Histopathological Evaluation of Urothelial Carcinomas in Transurethral Resection Urinary Bladder Tumor Specimens: Eight Years of Single Center Experience

Koyuncuer, Ali Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: Urothelial carcinoma (UC) is a malignant neoplasm that most commonly occurs in the urinary bladder. The primary aim of this study was to evaluate the clinicopathologic features, recurrence and progression in patients with bladder urothelial cancer. Materials and Methods: The medical records of patients diagnosed with UC in the state pathology laboratory between January 2006 and July 2014 were retrospectively included. Carcinomas were categorized according to age, gender, histologic grade, tumor configuration, pathologic staging, recurrence status, and progression. Results: A total of 125 (113 men, 12 women) patients were examined. The mean age was 65.9 years and the male-to-female urothelial cancer incidence ratio was 9.4:1. Low-grade UCs were observed in 85 (68%) and high-grade in 40 (32%). A papillary tumor pattern was observed in 67.2% of the UCs. Cases were classified with the following pathological grades: 34 (27.2%) cases of pTa, 70 (56%) of pT1, and 21 (16.8%) of pT2. Recurrence occurred in 27 (21.6%) patients. Ten progressed to a higher stage (pT1 to pT2), and three cases to higher grade (low to high). We also analyzed the results separately for 70 (56%) patients 65 years of age and older. Conclusions: With early detection and diagnosis of precursor lesions in older patients, by methods such as standard urologic evaluation, urinary cytology, ultrasound scanning and contrast urography, and cystoscopy, in addition to coordinated efforts between pathologists and urologists, early diagnosis may reduce the morbidity and mortality of patients with urothelial carcinoma.

ABSOLUTE IRREDUCIBILITY OF BIVARIATE POLYNOMIALS VIA POLYTOPE METHOD

Koyuncu, Fatih Korean Mathematical Society 2011 대한수학회지 Vol.48 No.5

For any field F, a polynomial f $\in$ F[$x_1,x_2,{\ldots},x_k$] can be associated with a polytope, called its Newton polytope. If the polynomial f has integrally indecomposable Newton polytope, in the sense of Minkowski sum, then it is absolutely irreducible over F, i.e., irreducible over every algebraic extension of F. We present some results giving new integrally indecomposable classes of polygons. Consequently, we have some criteria giving many types of absolutely irreducible bivariate polynomials over arbitrary fields.

Effects of Progestagen and Pmsg on Estrous Synchronization and Fertility in Kivircik Ewes during Natural Breeding Season

Koyuncu, M.,Ozis Alticekic, S. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.3

An experiment was conducted using indigenous Kivircik ewes to evaluate the effect of intravaginal progestagen sponges, containing 30 mg of fluorogestone acetate (FGA), followed by administration of pregnant mare serum gonadotrophin (PMSG) on inducing synchronized oestrus in the season and fertility. Three times of PMSG administration relative to sponge withdrawal (24 h before (n = 30), at (n = 29) or 24 h after (n= 29)) and two routes of PMSG administration (intramuscular (n = 46) and subcutaneous (n = 42) were compared for estrous response, number of multiple births and fecundity rates. There were no significant differences in terms of estrous response, due to differences in the time and route of PMSG administration. Lambing percentage, proportion of multiple births and fecundity were 75.6, 51.6 and 114.6%, respectively. The administration had a significant effect on lambing (p<0.05), multiple birth and fecundity rates (p<0.01). The subcutaneous administration of PMSG resulted in a significantly higher lambing rate (p<0.05) and fecundity rate (p<0.01), compared to the intramuscular injection of the PMSG.

ABSOLUTE IRREDUCIBILITY OF BIVARIATE POLYNOMIALS VIA POLYTOPE METHOD

Fatih Koyuncu 대한수학회 2011 대한수학회지 Vol.48 No.5

For any field F; a polynomial f ∈ F[x1, x2,...., xk] can be associated with a polytope, called its Newton polytope. If the polynomial f has integrally indecomposable Newton polytope, in the sense of Minkowski sum, then it is absolutely irreducible over F; i.e., irreducible over every algebraic extension of F:We present some results giving new integrally indecomposable classes of polygons. Consequently, we have some criteria giving many types of absolutely irreducible bivariate polynomials over arbitrary fields.

