비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

Polymorphisms of interleukin-10 and tumour necrosis factor-&agr; genes are associated with newly diagnosed and recurrent pulmonary tuberculosis

OH, Jae-Hee,YANG, Chul-Su,NOH, Yeon-Kyeong,KWEON, Yu-Mi,JUNG, Sung-Soo,SON, Ji Woong,KONG, Suck-Jun,YOON, Jang Uk,LEE, Ji-Sook,KIM, Hwa-Jung,PARK, Jeong-Kyu,JO, Eun-Kyeong,SONG, Chang-Hwa Blackwell Publishing Asia 2007 RESPIROLOGY Vol.12 No.4

<P>Background and objectives: </P><P>The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-&agr; (TNF-&agr;) and interleukin-10 genes (IL-10).</P><P>Methods: </P><P>A case–control study was conducted using two groups of cases—newly diagnosed TB (N-TB) and recurrent TB (R-TB)—and a control group.</P><P>Results: </P><P>One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF-&agr;−308 G/A genotype between the TB patient groups and the controls. The IL-10 −1082A alleles were markedly over-represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL-10 genotype frequency between the N-TB and R-TB patient groups.</P><P>Conclusion: </P><P>The −1082A allele of the IL-10 gene may be important in determining susceptibility to TB, however, the −308 allele of the TNF-&agr; gene does not affect differential TB susceptibility.</P>

G-, R- and C-band patterns of goral (Nemorhaedus caudatus) and comparison to goat (Capra hircus)

Oh, Seung Hyun,Yun, Young Min,Lee, Jung Eun,Kim, Il Yong,Shin, Jae Hoon,Kweon, Oh Kyeong,Lee, Hang,Yoon, Yeo Sung,Shin, Nam Sik,Seong, Je Kyung Springer-Verlag 2011 Molecules and cells Vol.31 No.4

급성 골수성 백혈병 환자에서 발생한 다발성 과립성 육종 1 예

권영미,이용구,정선관,유남진,김경년,오경아 대한내과학회 1994 대한내과학회지 Vol.47 No.6

Granulocytic sarcoma, or chloroma is a localized extramedullary tumor mass composed of immature cells of the granulocytic series. It was first described by Burns in 1811, subsequently termed $quot;Chloroma$quot; because of green color sometimes imparted by cellular myeloperoxidase, Dock was the first to note the association of granulocytic sarcoma with acute leukemia, it may by associated with such myeloproliferative disorder as hypereosinoplilia, polycythemia vera, or myeloid metaplasia. Granulocytic sarcoma is now regarded as an omnious habinger of acute myelocytic leukemia (AML), or the onset of blast crisis in chronic myelogeneous leukemia (CML). Granulocytic sarcoma can arise in various locations including the periosteum of the bones, lymph nodes, skin, epidural structures, female genitalia, gonads, breast, gastrointestinal tract, urinary bladder, and kidney. Although its overall incidence is low, the tumor can present in any organ. We report a case of a 18-year-old man who was diagnosed as having multifocal granulo cytic sarcoma in the soft tissue.

위절개술견에 있어서 소화관내영양식급여의 효과

권오경,Kweon Oh-Kyeong 한국임상수의학회 1990 한국임상수의학회지 Vol.7 No.1

The effects of enternal feeding on wound healing and intestinal movement in 30 gastrotomized dogs were investigated. The dogs were divided into enteral and parenteral feeding groups. Wound healing was evaluated with tensile strengh on the suture line 4 days after surgery and intestinal movement with the auscultation of borborygmus sound in the abdomen. There was no difference of the tensile strengh on the suture line between enternal and parenteral feeding groups. Borborygmus was auscultated in all dogs of the enteral feeding groups from day2 after surgery. It was thought that enteral feeding had no detrimental effect on wound healing as compared with the parenteral feeding and had good effect on the prevention of ileus in gastrotomized dogs.

