http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
김원석 ( W. S. Kim ),이기명 ( K. M. Lee ),차충근 ( C. K. Cha ),김덕기 ( D. K. Kim ),김영배 ( Y. B. Kim ),유병무 ( B. M. Yoo ),김진홍 ( J. H. Kim ),김영수 ( Y. S. Kim ),조성원 ( S. W. Cho ),함기백 ( K. B. Hahm ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
위암의 발생에 관여하는 종양 억제 유전자로는 p53이 잘 알려져 있으며, 주요 작용 기전 중의 하나가 apoptosis 장애 및 cell cycle 조절 실패로 보고되고 있다. 그러나 위암에서 p53의 변이는 30-65% 정도로 보고되고 있어 나머지 위암에서 발암 기전은 의문으로 남아있다. 최근에는 pS2/TFF1 단백질의 변이가 암화의 초기에 관여한다는 사실과 pS2/TFF1 knockout mice에서 위암의 발생되었다는 보고로 위암 발생시 pS2/
31 위점막의 장상피화생 아형에서 trefoil peptide (TFF1, TFF2, TFF3)의 발현
김병욱 ( B. W. Kim ),이아원 ( A. W. Lee ),이교영 ( K. Y. Lee ),김경미 ( K. M. Kim ),김재광 ( J. K. Kim ),이보인 ( B. I. Lee ),최황 ( H. Choi ),조세현 ( S. H. Cho ),최규용 ( K. Y. Choi ),채현석 ( H. S. Chae ),김성수 ( S. S. Kim ),정인식 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-
Fe-Co-W 소결체와 탄소강의 레이저 용융부 결함형성에 미치는 공정변수의 영향
김성욱(S. W. Kim),윤병현(B. H. Yoon),정우광(W. G. Jung),이창희(C. H. Lee) 한국레이저가공학회 2004 한국레이저가공학회지 Vol.7 No.3
This study was performed to clarification of the formation of weld discontinuities in the dissimilar laser fusion zone. Welding parameters were beam power of 1300, 1430, 1560, and 1700 W and travel speed of 1, 1.3, and 1.7 m/min. Most cavities in the fusion zone were observed near the tip. Cavities in the fusion zone observed to be formed and grown from pores in the tip. More cavities were formed as the beam position moves to the tip side. Small cavities were decreased but large cavities were increased when the energy input increased. W content in the fusion zone was increased with heat input and as the beam position close to the tip. In the fusion zone, W content in the dendrite boundary was increased with heat input. Considering the propagation path and fracture morphology, cracks were solidification cracking, and were initiated and propagated along the dendrite boundaries. The formation of cracks might be related with the W rich μ phase which was formed in the grain boundaries and dendrite boundaries.
포스터 발표 : 간 ; HBeAg 음성 만성 B 형 간염 환자에서 precore와 core promoter mutation이 간염의 경과에 미치는 영향 분석
이미경 ( K. M. Lee ),김성우 ( S. W. Kim ),김원석 ( W. S. Kim ),박소윤 ( S. Y. Park ),김영수 ( Y. S. Kim ),함기백 ( K. B. Hahm ),김진홍 ( J. H. Kim ),조성원 ( S. W. Cho ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 만성 B형 간염에서 HBeAg이 음전되면 대부분의 환자에서 바이러스의 증식이 감소되고 간염의 임상 양상이 호전된다고 알려져 있다. 그러나 HBeAg이 음성인 환자에서도 심한 간염이 지속되는 경우가 관찰되고 있으며, 간염 바이러스의 precore 또는 core promoter에 mutation이 있는 경우 HBeAg의 생산에 장애가 초래되고, precore mutation은 간염의 임상 양상에도 영향을 준다는 보고도 있다. 따라서 연자 등은 HB
알코올성 위염 발생시 cytokine/chemokine의 발현 및 항산화제에 의한 예방효과
안병옥 ( B. O. An ),이기명 ( K. Y. Lee ),김성우 ( S. W. Kim ),박소윤 ( S. Y. Park ),김정은 ( J. E. Kim ),김영배 ( Y. B. Kim ),오태영 ( T. Y. Oh ),김원배 ( W. B. Kim ),김진홍 ( J. H. Kim ),유병무 ( B. M. Yoo ),조성원 ( S. W. Cho ),함기백 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 알코올에 의한 위점막의 손상 기전으로는 nonprotein sulfhydryl 농도의 감소, reduced glutathionine의 감소, 위산분비 증가, 위액 내 prostaglandin의 감소, 산소 라디칼의 증가로 위염 및 위점막 출혈이 발생하고, 이러한 병변이 진행되면서 위미란과 위궤양으로 진전된다. 그러므로 알코올에 의한 위점막 손상시에 염증 정도를 결정할 수 있는 cytokine (IL-1β, TNF-β, IL-3, IL-4, IL
김창주(C . J . Kim),김병완(B . W . Kim) 한국축산학회 1991 한국축산학회지 Vol.33 No.5
This experiment, as a part of tire studies on soiling forage production for the dairy farm in the Taekw-anryong area was curried out to determine the appropriate keel and method of nitrogen application and examine proper level of lime application to the forage rape(Brassica napus Subsp. oleifera) Two cultivars of the forage rape, Akela and Ramon. were sown on the experimental field(840m above sea level) located in Hoengke-2-ri Toam-myon Pyongchang-gun Kangwon-do. Korea. and they were harvested 70 days after the sowing The plot, of nitrogen treatment consisted of three-level plots applied with 80㎏/㏊ 160 ㎏/㏊ and 240㎏/㏊ of nitrogen. respectively and each level of nitrogen was applied through two methods. One of the methods was applying the whole amount of nitrogen us basal fertilizer (treatment mark:B100). and the other was applying one half of the nitrogen as basal