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Qadir Bux alias Imran Latif,Ismail Abdul Rahman,Ahmad Mujahid Ahmad Zaidi,Kamran Latif 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.1
Penetration is the basic element of designing protective concrete structure against the local impact damage of hard missile. Impactenergy is the dominant cause of damage in moving accidents. When hard projectile collides with concrete target, it is the impactenergy of the projectile that makes concrete target to deform. Therefore, it is vital to study critical impact energy required to causespenetration. An analytical model is developed to predict the required critical impact energy for maximum penetration without reareffects in concrete slabs when it is impacted with hard projectile. The nose shape factor Ni also has been introduced with inclusion ofempirical friction factor Nf, as modification in Chen & Li nose shape factor for ogive nose hard projectile. The newly developedanalytical model and nose shape factor Ni is examined for CRH = 2.0, CRH = 3.0, and CRH = 4.25. It was found that the predictedresults from analytical model with nose shape Ni are in close relation with experimental data in all cases as compared to predictedresults with traditional Li and Chen nose shape N*. In, General, the analytical model generates encouraging prediction which isconsistent and follows a general trend of experimental results.
Latif Sana,Kang Young-Sook 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.1
Purpose Neuroinflammation and microglial activation are the key factors in neurodegenerative motor neuron diseases. Microglial activation has been link to disease progression in humans. This study investigated the transport and potential effects of l-arginine under pathological conditions in a human microglial cell line. Methods Transport study was performed using [ 3H]l-arginine isotope and uptake was measured in the human microglial clone 3 (HMC-3) cell line. MTT assay was performed for cell viability analysis. mRNA expression of cationic amino acid transporter-1 (CAT-1) was also determined. Results The transport of l-arginine was time- and concentration-dependent in HMC-3 cell lines. Kinetic parameters revealed carrier-mediated arginine transport via CAT-1, with high affinity and low capacity at high-affinity sites and low affinity and high capacity at low-affinity sites. HMC-3 cells pretreated with glutamate exhibited decreased viability. [ 3H]l-arginine uptake increased markedly with glutamate pretreatment, whereas co-treatment with arginine further increased the uptake. After tumor necrosis factor α and lipopolysaccharide pretreatment, [ 3H]l-arginine uptake significantly increased. In contrast, the uptake was significantly decreased after co-treatment of the cells with unlabeled l-arginine. The mRNA expression of CAT-1 showed a similar uptake pattern. Various pharmacological drugs including donepezil, quinidine, verapamil and tramadol significantly inhibited the uptake of [ 3H]l-arginine in HMC-3 cell line. Conclusion These results suggest that l-arginine supplementation may play an effective role against inflammatory states in neurodegenerative diseases.
Latif Rabia,Imran Sumera,Ahmad Ijaz,Ilyas Muhammad Saad,Aziz Amer,Zehra Uruj 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2
Study Design: Cross-sectional comparative. Purpose: To characterize the scores of disc degeneration, inflammation, and nerve density in herniated disc samples and associate findings with the presence of vertebral endplate (VEP) changes on magnetic resonance imaging (MRI). Overview of Literature: Considering the role of disc composition in spontaneous regression and persistence of pain during conservative management, it is important to identify the influencing factors. VEP changes are highly associated with disc degeneration, but their correlation with herniated disc composition has not yet been reported. Methods: Fifty-one discs were obtained from patients undergoing surgery for herniated disc. Their ages ranged from 19-65 years, and 31/51 were male. Pre-surgical T1 and T2 weighted lumbar-spine MRIs were analyzed to observe Pfirrmann grade, VEP defects, herniation type, Modic changes, and high-intensity zones (HIZ) at the affected level. Five-micron thick sections were stained with hematoxylin and eosin, Alcian blue periodic acid–Schiff stain; examined for histological degeneration scores (HDS; 0–15), inflammation (0 [absence]–3 [severe]), and presence of cartilaginous endplate (CEP). Three-micron thick sections were stained with protein-gene-product 9.5 and expression was counted/mm2. Data was analyzed, and p<0.05 was considered to indicate statistical significance. Results: VEP defects, Modic changes, and HIZ were respectively observed in 30/51, 16/51, and 6/51 of the samples. CEP was observed in 26/51 samples and in 23/51 with endplate defects. Discs with adjacent VEP defects showed increased HDS (p<0.001) and inflammation (p<0.001). Discs with adjacent Modic changes also revealed increased HDS (p=0.01). Histological sections with CEP showed increased HDS (p<0.001) and inflammation (p<0.001), and nerve density was significantly positively correlated with HDS (r=0.27, p=0.02). Conclusions: VEP changes can modulate degeneration and inflammation of herniated discs. Presence of these changes is highly predictive of the occurrence of CEP in herniated discs, which leads to slow resorption and persistent clinical symptoms.
