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Implementation of Cardiovascular Disease (CVD) Level Prediction Processor using Aptamer Biochip
Kyu-Yeul Wang,Sang-Seol Lee,Joo-Kyung Kim,Oh Hyuk Kwon,Ji-Yoon Kim,Byoung-Tak Zhang,Chong Ho Lee,Jeahyun Park,Duck-Jin Chung 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
In the developed country, cardiovascular disease (CVD) has considerably affected in a notice of death. In recent study, 40% of the disease mortality is related with CVD in the case of United States. Because of dangerousness of CVD, there is the growth of need that the method predicts whether some patient has CVD. To meet those need, there are so many efforts include our study. In our study, we propose the efficient diagnosis system to cover public people with cheap medical fee. The processor use aptamer biochip which is manufactured by Geno Prot Inc. to generate test pattern. This aptamer biochip is used for detection of specific protein included in patient’s serum. We can get abbreviated test set by using hypernetwork model. And then the processor generates CVD prediction results with the reduced data and only spends minimal processing time. The proposed CVD processor is verificated through Xilinx FPGA. The results show that the processor is well qualified as CVD diagonosis processor.
Ad Hoc 망에서 경로단절 사전감지를 통한 TCP 성능향상
이병열,임재성,Lee Byoung-Yeul,Lim Jae-Sung 한국통신학회 2004 韓國通信學會論文誌 Vol.29 No.11B
Ad hoc망에서는 이동 호스트들의 움직임으로 인해 경로 단절이 발생한다. 전송 경로의 단절은 목적지까지의 패킷을 전송할 수 없는 상태이므로 패킷의 손실과 지연을 가져온다. 따라서 TCP와 같은 전송 프로토콜은 이를 망의 혼잡으로 간주하여 혼잡 제어 알고리즘을 구동한다. 혼잡 제어 알고리즘은 망의 혼잡을 피하기 위한 수단으로 사용되는데, 경로 단절 시 혼잡 제어 알고리즘이 동작하면 TCP 성능이 떨어진다. 이를 해결하기 위해 본 논문은 TCP-P (TCP Pre-freezing) 기법을 제안한다. TCP-P는 라우팅 프로토콜에서 경로 단절에 대한 정보를 얻지 않고, MAC 계층에서 직접 경로 단절을 감지한다. 그리고 경로 단절 정보를 소스에게 보내어 TCP를 Pre-Freezing 하고 혼잡 제어 알고리즘을 멈추게 한다. 따라서 경로 단절로 인한 패킷 손실을 막고, 경로 재설정 후에도 경로 단절 이전 상태로 전송을 재개할 수 있게 한다. 실험 결과 TCP-P는 ad hoc 망의 경로 단절 환경에서 Proactive하게 반응하며, 패킷 손실 측면에서 다른 TCP 향상 기법들보다 좋은 성능을 보였다. Route failure is mainly caused by mobility of mobile host in ad hoc networks. Route failure, which may lead to sudden packet losses and delays, is losing the route from source to destination. In this situation, TCP assumes that congestion has occurred within the network and also initiates the congestion control procedures. Congestion control algorithm provides the means for the source to deal with lost packets. TCP performance in ad hoc environments will be degraded as TCP source cannot distinguish congestion from route failure. In this paper, we propose TCP-P as pre-detection approach to deal with route failure. TCP-P freezes TCP through pre-detection of route failure. Route failure information of the proposed mechanism is obtained not by routing protocol but by MAC protocol. The intermediated node, obtaining route failure information by its MAC layer, relays the information to TCP source and lets TCP source stop the congestion control algorithm. Results reveal that TCP-P responding with proactive manner outperforms other approaches in terms of communication throughput under the presence of node mobility.
