한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

후발브랜드가 성숙시장에서 선발브랜드를 앞서는 전략에 대한 사례연구 : -유한킴벌리의 그린핑거 성공사례-

최규복, 윤승기, 김근배 숭실대학교 2009 숭실경영연구 Vol.1 No.1

Prior studies show late entrants can overcome pioneer under several conditions as like innovative product, premium price, trendy category and overlapped target market effect and significantly heavier promotion supports. This study shows several similarities with prior studies. In case of superior product performance, concept and overlapped target market, this study and prior studies have very similarity. Furthermore, this study show GREEN FINGER case has more conditions than each of prior study to overpass pioneer within short period. As a result, this study shows a good case which late entrants can overtake in any category even though pioneer effect is so strong. Keywords: Green Finger, Pioneer, Late entrants, Innovative product, Premium product 선행 연구에 의하면 선발브랜드를 제압하는 후발브랜드가 되기 위한 조건에는 후발브랜드의 제품이 혁신적이거나, 프리미엄제품, 소비자의 취향이 빈번하게 변하는 제품, 후발브랜드의 기존제품과 유사한 타깃소비자, 유통 등을 가진 제품 경우와 선발브랜드보다 엄청나게 많은 광고판촉지원을 하는 경우라고 한다. 그린핑거의 사례는 선행연구를 지원하는 대표적인 사례가 될 수 있고, 어느 카테고리에서든지, 어느 시장에서든지 선발브랜드 효과가 아무리 강하더라도 후발브랜드가 어떤 제품전략과 마케팅전략으로 시장에 진입하고 활동하느냐에 따라 선발브랜드를 추월할 수 있다는 것을 보여주는 좋은 마케팅사례라고 할 수 있다. 주제어: 그린핑거, 선발브랜드, 후발브랜드, 혁신제품, 프리미엄제품, 유사시장효과

鬱金이 Angiogenesis 抑制機轉에 미치는 影響

崔昇勳,安圭錫,成熙根 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

This experimental study was carried out to evaluate the effects of Curcuma on angiogenic inhibition mechanism. In order to investigate the effects of Curcuma on angiogenic inhibition mechanism evaluate cell survival rate by MTT assay, cell adhesive inhibition effect, DNA fragmantaion analysis. Nuclear Condensation assay FACScan analysis, angiogenesis inhibition assay. Immunocytochemistry analysis, RT-PCR for mRNA expression. Western Blot analysis. The results were summarized as follows : 1. The IC50 was 10㎍/ml to ECV 304 cell. 2. The cell adhesive inhibition ability was strong from 5㎍/ml. 3. The G0/G₁arrest peak was existed on ECV304 cell-line. 4. The cells on Collagen plate were inhibition of proliferation and inducement of apoptosis by Cur water extract. 5. Lumen formation was inhibited by Cur water extract. 6. LFA-1 and ELAM-1's expression were inhibited by Cur water extract, they are commenly participation on inflammation and tumor regeneration. 7. The expression of MMP-9 and uPA were inhibited by Cur water extract. 8. The expression of integrin αvβ₃ was inhibited by Cur water extract. 9. The expression of intracellular molecule were successively inhibited by Cur water extract therefore the proliferation of ECV304 cell line was stopped and apoptosis was induced. According to the results Curcuma has been shown to be a key antagonist of intergrin αvβ₃and which seems to be apoptosis by P53 through Flow cytometry. This report demonstrated that expression of MMP-9 and uPA blocked to under angiogenesis model. Thus, we suggested that Curcuma water block angiogenesis by inducing unscheduled apoptosis in ECV304 and ECVPAR cell lines and another orient herbal medicine that treat Qi-stagnation and Blood-stasis type also have angiogenic inhibition effects.

