16세기 조선 사상계의 동향과 노수신(盧守愼)

이동환 ( Lee Dong Hwan ) 한국사상사학회 2015 韓國思想史學 Vol.0 No.51

17세기 주자학 교조주의의 억압체제가 16세기 조광조의 도학 근본주의, 이황의 주자학 절대주의의 추동으로 사상의 일원화, 단일화가 진행된 결과라는 가설을 가지고, 이러한 대국(大局)의 전개에 사상의 일정한다원성을 추구하여 특히 이황에 저항한 노수신의 사상사적인 위상을 드러내고자 하였다. 조광조의 소격서 혁파는 이단사상에 대한 숙정(肅正)을 실질적으로 한 것이지만, 그래도 그는 정주학(程朱學)을 중심으로 그 외곽의 기학(氣學), 상산학을 도학으로 포괄하여 그 범위 안에서는 사상적 자유 재량(裁量)이 가능했다. 그러나 이황의 주자학 절대주의에 이르면 주자 이외의 여타 사상에 대한 통제는 한층 가열(苛烈)하였다. 그는 위정척사적인 위도의식(衛道意識)으로 주자학 이외에는 모두 좌도(左道) 이단시하여 노장은 말할 것도 없고, 조광조 시대에 허용되었던 기학상산학, 그리고 새로이 전파되는 나정암(羅整庵) 왕양명 등의 학설을 전방위적으로 비판 통제하였다. 이것은 주자학을 위시한 도학 일반에 대한 그 누구도 추종을 불허하는 역량과, ‘위도’라는, 유교국가에서 누구도 거역하지 못할 명분을 떠매고 있었기에 가능하였다. 사대부 사회는 그의 이러한 도학에 대한 역량과 위도의 명분 앞에 거개가 순복(順服)하였다. 그런데 노수신은 이황의 권위에 저항해 사상의 일정한 다원화를 추구하였다. 그는 정주학(程朱學)을 거점으로 상산학, 나정암의 학설, 그리고 양명학을 수용하여 이황의 집요한 비판 통제에도 굽히지 않았다. 결과적으로 그는 이황의 다음으로 우리나라의 도통을 계승할 기대마저 거부한셈이 되었다. 그는 정주학에서 출발해, 한 때 그 스스로 비판한 상산학을 겸수(兼修)하다가 을사사화로 조정에서 쫓겨나자 그 충격으로 그 동안 독실히 믿었던 주자의 격물궁리의 도문학을 부정하고 상산의 존덕성으로 기울어졌으나 특히 정주계열의 경(敬) 수련에는 독실하였다. 이를 바탕으로 귀양지에서 .숙흥야매잠해.를 찬술하여 이황 김인후와 토론을 벌리기도 하여 호평을 받았다. 그러나 뒤이어 인심도심변 을 지어 주자의설에 반하자 사방에서 공격이 들어왔다. 특히 이황은 15 6년간에 걸쳐비판의 자세를 거두지 않았다. 확실하지는 않으나 그는 양명학도 30대전후에 접한 듯, 노년으로 올수록 더욱 기울어져 마침내 확신에 차기에 이르렀다. 노수신의 이러한 다양성, 비록 도학 성리학에 한정되기는 했지만 이러한 사상적 다양성의 추구는 그 시대 여건으로는 일종의 사상적자유주의자라고 할 수 있다. 그리고 이황의 주자학 절대주주의 추동에 대한 하나의 안티테제로서의 의의를 부여할 수 있다. This paper is to examine the place of Noh Susin in the history of thought who pursued ideological diversity and opposed to a prominent Neo-Confucianism scholar Lee Hwang. In this dicourse I premised that the repressive authoritarian regime of Neo-Confucianism in the 17^th century was the result of the unification of thought driven by Confucian fundamentalism introduced by Jo Gwangjo in the 16^th century and absolutism of the study of Zhu Xi proclaimed by Lee Hwang. Jo Gwangjo, though he rejected heresy rigorously, regarded the study of Qi and the study of Lu Jiuyuan as a part of Neo-Confucianism. It was rigorous Confucianism of Lee Hwang in the 16^th century by which censorship over ideas except Confucianism was strengthened. He treated every idea except the study of Zhu Xi as heresy and criticized them