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Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer
Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10
Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.
전찬민,우경헌,김중현,김경업,박태근 목원대학교 건축도시연구센터 2003 建築·都市環境硏究 Vol.11 No.-
The importance of LCC analysis has been enlarged. Also, it would be necessary to computerize LCC analysis for accurate and logical analysis of LCC. In other papers, they showed LCC analysis model but the study of database development which could be applied in LCC analysis have been undeveloped. This study showing the development of common database for the LCC analysis computerization inquires into cost breakdown structure by previous researches. Also, it makes cost breakdown structure for deriving LCC cost item. As a result, the standard of LCC analysis computerization by developing LCC DB of cost breakdown structure would be shown.
유아교육기관의 組織風土와 敎師의 職務萬足에 대한 基礎硏究
田慶和 부천대학 1987 論文集 Vol.8 No.-
The main purpose of this thesis is to study the relation between the organizational climate of preschool educational institutions (private kindergarten, saemaul nursling school, preschool annexed to primary school) and the trend of teachers job satisfaction using by random sampling method on 138 teachers in Buchon and Inchon Citys. There have been two questionaires employed to serve as a tool of measurement one is called the O.C.D.Q (Organizational Climate Description Questionaire), the other is teacher's job satisfaction questionaire and all of the data was analysed by frequency and ANOVA system. The results obtained from this investigute were as follows: 1. Organazational climate followed by preschool educational institute have a same tendency generaly. 2. Also for the teacher's satisfaction, the survey came in highest response to preschool annexed to primary school, next turned to saemaul nursling school and last to private kindergarten, even if there is no meaningful difference. 3. It proved that the teacher who is older, work at the small scale kindergarten, serve 8-9 hours a day would be satisfied
정신분열병 환자의 재발에 관한 연구 : 정신교육을 중심으로
전경수,이종일 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6
연구목적: 정신교육은 만성 정신질환자를 치료하고 그 가족을 도울 수 있는 좋은 방법으로 치료에 대한 순응도를 높여 재발을 방지하고, 사회기능과 삶의 질의 향상을 가져올 수 있는 것으로 치료에 중요한 요소로 생각된다. 이 연구는 정신분열병 환자의 정신교육이 재발에 미치는 영향을 알아보기 위해 실시되었다. 방 법: 총 33문항으로 구성된 설문지를 이용하여 국립서울정신병원에서 입원 및 외래통원치료중인 정신분열병 환자 97명을 대상으로 조사를 실시하였다. 대상군의 구분은 병원에 최소 3회 이상 반복적인 입원치료를 받고 있으며 6개월 이상 안정된 외래통원치료를 받지 못하고 있는 환자군(이하 실험군) 47명과 퇴원 후 최소한 3년 이상 안정된 외래통원치료를 받고 있는 환자군(이하 대조군) 50명을 대상으로 하였다. 결 과: 정신교육 측면에서 실험군은 대조군에 비해 질병 교육에서 재발의 부정과 같은 재발원인과 병식, 약물교육에서 약물부작용의 지각과 약물복용여부에서 유의한 차이를 보이고 있었으며, 치료진에 대한 부정적인 견해가 실험군에서 유의하게 높았다. 그리고 양군 모두에서 많은 대상자들이 충분한 정신교육을 받지 않은 것으로 보고하였고 실험군 46.8%, 대조군 46.0%가 교육의 필요성을 느끼지 못하고 있었다. 결 론: 이 연구는 정신교육과 재발과의 관계에서 정신교육의 필요성을 보여주고 있다. 그러나 정신교육과 순응도에 관한 전반적인 조사가 이루어지지 않은 점을 고려하면, 향후 개선된 연구가 필요할 것으로 생각된다. Objectives: Psychoeducation is an important factor in the treatment of chronic mental illness that increases drug compliance, then prevents relapse of illness, and brings the patient a progress of social function and quality of life. The purpose of this study was to elucidate the effect of psychoeducation on relapse of schizophrenic patients. Methods: Checklist including 33 items was applied to 97 schizophrenic patients that had been treated at Seoul National Mental Hospital. The subject was divided into two groups. The experimental group consisted of 47 cases that were not treated consistently more than 6 months in outpatient department and required at least 3 time hospital treatment. The control group consisted of 50 cases that were treated consistently in outpatient department at least 3 consecutive years. Results: The experimental group had significant differences in terms of deficiency of insight such as denial of disease or relapse, subjective experience of drug side effect, whether or not taking drug and they had higher negative attitude to therapist. Many schizophrenic patients reported that they had not been educated thoroughly about disease, drug, and prognosis. 46.8% in experimental group and 46.0% in control group did not recognized necessity of psychoeducation. Conclusion: This study suggested that we need the necessity of psychoeducation in terms of the relationship between the relapse of illness and psychoeducation. However, considering that we did not have an extensive study about psychoeducation and compliance, we need more improved study.
