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The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.
Lee, Jong Dae,Lee, Jae Yong,Baek, Byoung Joon,Lee, Byung Don,Koh, Yoon Woo,Lee, Won-Sang,Lee, Yu-Jin,Kwon, Byoung-Mog Triological Foundation [etc.] 2012 The Laryngoscope Vol.122 No.1
<P>As the molecular biology of vestibular schwannoma (VS) is better understood, new means of targeting the pathways involved for intervention in schwannoma cells are being developed. Honokiol, a bioactive constituent of Magnolia officinalis, has attracted attention due to its diverse biological effects. This study was conducted to determine the inhibitory effect of honokiol on schwannoma cell proliferation.</P>
The clinical impact of family history of cancer in female never-smoker lung adenocarcinoma
Lee, Youngjoo,Jeon, Jae Hyun,Goh, Sung-Ho,Roh, Hanseong,Yun, Ji-Young,Kwon, Nak-Jung,Choi, Jin Ho,Yang, Hee Chul,Kim, Moon Soo,Lee, Jong Mog,Lee, Geon Kook,Han, Ji-Youn Elsevier 2019 Lung cancer Vol.136 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Accumulating evidence reveals the association between the risk of never-smoker lung cancer and family history of cancer. However, the clinicogenomic effect of family history of cancer in never-smoker lung cancer remains unknown.</P> <P><B>Material and methods</B></P> <P>We screened 3,241 lung cancer patients who (a) underwent curative resection at National Cancer Center (Goyang, Korea) between 2001–2014, and (b) completed a pre-designed interview about family/smoking history at the time of diagnosis and identified 604 female never smoker lung adenocarcinoma. A positive family history of cancer [categorized as pulmonary cancer (FH-PC) or non-pulmonary cancer (FH-NPC)] was defined as a self-reported history of cancer in first-degree relatives. Survival data were followed up until January 2017. Multiplexed targeted next-generation sequencing was performed for genetic profiling.</P> <P><B>Results</B></P> <P>Of 604 patients, 29.1% (n = 176) had a FH, including 132 (21.9%) with FH-NPC and 44 (7.3%) with FH-PC. Patients with the FH-NPC had a higher proportion of young patients (≤45 years) than those without the FH-NPC (FH-NPC, FH-PC, and no FH; 13.6%, 2.3%, and 8.2%, respectively; <I>P</I> = 0.032). Patients with the FH-NPC had an increased risk of recurrence (hazard ratio [HR]: 1.90; 95% confidence interval [CI]: 1.40–2.56; <I>P<</I>0.001) and death (HR: 1.67; 95% CI: 1.18–2.37; <I>P=</I>0.004). In contrast, the FH-PC had no prognostic effect on recurrence (HR: 1.23; 95% CI: 0.71–2.15; <I>P = 0.456</I>) and death (HR: 0.93; 95% CI: 0.45–1.91; <I>P=</I>0.838). Among three driver oncogene alterations, <I>EGFR</I> mutation was significantly associated with the FH-PC (53.8%, 84.1%, and 65.8%, respectively; <I>P</I> = 0.016), <I>ALK</I>/<I>ROS1</I>/<I>RET</I> fusions was significantly associated with the FH-NPC (13.7%, 0.0%, and 5.0%, respectively; <I>P</I> = 0.004), but <I>KRAS</I> mutation was not associated with any type of the FH (13.8% vs. 6.0% vs. 7.8%, respectively; <I>P</I> = 0.288).</P> <P><B>Conclusion</B></P> <P>The type of family history of cancer was associated with distinct clinocogenomic subtypes and prognosis of never-smoker lung adenocarcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Family history of cancer is related to distinct subtypes of never smoker lung cancer. </LI> <LI> <I>ALK/ROS1/RET</I> fusions are enriched in patients with family history of nonlung cancer. </LI> <LI> <I>EGFR</I> mutations are enriched in patients with family history of lung cancer. </LI> <LI> Family history of nonlung cancer is associated with poor prognosis after operation. </LI> </UL> </P>
Lee, Dae-Sung,Eom, Sung-Hwan,Kim, Young-Mog,Kim, Hye Seon,Yim, Mi-Jin,Lee, Sang-Hoon,Kim, Do-Hyung,Je, Jae-Young Canadian Science Publishing 2014 Canadian journal of microbiology Vol.60 No.10
