만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

Cytochrome B 유전좌를 이용한 종 감별

이숭덕,이윤성,이정빈 대한법의학회 2001 대한법의학회지 Vol.25 No.1

The feasibility of species identification using sequence analysis of the cytochrome B (Cyt B) gene in mitochondrial DNA was investigated DNA was extracted from rune different animals that could be easily met in our surroundings and Cyt B gene was amplified. Direct sequencing results for the amplified PCR products were compared with each other. Human was also included Nucleotide sequence of the Cyt B gene for earth animals was also compared with the previously known ones registered in nucleotide databases, Genebank. The inter-species sequence variation was high as the percent similarity of each sequences ranged 64.6-83.5%. Compared to this the percent similarity of sequences obtained here were high when compared to the sequences of the same species registered in the database showing relatively low intra-species variation. This data shows that the nucleotide sequences of Cyt B gene in t certain biological materials can be identified at species level. The applicability of this method to the forensic field is also demonstrated by performing a casework, determination of the origin for the placentae which were commercial available as "invogorant". Points about the use of Cyt B gene in forensic field was also reviewed.

다량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별 : 삼풍백화점 사건에 대하여

이숭덕,신창호,김기범,최영태,이윤성,이정빈 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

서울지역 의과대학에서의 법의부검 : 서울의대에서 과거 5년동안 실시한 부검 경험 보고

이숭덕,이정빈,이윤성 대한법의학회 2000 대한법의학회지 Vol.24 No.1

This is the statistical analysis about the medicolegal autopsy cases performed by the Department of Forensic Medicine, Seoul National University Medical College during the last 5 years. 1.The total number of cases was 330, among which male took 256(77.5%) cases, female 74(22.5%) cases. The natural death took 134(40.6%) cases, unnatural death 177(53.6%) cases. For remaining 19(5.8%) cases the cause of death was known, although thorough analyses including microscopic examination, toxicology study were done. The thirties were most as 25.4% of the total cases and the forties followed the second. 2.The number of autopsy showed severe variation annually or monthly in a year. 3.Among unnatural death, death by violent injury took 87(49.2%) cases, asphyxia 48(27.1%) cases, intoxication 17(9.6%) cases and death by thermal injuries or electric injuries 25(14.1%) cases. 4.Among natural death the abnormality in cardiovascular system were the most as 73(54.5%) cases, gastrointestinal system 38(28.4%) cases and central nervous system 12(8.9%) cases. 5.There were some differences between these and the data from other institute in the ratio of male to female, ratio of natural death to unnatural death and the ratio of specific cause of death among natural and unnatural death. 6.During this work, there were some difficulties in the aspect the irregularity of the work, in requesting toxicology and in the expense needed for the process. Considering the educational aspect for the students and the residents in pathology, performing medicolegal autopsy in medical college should be encouraged. The small number of autopsy and the closeness of the scene made the scene investigation possible in several cases, which is the ideal form that we must consider when we set up our system for the postmortem investigation.

초음속 배기노즐의 공력음향과 유동특성

이동훈,임정빈 서울産業大學校 2000 논문집 Vol.51 No.2

This paper describes the experimental results for the flow characteristics and the aeroacoustics of a perforated tube attached at the exit plane of a circular convergent nozzle. The experimental results for the near and far field sound, the visualization of jet structures and the static pressure distributions in the jet passing through a perforated tube are presented and discussed in comparison with those for a simple tube. The perforated tube has a good performance to suppress the shock-associated noise as well as the turbulent mixing noise. This noise suppression is due to the modification and the elimination of shock waves in a jet plume that depend upon the porosity of a perforated tube. The pressure relief caused by the high-speed jets through holes on the tube results in the transformation of normal shock waves into weak shock waves like Mach wave.

심폐소생술에 의한 손상

이정빈 大韓法醫學會 1997 대한법의학회지 Vol.21 No.2

Cardiopulmonary resuscitation (CPR) is a routine procedure to survive the patient when abrupt cardiac failure develops. External cardiac compression with respiratory care is usually done, which produce much artifacts such as sternal or rib fracture, cardiac injuries, pulmonary injuries, fat embolism, liver injuries and so no. These lesions often resemble especially blunt force injury, and must be differentiated from the antemortem injury. Basic points about the CPR and some characteristics of the injuries by the CPR are described. And thorough history taking for the situation during the CPR is emphasized.

