제2형 당뇨병 외래 환자의 비만도에 따른 미세혈관합병증

이성규,조남한,김현만,이관우,정윤석,채봉남,김윤정,이미덕,노혜림,홍은경,조현경 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1

Background: Korean type 2 diabetic patients who are frequently non-obese, may be genetically different from Western type 2 diabetics who are frequently obese. Therefore, the diabetic complications of type 2 diabetes mellitus in Korea may be also different from those of Western countries. Until now, most studies reported in Korea did not analyse the microvascular complications of type 2 diabetes mellitus according to obesity, and also the criteria in the diagnosis of microvascular complications were different in each study. We investigated the microvascular complications and its relationship with obesity, in type 2 diabetic patients visiting an outpatient clinic. Methods: The study subjects were type 2 diabetic patients visiting an outpatient clinic of Ajou University Hospital. We selected patients participating in a 75 g oral glucose tolerance test, retrospectively. Type 2 diabetes was diagnosed according to the WHO/NDDG classification of diabetes. Biochemical studies including lipid profile, plasma insulin and C-peptide levels were done. Anthropometric measurements were performed. Based on BMI (㎏/㎡), the patients were divided into the following groups: the lean group, when the BMI was less than 20 ㎏/㎡ the ideal body weight (IBW) group, if the BMI was between 20 ㎏/㎡ and 25 ㎏/㎡ in women and 20 ㎏/㎡ and 27 ㎏/㎡ in men; and the obese group, when the BMI was $gt;25 ㎏/㎡ in women and $gt;27 ㎏/㎡ in men. Results: 1. Neuropathy (45.2%) was the most frequent among the microvascular complications, and the frequency of retinopathy was 15.1%, and that of nephropathy was 4.9%. Within 5 years of diabetes duration, the frequency of neuropathy, retinopathy, and nephropathy was 43.2%, 11.8%, and 2.9%, respectively. 2. Glycosylated hemoglobin (HbA_(1c)) and fasting blood glucose levels were not different among the three groups. Beta cell function{Δ (insulin 30min - insulin Omin)/Δ(glucose 30min - glucose 0min)} was the highest in the obese group. However, beta cell function(ΔI/ΔG) divided by the basal insulin level, considered insulin resistance, was not different among the three groups. 3. Within 5 years of diabetes duration, retinopathy tended to be the most frequent in the lean group, whereas neuropathy tended to be the most frequent in the obese group, and body mass index influenced the retinopathy and neuropathy, statistically significantly. Conclusion: Diabetic neuropathy was the most frequent among microvascular complications of type 2 diabetes mellitus in our study subjects. At the time of presentation within 5 years of diabetes duration, the lean group of type 2 diabetics had a tendency of the more frequent retinopathy, the obese group had a tendency of the more frequent neuropathy. These results suggest that type 2 diabetes mellitus in Korea is also not a single disease entity, as in Western countries and is a heterogenous group of disorders with a diversity of microvascular complications. However, the more studies about this will be required.

인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예

이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2

저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

텍스트종류 `부음`에서 `모토`의 형태와 기능

이성만 한국독일어문학회 2001 독일어문학 Vol.15 No.-

톨루엔 폭로 작업자에서 Aldehyde dehydrogenase2(ALDH2)의 유전자형과 요중 마뇨산

이강숙,노영만,박정일,허성옥 가톨릭대학 산업의학 센타 산업의학연구소 1995 韓國의 産業醫學 Vol.34 No.2

This study was conducted to evaluate the distribution and the effect to urinary hippuric acid excretion according to the polymorphism of aldehyde dehydrogenase2(ALDH2) which is major role in oxidaton of benzaldehyde to benzoic acid. For 39 workers exposed to toluene and 42 white collar workers, we extracted the DNA from venouse blood and confirmed the genotype of aldehyde dehydrogenase2 using the polymerase chain reaction(PCR) and artificial created restriction site method. In workers exposed to toluene, normal (NN) type were 34 (88%) and inactive(ND) type were (12%), but in white collar workers NN type were 27(65%) and ND type were 14(33%), DD type were 1(2%). It showed the significant lower rate of inactive type of ALDH2 in workers exposed to toluene than white collar workers. The results of workplace toluene measurement were below 20ppm. For urinary hippuric acid there was not significant differnce between normal and inactive type of ALDH2. It suggested that further evaluation should be conducted in high concentration of toluene exposure group.

논증의 언어학적 의미와 기능

이성만 培材大學校 1996 培材論叢 Vol.1 No.-

한약재 천마(Gastrodia elata Blume)의 증자조건 모니터링

이진만,김성호 東國專門大學 2002 金龜論叢 Vol.9 No.1

최근 기능성 식품에 대한 인식이 높아지면서 국내에서 재배되고 있는 생약제의 생리 활성에 관한 연구가 이루어지고 있으며, 그중 천마의 약리적인 효능이 인정됨에 따라 가공식품으로의 개발 확대가 더욱 요구되고 있다. 생약은 자연에서 채취한 그대로 이용하는 데에는 생체의 보존에 따른 불편과 독성, 자극성 등의 부작용이 있어 간단한 가공처리를 필요로 한다. 따라서 본 연구에서는 천마를 이용한 가공제품을 개발하기 위하여 반응표면분석법을 이용하여 각 조건별로 증자된 천마의 항산화적 특성을 모니터링하고 최적 증자조건을 예측하였다, 중심합성계획법에 따라 증자온도(80∼120℃), 증자시간(20∼60 min)을 달리하였을 때 총 페놀성 화합물 함량은 증자온도 94.43℃, 증자시간 42.38 min고 전자공여능은 증자온도 101.67℃, 증자시간 41.09 min이었다. 항산화능 및 아질산염소거능에 대한증자은도와 증자시간의 최적 조건은 100.00℃, 40.00 min으로 같게 나타났다. 이상과 같이 각각의 증자조건에 따른 천마의 항산화적 특성을 종합하여 superimposed contour map을 작성하여 최적 조건을 예측한 결과 증자은도 96∼107℃, 증자시간 28∼46 min이었다.

