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조병무,유익수,이동주 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-
The free-formed surface machining using a ball end mill is important and the geometric accuracy of a 3D workpiece is effected by the cutting characteristics. Machining error is defined by the normal distance between designed surface and actual tool path with tool deflection. This is inevitably caused by the tool deflection, tool wear, thermal effect and machine tool errors and so forth. The results will be useful as a guidance for cutting condition to improve the geometrical accuracy of free-formed surface in ball end milling.
조병무,유익수,이성휘,이동주 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-
In manufacturing process, the. free-formed surface machining using a ball end mill of CNC machining center is important and the geometric accuracy of a 3D workpiece is effected by the cutting characteristics. Machining error is defined the normal distance between designed surface and actual tool path with tool deflection. This is inevitably caused by the tool deflection, tool wear, thermal effect and machine tool errors and so forth. In this study, the geometric accuracies such as roundness in semi-cylinder, free-formed profile and surface roughness were measured using a Coordinate Measurement Machine(CMM) and a contact type surface roughness measuring device. The results will be useful as a guidance for cutting condition to improve the geometrical accuracy of free-formed surface in ball end milling.
( Ju Yup Lee ),( Sung Kook Kim ),( Kwang Bum Cho ),( Kyung Sik Park ),( Joong Goo Kwon ),( Jin Tae Jung ),( Eun Young Kim ),( Byung Ik Jang ),( Si Hyung Lee ),( Daegu-gyeongbuk Gastrointestinal Study 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.2
Background/Aims We aim to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rates according to the Los Angeles classification for esomeprazole alone, and esomeprazole plus mosapride. Methods A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at weeks 4 and 8. The primary endpoint was the endoscopic healing rate of ERD after 8 weeks of treatment. Results Endoscopic healing rates according to the Los Angeles classification was 32 (66.7%) in the E+M group and 26 (60.5%) in the E only group, but there was no statistically significant difference between the groups. Only at 4 weeks, the total GERD symptom score changes relative to the baseline significantly improved in the E+M group than that of the E only group (-13.4 ± 14.7 vs -8.0 ± 12.3, P = 0.041), and upper abdominal pain and belching score changes showed significantly improved in the E+M group than that of the E only group (P = 0.018 and P = 0.013, respectively). Conclusions The combination of a proton pump inhibitor with mosapride shows a tendency for upper abdominal pain, belching, and total GERD symptoms scores to improve more rapidly. This suggests that combination therapy with esomeprazole and mosapride will be useful for rapid improvement of specific GERD symptoms, such as upper abdominal pain and belching in ERD patients. (J Neurogastroenterol Motil 2017;23:218-228)
Lee, Hyun Ju,Hong, Cheol Yi,Kim, Mi-Hyun,Lee, Youn-Kyung,Nguyen-Pham, Thanh-Nhan,Park, Byoung Chul,Yang, Deok-Hwan,Chung, Ik-Joo,Kim, Hyeoung-Joon,Lee, Je-Jung Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.1
Anterior gradient-2 (AGR2) promotes tumor growth, cell migration, and cellular transformation, and is one of the specific mRNA markers for circulating tumor cells in patients with gastrointestinal cancer. We investigated the feasibility of AGR2 as a potent antigen for tumor immunotherapy against colorectal cancer (CRC) cells using dendritic cells (DCs) transduced with a recombinant adenovirus harboring the AGR2 gene (AdAGR2). DCs transduced with a recombinant adenovirus encoding the AGR2 gene (AdAGR2/DCs) were characterized. These genetically-modified DCs expressed AGR2 mRNA as well as AGR2 protein at a multiplicity of infection of 1,000 without any significant alterations in DC viability and cytokine secretion (IL-10 and IL-12p70) compared with unmodified DCs as a control. In addition, AdAGR2 transduction did not impair DC maturation, but enhanced expression of HLA-DR, CD80, and CD86. AdAGR2/DCs augmented the number of IFN-${\gamma}$-secreting T-cells and elicited potent AGR2-specific cytotoxic T lymphocytes capable of lysing AGR2-expressing CRC cell lines. These results suggest that AGR2 act as a potentially important antigen for immunotherapy against CRC in clinical applications.