Amelogenin 유전좌를 이용한 성별검색의 유용성에 관한 연구

이숭덕,이정빈,이윤성 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

The aim of this study was to validate the sex typing based on amplification of X-Y homologous Amelogenin locus in Korean including mutation rate in this locus. It was found that there was no case with reported mutation that may hinder the exact sex typing among 240 Koreans, and the sex typing was successful even with subnanogram quantities of male and female DNA. There was no difference in the sensitivity of reaction among male and female. Differential amplification between X and Y amelogenin bands in some samples was noted, and dilution study revealed that this phenomenon was more frequent when the quantity of sample was low, usually less than 10 ng. That phenomenon was variable between amplification reactions, and was also dependent on different Taq enzyme used for the amplification. When there was differential amplification, the intensity ratio (Y band/X band) ranged about 0.68-0.87.

한국어판 정신증상평가척도의 신뢰도와 타당도

정순민,김미경,이정빈,최진환,정봉주,변원탄 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Objectives : Psychotic Symptom Rating Scale (PSYRATS) is an assessment tool to measure the seventy of different dimen-sions of auditory hallucinations and delusions. The reliability and validity of the Korean version of PSYRATS (K-PSYRATS)were examined in Korean patients with major psychosis. Methods : The inter-rater reliability of the K-PSYRATS was determined from the videotaped interviews of the five Schizoph-renic patients. To measure validity and internal consistency reliability, the 109 patients with auditory hallucinations or delusions were assessed using the K-PSYRATS, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression-Se-verity (CGI-S) scale. Results : K-PSYRATS was found to have excellent inter-rater reliability (intra-class correlation coefficient of auditory haliu-cination=0.81, P<.001, intm-class correlation coefficient ofde1usion=0.97, P<.001) and internal consistency reliability (Cron-bach's a of auditory hallucination =0.77, Cronbach's α of delusion =0.76). Significant correlation was found between K-PSY-RATS and positive syndrome subscale of PANSS and CGI. Conclusion : K-PSYRATS is a useful assessment instrument for psychotic symptoms in Korea.

대량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별

이숭덕,김기범,이윤성,최영태,신창호,이정빈 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

The mitochondrial DNA(mtDNA) is a small extranuclear DNA molecule that has been sequenced in man. the mtDNA has distinct characteristics over nuclear DNA. First, the evolutionary rate of nucleotide substitution appears to be larger compared with the nuclear DNA. Second, mtDNA is maternally inherited, so the determination of the various haplotype is unequivocal and no recombination has to be involved. Third, there is a 1.1 kb long control region, which shows severe polymorphism. These characteristics have been applied for several evolutionary study. Furthermore, they exist in cytoplasm with numerous copy number and their size, 16,569 bp is small relative to nuclear DNA, so they are more resistant to degradation or can be types in samples with only cytoplasm such as hair shaft without hair root. These presented the possibility of mtDNA as a tool in individual identification, especially when the nuclear DNA be unavailable. Actually, polymorphism in control region has been applied to individual identification for the skeletal remain found in Vietnam war. So we decided to apply the polymorphism of mtDNA in control region for the individual identification in case of mass disaster-"Downfall of Sampoong Department". Human remains from total 27 different individuals and 178 control persons were submitted for the individual identification. As the mtDNA comparison could be done through maternal lineage, 12 individual from 9 families from the control group were ruled out, because these families were consisted of father or were seeking for their father. Sequencing for the mtDNA control region was done using ABI automatic sequencer and DyeDeoxy Terminator Cycle Sequencing Kit. For convenience, sequencing reaction was done for two separate control region, region I from 16016-16401 in Anderson sequence, and regionⅡ from 048-388. First, sequences in regionⅡ of all samples and control persons were compared, and 20 samples were ruled out with no identical sequences in control group. Remaining 7 samples showed identical sequences with some of the control persons in three groups, and these identical pairs underwent mtDNA region I study. After region I study all samples except two dropped out in blood relationship. For the confirmation, STR and VNTR study such as MCT118, apoB, YNZ22, vWF, MBP, D21S11, TC-11 were done for remaining the two samples. The result denied the blood relationship between these two samples and any of the control group.