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      • Diazepam의 腸管運動 抑制機轉에 關한 硏究

        鄭址昌,高啓昌 慶熙大學校 1985 論文集 Vol.14 No.-

        In order to investigate the mechanism of depression of intestinal motility with diazepam, the influences of metabolic substrates on the motility of isolated rabbit doudenum depressed with diazepam were observed. The following results were obtained; 1. motility of isolated duodenum was depressed about 40% with 0.3mM diazepam, as compared with the control. 3. Pyruvate, at concentration of 10nM, remarkably restored the motility of the duodenum depressed with diazepam in normal tyrode medium or glucose-free medium. 4. Acetate, at concentration of 10mM, also produced significant recovery of the motility of the diazepam-depressed duodenum in normal tyrode medium of blucose-free medium. 5. Fructose, at concentration of 30mM, showed little effect on the motility of the diazepam-depressed duodenum in normal tyrode medium or glucos-free medium. 6. The motility of the diazepam-depressed duodenum in the normal tyrode medium or glucose-free medium was little regained with glucose at concentration of 30mM 7. Pyruvate (10mM), acetate (10mM), fructose (30mM) and glucose (30mM) had no significant effects on the motility of the isolated control duodenum. It is concluded from the results that the glycolysis in the intestinal smooth muscle might be inhibited with diazepam and then the inhibited glycolysis might have depressed the motility of isolated rabbit-duodenum.

      • Cefotaxime과 Furosemide의 賢排泄 및 血漿蛋白 結合에 미치는 影響

        鄭址昌,金載學,韓大燮,高啓昌 慶熙大學校 1984 論文集 Vol.13 No.-

        The cephalosporins are eliminated by both glomerular filtration and tubular excretion. Chronic administration of cephalosporins may cause renal tubular necrosis. Cefotaxime is a new semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum. Therefore, to determine whether any variations at plasma protein binding with furosemide by cefotaxime were responsible for its diuretic action of urine volume and electrolytes in rabbits, author studies effects on drug-interaction of cefotaxime and furosemide. The following results were obtained. 1. The group, administrated simultaneously furosemide and cefotaxime, was significantly increased compared with furosemide alone group on the urine volume, urinary electrolytes, because markedly increased the inhibition of Na^+ and Cl^- reabsorption in the renal tubule, and glomerular filtration rate without any differences. 2. Serum concentration of cefotaxime in rabbits was significanly elevated by the combination with furosemide, and markedly inhibited the elimination levels of cefotaxime in urine of rabbits. Conclusion of above results; Synergistic effect of cefotaxime on diuretic action of furosemide showed the comparative inhibition of plasma protein binding with furosemide by cefotaxime, and the continuation of diuretic effect seems excretion of furosemide on the in-hibited by competition between furosemide and cefotaxime in renal tubular excretion.

      • Furosemide와 Cephapirin의 相互作用에 관한 硏究

        李淇範,鄭址昌,高啓昌,鄭柱浩 慶熙大學校 1988 論文集 Vol.17 No.-

        Cephapirin is a semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum, which is stable in beta-lactamase and is poorly absorbed from the gastro-intestinal tract and is given by intramuscular of intravenous injection as the sodium salt. High concentrations of furosemide and cephapirin are excreted in the urine by proximal tubular secretion. In order to investigate the drug-interaction between furosemide and cephapirin, the influences of cephapirin on the diuretic action of furosemide were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-cephapirin combined group, the furosemide-cephapirin combined group showed significant increase in urine flow and urinary electrolytes amounts. These findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. It is concluded from the result that synergistic effect of cephapirin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by cephapirin. It is also postulated that the cephapirin-elimination through the renal tubule may de delayed by the competition between furosemide and cephapirin in renal tubular secretion.

      • Ampicillin과 Furosemide의 相互作用에 관한 硏究

        李昇宰,鄭址昌,高啓昌,韓大燮 慶熙大學校 1986 論文集 Vol.15 No.-

        In order to investigate the durg-interaction between furosemide and ampicillin, the influences of ampicillin on the diuretic action of furosemide and the effects of furosemide on the urinary elimination rate and serum concentration of ampicillin were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-ampicillin combined group, the furosemide-ampicillin combined group showed significant increase in urine flow and urinary electrolytes amounts. Those findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. Throughout the combined administration of furosemide and ampicillin. the serum concentration of ampicillin were significantly elevated, but the urinary elimination rate of ampicillin were markedly decreased in the observed rabbits. It is concluded from the results that synergistic effect of ampicillin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by ampicillin. It is also postulated that the competition between furosemide and ampicillin in renal tubular secretion.

      • Metabolizable Substrates on Functional Activity of Isolated Human Myocardium

        KO, Kye-Chang 慶熙大學校 1974 論文集 Vol.8 No.-

        心臟의 搏動에 必要한 힘은 環境條件에 따라 포도糖을 비롯한 各種代謝基質을 燃料로 하여 生産된다는 事實은 過去 많은 動物 및 臨床實驗에 依하여 硏究 確認되어 왔다. 그러나 사람의 遊離心臟에 依한 代謝基質의 直接效力에 對한 報告는 文獻上 이를 찾아볼수 없었다. 本硏究者는 美 Indiana大 醫科大學 心臟外科의 協力下에 心臟手術時 摘出되는 사람 心臟右心房의 一部를 使用, 그의 體外搏動實驗에 成功, 遊離人 心臟의 收縮性에 對한 各種 代謝基質의 直接效果를 比較 檢索立證하였다.

      • MECHANISM OF DEPRESSANT ACTION OF INHALATION ANESTHETICS ON THE HEART : 第1報 Halothane에 依하여 低下된 遊離心房의 收縮性에 對한 Pyruvate의 效果 1. Effect of Pyruvate on Contractility of Halothane-Depressed Isolated Atria

        Ko, Kye-Chang,Jung, Jee Chang,Han, Dae Sup 中央醫學社 1972 中央醫學 Vol.23 No.1

        Certain metabolic aspects of halothane's ,cardiac depressant action on the contractility of the myocardium were elucidated from a study of the effect of pyruvate on halothane-depressed rat atria. Approximately 6mg% halothane was required to maintain a 50% depression of the contractility of rat atria :suspended in a modified Krebs-Ringer bicarbonate glucose medium, pH 7.4, 30°C for a 2 hr.period. Pyruvate was found to restore partially the contractility of halothanedepressed atria. The maximally effective concentration of pyruvate was 2.5mM. There was minimal pyruvate effect on the force of contraction of control atria. The effect of pyruvate on halothahe- depressed .,atria was shown to be due to the pyruvate and not the sodium ion of the sodium pyruvate. Pyruvate was found to produce no increase in the contractility of atria depressed by hypertonic medium, but caused a further depression. Selected aspects regarding the myocardial cells are discussed. The results are consistent with the hypothesis that at least a part of the negative inotropic action of halothane is due to an inhibition of glucose uptake or utilization in the glycolytic pathway.

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