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김흥재,조수동,권기락,안철진,주우홍,강진호,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1
본 연구에서는 황정 속에 포함되어 있는 생리활성 물질을 hexane, CHCl₃과 n-butanol층에서 각각의 성분들을 추출하였고, hexane층에서 분리된 화합물 I과 Ⅱ 중에서, 화합물 I의 봐학구조를 ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC 스펙트럼 및 MS 스펙트럼 등의 분광학적인 방법에 의해 결정하였다. 화합물 I의 구조는 9,12-(9E,12E) -octadecadienoyloxy) propanoic acid 임을 확인하였다. In this Paper, biologically active compounds were extracted using organic solvents as hexane. CHC1₃, n-butanol to give each component. Chemical structure of compound I was characterized using ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC spectrum and MS-spectrum, in separated compound I and Ⅱ from hexane layer. Finally, chemical structure of compound I was determined as 9,12-(9E,12E)-octadecadienoyloxy)propanic acid.
Development of Hydrogen-Storage Alloys by Mechanical Alloying of Mg with Fe and Co
Ahn, Dong Su,Song, Myoung Youp,Ahn, Hyo Jun,Kwon, Ik Hyun 대한금속재료학회(대한금속학회) 1999 METALS AND MATERIALS International Vol.5 No.5
The hydriding and dehydriding kinetics of Mg are reviewed. In order to improve the reaction kinetics of Mg with hydrogen, mechanically-alloyed Mg-10 wt.%Fe and Mg-10 wt.%Co mixtures are prepared and their hydrogen-storage properties are investigated. The activation of Mg-10 wt.%Fe is easier than that of Mg10 wt.%Co. However, The hydriding races (at 569-589 K, 7-11 bar H₂) and dehydriding rates (at 589 K, 1.0 bar H₂) of the mechanically-alloyed Mg-10wt.%Co are higher than those of the mechanically-alloyed Mg-10 wt.%Fe after activation. The H_a value of Mg-10 wt.%Co after 60 min is 3.08 wt.% at 589 K under 11 bar H₂ and its H_d value after 60 min is 1.48 wt.% at 589 K under 1.0 bar H₂. Mg-10 wt.%Co has a smaller particle size than has Mg-10 wt.%Fe after hydriding and dehydriding cycling. The mechanical alloying of Mg with Fe and Co and the hydriding-dehydriding cycling increased the hydriding and dehydriding rates by facilitating nucleation (by creating defects on the surface of the Mg particle and by the additive) and by shortening the diffusion distances (by reducing the Mg particle sizes).
A Study on How to Vitalize the ESG Management Strategy of SMEs through ESG Management Cases
Jin-Kwon KIM(Jin-Kwon KIM),Min-Su KIM(Min-Su KIM),Tony-DongHui AHN(Tony-DongHui AHN ) 국제융합경영학회 2022 융합경영연구 Vol.10 No.6
Purpose: The purpose of this study is to look at the current status and cases of ESG at home and abroad, and through this, seek ways to activate the ESG strategy of domestic SMEs and suggest a direction. Research design, data and methodology: This study examines the current status of ESG management at home and abroad and examples of companies through related literature on ESG management and performance. Through this, the strategic direction of ESG management of domestic SMEs was presented. Results: Compared to the government and major corporations, SMEs can be said to lack ESG management activities. ESG activities include environmental activities such as carbon neutrality, waste management, eco-friendly supply chain management, establishment of safety and health processes to improve workers' environment, expansion of governance to guarantee autonomy and profitability such as fair trade, protection of social and shareholder rights such as anti-corruption, etc. should be based on Therefore, there are difficulties in ESG activities of SMEs that lack funds and manpower. Conclusions: Compared to the government and major corporations, SMEs can be said to lack ESG management activities However, it will be possible to establish and implement ESG management strategies based on the strengths of SMEs and the characteristics of each company.