Latif, M.,Prabhakar, M.N.,Nam, Gi-Beop,Lee, Dong-Woo,Song, Jung-Il The Korean Society for Composite Materials 2017 Composites research Vol.30 No.5
Organo-montmorillonite (OMMT) has attracted much attention for fiber-reinforced polymer composites as a filler material due to high aspect ratio and low charge density. The present study focused on the fabrication of nanocomposites using Vinyl ester and Jute fabric as matrix and reinforcement respectively. The OMMT was uniformly dispersed in vinyl ester resin at 1, 2 and 3 wt%, loading through high speed mechanical stirrer at room temperature and further nanocomposites were manufactured through vacuum assisted resin infusion (VARI) technique. Effects of OMMT on the mechanical properties of vinyl ester/Jute composites were carefully investigated through tensile, bending and Izod impact tests, which revealed significant improvement in mechanical properties. The morphology of the nanocomposites after tensile test was investigated by SEM which affirmed that OMMT filled nanocomposites has improved interactions with the host matrix than the pure composites. Based on the nature and flame retardancy mechanism, the OMMT slightly improved the flammability property which was clearly explained by horizontal burning test.
Federated Learning for Cellular Networks: Joint User Association and Resource Allocation
Latif U. Khan,Umer Majeed,Choong Seon Hong 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
Recent years have shown a remarkable interest in federated learning from researchers to make several Internet of Things applications smart. Although, federated learning offers users’ privacy preservation, it has communication resources optimization challenge. In this paper, we consider federated learning for cellular networks. We formulate an optimization problem to jointly minimizes latency and effect of loss in federated learning model accuracy due to channel uncertainties. We decompose the main optimization problem into two sub-problems: resource allocation and device association sub-problems, due to the NP-hard nature of the main optimization problem. To solve these sub-problems, we propose an iterative approach which further uses efficient heuristic algorithms for resource blocks allocation and device association. Finally, we provide numerical results for the validation of our proposed scheme.
Synthesis and Biological Evaluation of Tetrapeptide Ketones as Reversible 20S Proteasome Inhibitors
Latif, Muhammad,Jung, Myoung Eun,Lee, Kwangho,Choi, Gildon Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
Proteasome, a multicatalytic protease complex, has been validated as a promising therapeutic target in oncology. Carfilzomib (Kyprolis$^{(R)}$), a tetrapeptide epoxyketone, irreversibly inhibits the chymotrypsin-like (CT-L) activity of the proteasome and has been recently approved for multiple myeloma treatment by FDA. A chemistry effort was initiated to discover the compounds that are reversibly inhibit the proteasome by replacing the epoxyketone moiety of carfilzomib with a variety of ketones as reversible and covalent warheads at the C-terminus. The newly synthesized compounds exhibited significant inhibitory activity against CT-L activity of the human 20S proteasome. When the compounds were tested for cancer cell viability, 14-8 was found to be most potent in inhibiting Molt-4 acute lymphoblastic leukemia cell line with a $GI_{50}$ of $4.4{\mu}M$. Cytotoxic effects of 14-8 were further evaluated by cell cycle analysis and Western blotting, demonstrating activation of apoptotic pathways.
Being a Khaddama: Narratives of home, belonging and identity for women domestic workers in the Gulf
LATIF Amal,BOSE Chandan 이화여자대학교 아시아여성학센터 2023 Asian Journal of Women's Studies(AJWS) Vol.29 No.2
With minimal access to legal protections, support, and exploitative conditions, Malayali women domestic workers in the Gulf struggle to forge meaningful connections and a sense of home in the UAE. This study aims to understand the experiences and perspectives of Malayali women, with a specific focus on the ways in which their idea of home and belonging are shaped by factors such as identity, diaspora, gender, and motherhood. The work also intends to comprehend how a sense of belonging helps the women to navigate through the sense of grief, guilt, and shame. Through their narratives, the article exposes how the migration of Malayali women domestic workers entail losing belonging, occupying liminal spaces, and relinquishing home.