<P> Methicillin-resistant Staphylococcus aureus (MRSA) is spreading worldwide, emphasizing the need to search for new antibiotics. The anti-MRSA activities of gallic acid-grafted-chitosans (GA-g-chitosans) were investigated against 2 MRSA standards and 10 MRSA clinical isolates by determining the minimum inhibitory concentrations (MICs). GA-g-chitosan (I), which has the highest gallic acid content, exhibited the strongest anti-MRSA activities, with MICs of 32-64 μg/mL. A time-kill investigation revealed that GA-g-chitosan (I) exhibited a bactericidal effect at twice the MIC, also demonstrating good thermal and pH stability. Investigation of cell envelope integrity showed the release of intracellular components with an increasing absorbance value at 260 nm, indicating cell envelope damage caused by the GA-g-chitosan (I), which was further confirmed by transmission electron microscopy. When GA-g-chitosans were combined with β-lactams, including ampicillin and penicillin, synergistic effects were observed on the 2 standard MRSA strains and on the 10 clinical isolates, with fractional inhibitory indices ranging from 0.125 to 0.625. In the time-kill dynamic confirmation test, synergistic bactericidal effects were observed for the combinations of GA-g-chitosans with β-lactams, and over 4.0 log CFU/mL reductions were observed after 24 h when combination treatment was used. These results may prove GA-g-chitosans to be a potent agent when combined with ampicillin and penicillin for the elimination of MRSA. </P>
Lee, Won-Chang,Lee, Sang-Mog 건국대학교 1990 學術誌 Vol.34 No.2
저자들은 모발중에 총수은함량과 메칠수은함량간의 상관성을 검토하기 위하여 서울 시민 중 남녀 315명의 모발을 대상으로 하여 정량분석한 격과(제1보)에 이어 제2보로서 본 연구를 시도한 바 다음과 같이 그 결과를 요약할 수 있었다. 연구대상 중 남성의 모발은 여성들의 모발 중에 총수은량과 메칠수은의 함량에 비하여 통계학적으로 유의하게 높았고(p<0.01), 그러나 극히 일부를 제외하고는 안전권 범위에 있어 공중보건학상 이직까지는 문제되지 않고 있었다. 그리고 모발중 총수은함량과 메칠수은량간의 통계학적 상관도를 검사한 바 남성들의 모발에서는 r=+0.862(p<0.01)과 여성 모발에서는 r=+0.721(p<0.01) 그리고 남녀양성을 통합하여 본 바는 r=+0.941(p<0.01)로 각각 높은 상관성이 있어, 이를 이용하여 모발 중의 총수은함량에 대한 예측되는 메칠수은량을 산출할 수 있는 회귀방정식을 각각 고안하여 보았다. The authors conducted an observative study on the relationship between total mercury (TM) and methylmercury (MM) contents in trace metal level of Korean scalp hair samples, which never been made before in the field of Environmental Health and Toxicology in Korea. The following results were summerized: A higher level of total mercury and methylmercury amount has been found in the scalp hair of Korean male than female (p<0.01). The statistical coefficient of correlation between total mercury and methylmercury contents in scalp hair of male was r=+0.862(p<0.01) and that of female was r=+0.721 (p<0.01) and that of sum in male and female was r=+0.941 (p<0.01), respectively.
( Sung Hwan Eom ),( Soo Jin Heo ),( Dae Sung Lee ),( Myung Suk Lee ),( Young Man Kim ),( Won Kyo Jung ),( Young Mog Kim ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Poncirus trifoliata was evaluated for antioxidant potential by several radical-scavenging assays, including 1,1-diphenyl-2-picrylhydrazyl, superoxide, hydroxyl, and alkyl radicals, using electron spin resonance technique. P. trifoliata extracts were prepared by using water and methanol, partitioning with different organic solvents. Among the tested samples, water extract and dichloromethane fraction evidenced relatively higher scavenging activities than those of other samples on reactive radicals and have high amount of antioxidant component such as flavonoids (8.5±0.3 and 8.3±0.2 mg rutin equivalents/g dry weight basis) and proanthocyanidin (2.6±0.3 and 2.8±0.5 mg catechin equivalents/g dry weight basis), respectively. Moreover, the water extract showed significantly high enhancement of cell viability against hydrogen peroxide-induced oxidative damage as well as reduction in the hydrogen peroxide-induced intracellular reactive oxygen species on CCL 13 cell line. These results indicate that P. trifoliate exerts various antioxidant effects against several reactive radicals and hydrogen peroxide-mediated cell damage. Thus, P. trifoliate could be a potential therapeutic modality for the treatment or prevention of several diseases associated with oxidative stress.