Lee, Keunsoo,Shin, Jin-Wook,Park, Jun-Hwan,Lee, Jonghee,Joo, Chul Woong,Lee, Jeong-Ik,Cho, Doo-Hee,Lim, Jong Tae,Oh, Min-Cheol,Ju, Byeong-Kwon,Moon, Jaehyun American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.27
<P>We propose and fabricate a random light scattering layer for light extraction in organic light-emitting diodes (OLEDs) with silver nanodots, which were obtained by melting silver nanowires. The OLED with the light scattering layer as an internal light extraction structure was enhanced by 49.1% for the integrated external quantum efficiency (EQE). When a wrinkle structure is simultaneously used for an external light extraction structure, the total enhancement of the integrated EQE was 65.3%. The EQE is maximized to 65.3% at a current level of 2.0 mA/cm(2). By applying an internal light scattering layer and wrinkle structure to an OLED, the variance in the emission spectra was negligible over a broad viewing angle. Power mode analyses with finite difference time domain (FDTD) simulations revealed that the use of a scattering layer effectively reduced the waveguiding mode while introducing non-negligible absorption. Our method offers an effective yet simple approach to achieve both efficiency enhancement and spectral stability for a wide range of OLED applications.</P>
A survey of the use of veterinary anesthetics in Korea
Lee, Jae-Won,Lee, Jeong Ik,Cho, Yoon Ju,Lee, Young-Ah,Kim, Jong-In,Hwang, Bo Ram,Kim, Hyung Joon,Jhun, Hyunjhung,Han, Jin Soo The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.2
This study was conducted to investigate actual conditions associated with veterinary anesthetic drug use in Korea, and to obtain responses from Korean veterinarians and researchers pertaining to the use of anesthetic drugs. To accomplish this, a nationwide survey was issued to veterinarians working at animal hospitals and to researchers in the Korean Association for Laboratory Animal Science (KALAS). A self-administered questionnaire-based survey was then conducted in which respondents were asked questions about actual conditions associated with the use of animal anesthetic drugs. The survey revealed that the distribution and management of animal medicines in Korea was quite vulnerable to misuse or abuse due to a variety of factors. Therefore, a relevant regulatory system should be strictly enforced to protect vulnerable individuals from abuse or misuse.
Lee, Seung-Hun,Kim, Ha-Young,Lee, Haeseung,Kim, Jong Wan,Lee, Yu-Ran,Chae, Myeong Ju,Oh, Sang-Ik,Kim, Jong Ho,Rhee, Man Hee,Kwon, Oh-Deog,Goo, Youn-Kyoung,Kim, Tae-Hwan,Geraldino, Paul John L,Kwak, Do BMJ Group Group Ltd 2018 The Veterinary record Vol.183 No.16
<P>This study evaluated the prevalence of <I>Eimeria</I> species, particularly <I>E bovis</I>, <I>E zuernii</I> and <I>E auburnensis</I> that are pathogenic to cattle, in faecal samples collected from cattle with diarrhoea reared in the Republic of Korea by using microscopy and PCR. In addition, the prevalence of <I>Eimeria</I> species was analysed according to age, type of cattle, region, season and nature of diarrhoea. Overall, <I>Eimeria</I> species were identified in 279 of the 1261 (22.1 per cent) faecal samples through microscopy, and statistical analysis revealed a lower prevalence in calves aged than three weeks or less and higher prevalence in cattle with haemorrhagic diarrhoea. Of the 279 microscopy-positive samples, <I>E bovis</I>, <I>E zuernii</I> and <I>E auburnensis</I> were identified in 100 (7.9 per cent), 83 (6.6 per cent) and 27 (2.1 per cent) faecal samples, respectively, by using PCR. To the authors' knowledge, this study is the first to apply PCR for epizootiology of bovine coccidiosis.</P>
Alto ShooterTM 로 조절된 말기 신부전증 환자에서의 다발성 표재성 위전정부 출혈
이상인,이준희,박효진,강진경,한기준,박인서,이세준,정준표,문병수,이관식,송기섭,손주익 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6
Diffuse or multifocal superficial gastrointestinal bleeding can be treated by endoscopic laser, argon plasma coagulation, heater probe, or electrocoagulation. However, these methods need relatively expensive equipments and clinical experience. Recently, Alto Shooter (Kaigen Co, Ltd, Osaka, Japan) which can spray 100% sodium alginate was developed to control gastrointestinal bleeding as a topical therapy. We herein present a 47-year-old man with end stage renal disease in whom multiple superficial gastric antral bleeding was successfully managed by the use of Alto Shooter. This method is easy and relatively cheap to use and seems to control superficial bleeding effectively from vascular lesions or after endoscopic biopsy.
