생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

결절성 황색종과 동반된 제 Ⅲ 형 과지질단백혈증 1예

김지현,김연진,김현주,조소연,황규광,함정희 梨花女子大學校 醫科大學 醫科學硏究所 2000 EMJ (Ewha medical journal) Vol.23 No.1

We report a case of type Ⅲ hyperlipoproteinemia associated with tuberous xanthoma, which is improved by treatment with lovastatin and bezafibrate. A 34-year-old female patient visited our clinic for evaluation of multiple yellowish-brown papulonodules on the kness, elbows and palms. Serum lipid examination showed an abnormal elevation of serum cholesterol and triglyceride. Lipoprotein electrophoresis showed a single peak at pre-β and β portion without separation. The biopsh specimen from a nodule on the knee and a papule on the palm revealed characteristic findings of xanthoma. We diagnosed the case as type Ⅲ hyperlipoprotei-nemia. After 3 months of treatment with diet restriction, lovastatin and bezafibrate, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesion of the palm showed complete regression and ones on both knees and elbows were moderate improvement.

The Sentence-Ending Suffix -Ketun in Spoken Korean Discourse: Sequential Organization of Informing as Account-Giving

Kyu- hyun Kim 한국사회언어학회 2010 사회언어학 Vol.18 No.1

Kim, Kyu-hyun. 2010. The Sentence-Ending Suffix - Ketun in Spoken Korean Discourse: Sequential Organization of Informing as Account-Giving. The Sociolinguistic journal of Korea 18(1). From a conversation-analytic perspective, this paper examines the ways in which the Korean sentence-ending suffix (SES) -ketun is used in naturally occurring spoken Korean discourse. Focusing on the question of how the practice of informing implemented by the ketun-utterance provides a basis for the sequentially implemented action of account-giving (Kim & Suh 2009), it analyzes (i) the nature of the information marked by -ketun in terms of how it is grounded, (ii) the sequential contexts where the informing sequence that -ketun generate i embedded, and (iii) features of the ketun-marked account with reference to the practices of formulating non-negotiable upshot, evoking positionaJly relevant identities, unpackaging information geared to enlightening the addressee. and stance-shifting. These practices are anaJyzed as being constitutive of the action-organizational features of the ketun-marked account, whose upshot is proposed to be that of evoking and managing the information gap or disparity in knowledge asserted by the speaker to exist between the participants.

Topic Marker -Nun as an Exploratory Device : Shifting Domains for Stance Management in Pursuit of Intersubjectivity

Kim, Kyu-hyun 한국사회언어학회 2017 사회언어학 Vol.25 No.2

Kim, Kyu-hyun. 2017. “Topic Marker -Nun as an Exploratory Device: Shifting Domains for Stance Management in Pursuit of Intersubjectivity“. The Sociolinguistic Journal of Korea 25(2), 29~72. From the conversation-analytic perspective, this paper investigates the interactional import of - nun used in assessment activities. The analysis of naturally-occurring interactions suggests that the domain-shifting function of - nun is closely attuned to shifting, or even reversing, the valence of the speaker s evaluative stance in a way that invokes a hitherto unmentioned domain as grounds for soliciting the interlocutor s agreement/affiliation, expressing partial agreement, or marking oblique disagreement. Often formulated as an overstatement to be retracted and/or as a move to solicit the interlocutor s collaborative uptake through claiming knowledge (or lack thereof), the nun- utterance furnishes the speaker with a resource for obliquely implementing face-threatening actions, pursuing common ground, or upgrading affect. Embodying the speaker s ‘exploratory’ stance, the use of - nun conveys the sense that the speaker is going beyond the ‘appearance’ of the matter at hand (e.g., a sub-domain from which a new generic feature may be drawn and attributed to the referent). This practice, which is further supported by the nun- marked adverbials formulated as a ‘logical guidepost expression’, provides for the basis on which the speaker organizes assessment activities in an other-attentive way, e.g., through upgrading affiliation and downgrading disaffiliation vis-à-vis the interlocutor s prior action, while sustaining his/her baseline stance and epistemic independency.

Topic and Subject in Spoken Korean Discourse

Kyu-hyun Kim 한국사회언어학회 2008 사회언어학 Vol.16 No.2

This paper analyzes the difference between nun and ka from an interactional perspective in terms of the practice of giving distinct types of ‘focus’ to the referent they mark. From a conversation-analytic perspective, Kim’s (1990) analysis that nun and ka index the speaker-relevant focus and the event-relevant focus respectively is further elaborated on, with systematic attention being paid to ‘sequential,’ rather than ‘cognitive,’ aspects of how the referent is highlighted in the context of dealing with the prior talk and projecting sequential trajectories that favor distinct types of uptake. Nun is shown to be embedded in the context where the speaker orients himself/herself to problematizing and counteracting the interlocutor’s action in the prior context, with the consequence that the interlocutor is solicited to make a decision and take a position vis-a-vis the speaker’s action, preferably in the direction of aligning with it. The upshot of the focus-giving practice involving nun is characterized as a process by which the speaker’s display of subjective and evaluative stance indexed by nun is empirically grounded by facts putatively observed by the speaker. The use of ka, in contrast, does not necessitate such a process of modulating the speaker’s subjectivity. The focus-giving practice involving ka is geared towards highlighting the referent per se, with any agenda it projectively proposes being limited to the factual import that the referent has towards the event/state of affairs it relates to. That the interlocutor orients to the ka-marked referent in such a straightforward and non-motivated fashion is demonstrated by his/her often successful attempt at collaborative completion of the ka-utterance in-progress.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

A Conversation Analysis of Korean Sentence-Ending Modal Suffixes -ney, -kwun(a), and -ta: Noticing as a Social Action

Kyu-hyun Kim 한국사회언어학회 2004 사회언어학 Vol.12 No.1

Kim, Kyu-hyun. 2004. A Conversation Analysis of Korean Sentence-Ending Modal Suffixes -ney, -kwun(a), and -ta: Noticing as a Social Action. Sociolinguistic Journal of Korea, 12(1). Drawing upon H. S. Lee's (1993) cognitively-oriented research on the functions of three sentence-ending modal suffixes in Korean that are used to express newly perceived information, -ney, -kwun(a), and -ta, this study analyzes the distinct meanings of these suffixes from a conversation-analytic perspective (Sacks et al. 1974). The suffix -ney is used in the context in which the speaker notices a referent/event and makes an assessment on the spot in such a way that the speaker's stance displayed through the action is formulated as something that is to be immediately oriented to and contingently taken up by the hearer. In contrast, the suffix -kwun(a) is used when the speaker is mainly oriented to displaying a stance congruent with the prior talk. The action it organizes is often limited to acknowledging a point of the prior talk or having the hearer acknowledge the speaker's observation, often with a salient topic-curtailing and sequence-terminating import. The suffix -ta tends to orient the hearer to the next stage of the speaker's action (e.g., suggestion, warning, offer, etc.) to whose directive force the hearer is variably implicated as a beneficiary/facilitator. The interactional account offered in this paper is shown to complement Lee's cognitive account, with emphasis placed on examining the ways in which these suffixes are used as resources for organizing distinct types of social action.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

성인에서 장기간 Furosemide오용과 연관된 신수질 석회화

김윤구,이윤하,이규백,장세호,김대중,오하영,김보현,김미경,조윤숙 대한신장학회 1996 대한신장학회잡지 Vol.15 No.4

위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.