Lee,Won-Chang,Lee,Sang-Mog,Lee,Tae-Jong,Lee,Joong-Bok 건국대학교 동물자원연구센터 1999 動物資源硏究誌 Vol.20 No.-
國內에서 牛型結核 發生의 豫防管理를 위하여 實施되고 있는 튜버클린 檢索과 陽性反應된 젖소를 殺處分하는 方法에 대하여 그 成果를 推移(retrospective study) 하고자 試圖하고, 1965年부터 1997年度 사이의 農林部刊行 統計資料를 收集 醫學統計學的 分析을 한 結果, 젖소의 튜버클린 陽性反應에 의한 牛型結核의 罹患率 每10萬頭當 最低 14.9頭부터 最高 669.3頭에 이르고 있었다. 1973年度부터 HCSM과 PPD 튜버클린 檢索을 竝行한 결과 그 效果가 있어 1990年度까지는 陽性反應率이 순조럽게 減少?형勢를 보였으나, 1997年度부터는 다시 多少 增加되는 傾向을 보이고 있었다. 以上의 結果로 미루어 보아 現在 進行되고 있는 젖소에 대한 튜버클린 檢索과 陽性反應된 젖소의 殺處分法은 酪農先進國의 境遇에서와 같이 繼續進行되어야 할 것으로 본다. This study was aimed at making a retrospective observation of the morbidity rate of bovine tuberculosis with tuberculin reactors through the effects on the expanded program of test and slaughter for eradication and management among dairy cattle in Korea, from 1965 to 1997. The morbidity rate of tuberculin reactors during the period varied from 14.9 to 669.3 per 100,000 dairy population, however, those tended to decreased from 1975 to 1990, but the rate of reactor were trended to increased after 1991. In conclusion, expanded program of test and slaughter reduced the incidence cases and morbidity rates of bovine tuberculosis with tuberculin reactor available for management of dairy cattle in Korea, when the tuberculin of HCSM and PPD together used after 1973. Finally, it is our hope that these information could be use for reference in further study of the field of veterinary public health and preventive medicine.
Lignans from the Fruits of Cornus kousa Burg. and Their Cytotoxic Effects on Human Cancer Cell Lines
Lee, Dae-Young,Song, Myoung-Chong,Yoo, Ki-Hyun,Bang, Myun-Ho,Chung, In-Sik,Kim, Sung-Hoon,Kim, Dae-Keun,Kwon, Byoung-Mog,Jeong, Tae-Sook,Park, Mi-Hyun,Baek, Nam-In 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H$_2$O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol(3), erythro-guaiacylglycerol-${\beta}$-coniferyl aldehyde ether (4), threo-guaiacylglycerol-${\beta}$-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carci-noma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC$_{50}$ values ranging from 19.1 to 71.3 ${\mu}$g/mL.
( Sung Hwan Eom ),( Young Mi Kang ),( Jae Hong Park ),( Dae Ung Yu ),( Eun Tak Jeong ),( Myung Suk Lee ),( Young Mog Kim ) 한국수산과학회(구 한국수산학회) 2011 Fisheries and Aquatic Sciences Vol.14 No.3
The objective of this study was to select an effective microbial strain to improve the functional qualities of Eisenia bicyclis water extract by fermentation. For this purpose, several microorganisms isolated from traditional Korean fermented foods were inoculated and cultivated in E. bicyclis water extract. Ultimately, yeast strain YM-1 was selected for further study based on its total phenolic compound (TP) content and antioxidant activity, which were enhanced by microbial fermentation. The extract fermented by YM-1 exhibited a superior TP content and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity compared to extracts fermented by other microbes. The highest TP content and DPPH radical scavenging activity were observed after one day of YM-1 fermentation. Yeast strain YM-1 was identified as Candida utilis based on an analysis of its physiological characteristics. During fermentation of the extract by C. utilis YM-1, no significant difference was observed in the proximate composition, including moisture, crude lipid, crude protein, and crude ash. Fermentation by C. utilis YM-1 resulted in enhanced biological activity, including increases in the TP content and antioxidant activity. Thus, fermentation by C. utilis YM-1 is an attractive strategy for developing value-added food ingredients.