소아 갑상선 수질암종 1례

정광윤,박찬,이재용,최종욱,유홍균,Jung, Kwang-Yoon,Park, Chan,Lee, Jae-Yong,Choi, Jong-Ouck,Yoo, Hong-Kyun 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.2

저자들은 좌측 전경부 종물을 주소로 내원한 9세 여아에서 발생한 갑상선수질암종을 갑상선 전절제술 및 술후 방사성요드로 치료한 경험을 보고하는 바이다. Medullary thyroid carcinoma constitutes about 5-10% of all thyroid malignancies, but rare in children. It has frequent association with multiple endocrine neoplasia(MEN) and frequent familial occurrence. They are derived from parafollicular cells of thyroid glands and produce calcitonin. They are capable of local invasion, spread to regional lymph nodes, or distant metastases. Histopathologically, the lesions are characterized by sheets of non-follicular cells surrounded by deposits of hyaline amyloid. Aggressive surgical intervention is recommended due to the propensity of medullary thyroid carcinoma for local microvascular invasion, late recurrence and metastasis. A total thyroidectomy is generally recommended because of the high incidence of bilaterality. Recently, authors experienced a case of medullary carcinoma in child. We report this case with review of the literatures.

분화성 갑상선암에 의한 후두기관침습의 치료

정광윤 ( Kwang-yoon Jung ),정은재 ( Eun-jae Chung ),백승국 ( Seung-kuk Baek ) 대한갑상선학회 2008 International Journal of Thyroidology Vol.1 No.2

Locally invasive thyroid cancer is an uncommon disease process, which carries significant morbidity and mortality. Differentiated thyroid cancer (DTC) invasion of the recurrent laryngeal nerve, strap muscles and trachea are the most common followed by invasion of the esophagus, internal jugular vein and carotid artery. Surgical resection is the primary treatment for locally advanced DTC. Although the optimal surgical approach (ranging from conservative shave excision to aggressive en bloc resection of tumor and vital structures) in patients with locally advanced DTC is controversial, a curative resection should be the goal unless complete tumor resection results in unwanted perioperative morbidity and mortality or widely metastatic disease is present. Postoperative radioiodine ablation with TSH suppression is imperative after surgical resection of locally advanced DTC. Patients with microscopic or small gross residual disease, after surgical resection, may benefit from postoperative external radiotherapy for local control of disease.

원발성 부갑상선 기능항진증에 대한 임상적 고찰

정광윤(Kwang Yoon Jung),이종수(Jong Soo Lee),최종욱(Jong Ouck Choi),백세현(Sei Hyun Baik) 대한두경부종양학회 1994 대한두경부 종양학회지 Vol.10 No.1

Primary hyperparathyroidism is rare disease entity which secretes parathyroid hormone in excessively resulting in hypercalcemia. It involves skeletal system, urinary tract, gastrointestinal tract, and central nervous system. Recently the determination of the serum calcium and parathyroid hormone level has become a routine laboratory test and the localization of involved gland by neck ultrasonogram and parathyroid gland substraction scan has reduced operative complications. For the purpose of improvement of diagnosis and treatment, the authors analyzed the clinical characteristics of 6 cases of primary hyperparathyroidism(adenoma 5 cases, carcinoma 1 case) during 10 years and report with literatures.

두경부 편평세포암종에 대한 UFT 투여 후 항종양효과에 관한 제2상 임상 연구

정광윤(Kwang Yoon Jung),최건(Geon Choi),최종욱(Jong Ouck Choi) 대한두경부종양학회 1994 대한두경부 종양학회지 Vol.10 No.1

