fabrication of high-performance polymeric field-effect transistors that were uniformly distributed, without a single failure, on a 4 inch wafer using only 40 μg of semiconducting polymers. The resulting transistor arrays showed an average mobility of 0.28 cm<SUP>2</SUP>V<SUP>−1</SUP>s<SUP>−1</SUP>, with a low standard deviation of 0.04, as well as ultra-uniform near-zero threshold voltages. Our simple strategy shows great promise for fabricating large-scale organic electronic devices in the future using a truly low-cost process.</P>