고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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마산만 퇴적물의 중금속 및 유기염화합물 오염에 관한 연구

이찬원,민병윤,권영택,양운진,이규환 경남대학교 환경문제연구소 1990 환경연구 Vol.12 No.-

마산내만 및 마산만 유임 주요하천의 오염퇴적물을 1988년 7월부터 1989년 8월에 걸쳐 채취하여 중금속 및 유기염소화합물을 분석하였다. 오염퇴적충의 뚜께는 10㎝에서 169㎝의 넓은 분포를 보였으며 조사지점의 중금속농도는 지점에 따라 많은 차이를 나타내었다. 특히 인근에 마산수출자유지역 및 조선산업이 위치한 조사 지점에서는 모든 중금속의 농도가 가장 높게 나타났다. 마산만 퇴적오염물 중금속 농도를 오염된 일본의 자료와 비교하였을때 Osaka만의 수온을 제외하고 모든 평균농도가 높게 나타났다. 유기염소화합물(PCB 및 DDE)의 농도는 주거지역 및 공장지대가 함께 위치한 산호천 및 마산시 연안지역에서 높게 검출되었다. 본 연구결과에 의하면 마산만과 같은 폐쇄성 해역에서 중금속 오염원으로 공장폐수가 고려될때는 퇴적된 오염물질의 중금속 분석이 좋은 척도가 철 수 있음을 시사하고 있다. Sediments were collected from Masan bay and two main waterways into Masan Bay in the period of July 1988 to August 1989 for the analysis of heavy metals and Organochlorine compounds. The polluted layer of black sludge had a wide range between 10㎝ to 169㎝ and the content of heavy motels was widely distributed from site to site. One site near the Masan free-export area and a shipmaking company was extremely contaminated by heavy metals. All the average concentration of heavy metals in the sediments from Masan Bay were higher than those from Japanese bays compared except Hg from Osaka Bay. Higher levels of PCBs and DDE were found in sediments from Sanho stream and along the coastal area of Masan city. The results obtained in this study imply that the heavy metal analysis of sediments may be a useful to reveal the pollution sources in a closed bay fuck as Masan Bay.

연쇄가지반응 모델에 의한 화학반응 장치의 안전성

이상록,염치호,박찬규 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

The method for determining the stability and multiplicity of steady states, and steady reaction region in phase plane for chain branching reaction model in perfectly mixed flow tank reactors is proposed. The results proposed are as follows : 1) stability and multiplicity of steady states exist 2 points (T_S1 : node, T_S2 : saddle) in T<T_1 range, and 2 points (T_S3 : focus, T_S4 : saddle) in T>T_2range on F(T)=0 curve. 2) steady reaction region containing the steady states can be constructed by the state varialbes of a reactor in phase plane. All trajectories of the representative points pass into the region at the boundary surface since the representative points in the region never drift out, it is safe to keep the reactor operation in the region.

태양열을 이용한 냉난방 온수기 개발에 관한 연구

이찬규 거제전문대학 1998 論文集 Vol.6 No.-

The energy consumption of our country has been increasing rapidly with the development of industries and living condition. But the reserves of oil and nuclear energy is uncounted with its limitations and coal energy is mineral source which is used for various productions, as well as fuel energy. Therefore, it is necessary to develop substitutes of coal energy, because consumption of oil is too wasteful, to produce thermal or electric energy only. The goal of this project is to carry out the R & D on the design, manufacture and performance test of the hot water producer by the combination of the solar thermal energy and freon gas compression heat and to develop the system including the solar absorption panel, which has no glassing and no insulation, and the frozen and burst problems were Intrinsically eliminated.

BaTiO_3결정의 사각형 강유전 구역에 관한 온도와 전기장 특성

이찬구,이수대,문준규 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.2

BaTiO_3 결정의 (100)면에 수직한 방향에서 관측되는 강유전 구역을 온도와 전기장의 변화에 따라 편광현미경으로 관측하였다. BaTiO_3 결정의 (100)면에 수직한 방향에서 관측되는 그물모양의 사각형 강유전 구역이 90℃-구역이라는 사실을 밝혔다 우리는 사각형 강유전 구역의 온도특성과 정전기장 특성에 관하여 조사하였다 사각형 강유전 구역은 상전이 온도인 120℃ 이상에서 사라졌다. 24℃에서 외부 전기장을 인가한 경우, 4 0×10^7 V/m에서 구역의 변화가 관측되며, 5.5×10^7 V/m의 전기장을 가하여도 단일 강유전 구역은 형성되지 않으며, 5.5×10^7 V/m 이상에서는 누설전류가 흘렀다. 한편 온도를 114℃로 올리고 전기장을 5 5×10^7 V/m 이상으로 가하면 단일 강유전 구역이 형성되었다. We observed the ferroelectric domain in a vertical direction of the (100) plane of BaTiO_3 crystal by a polarizing microscope We find out that ferroelectric domains of the square pattern are 90℃0domain. The electric field Properties and the temperature dependent of ferroelectric domain in BaTiO_3 Crystal was investigated From these results, it was concluded that the square domains disappeared from sight at above 120℃, and the Change of the domain pattern observed at 24℃ and 4.0×10^7V/m, it Showed the leakage current 5.5×10^7 V/m. A single domain do not formed 24℃ and above 5.5×10^7 V/m. On the other hand, a single domain formed at 114℃and above 5.5×10^7 V/m.