두경부에 발생한 편평세포암종 68례(재발암 32례 포함)에 대하여 UFT(400mg/m²)를 6∼8주간 경구투여한 후 항종양효과를 관찰한 제2상 임상시험결과 다음파 같은 성적을 얻었다. 1) 치료 경험이 없었던 두경부 편평세포암종 32례에 대한 주효융은 38.89%, 재발암종 32례에 대한 주효율은 21.88%로서, 평균 주효율은 30.88% 이었다. 2) 암종의 병기에 따른 주효융은 임상적으로 초기병기에서 높았으며, 병리조직학적으로 분화도가 좋은 경우에 높았고, 치료효과의 발현시기는 4주와 5주째가 높은 경향올 보였다. 3) 부작용은 식욕부진, 오심 및 구토가 다수 있었으나 용량을 반으로 감량하거나 일시 중단함으로써 극복이 가능하였으며 중증 부작용은 없었다. 이상의 성적에서 UFT는 두경부 편평세포암종에서 항암효과가 있으며, 투여방법이 간편하고 부작용이 적어 병합항암화학요법이나 고식적 항암화학요법으로 널리 이용될 수 있을 것으로 생각되었다. A Phase II study of UFT which is a mixture of Tegafur and Uracil was conducted in two institutions during past two years. Ninty-four patients of head and neck squamous cell carcinoma entered this trial, of which sixty-eight were evaluated. Among those, thirty-six cases were previously untreated and thirty-two cases were recurrent. UFT was administrated orally at a daily dose of 400mg/m² for eight weeks. The results were as following: 1) Overall response was 30.88%, but for 38.36% for 36 cases of the untreated cases, 21.88% for 32 cases of recurrent cases. 2) UFT was more effective in early stage and well differentiated squamous cell carcinoma and UFT tended to reduce the tumor size maximally at fourth or fifth week 3) There was no serious side effects except mild gastrointestinal disturbances such as nausea and vomiting, which were recovered immediately after stop or reducing a daily dose. Therefore, UFT therapy is clinically effective for head and neck squamous cell carcinoma and also may be useful for combination or palliative chemotherapy because of mild side effects.

진행된 성문상부암의 발생부위별 임상적 특성에 관한 연구

정광윤(Kwang Yoon Jung),최종욱(Jong Ouck Choi),이종수(Chong Soo Lee) 대한두경부종양학회 1993 대한두경부 종양학회지 Vol.9 No.2

The prognosis of supraglottic cancer is worse than that of glottic cancer. Supraglottic cancers by subsites have different microenvironment of cancer cells, locoregional spread patterns. Therefore we presume that high therapeutic efficacy, while preserving the organ, can be obtained when supraglottic cancer is treated effectively according to its biological behaviors. For the purpose of determination of clinical characteristics and causes of treatment failures by subsites of supraglottis, the authors analyzed 24 cases(stage III 14 cases, stage IV 10 cases) of supraglottic cancer which were managed mainly by surgery in our institute. The results were as follows; 1) The suprahyoid group had worse pathologic grades, more frequent spread to hypopharynx, more freguent recurrence at primary site, and better three-year survival rate than the infrahyoid group. 2) The infrahyoid group had more frequent spread to glottis, understaging, recurrence at cervical nodes than the suprahyoid group. 3) There was no differences in nodal metastasis by sub sites. These results suggest that the suprahyoid group may have more aggressive spread pattern but better prognosis than the infrahyoid group.

다형선종 수술 후 발생한 이하선 점액표피양암종

정광윤(Kwang-Yoon Jung),채양석(Yang-Seok Chae),백승국(Seung-Kuk Baek),박민우(Min-Woo Park),유준혁(Joon-Hyuk Yoo) 대한두경부종양학회 2012 대한두경부 종양학회지 Vol.28 No.1

Mucoepidermoid carcinoma is most frequent malignant tumor of parotid gland. However, mucoepidermoid carcinoma arising from pleomorphic adenoma has been disputed and rarely reported. 54-year-old woman with pleomorphic adenoma underwent superficial parotidectomy. And 15 years later, she diagnosed mucoepider-moid carcinoma at the same side. We report the case with a review of literature.