산업보건관리자를 위한 소음성 난청 예방지침서의 개발

이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1

Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.

기능 화용론적 텍스트분석의 가능성 : 엘리히와 레바인의 이론에 의한 감사 행위모형의 예시분석 Exemplarische Analyse des Handlungsmusters DANKEN auf der Basis der Theorie von K. Ehlich und J. Rehbein

이성만 한국독일어문학회 2003 독일어문학 Vol.22 No.-

Die Funktionale Pragmatik wurde hauptsachlich von Konrad Ehlich und Jochen Rehbein entwickelt und ausgearbeitet. Der Ausgangspunkt ist handlungstheoretisches Verstandnis von Sprache. Die theoretische Weiterentwicklung grundet auf der Kritik an Searle und Austin. Im Zentrum der Theorie steht die Auffassung, dass Sprechen eine Form des Handelns ist. Ein zentraler Begriff der Funktionalen Pragmatik ist der des 'Handlungsmusters'. Das sprachtheoretische Grundmodell der Funktionalen Pragmatik berucksichtigt bei der Analyse von Kommunikation folgende Kategorien: Sprecher und Horer, sowie deren mentale Prozesse werden ebenso analytisch berucksichtigt wie die reale Situation, in der die Kommuni-kation stattfindet. Die Realitat wird in der Kommunikation von Sprecher und Horer mental verarbeitet. Sie bildet den Ansatzpunkt fur die sprachliche Außerung des Sprechers, die wiederum vom Horer mental verarbeitet werden muss. Diese theoretischen Uberlegungen wurden bei der beispielhaften Prasentation des Handlungsmusters DANKEN konkretisiert.

W/O 마이크로에멀젼에 의한 나노크기의 TiO₂/SiO₂ 합성에서 물/계면활성제의 몰 비(W_(0)) 영향 및 그 광분해 특성

이만식,주창식,이근대,홍성수 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.4

나노크기의 TiO₂/SiO₂입자는 음이온 계면활성제 AOT(sodium bis(2-ethylhexyl) sulfosuccinate)를 사용하여 W/O 마이크로 에멀젼에서 TTIP(titanium isopropoxide)와 TEOS(tetraethylorthosilicate)의 가수분해 반응에 의해 제조하였다. 그때 TEOS의 몰분율은 0.1이였다. 나노입자 제조시 W_(0)(H₂O/AOT)비에 따른 열적안정성, 표면적, 결정성 및 결정크기 등과 같은 물리적 특성은 TEM, XRD, BET, FT-IR, TGA-DTA 등을 사용하여 분석하였다. 또한 광촉매적 특성을 알아보기 위해 회분식 반응장치를 이용하여 p-니트로페놀의 광분해 활성을 조사하였다. 제조된 Ti0₂/SiO₂ 나노입자는 열처리 온도 105℃, 300℃에서 비결정구조를 가졌으며, 소성온도 800℃에서는 Ti0₂ 결정입자 내에 무정형의 SiO₂로 인해 열적 안정성이 증가되었고, 여전히 anatase 결정을 유지하였다. 그리고 Ti0₂/SiO₂(90/10) 입자에서 SiO₂ 결정은 관찰되지 않았다. 제조된 촉매는 대체로 구형이며 아주 균일한 분포를 갖는 것으로 관찰되었다. W_(0) 비가 증가할수록 결정크기는 증가되었고, 표면적은 감소하는 경향을 나타내었다. 또한 p-니트로페놀에 대한 광분해 활성은 순수한 Ti0₂ 보다 Ti0₂/SiO₂(90/10) 촉매가 우수하였다. Nanosized TiO₂/SiO₂ particles were prepared by hydrolysis of TTIP (titanium isopropoxide) and TEOT (tetra-ethylorthosilicate) in sodium bis (₂-ethylhexyl)sulfosuccinate (AOT) reverse micelles. The mole fraction of TEOS was 0.1. The physical properties, such as surface area. thermal stability, crystallite size and crystallinity according to W_(0), ratio have been investigated by TEM, XRD, BET, FT-IR, TGA and DTA. In addition. the photocatalytic degradation of p-nitrophenol has been studied by using batch reactor in order to compare the photocatalytic activity of prepared nanosized TiO₂/SiO₂, particles. It is shown that the XRD pattern of the particle heat treated at 105℃ and 300℃ indicates amorphous and the major phase of all the prepared particles were anatase structure. No significant rutile phase was observed although the calcination temperature at 800℃ and no peaks SiO₂ crystal were also observed for TiO₂/SiO₂ (90/10). The presence of amorphous SiO₂ in TiO₂/SiO₂ particle enhanced the thermal stability of TiOz particle resulting in the suppression of the phase transformation from anatase to rutile phase. The crystallite size of prepared particles decreased with decreasing W_(0) ratio. The surface area increased with decreasing W_(0) ratio. In addition, TiO₂/SiO₂ (90/10) particles shows higher photoactivity than that of pure TiO₂ particles.