만성골수성백혈병에서의 동종골수이식 : 국내 경험의 후향적 분석 Retrospective Analysis of Korean Experience
이규형,이제환,이정신,김상희,김우건,김춘추,이종욱,김병국,박선양,이홍기,윤성수,김효철,남동기,한지숙,민유홍,현명수,황태주,정익주,박영석,이정애 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2
연구방법: 국내에서 시행된 만성골수백혈병의 치료를 위한 가족간 동종골수이식의 임상적 특징을 후향적으로 분석하였다. 9개의 병원에서 1986년 9월부터 1997년 6월까지 시행한 137예의 가족간 동종골수이식을 보고하였다. 결과: 전체 환자 중 62%인 85예가 남자였고 연령은 15세에서 50세까지 분포하였다(중앙치 30세). 95예(71%)의 환자는 이식 당시 만성골수성백혈병 만성기의 상태였고 38예(28%)는 가속기 또는 모세포성발증기의 상태였다. 70예(51%)의 환자는 이식전처치로 busulfan+cyclophosphamide (BuCy) 치료를 받았고 42예(31%)의 환자는 cyclophosphamide+전신방사선 조사(Cy-TBI)를 받았다. 환자에게 이식된 단핵구의 수는 0.06-9.5×10^(8)/kg(중앙치 1.2×10^*/kg)였다. 1 예를 제외한 모든 환자에서 이식 후 8-100일(중앙치 17일)에 중성구 500/㎕ 이상의 착상이 관찰되었다. 급성 및 만성이식편대숙주질환은 각각 46%와 43%의 환자에서 관찰되었다. 중앙추적기간 20개월(범위 3-135개월) 경과 후 137예의 환자 중 52예의 환자가 사망하였다. 사망 원인은 감염(27%), 백혈병의 지속 또는 재발(23%), 이식편대숙주질환(21%), 치료독성(15%), 그리고 이식편거부(8%) 등이었다. 환자들의 event-free survival에 영향을 주는 인자로는 이식전 병의 상태(p<0.001)와 환자의 혈청 HBsAg 양성여부(p=0.012)가 중요하였다. Overall survival에 영향을 주는 인자도 이식전 병의 상태와 환자 혈청 HBsAg 양성여부로 나타났다. 결론: 본 연구에서 국내 만성골수성백혈병에 대한 동종골수이식술은 그 시행 예가 급격히 증가하고 있음을 보여주었다. 환자들의 임상 특성과 생존 성적은 외국의 성적과 유사하였다. B형 간염 감염환자의 경우 예후가 유의하게 불량하였고, 이는 추후의 임상연구에서 확인이 필요한 소견으로 사료된다. Background and Methods: Clinical features of allogeneic bone marrow transplantation (BMT) performed for patients with chronic myelocytic leukemia (CML) in Korea were analyzed retrospectively. Nine hospitals reported a total of 137 cases of allogeneic BMT performed between September, 1986 and June, 1997. Results: There were 85 male (62%) and 52 female patients with median age of 30 years (range 15-50). Ninety five patients (71%) were in chronic phase and 38 patients (28 %) were in accelerated/blastic phase of the disease. Seventy patients (51%) received busulfan-cyclophosphamide (BuCy) regimen for preparation and 42 patients (31%) received cyclophosphamide-total body irradiation (Cy-TBI) regimen. The median mononuclear cell dose given to patients was 1.2×10^(8)/kg (range, 0.06-9.5×10^(8)/kg). All but one patient achieved absolute neutrophil count of 500/μl after median 17 days after BMT (range, 8-100 days). Acute and chronic graft-versus-host disease (GVHD) were reported in 61/133 (46%) and in 57/134 (43%) patients, respectively. The median follow-up time of survivors was 20 months (range, 3-135 months). There were 52 deaths (38%). The causes of death were infection (14 patients, 27%), recurrent/persistent disease (12 patients, 23%), GVHD (11 patients, 21%), regimen related toxicity (8 patients, 15%), graft rejection/failure (4 patients, 8%), and unknown (3 patients, 6%). The factors influencing event free survival of the patients were disease status before BMT (p<0.001, by log-rank test) and serum hepatitis B surface antigen status (p=0.012). Longer duration of disease before BMT showed poorer outcome but the difference did not reach statistical significance. The factors affecting overall survival of the patients were disease status before BMT (p=0.009) and hepatitis B surface antigen status (p=0.036). The donor hepatitis B antigen status did not influence event free survival or overall survival of the patients. Conclusion: Clinical features and survival patterns of patients with CML treated with allogeneic BMT in Korea were similar to historical data from other countries. Further data analyses are warranted for the role of hepatitis B virus infection influencing the outcome of allogeneic BMT for CML.
Dihydrobenzofuran Norlignans from the Leaves of Cedrela sinensis A. Juss
Lee, Ik-Soo,Kim, Hong-Jin,Youn, Ui-Jung,Chen, Quan-Cheng,Kim, Jin-Pyo,Ha, Do Thi,Ngoc, Tran Minh,Min, Byung-Sun,Lee, Sang-Myung,Jung, Hyun-Ju,Na, Min-Kyun,Bae, Ki-Hwan WILEY-VCH Verlag 2010 Helvetica chimica acta Vol.93 No.2
<P>Two new norlignans, cedralins A (1) and B (2), were isolated from the leaves of Cedrela sinensis. Their structures were established by extensive spectroscopic studies and chemical evidence. The absolute configurations of these compounds were determined by comparing their CD spectra with those of known compounds. In addition, their in vitro cytotoxic activity against two human-cancer cell lines was evaluated.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/0018019X-2010-93-2-HLCA200900180-content.gif' alt='wiley_img/0018019X-2010-93-2-HLCA200900180-content'> </P>