http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Conservation of the lethal giant larvae Tumor Suppressor Gene in Bos taurus coreanae
Baek, Kwang-Hyun,Kim, Yong-Soo,Chung, Hyung-Min,Ko, Jung Jae,Cha, Kwang Yul 한국유전학회 2002 Genes & Genomics Vol.24 No.2
We cloned a homologue of lethal giant larvae (lgl) tumor suppressor oncogene, bgl-l, in Bostaurus coreanae by RT-PCR using primers designed based on the conserved sequences for the lgl family members. The sequence analysis revealed that it encodes a 1,036 amino acid polypeptide containing a domain characteristic of WD-40 proteins. The amino acid sequence of bgl-1 showed a homology of 98.3%, 87.3%, 30.5%, 16.7%, 12.3% and 10.6% identity to that of mouse, human, fly, C. elegans, yeast SOP1 and SOP2, respectively. The complementation analysis revealed that the bovine bgl-1 partially restored Na^+ tolerance in the absence of yeast lgl homologues, suggesting that the bgl-l is a bovine homologue of the lgl family and is conserved for cellular functions.
유행성 이하선염 감염 후에 발생한 전구성 조기난소부전 1예
한세열,윤태기,차광열,남윤성 대한폐경학회 1998 대한폐경학회지 Vol.4 No.2
"Premature ovarian failure has been arbitrarily defined as failure of ovarian estrogen production occurring in a hypergonadotropic state at any age between onset of menarche and 35, although some authors extend the age at 40. Biopsies obtained from the ovaries of these patients have two differnet histologic patterns. Some have marked generalized sclerosis similar to normal postmenopausal ovaries: others lack follicular development to the antrum stage, although primoudial follicles can be seen (hypofolliculogenesis). The latter finding differs from that seen in patients with gonadal streaks, who have a total lack of follicles. Mumps was one of the first infectious causes that were associated with premature ovarian failure. Cytomegalovirus oophoritis has been described in association with transplantation, lymphoma, and AIDS. One characteristic is the presence of necrosis, which is sometimes accompanied by an inflammatory reaction. We have experienced a case of prodromal premature ovarian failure that occurred after mumps infection. So we report this case with a brief review of literatures. "
한세열(Se Yul Han),윤태기(Tae Ki Yoon),차광열(Kwang Yul Cha),최동희(Dong Hee Choi),남윤성(Yoon Sung Nam) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
Systemic lupus erythematosus(SLE) is a multisystem disorder with a peak age of onset in the second and fourth decades of life predominantly occuring in females who will usually have the potential to become pregnant. This female to male predominance is greatest during childbearing years approaching a ratio of 13:1, after the menopause it declines to a ratio of 3:1, the ratio also seen in prepubertal years. In practice, despite the higher prevalence of rheumatiod arthritis, pregnancy in SLE is the most common management problem confronting physician and obstetrician amongst the connective tissue disorders and it is particularly important as the outcome of pregnancy is more unpredictable in this disease. As well as having clinical consequences for the health of both mother and fetus, pregnancy in lupus provides a model for studying the importance of other biological phenomena characterizing the disease. For example, the transplacental passage of maternal antibodies to Ro(SSA) and La(SSB) and their strong association with the neonatal lupus syndrome suggests a pathogenetic role for these autoantibodies. Other relevant issues are feto-meternal immunological tolerance and hormonal interaction with the immune system. We have experienced a case of recurrent pregnancy loss associated with systemic lupus erythematosus. So we report this case with a brief review of literatures.
한세열(Se Yul Han),윤태기(Tae Ki Yoon),차광열(Kwang Yul Cha),최동희(Dong Hee Choi),남윤성(Yoon Sung Nam) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
Toxoplasma gondii, an intracellular coccidian protozoan, is the causative agent of toxoplasmosis, a widespread infection affecting various birds and mammals including humans. In immunocompetent hosts, the infection is usually asymptomatic and benign. Toxoplasmosis is either congenital or acquired. In general prenatal therapy of congenital toxoplasmosis is beneficial in reducing the ncy of infant infection. Therapies are based primarily on spiramycin because of the relative lack of toxicity and high concentration achieved in the placenta. Clindamycin is the standard drug for chemoprophylaxis in newborn infants, and is directed at preventing the occurrence of retinochoroiditis as a late sequel to congenital infection. The standard treatment for acquired toxoplasmosis in both immunocompetent and immunodeficient patients is the synergistic combination of pyrimethamine and sulphonamides. Toxoplasmic encephalitis is tbe most common manifestation of acquired toxoplasmosis in immunocompromised patients and if not treated is fatal. However, because of toxicity, the therapeutic efficacy of pyrimethamine sulphonamide combinations may be seriously limited in immunodeficient patients. We have experienced a case of toxoplasmosis during the workup of habitual aborter. So we report this case with a brief review of literatures.
성인둔상환자에서 평균동맥압과 위해사건발생의 관련성: 단면 조사 연구
차승용 ( Seung Yong Cha ),김용환 ( Yong Hwan Kim ),홍종근 ( Chong Kun Hong ),이준호 ( Jun Ho Lee ),조광원 ( Kwang Won Cho ),황성연 ( Seong Youn Hwang ),이경렬 ( Kyoung Yul Lee ),이영환 ( Young Hwan Lee ),최성희 ( Seong Hee Choi 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.2
Purpose: Non-invasive blood pressure measurement is widely used as a pre-hospital triage tool for blunt trauma patients. However, scant data exits for using the mean arterial pressure (MAP), compared to the systolic blood pressure, as a guiding index. The aim of this study was to determine the association between adverse outcomes and mean arterial pressure (MAP) and to exhibit the therapeutic range of the MAP in adult blunt trauma patients. Methods: The electronic medical records for all trauma patients in a single hospital from January 2010 to September 2012 were retrospectively reviewed. Patients below 17 years of age, patients with penetrating injuries, and patients with serious head trauma (injuries containing any skull fractures or any intracranial hemorrhages) were excluded. Adverse outcomes were defined as one of the following: death in the Emergency Department (ED), admission via operating theater, admission to the intensive care unit, transfer to another hospital for emergency surgery, or discharge as hopeless. Results: There were 14,537 patients who met entry criteria. Adverse outcomes occurred for MAPs in range from 90 to 120 mmHg. Adverse outcomes were found, after adjusting for confounding variables, to occur increasingly as the MAP declined below 90 mmHg or rose above 120 mmHg. Conclusion: Not only lower but also higher mean arterial pressure is associated with increased adverse outcomes in adult blunt trauma patients. Thus, patients with a MAP above 120 mmHg should be considered as a special group requiring higher medical attention, just as those with a MAP below 90 mmHg are.