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The Strategy for the Development of Bio-Resources Utilizing Sericultural Products and Insects
Lee, Won-Chu,Kim, Iksoo Korean Society of Sericultural Science 2000 International Journal of Industrial Entomology Vol.1 No.2
Experiments related to the field of sericulture started in the years 1900, in Korea. The sericultural experimental station in Korea was first organized among agricultural fields in Korea, indicating that sericulture in Korea was regarded as an important field of agriculture. Sericulture has been devoted to a great deal for the improvement of Korean economy during the past 100 years even under the coarse social circumstances caused particularly by the Korean War, However, the traditional Korean sericulture, aimed to produce silk yarn, was weakened, because of several reasons such as diminishment in silk consumption, increased labor charge in Korea, and so on. After this difficulty time, the Korean sericulture was revolutionized by shifting into functional sericulture from 1995, and the Korean sericulture now plays an important role for the improvement of human health. Mulberry tree, silkworm, and silk have a boundless potential to be developed as resources. We expect the know-how obtained through silkworm research would expand to the other insect research too. Thus, an area of entomological industry is hoped to prosper owing to insect research as well as sericulture. Mulberry tree is known to possess many bio-active substances, so it can be utilized as a resource for substitute medicine and a raw material for the functional food. In addition, an invention of genetically engineered mulberry variety, which will produce more bioactive substances, is expected. Silkworm is one of the most extensively studied insect organisms on the genome so far, Thus, silkworm is expected to be an "insect bio-factory", enabling mass-production of useful proteins by transformation, in which useful foreign genes are assimilated into silkworm. Silk can be transformed into several phases, because it possesses useful functional groups, which are sensitive to chemical reaction. Also, because silk fibrin itself is protein, it has a superior applicability as tissue membrane. Due to this usefulness, many researchers are now working on the silk as food, cosmetic, medical resource, and bioengineering resource, and even an expanded application is expected using silk in the future. Until now, the researches on insects were largely focused on the prevention of the damage caused by pest, instead of a beneficial aspect. However, insects are thought to be the fourth natural resource in the world, possessing unlimited potential as world resources in the near future. Therefore, our entomological research effort should be focused on the subject with potential for industrialization. Such subject includes selecting the insect species useful for environmental evaluation, construction of environment-friendly agricultural ecosystem, pollen mediation, pet, and advanced bio-resources.
LEE, CHU HEE,YANG, SUN A,RHO, JU WON,LEE, SEUNG TU[,NAM, DOO HYUN 한국미생물 · 생명공학회 1992 Journal of microbiology and biotechnology Vol.2 No.2
The fermentative characteristics in ethanol production from lactose, with increased ethanol tolerance, of a fusant yeast strain constructed by protoplast fusion of Saccharomyces cerevisiae and Kluyveromyces fragilis were studied. The ethanol tolerance of this strain was increased to 8.0%, compared with the parent K. fragills. During batch ethanol fermentation the optimal cultivation conditions for this fusant yeast were an initial pH of 4.5, a culture temperature 30℃, stirring at 100rpm without aeration in 10% lactose medium (supplied with 1.0% yeast extract). Using this fusant strain in whey fermentation to ethanol, maximum ethanol production reached 3.41% (w/v) (theoretical yield; 66.7%) after a 48 hour cultivation period.