severely including the study of Qi and the study of Lu Jiuyuan that had been allowed in former period, and the theory of Luo Qinshun and Wang Yangming as well that introduced newly from Ming dynasty. It was possible as he had great capabilities as a Confucianism scholar and at the same time he was responsible for what is called defending Tao, the first principle of Confucianism nation. Almost all of gentry society obeyed his academic capability and his moral justification. However, Noh Susin opposed to the authority of Lee Hwang and pursued ideological diversity. Based on the study Zhengzhu, he accepted the theory of Lu Jiuyuan, Luo Qinshun and Wang Yangming to stuck firmly to his contention despite of Lee Hwang’s criticism. As a result he was contrary to Lee’s expectation of succeeding the orthodox line of transmission of the Way, so-called Tao-tung, after him. He started his learning from the study of Zhengzhu and expended it to the study of Lu Jiuyuan. But as he was expelled from the Court after Eulsa Sahwa, the 1545 literati purge, he denied the theory of ‘maintaining constant inquiry and study’ emphasized by Zhu Xi and inclined toward the theory of ‘honoring virtuous nature’ emphasized by Lu Jiuyuan. Expecially he devoted himself to training ‘attentiveness’, a translation of the Chinese word ching emphasized by the school of Zhengzhu. Based on this view, he compiled Sukheung yamaejamhae(the Annotation to Admonition on Rising Early and Retiring Late) with which he had a discussion with Lee Hwang and Kim Inhu. But it was after his writing of Arguments against the ‘human mind’ and the ‘Tao mind’ that he was criticized severly by other scholars. Among them Lee Hwang didn’t cease to criticize him for over fifteen years. It seems that Noh first encountered the study of Yangming in his early thirties and at last convinced of it in his old age. He should be called a ideological liberalist in respect that he pursued ideological diversity though it was restricted to Neo-Confucianism. We can say that his ideological endeavor has great historical significance as the antithesis of the absolute Neo-Confucianism of Lee Hwang.

