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강보승,이정훈,송형곤,송근정,정연권 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3
Heat stroke, a medical emergency, occurs when the body's thermal regulation is upset and unable to dissipate adequate amounts of heat with a rise in body temperature. It is characterized by hyperpyrexia, with a core temperature of 40˚C or more. hot dry skin, and central nervous system disturbance and usually results in rhabdomyolysis and multiorgan failure. Our case, a 43-year-old healthy male, was caused by a marathon, half course, on a sunny day in late summer. He suddenly fell down on the road and was delivered to a nearby hospital, where a seizure developed. He was transfered to our hospital and then displayed Central Nervous System disturbance, hot dry skin, acute liver failure, rhabdomyolysis, anurlc acute renal failure, and disseminated intravasculular coagulopathy. He was treated with general supportive care and hemofiltration. Despite the aggressive management, he died of shock on the fifth day after admission.
ROX Index for High-flow Nasal Cannula Therapy in Patients with COVID-19
( Hyung-joo Oh ),( Hong-joon Shin ),( Young-ok Na ),( Hwa Kyung Park ),( Jae-kyeong Lee ),( Bo-gun Kho ),( Tae-ok Kim ),( Yong-soo Kwon ),( Yu-il Kim ),( Sung-chul Lim ),( Min-seok Kim ),( Cheol-kyu P 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Purpose This study aimed to evaluate the predictability of ROX index for failure of high-flow nasal cannula (HFNC) therapy in patients with coronavirus disease-2019 (COVID-19). Methods We retrospectively analyzed medical charts of COVID-19 patients treated with HFNC at two tertiary hospitals from January 2020 to June 2021. Cases who were died or underwent endotracheal intubation were defined as failure of HFNC, which were divided into 2 groups: early failure (≤ 48 h of HFNC therapy) and late failure (> 48 h). ROX index was calculated as SpO2/FiO2/ respiratory rate. Results Sixty-five patients were included, of whom 32 (49.2%) patients were experienced failure of HFNC. Multivariate analysis with logistic regression revealed that duration of HFNC (odds ratio [OR], 0.97; 95% confidence difference [CI], 0.96-0.99); P=0.002), age (OR, 1.10; 95% CI, 1.01-1.20; P=0.017), and ROX index at 2 h (OR, 0.23; 95% CI, 0.10-0.55; P=0.001) were associated with failure of HFNC. The cut-off ROX index at 2 h for predicting failure of HFNC was 6.6, with a sensitivity of 78.1%, a specificity of 81.8%, and an area under the curve (AUC) of 0.81 (95% CI, 0.70-0.91; P<0.000). Patients with early failure were 15 (23.0%) and patients with late failure were 17 (26.1%). A receiver operating characteristic (ROC) curve of ROX index at 2 h for predicting early failure of HFNC showed an AUC of 0.86 (95% CI, 0.70-0.91; P<0.000). Whereas, ROX index at 12 h was better predictable for predicting late failure of HFNC (AUC, 0.78; 95% CI, 0.64-0.91; P=0.001). Conclusions ROX index at 2 h after initiation of HFNC is useful for predicting early failure of HFNC in COVID-19 patients. Whereas ROX index at 12 h is useful for predicting late failure.
拘束스트레스 흰쥐에 미치는 四物安神湯의 效能에 關한 硏究
權保亨,李相龍 대한한방신경정신과학회 1994 동의신경정신과학회지 Vol.5 No.1
This exoeriments were conducted to study anti-stress effects Samulanshintang on the weight change, β-lipoprotein, total cholesterol and triglyceride consentration of rats stressed by immobilization. The following results have been obtained : 1. Samulanshintang reduced significantly the body weight loss of rats stressed by immobilization. 2. Samulanshintang decreased significantly the serum cortisol level of rats stressed by immobilization. 3. Samulanshintang decreased significantly the serum β-lipoprotein level of rats stressed by immobilization. 4. Samulanshintang decreased significantly the serum total cholesterol level of rats stressed by immobilization. 5. Samulanshintang decreased significantly the serum triglyceride level of rats stressed by immobilization. According to the above results, it is concluded that Samulanshintang has significant effect in reducing stress.
( Bo Mi Choi ),( Seong Wan Son ),( Chan Kwon Park ),( Sang Hoon Lee ),( Hyung Kyu Yoon ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3
Lemierre syndrome (LS) is a septic thrombophlebitis of the internal jugular vein (IJV) following an oropharyngeal infection. LS is commonly caused by normal anaerobic flora and treated with appropriate antibiotics and anticoagulation therapy. Although the incidence of disease is very rare, 15% cases of LS are fatal even in the antibiotic era because of disseminated septic thromboemboli. We reported a case of extensive bilateral LS due to methicillin-resistant Staphylococcus epidermidis in a 63-year-old female with lung adenocarcinoma. Initial examination revealed a retropharyngeal abscess; hence, intravenous ceftriaxone and steroid were initiated empirically. However, pulmonary thromboembolism developed and methicillin-resistant S. epidermidis was identified in the bacterial culture. Despite intensive antibiotic and anticoagulation therapies, extensive septic thrombophlebitis involving the bilateral IJV and superior vena cava developed. Adjunctive catheter-directed thrombolysis and superior vena cava stenting were performed and the patient received antibiotic therapy for an additional 4 weeks, resulting in complete recovery.