Design and performance evaluation of Korean traditional heating system—Ondol: Case study of Nepal
Chu, Won-Shik,Kim, Min-Soo,Lee, Kyung-Tae,Bhandari, Binayak,Lee, Gil-Yong,Yoon, Hae-Sung,Kim, Hyung-Soo,Park, Jae-Il,Bilegt, Erkhes,Lee, Jang-Yeob,Song, Ji-Hyun,Park, Gee-Hoon,Bhandari, Pratibha,Lee, Elsevier 2017 Energy and buildings Vol.138 No.-
<P><B>Abstract</B></P> <P>Poor infrastructure in developing countries, combined with challenging geographical characteristics, is associated with problems of limited access to resources, poor transportation and environmental health issues. In some developing countries, there are no heating systems during the winter season, which causes problems for both people and livestock. The most common heating source is from open fires using biomass from animal and plant residue, which are also used for cooking. Fireplaces are typically located inside the house, which can lead to respiratory health problems because of limited ventilation. Thus, heating systems with proper ventilation are desirable to mitigate health problems and improve living conditions. Here we describe the application of ‘Ondol’, a traditional Korean heating system that was redesigned for improved efficiency, in remote villages in a mountainous region of Nepal. Total 10 models of Ondol were designed and fabricated, and the temperature profile and uniformity were characterized to select the optimal design. The height and type of the ‘Gorae’ were the most important factors in determining the efficiency. The optimal design was provided to local people, who were trained to replicate and build the Ondol on their own. A post-installation survey was carried out to evaluate the effectiveness of the system.</P>
Lee, Byung Hoon,Lee, Seung Ho,Chu, Daehyun,Hyun, Jin Won,Choe, Han,Choi, Bok Hee,Jo, Su-Hyun Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.9
<P>To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects.</P>
( Won-mook Choi ),( Jonggi Choi ),( Danbi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Young-suk Lim ),( Han Chu Lee ),( Changhoon Yoo ),( Sook Ryun Park ),( Min-hee Ryu ),( Baek-yeol Ryoo ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Nivolumab showed durable response and safety in patients with hepatocellular carcinoma (HCC) in the previous trials. However, real-world data of nivolumab in HCC patients, especially those with Child-Pugh class B, is lacking. We aimed to investigate the efficacy and safety of nivolumab in a real- world cohort of patients with advanced HCC. Methods: This study retrospectively evaluated 203 patients with HCC who were treated with nivolumab between July 2017 to February 2019. Radiologic evaluation was based on mRECIST. Survival outcomes were estimated by Kaplan-Meier method and Cox proportional hazard model. Logistic regression model was used to identify the predictive factors of treatment response. Results: Of 203 patients, 132 patients were within Child-Pugh class A and 71 patients were within Child-Pugh class B. Objective response rate was lower in patients with Child-Pugh class B than A (2.8% vs. 15.9%; P=0.010 by unweighted analysis and P=0.034 by weighted analysis) and Child-Pugh class was an independent predictor for objective response (Odds ratio, 0.21; 95% confidence interval; 0.05-0.93; P=0.040). Median overall survival was shorter in Child-Pugh B patients (11.3 vs. 42.9 weeks; P<0.001 by both unweighted and weighted analyses). However, other efficacy outcomes including disease control rate, time to progression, and progression-free survival were comparable between Child-Pugh A and B patients by unadjusted, adjusted, matched, and weighted analyses. There was no significant difference in terms of safety between Child-Pugh A and B patients. Conclusions: Given the limited treatment options for advanced HCC in Child-Pugh B patients, nivolumab may be a viable option despite lower response in these patients. Further studies are needed in this patient population.
( Won-mook Choi ),( Jonggi Choi ),( Danbi Lee ),( Ju Hyun Shim ),( Young-suk Lim ),( Han Chu Lee ),( Young-hwa Chung ),( Young-sang Lee ),( Sook Ryun Park ),( Min-hee Ryu ),( Baek-yeol Ryoo ),( So Jun 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Regorafenib and nivolumab are drugs approved for second-line treatment of patients with hepatocellular carcinoma (HCC) after sorafenib failure. However, the effectiveness of regorafenib and nivolumab following sorafenib has not been directly compared. Methods: This study retrospectively evaluated 373 patients with HCC who were treated with regorafenib (n=223) or nivolumab (n=150) after sorafenib failure between July 2017 and February 2019. Results: Progression-free survival (PFS; hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.69-1.06; P=0.150), time to progression (TTP; HR, 0.95; 95% CI, 0.77-1.19; P=0.680), and overall survival (OS; HR, 0.83; 95% CI, 0.64-1.07; P=0.154) did not differ significantly between groups of patients treated with regorafenib and nivolumab, findings consistently observed by multivariable-adjusted, propensity score-matched, and inverse probability treatment weighting (IPTW) analyses. However, the objective response rate was significantly higher in the nivolumab than in the regorafenib group (13.3% vs, 4.0%; P=0.002). When the effectiveness of regorafenib and nivolumab was compared in non-progressors to treatment, defined as patients who achieved complete response, partial response, or stable disease after first response evaluation, PFS (HR, 0.50; 95% CI, 0.33-0.75; P=0.001), TTP (HR, 0.48; 95% CI, 0.31-0.73; P<0.001), and OS (HR, 0.51; 95% CI, 0.31-0.87; P=0.013) were significantly longer in the 59 non-progressors to nivolumab than in the 104 non-progressors to regorafenib, findings also observed by multivariable-adjusted and IPTW analyses. Conclusions: Survival outcomes in patients treated with regorafenib and nivolumab after sorafenib failure did not differ significantly. However, nivolumab may be more effective than regorafenib in non-progressors.
