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이원도(Weon-do Lee) 동남어문학회 2004 동남어문논집 Vol.18 No.-
Body in Sang Lee's poetry is an important perceptional object and is a medium of his self-research. And body is a subject mater never treated by his contempories and even by his precursors. Body to him is a physical foundation through which his poetic self accepts external world and makes his surroundings new. We can see his consciousness in which he as a doctor diagnoses himself, looks at another body in the mirror and goes toward compromise and correspondence whitout success. In poetry he ignores grammars intentionally. This means he does not respect literary tradition and history, and he, parodoxically, opens the door to death of a body in an isolated consciousness from reality. Human body is, as Tuan put it, an image of universe and a center of universal frame. Body is a part of concrete universe, a condition to experience external world and an object to the world. In narrator-author's consciousness lineal progression does not exist-his past ends in the past, his present does not proceed to the future and his future means only closure and does not have any continous significance. The death of body denotes total biological close which terminates all human construction. His symmetrical meeting of ordinary-self and idaal-self in the mirror shows his formation of self-socscious world and existential consciousness. This is possible by his body capable of seeing another world rather than by the intellectual construction of his self. In the basis of his poetry, the following images are abundant: adherence to the closed boyhood, isolation of hopeless otherness, ambiguities of eroticism, symbol of physical otherness and self-consciousness within and without the mirror.
Bridgman 방법으로 성장된 Cd0.8Mn0.2Te 의 전기적 특성연구
이정주,황도원,유인근,박영신 慶尙大學校 1991 論文集 Vol.30 No.2
본 실험에서 자체 제작한 전기로를 이용하여 Bridgman-Stockbarger 방법으로 Cd0.8Mn0.2Te를 성장시켜 전기적 특성을 조사하였는데, 주로 Hall effect 측정과 TSC측정으로 비저항, Hall 이동도, Hall계수, carrier 농도, ,trap energy level, 이탈 진동수, 포획 단면적 등을 구하였다.
함암요법으로 골수기능이 억제된 악성종양환자에서 rhG-CSF의 임상적 효과
김원민,서영환,조경상,유병전,김상도,이승일,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2
We have studied the efficacy of rhG-CSF in patients with non-hodgkin's lymphoma, acute leukemia, and small cell lung cancer undergoing anticancer chemotherapy. These patients were below leukocyte count 3,000 cubic millimeter due to myelosuppression induced by the first cycle of intensive chemotherapy. Treatment with rhG-CSF (100㎍ per square meter of body surface area per day in a 30-minute intravenous infusion) was begun two days and for 14 consecutive days after the end of the second cycle of chemotherapy. The results were as follows. 1. The onset of myelosuppression was 6 days after chemotherapy, and the onset of recovery was 16.7 days after chemotherapy, and the duration of granulocytopenia was 10.7 days in patients with malignant tumor during contrast period. 2. The duration of granulocytopenia was shortened 5.2 days in patients administered rhG-CSF than without rhG-CSF, and we observed the shortest duration of granulocytopenia with increasing granulocyte in patients with small cell lung cancer. 3. Observing the differential count of leukocyte checked the highest level of leukocyte in contrast and rhG-CSF period, the persentage of neutrophil was increased in patients with acute leukemia and small cell lung cancer during rhG-CSF period, but not increased in patients with non-hodgkin's lymphoma. 4. rhG-CSF was not influenced on liver faction, renal fuction, uric acid, and glucose metabolism, also had no effect on recovery of platelet. In conclusion, rhG-CSF can be administered to patients with hematologic or nonhematologic malignant tumor that myelosuppression induced by anticancer chemotherapy result in shortening the duration of granulocytopenia and increasing the peripheral neutrophil, therefore full dose chemotherapy can be administered on time, and rhG-CSF may reduce the morbidity and mortality of patients with malignant tumor undergoing chemotherapy.
Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth
( Weon Ju Lee ),( Hyun Bo Sim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Soon Ho Yim ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4
Background: Pattern hair loss is a very common problem. Although effective therapeutics for the treatment of pattern hair loss have been used, novel therapeutic modalities are still required to enhance hair growth. Objective: We investigated the efficacy and safety of a complex (ALAVAX) of 5-aminolevulinic acid (5-ALA) and glycyl-histidyl-lysine (GHK) peptide for the treatment of pattern hair loss. Methods: Forty-five patients with male pattern hair loss were treated with ALAVAX 100 mg/ml (group A), ALAVAX 50 mg/ml (group B) or placebo (group C) once a day for 6 months. Total hair count, hair length, hair thickness, patient’s assessment and adverse events were evaluated at month 1, 3, and 6. Results: An increase in hair count for 6 months was 52.6 (p<0.05) in group A, 71.5 (p<0.05) in group B, and 9.6 in group C. The ratio of changes in hair count between group B (2.38) and group C (1.21) at 6 months showed a statistically significant difference (p<0.05). The proportion above good satisfaction was higher in group A (26.7%) than in the other groups (group B: 14.3%, group C: 7.1%). There was no statistically significant difference in hair length and hair thickness among 3 groups at 6 months. There was no adverse event in 3 groups. Conclusion: Our study showed that a complex of 5-ALA and GHK peptide may be considered as one of the complementary agents for the treatment of male pat-tern hair loss. (Ann Dermatol 28(4) 438∼443, 2016)
( Weon Ju Lee ),( Seong Geun Chi ),( Dong Jae Park ),( Jun Young Kim ),( Ho Youn Kim ),( Seok Jong Lee ),( Do Won Kim ),( Moon Kyu Kim ),( Jung Chul Kim ),( Mi Woo Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.23 No.1
Background: Epidermal growth factor receptor (EGFR) inhibitors are being used to treat malignancies originating from epithelia. Unfortunately, blocking the EGFR pathway leads to various side effects, most frequently acneiform eruptions. Objective: To probe the mechanism underlying this side effect, we investigated the effect of EGFR inhibitors on cultured sebocytes. Methods: To examine the effects of an EGFR inhibitor (cetuximab, Erbitux(R) 10 ng/ml) and the effects of EGFR ligands, such as epidermal growth factor (EGF, 10 ng/ml) and transforming growth factor-α (TGF-α, 5 ng/ml), on the production of inflammatory cytokines in cultured sebocytes, we used reverse transcriptase-polymerase chain reaction, immunocytofluorescence and Western blots. Outcomes included the expression of interleukin (IL)-1, IL-6, tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPAR-γ) and EGFR. Results: There were no significant differences in the expression of IL-1, IL-6, TNF-α, PPAR-γ and EGFR between (a) groups treated with an EGFR inhibitor or an EGFR ligand and (b) the control group, except for a significant increase in the expression of IL-1 in the EGF-treated group. Conclusion: EGFR inhibitors and EGFR ligands do not provoke the expression of inflammatory biomarkers in cultured sebocytes. The role of the sebaceous glands in EGFR inhibitor-induced acneiform eruption should be investigated more thoroughly. (Ann Dermatol 23(1) 12~18, 2011)
( Weon Ju Lee ),( Sang Lim Kim ),( Yoon Seok Choe ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4
Background: Acne is an inflammatory skin disorder caused by inflammatory biomarkers. Magnesium ascorbyl phosphate (MAP) is a stable precursor of vitamin C. It achieves a constant delivery of vitamin C into the skin and has antioxidative effects. Objective: We performed this study to evaluate the effect of MAP on the expression of inflammatory biomarkers in cultured sebocytes. Methods: Reverse transcription- polymerase chain reaction (RT-PCR) and enzyme- linked immunosorbent assay were performed for inflammatory cytokines and matrix metalloproteinases (MMPs) before and after treatment of cultured sebocytes with MAP (10-2 M), lipopolysaccharide (LPS) (5 μg/ml) and a combination of MAP and LPS. RT-PCR and western blotting were also performed for antimicrobial peptides (AMPs) and Toll-like receptor (TLR)-4 before and after treatment of cultured sebocytes with MAP, LPS, and a combination of MAP and LPS. Quantification of lipid peroxidation was also conducted. Results: The increased expression of inflammatory cytokines after treatment of cultured sebocytes with LPS was decreased after treatment with MAP. MMPs, AMPs, and TLR-4 were decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS, and increased after treatment of cultured sebocytes with LPS alone. Lipid peroxidation was significantly decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS. MAP decreased the increased lipid peroxidation after treatment of cultured sebocytes with LPS. Conclusion: MAP may be an effective alternative agent to improve inflammatory reactions in acne. (Ann Dermatol 27(4) 376∼382, 2015)