Ki-67 labeling index as a prognostic marker in advanced stomach cancer

Sang Hyuk Seo,Kwang Hee Kim,Sang Hoon Oh,Yunseon Choi,Ki Jung Ahn,Ji Young Lee,Sang Min Lee,박지선,Woo Gyeong Kim 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.96 No.1

Purpose: Proliferation marker Ki-67 is widely used in cancer prognosis prediction. We tried to investigate the role of Ki-67 as a prognostic factor in stomach cancer after surgery in this study. Methods: We retrospectively evaluated 251 patients who underwent curative resection for gastric cancer from 2010 to 2015. In pathologic examination, Ki-67 labeling index was defined as the percentage of Ki-67 antigen positive cells. Prognostic significance of Ki-67 for gastric cancer was evaluated. Disease-free survival (DFS) was assessed as a primary end-point. Results: The median follow-up period was 28.0 months. Thirty-one patients (12.4%) showed Ki-67 labeling index (LI) lower than 25%. Sixty-eight patients (26.6%) showed recurrence during follow-up period. Recurrence was associated with Ki- 67 LI level (≤25%, P = 0.016), and lymph node metastasis status (P = 0.002). High Ki-67 LI level (>25%) was also related to p53 positivity (P < 0.001) and poorly cohesive type (P = 0.002). The 3-year DFS was 69.4%. Low Ki-67 LI level (≤25%) was related with low DFS (47.6% vs. 72.6%, P = 0.016). T stage (P < 0.001), N stage (P = 0.006), lymphovascular invasion (P = 0.010), and neuronal invasion (P = 0.001) also affected the DFS. In addition, T stage (P = 0.03) and Ki-67 LI (P = 0.035) were independent prognostic factors for DFS. In patients treated with adjuvant chemotherapy (n = 239, 93.4%), low Ki-67 (≤25%) was a poor prognostic factor for DFS (P = 0.013). Conclusion: Low Ki-67 LI predicts high rate of progression and low DFS of stomach cancer. Ki-67 LI can be a predictive marker in resected stomach cancer treated with surgery and adjuvant chemotherapy.

간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

민영일(Young Il Min),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),이승규(Sung Gyu Lee),남승우(Seung Woo Nam),서동완(Dong Wan Seo),김연석(Yeon Suk Kim),공경엽(Gyoung Yub Gong),박능화(Neung Hwa Park),심기남(Ki Nam Shim) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma. (Korean J Gastroenterol 1997; 30:655-663)

Cloning and Characterization of Autonomously Replicating Sequence ( ARS ) from Kluyveromyces fragilis

LEE,JUNG - KEE,MOON - HEE SUNG,KI - HONG YOON,JAE - GU PAN,JU - HYUN YU,TAE - KWANG OH 한국미생물생명공학회 1993 Journal of Microbiology and Biotechnology Vol.3 No.1

Yeast Biomass Production from Concentrated Sugar Cane Stillage Using a Thermotolerant Candida rugosa

LEE,KI - YOUNG,LEE,SUNG - TAEK 한국미생물생명공학회 1995 Journal of Microbiology and Biotechnology Vol.5 No.2

Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer

Jung, So-Youn,Han, Wonshik,Lee, Jong Won,Ko, Eunyoung,Kim, Eunkyu,Yu, Jong-Han,Moon, Hyeong-Gon,Park, In Ae,Oh, Do-Youn,Im, Seock-Ah,Kim, Tae-You,Hwang, Ki-Tae,Kim, Sung-Won,Noh, Dong-Young Springer - Society of Surgical Oncology 2009 Annals of Surgical Oncology Vol.16 No.5

Antigastritis effects of <i>Armillariella tabescens</i> (Scop.) Sing. and the identification of its anti-inflammatory metabolites

Lee, Seulah,Lee, Dahae,Park, Jun Yeon,Seok, Soonja,Jang, Tae Su,Park, Hyun Bong,Shim, Sang Hee,Kang, Ki Sung,Kim, Ki Hyun Pharmaceutical Society of Great Britain 2018 Journal of pharmacy and pharmacology Vol.70 No.3

Adult Patients with Congenital Muscular Torticollis Treated with Bipolar Release : Report of 31 Cases