Gamijiya-tang Decreases the Dimethylnitrosamine-Induced Hepatic Fibrosis in the Rats
Ma, Jin-Yeul,Yang, Jai-Man,Nam, Jeong-Seok,Che, Jeong-Hwan,Cheon, Won-Kyung,kim, Nam-Joo,Ko, Byoung-Seob,Park, Kap-Joo,Lee, Yong-Soon,Kyu, Yong-Jung The Korean Society of Pharmacognosy 1997 생약학회지 Vol.28 No.4
Gamijiyu-tang (GJT) described originally in the Dong Eui Bo Gam, a traditional reference for oriental medicine in the Korea, has been clinically used for treatment of chronic liver disease. In order to evaluate scientifcally a hepatoprotective effect of GJT in the liver fibrotic disease, the present study investigated how GJT improves a hepatic function in the dimethylnitrosamine (DMN)-treated rat. DMN treatment caused a significant increase of relative liver weight to the body at 28 days after DMN induction. Administration of with a clinical dose decreased significantly the sAST level $(158.8{\pm}7.76\;IU/L)$ elevated by DMN in jection (p<0.01). A similar phenomenon was also observed at change of both Salt and Salt level in the GJT and/or DMN-treated animal (p<0.01, p<0.05, respectively). A remarkable increase of hydroxyproline was observed by treatment of DMN with comparing to the normal rat $(361.9{\pm}7.35\;vs.\;1278.1{\pm}52.9\;{\mu}g/g\;tissue,\;p<0.01)$. This was significantly reduced by a simultaneous treatment of GJT with DMN for 21 days (p<0.05), but not recovered completely to its normal value. In addition. GJT administration ameliorated conspicuously the DMN-induces histopathological changes of liver such as hemorrhage. Cell necrosis and fibrosis. Tak'en together, results described here demonstrated scientifically in first the medicinal efficacy of GJT by using in vivo animal model, indicating that GJT improves the DMN-induced hepatic injury through reducing an excessive accumulation of collagen and histopathological changes. The decreased collagen content may be a pivotal process for GJT to improve hepatic function in the DMN-induced liver fibrosis. The present study suggests that GJT may be useful for and applicable to the treatment of hepatic fibrosis in chronic liver disease.
Yun, Jung-Yeul,Lee, Hye-Moon,Choi, Si-Young,Yang, SangSun,Lee, Dong-Won,Kim, Young-Jin,Kim, Byoung-Kee The Japan Institute of Metals 2011 Materials transactions Vol.52 No.2
<P>Fe-Cr-Al alloy nanopowders were successfully prepared by electrical wire explosion method in ethyl alcohol media. The formation of Fe-Cr-Al alloy nanopowder was monitored by X-ray diffraction. The alloy powders have spherical shape and nanometer size. The alloy powders prepared by the electrical wire explosion method have main crystal structures of bcc Fe-Cr alloy. The geometric mean diameter and geometric standard deviation of an alloy powder formed from a wire with diameter of 0.1 mm were 10.2 nm and 1.62, respectively. However, the geometric mean diameter and geometric standard deviation of an alloy powder formed from a wire with diameter of 0.2 mm were 15.4 nm and 1.66, respectively. These values indicate that the particle size of the alloy powders prepared by the EWE method was increased with wire diameter. Fe, Cr, and Al components are uniformly dispersed inside the powder.</P>
이영미(Young-Mee Lee),안덕선(Duck-Sun Ahn),김병수(Byoung-Soo Kim),박정율(Jung-Yeul Park) 한국의학교육학회 2001 Korean journal of medical education Vol.13 No.2
Background: One of major weakness in medical education in Korea is clinical skills has not been uniformly well taught during undergraduate period. To reinforce the basic clinical skill education, we developed introduction to clinical medicine (ICM) course In this study, we described the ICM course development process and the experience. Methods: We performed comprehensive literature review related to ICM and doctoring curriculum. ICM/OSCE sub-commitee members discussed several time to develop the course. To assess the level of accomplishment of this course, we got feedback from 115 third year medical students by questionnaires. Results: ICM was composed of 9 topics which covers the basic clinical skills. For each topic, three hours per week was allocated, one hour for didactic session and the other 2 hours for practical exercise. Standardized patients were used to teach interview skill. Most of students revealed history taking, abdominal examination, musculo-skeletal system, and interview skill session were valuable learning experience. However, for Gynecology and Pediatric session which were taught by mainly lectures, students evaluated them negatively. Interpretation: This year, we focused on teaching basic clinical skills at ICM. However, our ultimate goal is to develop the ICM course which can allow the students to learn both the art and the science of Medicine.
신의섭(Euiseob Shin),민병권(Byoung Kwon Min),이춘열(Choon Yeul Lee) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.1
한국통신 소프트웨어연구소에서는 통합 프로그래밍 지원도구로써 LACE (Language Associated Common Editor)를 설계, 개발하였다. 본 논문에서는 LACE개발을 위하여 채택한 모형을 소개하고, 통합프로그래밍 지원도구인 LACE가 개별적 프로그래밍 도구들에 대하여 지니는 장점을 비교제시한다.