지구성 운동이 자연발생 고혈압 흰쥐의 혈압에 미치는 영향

이규승,전병화,김일곤,전종귀 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1

The purpose of this study is to investigate the effects of indurance exercise on BP of SHR Experimental animals were SHR(180) and SD(90) and they were divided into three groups ; a experimental group1( practice group), a experiment group2(non practice group), and a comparative group (normal group). The experimental group 1 was practicing on a treadmill at 15m/min exercise intensity for 30 minutes a day four times per week for eight weeks. While raising experimental animals, We measured BP for each group once a week, and took the weight of the heart after killing a rat. and then we examined the concentration of ?? and ??, compared, and analyzed them. we have reached the following results. 1. As time passed, BP in the experimental group 1 was almost equal to BP eight weeks ago. BP in the experimental group 2 continued to rise and then showed typical hypertension. 2. The three groups were inclined to increase the weight of their hearts as time passed. However, the experimental group 2 presented the weight of hearts increasing compared with the experimental group1 after eight weeks. 3. In the experimental group 1, and experimental group 2 groups, ?? concentration was but ?? concentration increased as time passed. However, the experimental group1 showed fewer changes than the experimental group 2. 4. The weight of all three groups were inclined to increase as time passed, but it didn't present any noteworthy differences. According to the analysed result of the above experiment, endurannsce exercise becomes an important factor in preventing the raising of BP of SHR, and the hypertrophy of hearts. Key Words : Spontaneously Hypertension Rats, Blood Pressure, Endurance Ecercise

INCOTERMS 2000D의 限界와 INCOTERMS 1990과의 比較硏究

박남규,신승만 건국대학교 사회정책연구소 2001 사회과학연구 Vol.14 No.1

장기간의 트레이닝이 체격 및 체력에 미치는 영향

윤규태,이승준,이승준 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

The purpose of this study is to investigate how a long-term training affect a physique and a physical strength on two groups of being trained and untrained. There are 11 items divided under as a factor of the physique and 12 items as a factor of the physical strength to be measured and compared the relationship between two factors. The results of this study are as follows: 1.The most significant differences statistically among factors of the physique in this study appears in chest, lower limb length and upper arm girth. 2.In case of the physical strength, there are significant differences in vertical jump, side step, sit-up, chinning bar, toe touching and mobility tests Like above the results showing, it causes that trainees have been more grown up than untrainees in the development of Staying power, muscular power and promptitude. In addition, there are a lot of benefit to keep the continuant exercises for the development of the body and the physical strength

當歸鬚散이 壓迫으로 인한 白鼠의 外傷瘀血病態模型에 미치는 影響

崔昇勳,安圭錫,李金浩 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

In order to investigate the effects of Dangguixusan on experimental blood stasis model induced by compression, 7.5kg weight was placed on the thigh(4.9㎠) of rats for one hour and 30 minutes. Then the local and hematological changes were measured. The sample groups were orally administrated extracts of Dangguixusan one hour before the compression. The measurements were carried for sample control group Ⅰ 2 hours after inducement and for sample control group Ⅱ 4 hours after inducement. The results are summarized as follows ; 1. Thigh circumference in sample group Ⅰ and Ⅱ decreased significantly when compared to their respective control groups. 2. The dermal temperature in sample group Ⅰ and Ⅱ increased roughly when compared to their respective control groups. In sample group Ⅱ, it decreased much significantly when compared to control group Ⅱ. 3. The platelet count in sample group Ⅰand control group Ⅰ decreased. in sample group Ⅱ and control group Ⅱ increased when compared to their respective control groups. 4 The fibrinogen count in sample group Ⅰ increased significantly when compared to its control group Ⅰ. 5. The prothrombin time in sample group Ⅰ and Ⅱ did not decrease significantly when compared to control groups. 6. The FDP level in sample group Ⅰ and Ⅱ did not decrease significantly when compared to their respective control groups. In conclusion, Dangguixusan has effects on experimental blood stasis model induced by short-term compression. So, Dangguixusan can be used limitedly in the early stage of compression induced blood stasis symptoms. In subsequential experiments, the model should be further investigated.

다공성 물질에 부착한 토양미생물에 의한 유기성 폐수처리에 관한 실험적 연구

정연규,홍승모,박준환 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.1

In this research, Briquette Ashes, one of the important solid wastes in Korea, were used as media in a fixed-film biological process to evaluate the efficiency of organic wasterwater treatment by soil microbes attached to porous media and adsorption capacity of Briquette Ashes in the reactors. As the result, hydraulic retention time and aeration rate for optimum operation were 24 hours, 5ℓ/min in the reactors seeded with microbes. And the adsorption capacity of Briquette Ashes came to get maximum removal efficiency when it was controlled to (24 hours, 4ℓ/min), but removal efficiency was decreased with time. In addition, the organic removal efficiencies were 93.4, 90.8% under these operating conditions respectively. Particularly, NH₃-N efficiency was about 85%, the average value of F/M ratio was 0.15g COD/g VS-day. Setting characteristics of sludge were good, for SVI was 23.6 in the seeding reactors.