Lee, Gun Sang,Lee, Myung Ki,Kim, Woo Jae,Kim, Ho Sang,Kim, Jeong Ho,Kim, Yun-Suk The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1

Objective : We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. Methods : Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting. Results : The modified Lee's scoring system indicated excellent results in 4 (12.9%) patients, good in 18 (58.1%), and fair in 9 (29.0%) at the last follow-up after surgery. The improvements in neck movement and head tilt were statistically significant (p<0.05). The preoperative mean CMA was $15.4^{\circ}$ (range, 5.4-29.0), which was reduced to a mean of CMA of $6.3^{\circ}$ (range, 0-25) after surgery (p<0.05). The global satisfaction rating scale was 93.7% (range, 90-100). A transient sensory deficit on the ipsilateral lower ear lobe was noted in three cases. No significant permanent complications occurred. Conclusion : Bipolar release of the SCM is a safe and reliable technique for the treatment of CMT in adults.

Korean Dictionaries and Some Model Dictionaries of the World : Critical Essays toward the Plan for a New Korean Dictionary

Lee, Sang Sup,Nam, Ki Shim,Ahn, Sam Huan,Choi, Young Ai,Hong, Chai Song 연세대학교 언어정보개발원 1988 사전편찬학 연구 Vol.1 No.1

After briefly reviewing the history of lexcoigraphy in modem Korea, Nam Kishim tackles many problems created by the general deficiency of current Korean monolingual dictionaries in phonological morphological and semantic points. For example, most Korean dictionaries do not treat such phonological changes as the shortening of the stem vowel ㅓ in 더운, the prenominal form of the adjective 덥다, whose stem vowel ㅓ is pronounced long. He also takes issue with the practice of Korean dictionaries of including all kinds of proper names on little reliable principles : a typical dictionary enters a 600m-high hill while excluding better-known mountains higher than that. Hong Chai-song concentrates on the often misguiding information on transitive / intransitive verbs in current dictionaries. For example, a representative dictionary designates the verb 뛰다 simply as intransitive. But it is quite often used as an transitive also. In the sentence, 철수는 운동장을 뛰었다, 운동장 is the object of the transitive verb 뛰다. How could the compilers miss such an obvious fact? Hong suggests that they may have not been interested in being grammatically informative. A historical survey of the Oxford English Dictionary(OED) is given by Lee Sang-sup, with special emphasis on the vast amount of quotations from real sources contributed by thousands of volunteer readers through several decades and on its unwavering historical principle. A comparison between the OED's definition of Kimchi and a Korean dictionary's 김치 is given, showing the difference of principle in treating the same lexical item. Ahn Sam-huan presents a detailed account of Grimm's Deutsches Wo¨rterbuch which took generations of German lexicographers 133 years from its inception to its completion in 1971. On the basis of his study, Ahn suggests that future dictionary makers should cooperate as a group on a long-range comprehensive project. A moltivolume dictionary is an all-important cultural event for the whole nation, not to be influenced by private commercial interests. Choi Young-ai's survey of Chinese lexicography highlights the now on-going publication of 漢語字典 and 漢語詞典, admirable results of the cooperative effort of hundreds of Chinese scholars, a modus operandi for the Yonsei University graze to adopt in planning a new dictionary of the Korean language.

Ki - 1 임파종 1 예

강민모(Min Mo Kang),김경재(Kyoung Jae Kim),이지현(Ji Hyun Lee),최석문(Seog Mun Choi),안기성(Ki Sung Ahn),황기석(Kee Suk Whang),김용진(Yong Jin Kim),박재복(Jae Bok Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

A 60-year-old man was admitted to our hospital complaining of fever with chillness and anarexia for 12 weeks. Physical examination revealed supraclavicular lymphadenopathy and left inguinal lymphadenopathy. Abdominal CT scan showed the evidence of maked lymphadenopathy on retraperitoneal, external iliac, obturator, left inguinal, and celiac lymph nodes. A pathologic diagnosis of Ki-1(+) lymphoma was made by the biopsed supraclavicular lymph node because the node consisted of large cells with pleomorphic nuclei, scanty cytoplasm, large basophilic nucleoli, atypical vacuoli and large cells were positive for leukocyte common antigen, Ber-H2, marker, and B-cell marker.

