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RISS 인기검색어
- 검색키워드
- 저자 : Laurence Pelletier (검색결과 3 건)
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The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate
Goncalves, Joao,Pelletier, Laurence Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.4
Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for embryonic development and adult tissue homeostasis. Importantly, a multitude of human diseases is caused by abnormal cilia biogenesis and functions which rely on the compartmentalization of the cilium and the maintenance of its protein composition. The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes. Here we review recent developments in the study of TZ proteomes, the mapping of individual components to the TZ structure and the establishment of the TZ as a lipid gate.
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The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate
João Gonçalves,Laurence Pelletier 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.4
Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for em-bryonic development and adult tissue homeostasis. Importantly, a multitude of human diseases is caused by abnormal cilia biogenesis and functions which rely on the com-partmentalization of the cilium and the maintenance of its protein composition. The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes. Here we review recent developments in the study of TZ proteomes, the mapping of individual compo-nents to the TZ structure and the establishment of the TZ as a lipid gate.
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Kaniuk, Natalia A.,Canadien, Veronica,Bagshaw, Richard D.,Bakowski, Malina,Braun, Virginie,Landekic, Marija,Mitra, Shuvadeep,Huang, Ju,Heo, Won Do,Meyer, Tobias,Pelletier, Laurence,Andrews‐,Poly Blackwell Publishing Ltd 2011 Cellular microbiology Vol.13 No.11
<P><B>Summary</B></P><P>The facultative intracellular pathogen <I>Salmonella enterica</I> serovar Typhimurium establishes a replicative niche, the <I>Salmonella</I>‐containing vacuole (SCV), in host cells. Here we demonstrate that these bacteria exploit the function of Arl8B, an Arf family GTPase, during infection. Following infection, Arl8B localized to SCVs and to tubulated endosomes that extended along microtubules in the host cell cytoplasm. Arl8B<SUP>+</SUP> tubules partially colocalized with LAMP1 and SCAMP3. Formation of LAMP1<SUP>+</SUP> tubules (the <I>Salmonella</I>‐induced filaments phenotype; SIFs) required Arl8B expression. SIFs formation is known to require the activity of kinesin‐1. Here we find that Arl8B is required for kinesin‐1 recruitment to SCVs. We have previously shown that SCVs undergo centrifugal movement to the cell periphery at 24 h post infection and undergo cell‐to‐cell transfer to infect neighbouring cells, and that both phenotypes require kinesin‐1 activity. Here we demonstrate that Arl8B is required for migration of the SCV to the cell periphery 24 h after infection and for cell‐to‐cell transfer of bacteria to neighbouring cells. These results reveal a novel host factor co‐opted by <I>S</I>. Typhimurium to manipulate the host endocytic pathway and to promote the spread of infection within a host.</P>
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