전경준 한국 프랑스어문교육학회 1999 프랑스어문교육 Vol.7 No.-
Cet article est consacre a des phenomenes concernant l'occurrence du pronom clitique francais EN. Le pronom clitique EN a un comportement tres particulier par rapport aux autres pronoms clitiques francais en ce qu'il peut avoir pour antecedent des elements appartenant a des categories differentes et anaphoriser une partie d'un syntagme nominal. ce qui a incite une abondance des recherches syntaxiques. L'un des enseignements de la linguistique chomskyenne est qu'il convient de separer scrupuleusement les composantes de la theorie grammaticale. Selon cette hypothese, les principes discursifs et syntaxiques doivent etre presentes comme deux ordres de principes differents, et complementaires. Il s'ensuit que, pour elaborer une theorie grammaticale adequate, il faut tracer avec precision la ligne de demarcation entre la grammaire de la phrase et la grammaire du discours. Mais la distinction entre la grmmaire de la phrase et la grmmaire du discours ne semble pas explicitee dans les recherches generatives, meme dans les cas ou elle est necessaire. Faute de tracer une separation nette entre syntaxe et discours, on est conduit a laisser entrer dans la description syntaxique toutes sortes de phenomenes qui en fait echappent a la grammaire de la phrase, parce qu'ils concernent ono pas la structure interne des phrases, mais l'enchainement des phrases entre elles et les contextes discursifs et enonciatifs ou elles sont realisees. Ainsi, certaines proprietes ont ete "poussees" vers la syntaxe. Les contraintes sur les occurrences des pronoms francais, en particulier le pronom EN, illustrent bien ce point: dans les recherches syntaxiques, on a souvent tente de rendre compte des contraintes sur la distibution du pronom EN par les seuls principes syntaxiques, ce qui conduit a envisger les hypotheses qui ne donnent pas d'explication satisfaisante de l'ensemble des donnees, et creent souvent d'autres problemes empiriques qui ne surgiraient pas sans elles. EN s'interessant surtout a la pronominalisation du complement de nom par EN, cet article montre qu'on obtient une explication satisfaisante des qu'onconsidere comme discursives certaines contraintes sur la pronominalisation par EN, en distinguant la grammaire de la phrase et la grammaire du discours. Ainsi, on observe d'abord qu'il existe des phrases dont les contrastes d'acceptabilite ne peuvent pas s'expliquer par la difference structurale (par exemple, la difference entre argument et non argument). On remarque, ensuite, que le pronom EN est lie au theme phrastique et qu'il faut enir compte de la thematicite des deux SN quand il s'agit de l'antecedent de EN qui est le complement de nom. On propose donc une contrainte discursive (44) qui ne met pas en jeu de concept syntaxique, mais un concept discursif 'thematicite': dans un SN complexe 'SN1 de SN2', le complement de nom 'de SN2' peut etre pronominalise par EN si, et seulement si, il est plus thematique que sa tete SN1. Ainsi, les donnees mettant en jeu le pronom clitique francais EN montrent que, pour rendre compte de sa distibution, on doit faire appel non seulement a des principes syntaxiques mais aussi a la notion discursive de thematicite.
田璟秀,李種樂,柳澤圭 경희대학교 부설 식량자원개발연구소 1991 硏究論文集 Vol.12 No.-
The objectives of forest management is in a state of equilibrium between economic timber production and the indirect utility of forest. But establishment conditions for forest management is to maintain the poor equilibrium, in korea. In order to accomplish of these objective, forest road is prerequisite. So the purpose of this study is to analyse the economic efficiency on constructed forest road, in CheonBuk province. The results were as follows : 1. As the growing stock is expected to increase in the future, it is suggested that the enlargement of forest road networks and mechanization of forest works should be excellerated in order to retrench a large amount of labor required. 2. The average of density, vertical gradient and curve radius in investigated forest road were 5.61m/ha, 8.13% and 23.8m, respectively. 3. In the constructed forest road, not only forest management but also multiple use are gradually increasing.
