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Kubra Degirmenci,Ayse Kocak-Buyukdere,Bulent Ekici 대한치과보철학회 2019 The Journal of Advanced Prosthodontics Vol.11 No.2
PURPOSE. Zirconia materials have been used for implant-retained restorations, but the stress distribution of zirconia is not entirely clear. The aim of this study is to evaluate the stress distribution and risky areas caused by the different design of zirconia restorations on the atrophic bone of the posterior maxilla. MATERIALS AND METHODS. An edentulous D4-type bone model was prepared from radiography of an atrophic posterior maxilla. Monolithic zirconia and zirconia-fused porcelain implant-retained restorations were designed as splinted or nonsplinted. 300-N occlusal forces were applied obliquely. Stress analyses were performed using a 3D FEA program. RESULTS. According to stress analysis, the bone between the 1) molar implant and the 2) premolar in the nonsplinted monolithic zirconia restoration model was stated as the riskiest area. Similarly, the maximum von Mises stress value was detected on the bone of the non-splinted monolithic zirconia models. CONCLUSION. Splinting of implant-retained restorations can be more critical for monolithic zirconia than zirconia fused to porcelain for the longevity of the bone.
Kubra Akyildiz,Ji-Hye Kim,소주희,구형준 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Gallium-based liquid metals are an attractive material for various applications, due to their excellent featuressuch as high electrical and thermal conductivity, low toxicity, and low viscosity with fluidic natureat room temperature. In particulate form, novel properties are endowed to the liquid metal, such as thecapabilities of shape transformation, plasmonic resonance and photothermal conversion. As a result,gallium-based liquid metal particles (GaLMPs) are of great importance in recent use for applications rangingfrom composites and electronics to biomedical applications. This review discusses the various preparationmethods of GaLMPs and their advantages and challenges. Up-to-date applications based on theGaLMPs are also introduced.
Kubra Yilmaz,Ilkay Hilal Gubbuk,Esra Maltas Cagil 한국고분자학회 2024 Macromolecular Research Vol.32 No.1
A new pH stimuli drug carrier platform was fabricated based on amine modified sporopollenin for targeted and controlled drug delivery. For this purpose, human serum albumin (HSA) was immobilized on 3-aminopropyltrimethoxysilane functionalized sporopollenin (Sp-APTS). Then, irinotecan (IR) was loaded to the albumin modified sporopollenin at various pH levels (2.2, 4.0, 6.0, 7.4, and 9.0). The release studies of irinotecan from drug loaded sporopollenin systems were carried out by using buffers at various pH levels such as 2.2, 4.0, 6,0, 7.4, and 9.0. The loading and release amount of IR were determined by using fluorescence spectroscopy. the results showed that the maximum loading pH was pH 4.0 with 23.44 μg. we evaluate the results in terms of the controlled release, the systems are more controllable towards basic region after pH 4.0 depends on time and pH level. Characterization of the systems was run by using thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis. One of the biodegradable biopolymers, polysaccharide based controlled drug delivery system makes the pharmaceutical formulation more bioavailable in cancer therapy.
Kubra Koc 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.1
Hippophae rhamnoides exhibit a wide variety of medicinal and pharmacological effects. The present studyaims to determine the role of ethanol extract of H. rhamnoides on oleic acid (OA)-induced acute respiratory distress syndrome(ARDS) in rats. Male rats were randomly divided into the following groups: (I) Control, (II) OA, and (III) OA+H. rhamnoides. H. rhamnoides extract (500 mg/kg) was given orally for 2 weeks before OA in Group III. Levels of total antioxidant capacity,total oxidant status (TOS), myeloperoxidase (MPO), mitogen-activated protein kinase (MAPK), acetylcholinesterase (AChE),and angiotensin-converting enzyme (ACE) were quantified by enzyme-linked immunosorbent assay (ELISA). Real timequantitative polymerase chain reaction was utilized to evaluate the expression of nuclear factor kappa B (NF-jB), tumornecrosis factor-alpha (TNF-a), interleukin (IL)-6, and matrix metalloproteinase 2 (MMP2). Also, Caspase-3 immunostainingand expression were performed to evaluate apoptosis. Compared with the OA group, there was a significantly decrease in thelevels of MPO, TOS, MAPK, and ACE and in the expression of NF-jB, TNF-a, IL-6, MMP2, and Caspase-3 in the H. rhamnoides administration group. Moreover, the activity of AChE and level of TAS were substantially higher in the H. rhamnoides administration compared with the OA group. The findings in the study suggest that the protective effect of H. rhamnoides pretreatment may act through inhibition of the ACE activity, releasing AChE, regulation of inflammatorycytokine levels, and suppression of apoptotic process in ARDS.