A PSO based approach: Scout particle swarm algorithm for continuous global optimization problems

Hasan Koyuncu,Rahime Ceylan 한국CDE학회 2019 Journal of computational design and engineering Vol.6 No.2

In the literature, most studies focus on designing new methods inspired by biological processes, however hybridization of methods and hybridization way should be examined carefully to generate more suitable optimization methods. In this study, we handle Particle Swarm Optimization (PSO) and an efficient oper-ator of Artificial Bee Colony Optimization (ABC) to design an efficient technique for continuous function optimization. In PSO, velocity and position concepts guide particles to achieve convergence. At this point, variable and stable parameters are ineffective for regenerating awkward particles that cannot improve their personal best position (Pbest). Thus, the need for external intervention is inevitable once a useful par-ticle becomes an awkward one. In ABC, the scout bee phase acts as external intervention by sustaining the resurgence of incapable individuals. With the addition of a scout bee phase to standard PSO, Scout Particle Swarm Optimization (ScPSO) is formed which eliminates the most important handicap of PSO. Consequently, a robust optimization algorithm is obtained. ScPSO is tested on constrained optimization problems and optimum parameter values are obtained for the general use of ScPSO. To evaluate the performance, ScPSO is compared with Genetic Algorithm (GA), with variants of the PSO and ABC methods, and with hybrid approaches based on PSO and ABC algorithms on numerical function optimization. As seen in the results, ScPSO results in better optimal solutions than other approaches. In addition, its convergence is superior to a basic optimization method, to the variants of PSO and ABC algorithms, and to the hybrid approaches on different numerical benchmark functions. According to the results, the Total Statistical Success (TSS) value of ScPSO ranks first (5) in comparison with PSO variants; the second best TSS (2) belongs to CLPSO and SP-PSO techniques. In a comparison with ABC variants, the best TSS value (6) is obtained by ScPSO, while TSS of BitABC is 2. In comparison with hybrid techniques, ScPSO obtains the best Total Average Rank (TAR) as 1.375, and TSS of ScPSO ranks first (6) again. The fitness values obtained by ScPSO are generally more satisfactory than the values obtained by other methods. Consequently, ScPSO achieve promising gains over other optimization methods; in parallel with this result, its usage can be extended to different working disciplines.

AN EMPIRICAL EVALUATION OF THE MIDDLE-INCOME TRAP AND IMMISERIZING GROWTH IN BRICS COUNTRIES

Sudi Apak,HAŞMET SARIGÜL,TUĞBA KOYUNCU ÇAKMAK 중앙대학교 경제연구소 2023 Journal of Economic Development Vol.48 No.3

This study explores the middle-income trap and immiserizing growth with a particular focus on BRICS countries, which are at the center of the global economy due to many economic aspects. The existence of a middle-income trap was investigated by testing the stationarity of the time series of each BRICS country’s per capita income relative to the USA which has a balanced-growth path close to the global technology frontier’s growth rate. The findings indicate that Russia is lying within the middle-income trap. Cointegration analysis and robust regression techniques were performed to explore the immiserizing growth effects of merchandise exports. The findings reveal evidence of immiserizing growth for India and South Africa.

