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이봉학,윤경구,홍창우,김동호 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-
콘크리트의 취성적 성질을 개선하고 부재의 인성을 증가시킨 강섬유보강 콘크리트는 건설분야에 활용할 가치가 크다. 그러나 설계규준이나 해석방법이 정비되지 못한 현 실정에서 거동 특성을 규명하고 이에 유효하고 타당한 해석모델을 제시하는 것이 요구된다. 본 논문에서는 강섬유보강 콘크리트의 강도특성실험, 직접인장실험 및 피로실험을 수행하여 이에 대한 역학적 특성을 고찰하고 거동특성을 규명함으로서 설계와 해석의 기초 자료로 활용하고자 하였다. This study is conducted on the test to find tension stiffening, flexural fatigue characteristics and mechanical properties of steel fiber reinforced concrete. Experimental investigation is examined accord to hooked type fiber contents(0, 0.4 , 0.7, 1.0%), fiber aspect ratio(60.83). The principal results obtain through this study are as follows; steel fiber reinforced concrete is increased completely tensile & flex strength properties compared with normal concrete. The tension stiffening and fatigue life tend considerably increase with fiber contents, fiber aspect ratio.
이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1
특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.
A genome-wide association study of a coronary artery disease risk variant.
Lee, Ji-Young,Lee, Bok-Soo,Shin, Dong-Jik,Woo Park, Kyung,Shin, Young-Ah,Joong Kim, Kwang,Heo, Lyong,Young Lee, Ji,Kyoung Kim, Yun,Jin Kim, Young,Bum Hong, Chang,Lee, Sang-Hak,Yoon, Dankyu,Jung Ku, Hy Springer-Verlag 2013 Journal of human genetics Vol.58 No.3
<P>Although over 30 common genetic susceptibility loci have been identified to be independently associated with coronary artery disease (CAD) risk through genome-wide association studies (GWAS), genetic risk variants reported to date explain only a small fraction of heritability. To identify novel susceptibility variants for CAD and confirm those previously identified in European population, GWAS and a replication study were performed in the Koreans and Japanese. In the discovery stage, we genotyped 2123 cases and 3591 controls with 521 786 SNPs using the Affymetrix SNP Array 6.0 chips in Korean. In the replication, direct genotyping was performed using 3052 cases and 4976 controls from the KItaNagoya Genome study of Japan with 14 selected SNPs. To maximize the coverage of the genome, imputation was performed based on 1000 Genome JPT+CHB and 5.1 million SNPs were retained. CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans. From GWAS and a replication, SNP rs3782889 showed a strong association (combined P=3.95 10(-14)), although the association of SNP rs3782889 doesn't remain statistically significant after adjusting for SNP rs11066015 (proxy SNP with BRAP (r(2)=1)). But new possible CAD-associated variant was observed for rs9508025 (FLT1), even though its statistical significance did marginally reach at the genome-wide a significance level (combined P=6.07 10(-7)). This study shows that three CAD susceptibility loci, which were previously identified in European can be directly replicated in Koreans and also provides additional evidences implicating suggestive loci as risk variants for CAD in East Asian.</P>
Lee, Chang-Soo,Lee, Ji-Hye,Kang, Kyoung-Ku,Song, Hwan-Moon,Kim, In-Ho,Rhee, Hyun-Ku,Kim, Byung-Gee Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.2
In this study, mesoporous silicate was applied as a matrix for the analysis of various molecules from small molecules to medium sized peptides in laser desorption/ionization mass spectrometry. In contrast with conventional matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), the proposed approach, desorption/ionization on mesoporous silicate mass spectrometry (DIOM-MS), significantly reduces the problem of matrix interference in low mass region and can be applied to the analysis of versatile chemicals including amino acids, synthetic drugs, peptides and others. In addition, distinctive advantage of DIOM-MS showed higher salt tolerance and could be applied to identify the proteins from the analysis of tryptically digested peptides. DIOM-MS has several availabilities such as easy sample preparation, rapid analysis of small molecules without noise, peptide analysis without organic matrix, high salt tolerance, versatile coupling with other separation techniques, and high throughput manner.
Lee, Byungjin,Jeong, Heon-Ho,Kang, Kyoung-Ku,Lee, Chang-Soo,Lee, Sang-Ho Elsevier 2019 Chemical engineering science Vol.202 No.-
<P><B>Abstract</B></P> <P>Microfluidic chemotaxis analysis requires stable and reproducible formation of chemical gradient with low batch-to-batch variation. Dimensional uniformity of a junction channel plays a key role in diffusion-based gradient generation. Conventional methods for the analysis of bacterial chemotaxis are limited in stability and reproducibility of the chemical gradient. Here, we report a microfabrication method employing plasma enhanced chemical vapor deposition for silicon oxide deposition and consecutive reactive ion etching processes to reduce the experimental errors of chemotaxis analysis occurring from dimensional inaccuracy of the junction channel. This approach produces precise dimensional junction channels with below 1% variation. Thus, we confirm the reproducibility of chemotaxis analysis and obtain the chemotaxis index of <I>Pseudomonas aeruginosa</I> PAO1 with bacterial chemoeffectors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Precise fabrication of microchannel with low dimensional errors (C.V. = 0.42%). </LI> <LI> Spatiotemporally reliable formation of a diffusion-based chemical gradient. </LI> <LI> Improved reproducibility of chemotaxis assay by reliable chemical gradient. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Bone Mineral Density in Prediabetic Men
Lee, Ju Hee,Lee, Yun Hyeong,Jung, Kyoung Hye,Kim, Min Kyeong,Jang, Hye Won,Kim, Tae Kyun,Kim, Hyun Jin,Jo, Young Suk,Shong, Minho,Lee, Tae Yong,Ku, Bon Jeong Korean Diabetes Association 2010 Korean diabetes journal Vol.34 No.5
<P><B>Background</B></P><P>There are many studies regarding the effects of insulin on bone metabolism and changes in bone mineral density (BMD) in the setting of diabetes. The effect of prediabetes on BMD is not known.</P><P><B>Methods</B></P><P>A total of 802 men participated in the Korea Rural Genomic Cohort Study (in Geumsan County). According to the results of an oral glucose tolerance test, subjects were classified into normal, prediabetic, and diabetic categories. One hundred twenty-four subjects diagnosed with type 2 diabetes were excluded, leaving 678 subjects for the study inclusion. BMD was estimated with a quantitative ultrasonometer.</P><P><B>Results</B></P><P>The average BMD T scores of normal and prediabetic subjects were -1.34 ± 1.42 and -1.33 ± 1.30, respectively; there was no significant difference in the BMD T scores between these groups. The BMD T score was inversely associated with age and positively correlated with body weight, body mass index, total cholesterol, low density lipoprotein cholesterol, and HbA1c. On multiple linear regression analysis, low density lipoprotein cholesterol was the only statistically significant variable for prediabetes (β = 0.007, <I>P</I> = 0.005). On the stepwise regression analysis, age (β = -0.026, <I>P</I> < 0.001), the body mass index (β = 0.079, <I>P</I> < 0.001), and low density lipoprotein cholesterol (β = 0.004, <I>P</I> = 0.016) were significant variables for prediabetes.</P><P><B>Conclusions</B></P><P>There was no significant difference in the BMD T score between the normal and prediabetic subjects. Further studies are needed regarding the association of fracture risk and changes in BMD with the development of overt diabetes.</P>