출판학 연구 동향 및 특성에 관한 논문 - 한국출판학연구(1982~2006)를 중심으로 : 출판학 연구 동향 및 특성에 관한 논문

이기성(Lee Ki-Sung) 한국출판학회 2006 한국출판학연구 Vol.0 No.51

‘출판학 연구 동향 및 특성에 관한 논문―한국출판학연구(1982~2006)를 중심으로’ 연구 논문은 1982년도부터 2006년 6월 통권 제50호까지 한국출판학연구에 실린 272건의 논문을 분석한 것이다. 본 논문은 서론, 선행 연구 검토, 최종 매체별 구분, 출판 분야 및 단계별 구분, 언어 문자별 구분, 필자별 논문 구분, 결론의 7개 내용으로 구성되었다. 출판에 관한 분류 방법에 대하여는 민병덕 교수, 이기성 교수, 남석순 교수, 이종국 교수, 팽건염 교수, 기륜성남 교수 등 여러 학자가 이미 연구한 바 있다. 필자는 매체별 분류, 분야별 분류, 단계별 분류, 언어 문자별 분류의 4가지를 하나의 같은 범주 내에서 구분하는 것이 아니라 각기 다른 위치(차원)에서 구분하는 것이므로 논문이나 출판물은 하나이지만, 이것을 각기 4가지씩으로 분류하는 방법을 2000년도에 제안한 바 있다. 첫 번째 : 최종 매체(media)에 의한 논문 구분(① 종이 매체, ② 전자 매체(비종이 매체), ③ 공용의 3가지), 두 번째 : 분야(field)에 의한 논문 구분(① 교과서류, ② 단행본류, ③ 잡지류, ④ 신문류, ⑤ 일반), 세 번째 : 단계(step)에 의한 논문 구분(① 기획, ② 편집, ③ 제작, ④ 마케팅, ⑤ 총괄), 네 번째 : 언어(language) 문자에 의한 논문 구분(① 한국어, ② 영어, ③ 중국어, ④ 일본어, ⑤ 기타 문자) 결론적으로 첫째, 출판학이나 출판 산업을 분석하려면 2차원 이상으로 분류하는 방법(멀티차원분석법)이 필요하다. 둘째, 제작 단계와 편집 단계의 논문이 매우 필요하다. 셋째, 출판 관련 논문을 작성하는 필자가 절대적으로 부족하다. This study is divided into 7 parts ; Introduction, Classification systems, Classification -based on output media, Classification -based on publication fields and steps, Classification -based on language and letters, Classification -based on authors, and Conclusion. Theses given in the collection of learned papers of Studies of Korean Publishing Science have been issued from 1982 to 2006 are two hundred and seventy two. Many scholars have suggested the way of analyzing the publications and publishing industry. Professor B.D. Min’s method : General remark, Selection, Production, Distribution, Managing, and History. Professor K.S. Lee’s method : Divided with final output Media, Divide with publication Field(contnents), Divided with publication production Step, and Divided with typeset Language and letters. Professor S.S. Nam’s method : Theory of publishing, Education, Production, Circulation, Reception, Environment, Industry, Electronic Publishing, Law, and International Publishing. Professor J.G. Lee’s method : Theory, Copyright/Morals, Editing/Production, Textbook, Book, Magazine, Electronic Publishing, Management/Industry, Circumstances, International Publishing, and Reading/Reader. In this study, I propose the analyzing publications and publishing industry is not only one dimension but also more than two dimensions according to the angles of vision. The first dimension is divided into 3 sections based on output media, such as Paper, Electron(non-paper), and altogether. The second dimension is divided into 5 sections based on publishing field, such as Textbook, Book, Magazine, Newspaper, and General(the others). The third dimension is divided into 5 sections based on production step, such as Planning, Editing, Production, Marketing, and General(basis). The fourth dimension is also divided into 5 sections based on language and letters, such as Korean character, English, Chinese, Japanese, and the others. Multi Dimension Analysis(MDA) which is using more than two dimensions is the most suitable way of analyzing the publications and the theses related to publishing.