Ti-6Al-4V 합금의 동적변형특성과 탄도충격성능 : 1. 초고속 폭발충격 특성 1. Ultra-high-speed Exploding Properties

이유환,이동근,이성학,이종수,최준홍,허선무 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

The effects of microstructural morphology on ultra-high-speed exploding properties of Ti-6Al-4V alloy were investigated in this study. Exploding bridge wire (EBW) test was conducted on equiaxed and bimodal microstructures, which were processed by different heat treatments. From the test, moving velocity of free surface vs time profiles were obtained to measure strength at Hugoniot elastic limit (HEL) and spall strength and to subsequently predict ballistic mass efficiency. The EBW results indicated that impact resistance of the bimodal microstructure was better than that of the equiaxed microstructure when the measured strength at HEL and spall strength were considered. It was also learned from the observation of fractured EBW specimens that fracture occurred by the initiation and propagation of long cracks in the equiaxed microstructure, whereas a number of microcracks were formed and connected each other in a zig-zag pattern to reduce the driving force for crack propagation in the bimodal microstructure. Since the EBW test helped experimentally estimate ultra-high-speed deformation and fracture behavior, it could be effectively used for the prediction of ballistic impact performance.

가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Ti-6Al-4V 합금의 동적변형특성과 탄도충격성능 : 2. 동적비틀림 특성과 탄도충격성능 2. Dynamic Torsional Properties and Ballistic Performance

이동근,이유환,이성학,이종수,이충열,허선무 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

The effects of microstructural morphology on dynamic deformation and fracture behavior and ballistic performance of a Ti-6Al-4V alloy were investigated in this study. Ballistic impact tests were conducted on equiaxed and bimodal microstructures, which were processed by different heat treatments, and then the test data were analyzed in relation to microstructures, tensile properties, and dynamic torsional test data. In the impacted region of the equiaxed microstructure, a number of adiabatic shear bands and cracks were observed to be formed along plastic flow lines, and delamination occurred because of cracking along the plastic flow lines or shear bands. In the case of the bimodal microstructure, shear bands were found in limited area near the impacted region without occurring delamination, and their number was fewer than that of the equiaxed microstructure. Thus, ballistic performance of the bimodal microstructure was better than that of the equiaxed microstructure. The ballistic performance of the two microstructures was also discussed by comparing the possibility of adiabatic shear band formation obtained from dynamic torsional test data.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

이중조직을 가지는 Ti-6Al-4V 합금의 동적 변형특성에 미치는 템퍼드 마르텐사이트 분율의 영향

이동근,이유환,이종수,이성학 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.6

The effects of volume fraction of tempered martensite on quasi-static tensile and dynamic deformation properties of Ti-6Al-4V alloy with bimodal microstructure were investigated in this study. Five microstructures with various tempered martensite volume fractions were obtained by varying heat-treatment temperatures and times. Dynamic torsional tests were conducted on them by using a torsional Kolsky bar. The test data were analyzed in relation to microstructures, tensile properties, and adiabatic shear band formation. Under a dynamic loading condition, maximum shear stress increased with increasing tempered martensite volume fraction, whereas fracture shear strain decreased. Observation of the deformed area beneath the fracture surface after the dynamic torsional test indicated that a number of voids initiated mainly at a/martensite interfaces, and that the number of voids increased with increasing martensite volume fraction. Adiabatic shear bands of 6-10 lam in width were formed in the specimens having lower martensite volume fractions, while they were not formed in those having higher martensite volume fractions. The possibility of the adiabatic shear band formation was explained by concepts of absorbed deformation energy and void initiation. (Received April 7, 2004)

소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구

김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.

유기용제 폭로가 여성 근로자들의 월경에 미치는 영향

김대환,이채관,김휘동,강동묵,문덕환,김정호,손병철,이창희,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

유기용제는 산업장에서 널리 사용되고 있다. 특히 여성근로자들의 폭로기회가 증가하고 있으며 이로 인한 자연유산, 수태능력 감소, 월경이상 등이 보고되고 있다. 따라서 유기용제 폭로가 여성근로자들의 월경에 미치는 영향을 보기 위해 설문조사와 월경주기별 여성생식 호르몬(progesterone, estrogen) 분석을 하였다. 그 결과 폭로군에서 progeterone의 억제효과가 유기용제에 폭로되는 여성근로자들의 다양한 월경이상을 초래할 가능성이 있는 것으로 생각된다. ■ Objectives This study was conducted to evaluate the effects of menstrual function in female workers exposed to organic solvents. ■ Methods Rates of menstrual disorders were studied in 87 female workers with exposure to organic solvents(Cn/Hn-value 0.713) in a factory manufacturing shoes and compared with 83 general female workers who had no exposure to organic solvents, Detailed menstrual and reproductive histories were obtained by personal interview using structured questionnaire, and plasma concentrations of progesterone and estrogen were assayed by radioimmunoassay(RIA). ■ Results The rates for menstrual irregularity, menstrual duration, blood clot in menstrual flow and dysmenorrhea were not significantly different in both groups. Number of using menstrual pad was significantly higher and the plasma level of progesterone during 6-11th day of menstrual cycle was significantly lower in the exposed group compared with non-exposed group(P<0.05). ■ Conclusions It seemed to be suppression effect of organic solvents on the reproductive hormones(progesterone and estrogen) in female workers. But there was no evidence that menstrual disorder was likely to result from exposure to organic solvents, because other behavioral, psychological and work related factors may also affect menstrual function.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>