Ahn, Suk-Won,Kim, Su-Hyun,Oh, Dong-Hoon,Kim, Sung-Min,Park, Kyung Seok,Hong, Yoon-Ho,Kwon, Oh-Sang,Sung, Jung-Joon,Lee, Kwang-Woo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.9
<P>We investigated the availability of motor unit number estimation (MUNE) as a quantitative method to assess the severity and clinical progression of amyotrophic lateral sclerosis (ALS). The 143 ALS patients were evaluated by statistical MUNE and the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). By using mean values of MUNE according to disease duration, regression equation between mean MUNE and disease duration was presented as a formula. The individual MUNE ratio was calculated by dividing individual MUNE value by mean MUNE value. All patients were classified into 2 groups (MUNE ratio <1 vs. MUNE ratio ≥1) according to the MUNE ratio. Comparison between the 2 groups revealed that the patients in MUNE ratio <1 group or MUNE ratio ≥1 group were respectively assigned to rapid progression or slow progression. We recommended informative mean values of MUNE and best regression equation in ALS patients according to disease duration. These values allow us to evaluate the severity and rapidity of progression in ALS.</P>
Ahn, Hee-Jin,Khalmuratova, Roza,Park, Su A.,Chung, Eun-Jae,Shin, Hyun-Woo,Kwon, Seong Keun 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.12 No.3
<P>Tracheal restenosis is a major obstacle to successful tracheal replacement, and remains the greatest challenge in tracheal regeneration. However, there have been no detailed investigations of restenosis. The present study was performed to analyze the serial changes in recruited inflammatory cells and associated histological changes after tracheal scaffold implantation. Asymmetrically porous scaffolds, which successfully prevented tracheal stenosis in a partial trachea defect model, designed with a tubular shape by electrospinning and reinforced by 3D-printing to reconstruct 2-cm circumferential tracheal defect. Serial rigid bronchoscopy, micro-computed tomography, and histology [H&E, Masson's Trichrome, IHC against alpha-smooth muscle actin (alpha-SMA)] were performed 1, 4, and 8 weeks after transplantation. Progressive stenosis developed especially at the site of anastomosis. Neutrophils were the main inflammatory cells recruited in the early stage, while macrophage infiltration increased with time. Recruitment of fibroblasts peaked at 4 weeks and deposition of alpha-SMA increased from 4 weeks and was maintained through 8 weeks. During the first 8 weeks post-transplantation, neutrophils and macrophages played significant roles in restenosis of the trachea. Antagonists to these would be ideal targets to reduce restenosis and thus play a pivotal role in successful tracheal regeneration.</P>
Ahn, Jae-Jun,Kim, Gui-Ran,Akram, Kashif,Kim, Kyong-Su,Kwon, Joong-Ho Elsevier 2012 Radiation physics and chemistry Vol.81 No.8
<P><B>Abstract</B></P><P>The aim of this study was to determine the effects of light conditions during 2 years of storage on the luminescence characteristics of contaminating minerals, isolated from irradiated onions of 2 different origins. The potential use of photostimulated luminescence (PSL) as a screening and thermoluminescence (TL) as a confirmatory identification method was investigated during post-irradiation periods. Nonirradiated onions had 1,612 photon counts (PCs), However, the irradiated onions had much higher PCs (45,672–469,696, positive). The PCs of the irradiated onions decreased with storage time. However, all the irradiated onions had PCs with positive values (>5,000) even after 2 years of storage except onions stored under natural light. The decline in PCs because of light conditions during storage was in the order of sunlight, artificial light, and a darkroom, respectively. Minerals extracted from the nonirradiated samples exhibited TL glow curves of low intensities with maximum peak after 300<SUP>°</SUP>C. However, all irradiated samples had TL glow peaks in the temperature ranges of 185–225<SUP>°</SUP>C. The TL intensity and TL ratio of the irradiated samples decreased during storage with a slight shift in the TL peak temperature towards higher temperatures. The TL characteristics were most promising for samples stored under natural light conditions, however all the irradiated onions could be identified even after 2 years of storage.</P> <P><B>Highlights</B></P><P>► The luminescence properties are known sensitive to adverse storage conditions. ► Effect of storage under different light conditions on PSL & TL was evaluated. ► The most drastic effect was observed in case of storage under natural light. ► Identification was possible even after 2 years of storage using TL. ► The minerals were characterized using XRD analysis.</P>
Alagille syndrome and a JAG1 mutation: 41 cases of experience at a single center
Ahn, Kyung Jin,Yoon, Ja Kyoung,Kim, Gi Beom,Kwon, Bo Sang,Go, Jung Min,Moon, Jin Su,Bae, Eun Jung,Noh, Chung Il The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.10
Purpose: Alagille syndrome is a complex hereditary disorder that is associated with cardiac, hepatic, skeletal, ocular, and facial abnormalities. Mutations in the Notch signaling pathway, such as in JAG1 and NOTCH2, play a key role in embryonic development. A cardiac or hepatic presentation is a critical factor for determining the prognosis. Methods: We conducted a retrospective study of 41 patients with Alagille syndrome or a JAG1 mutation between 1983 and 2013. Results: The first presentations were jaundice, murmur, cyanosis, and small bowel obstruction at a median age of 1.0 months (range, 0-24 months). The JAG1 mutation was found in 27 of the 28 genetically-tested patients. Cardiovascular anomalies were identified in 36 patients, chronic cholestasis was identified in 34, and liver transplantation was performed in 9. There was no significant correlation between the severity of the liver and cardiac diseases. The most common cardiovascular anomaly was peripheral pulmonary stenosis (83.3%), with 13 patients having significant hemodynamic derangement and 12 undergoing surgical repair. A total bilirubin level of >15 mg/dL with a complex surgical procedure increased the surgical mortality (P=0.022). Eight patients died after a median period of 2.67 years (range, 0.33-15 years). The groups with fetal presentation and with combined severe liver and heart disease had the poorest survival (P<0.001). Conclusion: The group with combined severe liver and heart disease had the poorest survival, and a multidisciplinary approach is necessary to improve the outcome.