fertilizer and the other half as top dressing(treatment mark: B50/T50). the plots of lime treatment consisted 01 three-level plots applied with 0㎏/㏊, 1500㎏/㏊ and 3000㎏/㏊ of lime. respectively. The results obtained were summarized a, follows 1. In plant length in the B100. Ramon marked 41.9㎝ 48.8㎝ and 53.6㎝ in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level. respectively Akela was shorter than Ramon by 1.9-3.7㎝ and the B50/T50 was shorter than the B1011 by 3.9-4.1㎝ in the both cultivars. Throughout the three level of lime application. tile plant length of Akela and Ramon ranged narrowly in 46.5-47.8㎝ and 49.3-51.1㎝ respectively: differences of plant length found among all the levels of lime application were slight. 2. In fresh forage yield in the B100, Akela and Ramon showed 32.12t/㏊ and 38.61t/㏊. 37.63t/㏊ and 52.08 t/㏊ 43.86 and 59.01t/㏊ in the plots of 80㎏/㏊ 160㎏/㏊ and 240㎏/㏊ of nitrogen level, respectively. Fresh forage yield of the B50/T50 was lower than the B100 by 4.01t/㏊ in Akela, and by 9.52t/㏊ in Ramon. Throughout the three levels of lime application. the fresh forage yield of Akela ranged narrowly in 36.18-36,70t/㏊ and Ramon narrowly in 50.64-50.82t/㏊: the effect of lime application was inconsiderable. 3. In dry matter yield in the B100, Ramon recorded 5.14t/㏊ 6.82t/㏊ and 7.22t/㏊ in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level respectively: the yield increased remarkably along with the rising level of nitrogen application(p$lt;0.05). Ramon recorded higher dry matter yield than Akela by 16.8%, 5% and 37.0% in the plots of 80㎏/㏊, 160㎏/㏊ and 240㎏/㏊ of nitrogen level, respectively(p$lt;0.05). The B50/T50 was lower in dry matter yield than the B100 by 10.0% in Akela, and by 24.3% in Ramon(p$lt; 0.05). Significant differences were not recognized among all the levels of plot treated by lime, with Akela ranging narrowly in 4.92-5.14t/㏊ and Ramon narrowly in 6.84-7.07t/㏊. 4. It seems that the appropriate level of nitrogen application is 240㎏/㏊ in the Tackwanryong area. 5. It is recommendable that the whole amount of nitrogen should he applied only as basal fertilizer rather than splitting it into one half as basal fertilizer and the other half as top dressing. 6. It is difficult to confirm the necessity of lime application.
Kim, I,Kang, E S,Yim, Y S,Ko, S J,Jeong, S-H,Rim, J H,Kim, Y S,Ahn, C W,Cha, B S,Lee, H C,Kim, C H Nature Publishing Group 2011 The pharmacogenomics journal Vol.11 No.3
SLC30A8 encodes the β-cell-specific zinc transporter-8 (ZnT-8) expressed in insulin secretory granules. The single-nucleotide polymorphism rs13266634 of SLC30A8 is associated with susceptibility to post-transplantation diabetes mellitus (PTDM). We tested the hypothesis that the polymorphic residue at position 325 of ZnT-8 determines the susceptibility to cyclosporin A (CsA) suppression of insulin secretion. INS (insulinoma)-1E cells expressing the W325 variant showed enhanced glucose-stimulated insulin secretion (GSIS) and were less sensitive to CsA suppression of GSIS. A reduced number of insulin granule fusion events accompanied the decrease in insulin secretion in CsA-treated cells expressing ZnT-8 R325; however, ZnT-8 W325-expressing cells exhibited resistance to the dampening of insulin granule fusion by CsA, and transported zinc ions into secretory vesicles more efficiently. Both tacrolimus and rapamycin caused similar suppression of GSIS in cells expressing ZnT-8 R325. However, cells expressing ZnT-8 W325 were resistant to tacrolimus, but not to rapamycin. The Down's syndrome candidate region-1 (DSCR1), an endogenous calcineurin inhibitor, overexpression and subsequent calcineurin inhibition significantly reduced GSIS in cells expressing the R325 but not the W325 variant, suggesting that differing susceptibility to CsA may be due to different interactions with calcineurin. These data suggest that the ZnT-8 W325 variant is protective against CsA-induced suppression of insulin secretion. Tolerance of ZnT-8 W325 to calcineurin activity may account for its protective effect in PTDM.