Lee, Hee-Jun,Choi, Kang-Won,Eo, Dae-Su,Chu, Yong-Shik The Korean Society of Oceanography 2001 Journal of the Korean Society of Oceanography Vol.36 No.3
The progress of giant dyke construction off the Mangyung and Donajin rivers, has yielded enormous impact on the estuarine environment, both hydrodynamically and sedimentologically. Especially the inter-dyke gap in the northern Saemankeum area, 4 km wide between Yamido and Piungdo, has acted as an artificial tidal inlet. Due to such a changed geometry, tidal regime has been reversed from being flood- to ebb-dominated with a directional change from NE-SW to E-W. As a result, a large tongue-like tidal sand bar (named Saemankeum Bar) has conspicuously grown seaward through the artificial tidal inlet. The Saemankeum Bar composed of well-sorted very fine sands (3.0-3.5${\phi}$) has grown at a rate of 1.63 km/yr for the past three yews (1996-1998). Such a rapid growth of the sand bar is attributed to enhanced sediment supply derived from the degradation of former tidal sand bars at the mouth of the Mangyung River. Eventually the reworking of the tidal sand bars also caused the pre-existing tidal channels to be wider, deeper and more straightened. All of these phenomena well examplify the critical effect of artificial modifications on the natural estuarine environments.
Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10
Lee, Joo-Young,Song, Dae-Geun,Lee, Eun-Ha,Jung, Sang-Hoon,Nho, Chu-Won,Cha, Kwang-Hyun,Pan, Cheol-Ho The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
AKR1B10 is a human NADPH-dependent aldo-keto reductase family 1 B10, which has been considered as a potential cancer therapeutic target. 3,5-O-Dicaffeoyl-epi-quinic acid (3,5-DCQA) was isolated from ethyl acetate fraction of Gymnaster koraiensis (Nakai) Kitam as an AKR1B10 inhibitor. 3,5-DCQA inhibited the activity of recombinant human AKR1B10 (rhAKR1B10) with its $IC_{50}$ value of 1.2 ${\mu}M$ and its inhibition mode was uncompetitive from enzyme kinetic analysis.
Influences of Music Signals on Plant Growth and Insect Development
Won Chu Lee,Song Joong Yun,Hea Son Bang 한국토양비료학회 2012 한국토양비료학회 세미나 Vol.2012 No.6
Green Music (GM), a Korean-style light music, was composed to encompass frequency range of 0~2 kH by combined use of natural sounds such as water flow, bird chirping, and animals. Crop plants were exposed to GM for two hours from six to eight o’clock in the morning during the cultivation period. Growth of plants exposed to GM increased up to 44% but the effect was variable among plant species. Sweetness of cucumber increased from 4.4 to 5.1 Brix by GM treatment. Content of rutin and GABA increased in plants exposed to GM. Foliar absorption of mineral nutrients such as N, Ca, Mg, Fe, and Zn was significantly increased in plant exposed to GM. In addition, fertility and longevity of aphids were significantly decreased in the plants exposed to ultrasonic waves, and these decreases were associated with increases of substances inhibiting feeding and pupation of pest insects. Contents of some compounds known to be involved in the disruption of feeding and pupation habits, such as rutin, GABA, and dopamine, were modulated in plants or aphids exposed to GM. With the increase of substances inhibiting pest growth and survival, the amount of insecticide applied to control pest was reduced up to 80% in farms used GM for crop production. However, the effects of sound waves were variable among plant species, seasons and farming conditions. The underlying mechanisms of the effects of sounds waves are to be understood through further studies.