국내 무연탄용 순환유동층 Boiler의 Clinker생성에 관한 연구
전문택,김진호,김경남 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1
The analysis of anthracite coal as fired basis and clinkers located on combustor, seal pot and cyclone to find out the reason why the bed materials agglomerated and resulted in clinkers were studied. It was one of the most serious problem in early period operating the Tonghae CFBC(Circulating Fluidized Bed Combustor). The proximate analysis, heat value analysis, ash fusion temperature analysis and size distribution analysis of coal & ash were studied using TGA, Bomb Calorimeter, Ash Fusibility Determination and Sieve Shaker. The chemical compositions and microstructure of raw material and clinker located on combustor, seal pot and cyclone were investigated by the scanning electron microscope(SEM) with an energy dispersive X-ray spectrometer(EDS), ICP-AES, X-ray diffractometer(XRD). The domestic anthracite coal had much fine size portion which could cause after burning. Furthermore domestic coal had higher ignition temperature and lower volatile matter portion than bituminous coal, which finally ended in low combustion velocity. So it is fundamental to lengthen the furnace residence time to reach complete combustion. And it is possible to use auxiliary fuel but its dependence is low for CFBS because combustion temperature is at around 800~850℃, which range is very lower than general fine size coal combustion type. Fine size coal could do after burning, so it could cause temperature rising at combustor upper region and clinker formation by means of fouling. The short residence time of fine size coal in furnace can bring out high content of unburned carbon in fly ash, so it is necessary to reduce the fine size coal content. Assembling the result of chemical composition analysis, crystal structure analysis and EDS analysis of clinker, we could conclude that calcium in limestone and iron in bed material did the main effect in agglomeration.
전재영,김태운,백영호,최문기,이경희 釜山大學校 附設 體育科學硏究所 2006 體育科學硏究所 論文集 Vol.22 No.2
The purpose of this study was to investigate the daily nutrition intake of high school girl students according to the BMI. The subjects of this study were classified into under weight group; UG(<14.9percentile; n=9), normal weight group; NG(15.0~84.9percentile; n=12), and obese group; OG(>85percentile; n=12) by BMI.......
전우선,정원지,김원제,남경원 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-
HILS(Hardware In Loop Simulation) is an effective means of testing unmanned underwater vehicle under extreme operational conditions and a variety of operational environments. In order to verify the vehicle performance under time-varying pressure conditions, a reliable pressure simulator is vital to an integrated system for the HILS. This paper presents the results of design research for the pressure simulator using pneumatic pressure (nitrogen), a high speed solenoid valve and a PWM control method. The test and evaluation results of the pressure simulator show that the simulator can generate an appropriate level of desired pressure with an average error below 1m depth for time-varying pressure change conditions corresponding to vehicle dynamics. In addition, the levels of overshoot and vibration have been shown to be under the requirements of design specifications.
전은례,김경애 全南大學校家政科學硏究所 1998 生活科學硏究 Vol.8 No.-
The amylase activity of milled rice and brown rice sikhe were decreased as saccharification time was processed during saccharification. Brix of sikhe made of milled rice increased from 3.6˚to 10.8˚after saccharification for 8 hrs. and that of sikhe made of brown rice increased from 3.6˚to 9.7˚after saccharification for 10 hrs. The sikhe saccharified at 60˚C for 8 and 10 hrs. showed that total sugar was increased from 4.90 to 9.07% in milled rice, from 2.62 to 8.11% in brown rice and reducing sugar was increased from 3.58 to 7.71% in milled rice, from 1.83 to 7.34% in brown rice. But pH of sikhe juicy was decreased gradually according to time increase and then little changed after 4 hrs. SEM and TEM clearly showed that the starch granule were disappeared from endosperm cell leaving cellular materials. Changes of components and morphology of milled rice sikhe was processed quickly more than that of brown rice about 2 hrs.