膽石症의 韓方治療 및 豫防에 관한 實驗的 硏究

安圭錫,崔昇勳 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 담석증은 개복수술의 중요원인이 되는 질환으로서, 최근 우리 나라에 있어서도 생활양식의 서구화로 콜레스테롤 담석증이 증가하고 있는 추세이다. 이에 guinea pig에 콜레스테롤 담석증 병태 모델을 유발하여, 약물치료를 시행함으로써 담석증의 약물 치료 기전을 밝히고, 그에 근거하여 높은 치료 효과를 거두는 제재를 개발함으로써 담석증의 치료에 기여하고 아울러 수술후의 재발을 방지하는 근본적인 예방 치료에 대한 새로운 방법을 제시하고자 함. 방법 : Guinea pig에 cholesterol과 sodium cholate를 이용하여 콜레스테롤 담석증을 유발시키면서, 大柴胡湯을 투여하여 담석의 발생비율, bile acid, bilirubin, cholesterol의 함량변화를 관찰한다. 결과 : 담석의 발생률은 대조군에 비하여 감소하였고, 담즙중 TUDCA·TCDCA·GCDCA 함량은 대조군에 비하여 유의성 있는 증가가 나타났으며, 혈청증 cholesterol함량은 대조군에 비하여 현저한 감소를 보였고, 담즙중 bilirubin과 혈청중 bilirubin의 함량은 대조군에 비하여 유의성은 인정되지 않지만 감소하는 경향이 있었다. 결론 : 大柴胡湯은 콜레스테롤 담석증 모형에 대하여 bile acid의 분비를 촉진시키고 cholesterol 함량을 저하시켜 담석 유발을 억제시키는 효과가 있어 담석증의 한방치료 및 예방에 응용할 수 있을 것으로 사려된다. In order to investigate the effects of Daeshihotang on gallstone, guinea pig which were fed with lithogenic diet were administered solid extracts of Daeshihotang and then observed about gallstone incidence, bile acid in bile, bilirubin in bile and in serum, total cholesterol in serum The results were obtained as follows 1. Pigment stone were formed by lithogenic diet in guinea pig and the incidence rates of gallstone were reduced in Daeshihotang group. 2. The level of taurochenodeoxycholic acid in bile had little changes in control group and it was remarkably increased in Daeshihotang group as compared with that of control group. 3. The level of tauroursodeoxycholic acid and glycochenodeoxycholic acid in bile had also little changes in control group and it was remarkably increased in Daeshihotang group as compared with that of control group. 4. The level of total bilirubin in bile was remarkably increased in control group, and had attendancy of reduce in Daeshihotang group but had no statistical significance. 5. The level of total bilirubin in serum was remarkably increased in control group, and had attendancy of reduce in Daeshihotang group but had no statistical significance. 6. The level of total cholesterol in serum was increased in control group and it remarkably reduced in Daeshihotang group as compared with that of control group. According to the above results, it is considered that Daeshihotang has preventive and therapeutic effects on cholecystolithasis induced by lithogenic diet in guinea pig. Clinically we can make use of Daeshihotang for therapeutic and preventive effects on cholecystolithithiasis but the mechanism concerned for the effects is to be investigated detaily in future.

도시폐기물 매립지의 침출오수 재순환과 함수율 조정에 의한 조기 안정화 방안에 관한 연구

정연규,전승렬 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.1

This study is an experimental research on some factors that affect the efficiency of organic content removal and stabilization of leachate from municipal sanitary landfill when the moisture content is control to (30, 50, 90%), washout and leachate recirculation with detention time(1, 5, 10 days). As the results pH of the system may decrease during the increase in volatile acids and will then rise steadily while the volatile acids diminish. Adding water to raise moisture content accelerates stabilization of refuse materials, flushes out soluble materials, and increase the rate of settlement of fill materials. Notwithstanding dilution effects, daily recirculation of leachate has particulary increased the rate of biological stabilization of the organic fraction of the refuse, as evidenced by large reduction in BOD and COD.