후두암 세포주에서 TGF-β1에 의한 MMP2와 MMP9의 발현 양상

정광윤(Kwang Yoon Jung),권순영(Soon Young Kwon),우정수(Jeong Su Woo),김형진(Hyung Jin Kim),권남영(Nam Young Kwon) 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.2

Backgrounds and Objectives: Metastasis is a complex multistep process that requires sequential interactions between the invasive cell and the extra-cellular matrix. Transforming growth factor-β1 (TGF-β1) is a multifunctional regulator of cellular differentiation, motility and growth. Loss of sensitivity to the growth inhibitory effects by TGF-β1 plays important roles in neoplastic progression. The aim of this study was to investigate the role of TGF-β1 in the neoplastic invasion and metastasis through matrix metalloproteinase (MMP) of laryngeal cancer cell lines. Material and Methods: Two laryngeal cancer cell lines, SNU-899 and SNU-1076 were treated with recombinant TGF-β1 , and the expression of MMP-2 and MMP-9 was immunohistochemically evaluated and gelatinase activity was studied by gelatin zymogram. Results: The cell growth inhibition was evident on 4th days after 1ng/ml and 10ng/ml TGF-β1 treatment. The expressions of MMP-2 and MMP-9, and their gelatinase activities were increased in dose-dependent manner. Conclusion: TGF-β1 treatment in laryngeal cancer cell lines induces the expression of MMP-2 and MMP-9, thus playing a role in the digestion of extracellular matrix gelatin.

두경부 수술후 발생한 인두피부누공의 치료

정은재,정광윤,Chung, Eun-Jae,Jung, Kwang-Yoon 대한기관식도과학회 2008 大韓氣管食道科學會誌 Vol.14 No.1

Subcutaneous cervicofacial, mediastinal emphysemas are complications associated with head and neck surgery, trauma, infectious processes, tooth extraction. Drill cooling stream and dental syringe air ject are the sources of high pressure air that may enter exposed soft tissue. Since the introduction of the high-speed air turbine drill in the 1960s, The incidence of iatrogenic subcutaneous emphysema has increased. Most cases begin to resolve after 2 to 3 days and residual swelling is usually minimal at the end of 7 to 10 days. Surgical approach is not advised because it is likely to be ineffective. The differential diagnosis of neck swelling after dental procedure includes hematoma, cellulitis, angioedema, allergic reaction, subcutaneous emphysema. We report a rare case of patient with subcutaneous cervicofacial emphysema and mediastinal emphysema secondary to third molar extraction.

갑상연골과 설골 골절을 동반한 후두외상 1례

강선묵,최환,정광윤,백승국,Kang, Sun-Mook,Choe, Hwan,Jung, Kwang-Yoon,Baek, Seung-Kuk 대한기관식도과학회 2007 大韓氣管食道科學會誌 Vol.13 No.1

Laryngeal trauma is an uncommon injury but can be life-threatening event. So, early diagnosis is important for appropriate surgical management and better outcome. Because there have been some controversies about Initial airway management, appropriate diagnostic evaluation, operative indication and timing, operative technique, it is difficult to make a common management pathway in laryngeal trauma. A case of laryngeal trauma with thyroid cartilage and hyoid bone fracture is presented with a brief review of literature.

경동맥 절제후 혈관치환술을 시행한 경동맥체 종양

최건,이은수,정광윤,최종욱,Choi, Geon,Lee, Eun-Soo,Jung, Kwang-Yoon,Choi, Jong-Ouck 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.2

Carotid body tumors are uncommon tumors of the head and neck Surgery is the primary treatment for the tumor. Large carotid body tumors frequently encircle the common, internal, and exernal carotid arteries, and extensive bleeding often complicates the resection, increasing the risk of carotid artery rupture and damange to major cranial nerves. Grafting should be used in high-risk patients. We have experienced a case of carotid body tumor which encircle the common, internal and external carotid arteries, treated with ligation of external carotid artery and grafting using Gortex between common carotid artery and internal carotid artery.