면양에 있어서 염증유발후의 혈중대사물의 동태 그리고 그후의 과잉배란처치에 대한 난소반응

권오경,Kweon Oh-Kyeong 한국임상수의학회 1988 한국임상수의학회지 Vol.5 No.1

The effects of inflammation on the changes in some blood metabolites and ovarian response to super-ovulation treatment in sheep were investigated. Inflammation was induced artificially with LPS(Lipopoly-saccharide E. coli; 0.2mg/kg). Changes in the levels of NEFA, GOT, ${\gamma}$-GTP and body temperature after LPS injection were observed. Superovulation was carried out about 2 months after LPS injection. The body temperature, the levels of NEFA and GOT increased, and the level of total cholesterol decreased transiently. However, the level of ${\gamma}$-GTP did not change significantly. Superovulation results were not different between LPS injection and control groups. It was indicated that superovulation results did not decrease in the sheep which showed regular estrous cycle even after the induction of inflammation.

우의 우심방증식성심내막염의 초음파단층영상진단 1예

권오경,Kweon Oh-Kyeong 대한수의사회 1988 대한수의사회지 Vol.24 No.1

약 2개월간에 걸친 치료에도 불구하고 식욕부진, 심박수증가, 파상열의 임상증상을 되풀이한 한 젖소에 대해 각종 임상진단검사를 실사하였다. 혈액학적 검사에서는 PCV치의 저하, 백혈구의 해좌방이동, 혈청단백분화에서는 albumin치의 저하, $\gamma$-globulin치의 증가 그리고 A/G비의 저하를 보였다. 심장에 대한 초음파검사를 실시한 결과, 우심방내에 이물의 존재를 관찰할 수 있었으며 부검소견에서 유형의 증식물로 확인되었다. 심음도에서 고음역의 I 음발생전에 특이한 심내잡음을 청취할 수 있었으며, 심전도에서는 T파의 증고, ST의 상승, 심박수의 증가를 인정할 수 있었다. 일차임상소견, 혈액학적검사 그리고 심음, 심전도소견으로는 본 증예우에 대한 확정진단이 어려웠으나, 초음파진단에 의해 우심방증식성 심내막염으로 확정진단할 수 있었다. A lactating Holstein cow which did not have had responded to drug therapy during 2 months was clinically examined. Right atrial vegetative endocarditis was determined dy ultrasonographic diagnosis, and later it was confirmed at necropsy. An early systolic

생쥐 및 소초기배의 체외보존에 관한 연구

권오경,Kweon Oh-Kyeong 한국임상수의학회 1991 한국임상수의학회지 Vol.8 No.1

It was carried out to investigate the effect of the kind of medium, the concentration of serum added and the temperature of storage on the survival of mouse and bovine embryos preserved In vitro. The survival of frozen-thawed mouse embryos after cooling at 4$^{\circ}C$ was also investigated. It was possible to preserve the embryos of mouse until 4 days and of cattle in a day without significant decrease of the survival rates. The survival rates of frozen-thawed mouse embryos after cooling at 4$^{\circ}C$ over 3 days were below 20%.

염증유발 생쥐에 있어서 과잉배란처치후 난소내 난포의 정량형태학적관찰

권오경,Kweon Oh-kyeong 한국임상수의학회 1988 한국임상수의학회지 Vol.5 No.2

Morphometric observation on the ovarian follicles of ICR strain-female mice has been conducted to investigate the effect of induced inflammation on the follicular populations. Inflammation was induced by administering 25${\mu}\ell$ of turpentine oil intraperitoneally 2 times at the interval of 3 days. Mice showing 5-day estrous cycle about 20 days after induction of inflammation are placed in experimental group. Normal follicles of 100~399$\mu\textrm{m}$ in diameter increased at estrus but those of over 400$\mu\textrm{m}$ decreased. super-ovulation increased the number of normal follicles of over 400$\mu\textrm{m}$. The number of normal follicles of over 400$\mu\textrm{m}$ 48 hours after superovulation was not significantly different between experimental and control groups. Present results indicated that the number of preovulatory follicles 48 hours after PMSG injection did not decrease in the mice which showed regular estrous cycle even after the induction of inflammation.