A new biomarker for the early diagnosis of ovarian torsion: SCUBE-1

Uyanikoglu, Hacer,Hilali, Nese Gul,Yardimciel, Mesut,Koyuncu, Ismail The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.2

Objective: Prompt diagnosis and management are essential for saving the adnexal organs from infarction in cases of ovarian torsion (OT). This study aimed to determine the diagnostic significance of signal peptide, complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels in cases of OT, an emergent ischemic condition, and the relationship of SCUBE-1 with oxidative stress parameters. Methods: This prospective study was conducted among 15 OT patients and 20 age- and gravidity-matched healthy women. SCUBE-1 serum concentrations were determined by using enzyme-linked immunosorbent assays. In addition, oxidative stress was evaluated by measuring the serum levels of advanced oxidation protein products (AOPP), ferric reducing ability of plasma (FRAP), and glutathione (GSH). Results: The SCUBE-1 titers were significantly higher in the patients with OT than in the controls (p=0.008). In addition, serum FRAP and GSH levels were significantly lower in the OT patients than in the controls (p<0.001 for both). Serum AOPP levels were higher in the OT patients, but this trend was not statistically significant (p>0.05). Furthermore, there were no correlations between SCUBE-1 levels and age, gravidity, parity, cyst size, and AOPP, FRAP, or GSH levels (p>0.05). Conclusion: We believe that SCUBE-1 may be a promising biomarker for the early diagnosis of OT.

Quorum quenching for effective control of biofouling in membrane bioreactor: A comprehensive review of approaches, applications, and challenges

Borte Kose-Mutlu,Tulay Ergon-Can,Ismail Koyuncu,Chung-Hak Lee 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.4

In comparison to alternative advanced wastewater treatment technologies, the main problem associated with membrane bioreactor (MBR) technology, which has become prominent in recent years, is biofouling. Within these systems, biofouling is typically the result of a biofilm layer resulting from bacterial gathering. One biological system that can be employed to interrupt the process of bacterial gathering is called ‘Quorum Quenching (QQ)’. Existing QQ applications can be classified using three main types: 1) bacterial/whole-cell applications, 2) direct enzyme applications, and 3) natural sourced compounds. The most common and widely recognized applications for membrane fouling control during MBR operation are bacterial and direct enzyme applications. The purpose of this review was to identify and assess biofilm formation mechanism and results, the suggestion of the QQ concept and its potential to control biofilm formation, and the means by which these QQ applications can be applied within the MBR and present QQ MBR studies.

Pollen performance modelling with an artificial neural network on commercial stone fruit cultivars

Sultan Filiz Güçlü,Ziya Öncü,Fatma Koyuncu 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.1

Pollen tube growth and pollen germination percentage are key factors for successful fruit set. Pollen performance is critical for the production and breeding of flowering plants and in agricultural systems in terms of fruit development. This study was carried out to predict pollen tube growth and pollen germination percentage in four stone fruits species (cherry (Prunus avium), apricot (Prunus armeniaca), plum (Prunus domestica), and peach (Prunus persica)) using a neural network. For this purpose, we measured pollen tube length and pollen germination rates under in vitro conditions. For the in vitro test, pollen grains of four stone fruit cultivars were sown in three different media and incubated at seven different temperatures for four incubation periods. A layered neural network was used for estimating the pollen germination rate and pollen tube length related to the in vitro condition. This study suggests a method for estimating the pollen germination rate and pollen tube length using artificial neural networks. The performed artificial neural networks produced an efficient prediction from in vitro data. The determination coefficients obtained between the observed and predicted data sets are 0.86 (for germination rate) and 0.81 (for tube length), indicating an accurate estimation of the in vitro data. In our case, the network that produced the best result had a 4:9:2 architecture.

Comparison of Milk Yield and Animal Health in Turkish Farms with Differing Stall Types and Resting Surfaces

Nurcan Karslioglu Kara,Askin Galic,Mehme Koyuncu 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.2

The current study was carried out to determine the influence of different resting surfaces and stall types on milk yield and animal health. Study was carried out in Bursa that is one of the most important cities of Turkey in terms of dairy production. Effects of resting surfaces and stall types on milk yield were found to be important. Also influence of different resting surfaces and stall types on lactation length was examined and found that rubber mats were different from the two other options. Relationships between different resting surfaces or stall types and health problems were examined and connection between stall type and repeat breeding (RB), dystocia, retained placenta and a connection between resting surface types and RB and clinical mastitis were found to be important. Considering their economic reflections, it can be said that results are quite important to the Turkish dairy industry.